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TGF beta Signaling
smpdb.ca/view/SMP0524572SignalingJNK then activates ATF-2 and Jun, important transcription factors. Moreover, MKNK1 also activates Proto-oncogene c-Fos, a key transcription factor involved in cellular responses. … The TGF beta signaling pathway plays a role in regulating various cellular processes, including growth, differentiation, and immune responses.
Drugs: Magnesium cationEnzymes: Transforming growth factor beta-1, Transforming growth factor beta-3MAPK/p38
smpdb.ca/view/SMP0649855Signalingp38 kinases have been implicated to be involved in the cellular response to stress. They are proline-directed serine/threonine kinases of the mitogen-activated protein kinase (MAPK) family. This family is found in all eukaryotes for thei...
Drugs: Magnesium cationEnzymes: Transforming growth factor beta-1, Transforming growth factor beta-3Mechanisms of Fibrosis
smpdb.ca/view/SMP0540197SignalingIn this pathway, the binding of Wnt-1 to the Frizzled receptor complex results in the stabilization of β-catenin, which then translocates to the nucleus and activates transcription factors that promote … These integrin-ECM interactions, combined with the activation of transcription factors such as YAP1 and TAZ, further enhance the fibrotic response by promoting gene expression associated with ECM production
Drugs: Magnesium cationEnzymes: Transforming growth factor beta-1, Transforming growth factor beta-3VEGF Signaling
smpdb.ca/view/SMP0524112SignalingVascular Endothelial Growth Factor (VEGF) is a critical protein that promotes angiogenesis, vascular permeability, and endothelial cell function. … MAPK (ERK1/2) and PKA-PKC pathways, regulating cell growth, survival, and migration.
Enzymes: Growth factor receptor-bound protein 2, Vascular endothelial growth factor AErlotinib Action Pathway (New)
smpdb.ca/view/SMP0123148Drug actionIt reversibly binds to the intracellular tyrosine kinase ATP binding region of the epidermal growth factor receptor and acts as an inhibitor to prevent ATP from binding to the receptor at its site. … This drug is indicated to treat metastatic non-small cell lung cancer (NSCLC) with tumors showing epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) substitution mutations.
Enzymes: Pro-epidermal growth factor, Epidermal growth factor receptorInsulin (New)
smpdb.ca/view/SMP0127691PhysiologicalIn addition, various hormones, such as melatonin, estrogen, leptin, growth hormone, and glucagon like peptide-1 also regulate insulin secretion. … Insulin promotes glycogen synthesis, lipid synthesis, protein synthesis, DNA synthesis, and cellular growth and differentiation.
Enzymes: Growth factor receptor-bound protein 2, SHC-transforming protein 1mTOR Signaling pathway
smpdb.ca/view/SMP0535455Signalingfactor input. … factors, nutrients, cellular energy status, oxygen levels, and stress to orchestrate cell growth, metabolism, survival, and cytoskeletal organization.
Enzymes: Insulin-like growth factor I, Insulin-like growth factor 1 receptorInsulin Signalling
smpdb.ca/view/SMP0000391SignalingInsulin is responsible for the regulation of glucose levels in the body. It stimulates the storage of energy and inhibits the breakdown of high energy metabolites. Glycogen and lipid biosynthesis are upregulated, and conversely, glycogen...
Enzymes: Growth factor receptor-bound protein 2, SHC-transforming protein 1Ras Signaling Pathway
smpdb.ca/view/SMP0063784SignalingRAS signalling pathway is one of the main pathways to transduce intracellular signals in response to mitogens to controls cell growth, survival and anti-apoptotic programs. … RAS also effects exchange factors causing inhibition of transcription factors from FoxO family, part of promoting cell cycle arrest and apoptosis.
Enzymes: Transforming protein RhoA, Apoptotic protease-activating factor 1