Tyrosine-protein kinase JAK3

BE0003493ProteinHumansJAK3

Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. It is acted on by 24 drugs in DrugBank.

Gene name
JAK3
UniProtKB entry
P52333Swiss-Prot
Cellular location
Endomembrane system
Residues / weight
1,124 residues · 125,098 Da
Also known as
2.7.10.2 · JAK-3 · Janus kinase 3 · L-JAK · Leukocyte janus kinase

Resolves to

Protein
UniProtP52333UniProt nameJAK3_HUMAN
Gene
HGNCHGNC:6193NCBI Gene3718GeneCardsJAK3
Pharmacology
IUPHAR/GtoPdb2049KEGGhsa:3718
Structure
PDB1YVJPDB3LXKPDB3LXL
Drugs

What you can answer from here — as of September 07, 2019

24DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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16GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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89+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tyrosine-protein kinase JAK3, how selective are they, and which programs against it are still in active trials?

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