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Interleukin-11 receptor subunit alpha
go.drugbank.com/bio_entities/BE0000416TargetHumansReceptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or dif...
Synonyms: IL-11RA, IL-11R-alphaInterleukin-3 receptor subunit alpha
go.drugbank.com/bio_entities/BE0001036TargetHumansCell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells (PubMed:10527461). Li...
Synonyms: IL-3RA, IL-3R-alphaInterleukin-7 receptor subunit alpha
go.drugbank.com/bio_entities/BE0010557TargetHumansReceptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP)
Synonyms: IL-7RA, IL-7R-alphaInterleukin-5 receptor subunit alpha
go.drugbank.com/bio_entities/BE0003471TargetHumansCell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:9378992). Acts by forming a heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5 (...
Synonyms: IL-5RA, IL-5R-alphaInterleukin-6 receptor subunit alpha
go.drugbank.com/bio_entities/BE0002859TargetHumansPart of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal (PubMed:28265003). Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response...
Synonyms: IL-6R 1, IL-6RAInterleukin-23 receptor
go.drugbank.com/bio_entities/BE0015564TargetHumansAssociates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 function...
Synonyms: IL-23R, IL-23 receptorInterleukin-15 receptor subunit alpha
go.drugbank.com/bio_entities/BE0010620TargetHumansHigh-affinity receptor for interleukin-15 (PubMed:8530383). Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (By similarity). In neutrophils, binds and activates ki...
Synonyms: IL-15RA, IL-15R-alphaInterleukin-4 receptor subunit alpha
go.drugbank.com/bio_entities/BE0002420TargetHumansReceptor for both interleukin 4 and interleukin 13 (PubMed:17030238). Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production ...
Synonyms: IL-4RA, IL-4R-alphaInterleukin-12 receptor subunit beta-2
go.drugbank.com/bio_entities/BE0018860TargetHumansReceptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly en...
Synonyms: IL-12RB2, IL-12R-beta-2Interleukin-17 receptor E
go.drugbank.com/bio_entities/BE0017393TargetHumansSpecific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 ma...
Synonyms: IL-17RE, IL-17 receptor E