Search

Displaying results 1 - 10 of 94 in total
  1. Target

    Apolipoprotein E

    go.drugbank.com/bio_entities/BE0001119
    TargetCarrierHumans

    First, it is functionally associated with ABCA1 in the biogenesis of HDLs in tissues (PubMed:14754908, PubMed:23620513). … APOE also plays an important role in lipid transport in the central nervous system, regulating neuron survival and sprouting (PubMed:25173806, PubMed:8939961).

    Polypeptides: Apolipoprotein ESynonyms: Apo-E
  2. Target

    Carboxypeptidase E

    go.drugbank.com/bio_entities/BE0001123
    EnzymeTargetHumans

    Also acts as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage

    Polypeptides: Carboxypeptidase E
  3. Target

    E-selectin

    go.drugbank.com/bio_entities/BE0001074
    TargetHumans

    Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. … May have a role in capillary morphogenesis

    Polypeptides: E-selectinSynonyms: CD62 antigen-like family member E
  4. Target

    Endoglucanase E-4

    go.drugbank.com/bio_entities/BE0003251
    TargetThermomonospora fusca

    Polypeptides: Endoglucanase E-4Synonyms: Cellulase E-4, Endo-1,4-beta-glucanase E-4
  5. Target

    Prostaglandin E synthase

    go.drugbank.com/bio_entities/BE0011075
    TargetHumans

    Plays a key role in inflammation response, fever and pain (By similarity). … Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (PubMed:10377395, PubMed:10869354, PubMed:12244105

    Polypeptides: Prostaglandin E synthaseSynonyms: Microsomal prostaglandin E synthase 1
  6. Target

    Prostaglandin E synthase 3

    go.drugbank.com/bio_entities/BE0002480
    TargetHumans

    Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory

    Polypeptides: Prostaglandin E synthase 3
  7. Target

    Centromere-associated protein E

    go.drugbank.com/bio_entities/BE0003434
    TargetHumans

    Plays a role in spindle assembly checkpoint activation (SAC) via its interaction with BUB1B resulting in the activation of its kinase activity, which is important for activating SAC. … Suppresses chromosome congression in NDC80-depleted cells and contributes positively to congression only when microtubules are stabilized (PubMed:25743205).

    Polypeptides: Centromere-associated protein ESynonyms: CENP-E, Centromere protein E
  8. Target

    Botulinum neurotoxin type E

    go.drugbank.com/bio_entities/BE0009355
    TargetClostridium botulinum

    Precursor of botulinum neurotoxin E which has 2 coreceptors; complex polysialylated gangliosides found on neural tissue and specific membrane-anchored proteins found in synaptic vesicles. … Requires trypsinization and reduction before it can be used in assays in vitro (PubMed:8294407).

    Polypeptides: Botulinum neurotoxin type ESynonyms: BoNT/E, Bontoxilysin-E
  9. Target

    Interleukin-17 receptor E

    go.drugbank.com/bio_entities/BE0017393
    TargetHumans

    May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms.

    Polypeptides: Interleukin-17 receptor ESynonyms: IL-17 receptor E
  10. Target

    Melanoma antigen preferentially expressed in tumors

    go.drugbank.com/bio_entities/BE0010493
    TargetHumans

    In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role in chromstin

    Polypeptides: Melanoma antigen preferentially expressed in tumors