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  1. Pathway

    Nicotinate and Nicotinamide Metabolism

    smpdb.ca/view/SMP0000048
    Metabolic

    Nicotinate (niacin) and nicotinamide - more commonly known as vitamin B3 - are precursors of the coenzymes nicotinamide-adenine dinucleotide (NAD+) and nicotinamide-adenine dinucleotide phosphate (NADP … The precursors are fed into the NAD+ biosynthetic pathwaythrough adenylation and phosphoribosylation reactions.

    Drugs: Ademetionine · L-Glutamine · Adenosine phosphate · Glutamic acid · NADH · ATP +8 more
  2. Pathway

    NAD+ Signalling and Aging

    smpdb.ca/view/SMP0084271
    Signaling

    An interesting link has emerged between NAD+ metabolism, SIRT1, SIRT3, and mitochondrial function. … NR and PARP inhibitors increased life span in worms via activation of the mitochondrial unfolded protein response UPRmt by sir2.1.

    Drugs: 5-O-phosphono-alpha-D-ribofuranosyl diphosphate · Nicotinamide · Flavin adenine dinucleotide
  3. Pathway

    NAD+ Signalling Pathway (Cancer)

    smpdb.ca/view/SMP0083297
    Signaling

    NAD+-dependent signalling pathways regulate many fundamental processes such as DNA repair, DNA transcription, cell proliferation, cell survival, cell cycle progression, apoptosis, and metabolism.

    Drugs: 5-O-phosphono-alpha-D-ribofuranosyl diphosphate · Nicotinamide · Flavin adenine dinucleotide