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Displaying all 8 results
  1. Target

    Janus (JAK) kinases

    go.drugbank.com/bio_entities/BE0027976
    TargetHumans

    Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors (PubMed:16239216, PubMed:32750333, PubMed:8232552

    Synonyms: JAK-1, JAK-2
  2. Target

    Citrate synthase, mitochondrial

    go.drugbank.com/bio_entities/BE0004459
    TargetEnzymeHumans

    Key enzyme of the Krebs tricarboxylic acid cycle which catalyzes the synthesis of citrate from acetyl coenzyme A and oxaloacetate

    Synonyms: Citrate (Si)-synthase
  3. Target

    Tyrosine-protein kinase JAK3

    go.drugbank.com/bio_entities/BE0003493
    TargetHumans

    Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-...

    Synonyms: JAK-3, L-JAK
  4. Target

    Tyrosine-protein kinase JAK2

    go.drugbank.com/bio_entities/BE0002408
    TargetHumans

    Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin receptor (MPL/TPOR); or type II receptors including I...

    Synonyms: JAK-2
  5. Target

    Tyrosine-protein kinase JAK1

    go.drugbank.com/bio_entities/BE0004145
    TargetHumans

    Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors (PubMed:16239216, PubMed:32750333, PubMed:8232552

    Synonyms: JAK-1
  6. Target

    Aldo-keto reductase family 1 member B10

    go.drugbank.com/bio_entities/BE0004353
    TargetEnzymeHumans

    Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:12732097, PubMed:18087047, PubMed:19013440, PubMed:19563777, PubMed:9565553). Displays strong enzymatic ac...

    Synonyms: SI reductase
  7. Target

    Protein arginine N-methyltransferase 5

    go.drugbank.com/bio_entities/BE0011121
    TargetHumans

    Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, P...

    Synonyms: Jak-binding protein 1
  8. Target

    Aldo-keto reductase family

    go.drugbank.com/bio_entities/BE0009802
    EnzymeHumans

    Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol (By similarity). Has low NADPH-dependent reductase activity towards 9,10-phenanthrenequinone (in vitro) (PubMed:12604216, PubMed:15118078)

    Synonyms: SI reductase