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Interleukin-20
go.drugbank.com/bio_entities/BE0020481TargetHumansExert its effects via the type I IL-20 receptor complex consisting of IL20RA and IL20RB (PubMed:11706020). … Alternatively, can mediate its activity through a second receptor complex called type II IL-20 receptor complex composed of IL22RA1 and IL20RB (PubMed:11564763).
Polypeptides: Interleukin-20Synonyms: IL-2020-ketosteroid reductase (20-hydroxysteroid dehydrogenase)
go.drugbank.com/bio_entities/BE0009795EnzymeHumans and other mammalsInactivates 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha,5alpha-THP) into less potent neurosteroid 3alpha,20alpha-dihydroxy-5alpha-pregnane (PubMed:11995921, PubMed:12604236). … Acts together with AKR1C4 to convert 5alpha-dihydroprogesterone (5alpha-DHP) to 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha,5alpha-THP/allopregnanolone), leading to 5alpha-DHT secretion necessary for
Synonyms: 20-alpha-HSDFunction: 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activityMatrix metalloproteinase-20
go.drugbank.com/bio_entities/BE0003696TargetHumansDegrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role i...
Polypeptides: Matrix metalloproteinase-20Synonyms: MMP-20Galectin-10
go.drugbank.com/bio_entities/BE0001886TargetHumansRegulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg)
Polypeptides: Galectin-10Synonyms: Gal-10Frizzled-10
go.drugbank.com/bio_entities/BE0020969TargetHumansReceptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclea...
Polypeptides: Frizzled-10Synonyms: Fz-10Interleukin-10
go.drugbank.com/bio_entities/BE0002484TargetHumansMajor immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetram...
Polypeptides: Interleukin-10Synonyms: IL-10Aquaporin-10
go.drugbank.com/bio_entities/BE0018706TransporterHumansAquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:11573934, PubMed:12084581, PubMed:217338...
Polypeptides: Aquaporin-10Synonyms: AQP-10, Aquaglyceroporin-10Immunoglobulin kappa variable 3-20
go.drugbank.com/bio_entities/BE0000616TargetHumansV region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocy...
Polypeptides: Immunoglobulin kappa variable 3-20Monocarboxylate transporter 10
go.drugbank.com/bio_entities/BE0003654TransporterHumansSodium- and proton-independent thyroid hormones and aromatic acids transporter (PubMed:11827462, PubMed:18337592, PubMed:28754537). Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) wit...
Polypeptides: Monocarboxylate transporter 10Synonyms: MCT 10, Solute carrier family 16 member 10Interferon-stimulated gene 20 kDa protein
go.drugbank.com/bio_entities/BE0001938TargetHumansInterferon-induced antiviral exoribonuclease that acts mainly on single-stranded RNA (PubMed:11401564, PubMed:12594219, PubMed:16033969). Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A viru...
Polypeptides: Interferon-stimulated gene 20 kDa protein