Tyrosine-protein kinase JAK2

BE0002408ProteinHumansJAK2

Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin receptor (MPL/TPOR); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins... It is acted on by 40 drugs in DrugBank.

Gene name
JAK2
UniProtKB entry
O60674Swiss-Prot
Cellular location
Endomembrane system
Residues / weight
1,132 residues · 130,672 Da
Also known as
2.7.10.2 · JAK-2 · Janus kinase 2

Resolves to

Protein
UniProtO60674UniProt nameJAK2_HUMAN
Gene
HGNCHGNC:6192NCBI Gene3717GeneCardsJAK2
Pharmacology
IUPHAR/GtoPdb2048KEGGhsa:3717
Structure
PDB2B7APDB2W1IPDB2XA4
Drugs

What you can answer from here — as of September 07, 2019

40DrugsApproved to experimental, with action, bond type and pharmacological action
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46Clinical trialsTrials of drugs acting on it, by phase and status
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63GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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148+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tyrosine-protein kinase JAK2, how selective are they, and which programs against it are still in active trials?

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