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Copper chaperone for superoxide dismutase
go.drugbank.com/bio_entities/BE0005815CarrierTargetHumansDelivers copper to copper zinc superoxide dismutase (SOD1)
Polypeptides: Copper chaperone for superoxide dismutaseReceptor for retinol uptake STRA6
go.drugbank.com/bio_entities/BE0009879TransporterHumansImportant for the homeostasis of vitamin A and its derivatives, such as retinoic acid (PubMed:18316031). … STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency (Probable). Does not transport retinoic acid (PubMed:18316031)
Polypeptides: Receptor for retinol uptake STRA6Melanoma antigen preferentially expressed in tumors
go.drugbank.com/bio_entities/BE0010493TargetHumansIn the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role in chromstin
Polypeptides: Melanoma antigen preferentially expressed in tumorsMembrane protein involved in aromatic hydrocarbon degradation
go.drugbank.com/bio_entities/BE0003979TargetPseudomonas putida (strain F1 / ATCC 700007)Polypeptides: Membrane protein involved in aromatic hydrocarbon degradationDual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
go.drugbank.com/bio_entities/BE0001300TargetHumansMay act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K
Polypeptides: Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositideChemotaxis protein CheA
go.drugbank.com/bio_entities/BE0001431TargetThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY (By similarity).
Polypeptides: Chemotaxis protein CheAFlavohemoprotein
go.drugbank.com/bio_entities/BE0001704TargetCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various … Therefore, plays a central role in the inducible response to nitrosative stress.
Synonyms: NO oxygenaseFlavohemoprotein
go.drugbank.com/bio_entities/BE0002917TargetEscherichia coli (strain K12)Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various … Therefore, plays a central role in the inducible response to nitrosative stress.
Synonyms: NO oxygenaseAdvanced glycation end product-specific receptor
go.drugbank.com/bio_entities/BE0010032TransporterTargetHumansAdvanced glycation end products (AGEs) are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes (PubMed:21565706). … Protects cells from DNA replication stress by localizing to damaged replication forks where it stabilizes the MCM2-7 complex and promotes faithful progression of the replication fork (PubMed:36807739).
Synonyms: Receptor for advanced glycation end products, Receptor for advanced glycosylation end productsCalcium-dependent secretion activator 2
go.drugbank.com/bio_entities/BE0008710TargetHumansProbably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. … Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides.
Synonyms: Calcium-dependent activator protein for secretion 2