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Displaying results 1 - 10 of 46 in total
  1. Target

    Endothelial PAS domain-containing protein 1

    go.drugbank.com/bio_entities/BE0009679
    TargetHumans

    Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). ...

    Polypeptides: Endothelial PAS domain-containing protein 1Synonyms: Member of PAS protein 2, PAS domain-containing protein 2
  2. Target

    Homeobox protein engrailed-2

    go.drugbank.com/bio_entities/BE0004484
    TargetHumans

    Synonyms: Hu-En-2, Homeobox protein en-2
  3. Target

    Hypoxia-inducible factor 1-alpha

    go.drugbank.com/bio_entities/BE0002374
    TargetHumans

    Functions as a master transcriptional regulator of the adaptive response to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:18658046, PubMed:20624928, PubMed:22009797, PubMed:30125331,...

    Synonyms: Member of PAS protein 1, PAS domain-containing protein 8
  4. Target

    Platelet glycoprotein 4

    go.drugbank.com/bio_entities/BE0010538
    TargetTransporterHumans

    Multifunctional glycoprotein that acts as a receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-densit...

    Synonyms: PAS-4, PAS IV
  5. Target

    Hypoxia-inducible factor 1

    go.drugbank.com/bio_entities/BE0010297
    TargetHumans

    Transcription factor that functions as an obligate heterodimerization partner for several basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) proteins.

    Synonyms: Member of PAS protein 1, PAS domain-containing protein 8
  6. Target

    Chemotaxis protein CheY

    go.drugbank.com/bio_entities/BE0002023
    TargetEscherichia coli (strain K12)

    In its active (phosphorylated or acetylated) form, CheY exhibits enhanced binding to a switch component, FliM, at the flagellar motor which induces a change from counterclockwise to clockwise flagellar … Overexpression of CheY in association with MotA and MotB improves motility of a ycgR disruption, suggesting there is an interaction (direct or indirect) between the c-di-GMP-binding flagellar brake protein

    Polypeptides: Chemotaxis protein CheY
  7. Target

    Chemotaxis protein CheA

    go.drugbank.com/bio_entities/BE0001431
    TargetThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

    CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY (By similarity).

    Polypeptides: Chemotaxis protein CheA
  8. Target

    Glial cell line-derived neurotrophic factor

    go.drugbank.com/bio_entities/BE0002486
    TargetHumans

    Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake (PubMed:8493557). Acts by binding to its coreceptor, GFRA1, leading to autophosphoryla...

    Polypeptides: Glial cell line-derived neurotrophic factor
  9. Target

    Protein S100-A12

    go.drugbank.com/bio_entities/BE0001206
    TargetHumans

    S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its pro-inflammatory activity involves recruitment of leukocytes, promotion of cytokine...

    Synonyms: EN-RAGE
  10. Target

    Serine/threonine-protein kinase PAK 1

    go.drugbank.com/bio_entities/BE0009505
    TargetHumans

    Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in v...

    Polypeptides: Serine/threonine-protein kinase PAK 1Synonyms: PAK-1, p65-PAK