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Displaying results 1 - 10 of 53 in total
  1. Target

    Copper chaperone for superoxide dismutase

    go.drugbank.com/bio_entities/BE0005815
    CarrierTargetHumans

    Delivers copper to copper zinc superoxide dismutase (SOD1)

    Polypeptides: Copper chaperone for superoxide dismutase
  2. Target

    Receptor for retinol uptake STRA6

    go.drugbank.com/bio_entities/BE0009879
    TransporterHumans

    Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid (PubMed:18316031). … STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency (Probable). Does not transport retinoic acid (PubMed:18316031)

    Polypeptides: Receptor for retinol uptake STRA6
  3. Target

    Melanoma antigen preferentially expressed in tumors

    go.drugbank.com/bio_entities/BE0010493
    TargetHumans

    In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role in chromstin

    Polypeptides: Melanoma antigen preferentially expressed in tumors
  4. Target

    Membrane protein involved in aromatic hydrocarbon degradation

    go.drugbank.com/bio_entities/BE0003979
    TargetPseudomonas putida (strain F1 / ATCC 700007)

    Polypeptides: Membrane protein involved in aromatic hydrocarbon degradation
  5. Target

    Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

    go.drugbank.com/bio_entities/BE0001300
    TargetHumans

    May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K

    Polypeptides: Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
  6. Target

    Flavohemoprotein

    go.drugbank.com/bio_entities/BE0001704
    TargetCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)

    Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various … Therefore, plays a central role in the inducible response to nitrosative stress.

    Synonyms: NO oxygenase
  7. Target

    Flavohemoprotein

    go.drugbank.com/bio_entities/BE0002917
    TargetEscherichia coli (strain K12)

    Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various … Therefore, plays a central role in the inducible response to nitrosative stress.

    Synonyms: NO oxygenase
  8. Target

    Advanced glycation end product-specific receptor

    go.drugbank.com/bio_entities/BE0010032
    TransporterTargetHumans

    Advanced glycation end products (AGEs) are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes (PubMed:21565706). … Mediates the production of reactive oxygen species (ROS) in human endothelial cells (PubMed:25401185)

    Synonyms: Receptor for advanced glycation end products, Receptor for advanced glycosylation end products
  9. Target

    Calcium-dependent secretion activator 2

    go.drugbank.com/bio_entities/BE0008710
    TargetHumans

    Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. … Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides.

    Synonyms: Calcium-dependent activator protein for secretion 2
  10. Target

    Interferon-inducible protein AIM2

    go.drugbank.com/bio_entities/BE0011287
    TargetHumans

    Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation (PubMed: … Also acts as a regulator of neurodevelopment via its role in the DNA damage response: acts by promoting neural cell death in response to DNA damage in the developing brain, thereby purging genetically

    Synonyms: Absent in melanoma 2