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Mycophenolic Acid Metabolism Pathway (old)
smpdb.ca/view/SMP0000652Drug metabolismMycophenolic Acid (MPA) is an immunosuppressive agent that acts as a noncompetitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). … Other metabolites of MPA include MPA-acyl glucoronide, which is formed by UGT2B7, and 6-O-desmethyl-MPA, which is formed by the CYP enzymes CYP3A4, CYP3A5 and CYP2C8.
Lysosomal Acid Lipase Deficiency (Wolman Disease)
smpdb.ca/view/SMP0000319DiseaseLysosomal Acid Lipase Deficiency, also known as Wolman disease, is predictably enough the result of a specific defect in lysosomal acid lipase.
Drugs: Cholecalciferol · ATP · Magnesium cation · Iron · Dimethylallyl Diphosphate · Formic acid +8 moreEnzymes: Lysosomal acid lipase/cholesteryl ester hydrolaseLysosomal Acid Lipase Deficiency (Wolman Disease)
smpdb.ca/view/SMP0125640DiseaseLysosomal Acid Lipase Deficiency, also known as Wolman disease, is predictably enough the result of a specific defect in lysosomal acid lipase.
Drugs: Cholecalciferol · ATP · Magnesium cation · Iron · Dimethylallyl Diphosphate · Formic acid +8 moreEnzymes: Lysosomal acid lipase/cholesteryl ester hydrolaseMetabolism and Physiological Effects of 2-Aminobenzoic acid
smpdb.ca/view/SMP0126869DiseaseIn particular, 2-aminobenzoic acid and formic acid can be biosynthesized from formylanthranilic acid through its interaction with the enzyme kynurenine formamidase. … 2-Aminobenzoic acid, also known as anthranilic acid or O-aminobenzoate, belongs to the class of organic compounds known as aminobenzoic acids.
Enzymes: Neutral amino acid transporter A, B(0,+)-type amino acid transporter 1Metabolism and Physiological Effects of Kynurenine
smpdb.ca/view/SMP0125524DiseaseTryptophan is then transported from the small intestine into the blood by an amino acid transport. … In the blood it travels to the liver and is transported into a hepatocyte by an amino acid transporter.
Enzymes: Neutral amino acid transporter A, B(0,+)-type amino acid transporter 1Fluconazole Action Pathway
smpdb.ca/view/SMP0125079Drug actionThis enzyme catalyzes the reaction of lanosterol with 3 oxygen and 3 NADPH to become 4,4-Dimethylcholesta-8,14,24-trienol with byproducts of formic acid, 4 hydrogen ions, 4 water, and 3 NADP+. … Fluconazole, known commonly as the brand name Driflucan, is an antifungal drug taken mainly orally in the form of a pill, but can also be applied topically.
Itraconazole Action Pathway
smpdb.ca/view/SMP0125099Drug actionThis enzyme catalyzes the reaction of lanosterol with 3 oxygen and 3 NADPH to become 4,4-Dimethylcholesta-8,14,24-trienol with byproducts of formic acid, 4 hydrogen ions, 4 water, and 3 NADP+.
Econazole Action Pathway
smpdb.ca/view/SMP0125404Drug actionThis enzyme catalyzes the reaction of lanosterol with 3 oxygen and 3 NADPH to become 4,4-Dimethylcholesta-8,14,24-trienol with byproducts of formic acid, 4 hydrogen ions, 4 water, and 3 NADP+.
Itraconazole Metabolism
smpdb.ca/view/SMP0125100MetabolicItraconazole is taken mainly in a pill form. The oral bioavailability of itraconazole is only 55% and is best when taken with food.
Ketoconazole Anti-fungal Action Pathway
smpdb.ca/view/SMP0125162Drug actionKetoconazole is an antifungal imidazole, known as the brand name Extina, Ketodan, Ketoderm, Nizoral, Xolegel. It is typically applied as a topical cream since there are now better oral anti-fungal drugs with less side-effects. Ketoconazo...