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Displaying all 8 results
  1. Target

    Janus (JAK) kinases

    go.drugbank.com/bio_entities/BE0027976
    TargetHumans

    Then, STAT5A and STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. … Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors (PubMed:16239216, PubMed:32750333, PubMed:8232552

    Polypeptides: Tyrosine-protein kinase JAK1, Tyrosine-protein kinase JAK2Synonyms: JAK-1, JAK-2
  2. Target

    Tyrosine-protein kinase JAK3

    go.drugbank.com/bio_entities/BE0003493
    TargetHumans

    Then, STAT5A and STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. … For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic

    Polypeptides: Tyrosine-protein kinase JAK3Synonyms: JAK-3, L-JAK
  3. Target

    Tyrosine-protein kinase JAK2

    go.drugbank.com/bio_entities/BE0002408
    TargetHumans

    Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. … Binding of CNTF or the CLCF1/CLF heterodimer to CNTFR leads to IL6ST/gp130-LIFR dimerization followed by activation of JAK1 and JAK2 which in turns phosphorylate IL6ST/gp130 and LIFR (PubMed:11294841).

    Polypeptides: Tyrosine-protein kinase JAK2Synonyms: JAK-2
  4. Target

    Tyrosine-protein kinase JAK1

    go.drugbank.com/bio_entities/BE0004145
    TargetHumans

    Binding of CNTF or the CLCF1/CLF heterodimer to CNTFR leads to IL6ST/gp130-LIFR dimerization followed by activation of JAK1 and JAK2 which in turns phosphorylate IL6ST/gp130 and LIFR (PubMed:11294841). … Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors (PubMed:16239216, PubMed:32750333, PubMed:8232552

    Polypeptides: Tyrosine-protein kinase JAK1Synonyms: JAK-1
  5. Target

    Citrate synthase, mitochondrial

    go.drugbank.com/bio_entities/BE0004459
    TargetEnzymeHumans

    Key enzyme of the Krebs tricarboxylic acid cycle which catalyzes the synthesis of citrate from acetyl coenzyme A and oxaloacetate

    Synonyms: Citrate (Si)-synthase
  6. Target

    Aldo-keto reductase family 1 member B10

    go.drugbank.com/bio_entities/BE0004353
    TargetEnzymeHumans

    Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:12732097, PubMed:18087047, PubMed:19013440, PubMed:19563777, PubMed:9565553). Displays strong enzymatic ac...

    Synonyms: SI reductase
  7. Target

    Protein arginine N-methyltransferase 5

    go.drugbank.com/bio_entities/BE0011121
    TargetHumans

    Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, P...

    Synonyms: Jak-binding protein 1
  8. Target

    Aldo-keto reductase family

    go.drugbank.com/bio_entities/BE0009802
    EnzymeHumans

    Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol (By similarity). Has low NADPH-dependent reductase activity towards 9,10-phenanthrenequinone (in vitro) (PubMed:12604216, PubMed:15118078)

    Synonyms: SI reductase