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Afadin
go.drugbank.com/bio_entities/BE0004342TargetHumansBelongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin...
Synonyms: ALL1-fused gene from chromosome 6 proteinInterleukin-33
go.drugbank.com/bio_entities/BE0010097TargetHumansCytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016, PubMed:19841166). Involved in the maturation of Th2 cells inducing the se...
Synonyms: Nuclear factor from high endothelial venulesSerine/threonine-protein kinase TAO2
go.drugbank.com/bio_entities/BE0004632TargetHumansIsoform 2, but not isoform 1, is required for PCDH8 endocytosis. … Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation.
Synonyms: Kinase from chicken homolog CSerine/threonine-protein kinase TAO1
go.drugbank.com/bio_entities/BE0009392TargetHumansActs as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules
Synonyms: Kinase from chicken homolog BForkhead box protein M1
go.drugbank.com/bio_entities/BE0014280TargetHumansTranscription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DN...
Synonyms: Winged-helix factor from INS-1 cellsSerine/threonine-protein kinase TAO3
go.drugbank.com/bio_entities/BE0009393TargetHumansSerine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38...
Synonyms: Kinase from chicken homolog AInactive phospholipase C-like protein 1
go.drugbank.com/bio_entities/BE0001081TargetHumansInvolved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A recepto...
Synonyms: Phospholipase C-related but catalytically inactive proteinImmunoglobulin heavy constant alpha 2
go.drugbank.com/bio_entities/BE0004610TargetHumansConstant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglo...
Synonyms: Ig alpha-2 chain C region BUTImmunoglobulin heavy constant alpha 1
go.drugbank.com/bio_entities/BE0005097TargetHumansConstant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglo...
Synonyms: Ig alpha-1 chain C region BURImmunoglobulin heavy variable 3-30
go.drugbank.com/bio_entities/BE0004312TargetHumansV region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocy...
Synonyms: Ig heavy chain V-III region BUR