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  1. Pathway

    Tramadol Metabolism Pathway

    smpdb.ca/view/SMP0000637
    Drug metabolism

    Tramadol (also named Ultram) is a class of opioid pain medication that used for treating pain. Metabolism of tramadol mainly happened in liver cell. … The O-demethylation of tramadol is catalyzed by the cytochrome CYP2D6 to form O-Desmethyltramadol, which further metabolized to O-Desmethyltramadol glucuronide through UDP-glucuronosyltransferase 2B7 and

    Drugs: NADH · ATP · Tramadol · Mesoheme · Uridine-5'-Diphosphate · Formaldehyde
  2. Pathway

    Tramadol Action Action Pathway

    smpdb.ca/view/SMP0000671
    Drug action

    Tramadol is an analgesic drug consisting of two enantiomer forms (+)-Tramadol and (-)-Tramadol. … (-)-Tramadol inhibits norepinephrine reuptake in the central nervous system.

    Drugs: ATP · Tramadol · Norepinephrine · Dopamine · Potassium cation · Calcium
  3. Pathway

    Tramadol Opioid Agonist Action Pathway

    smpdb.ca/view/SMP0125025
    Drug action

    Tramadol binds to mu opioid receptors, stimulating the exchange of GTP for GDP on the G-protein complex. … Tramadol is a centrally-acting opioid agonist and SNRI (serotonin/norepinephrine reuptake inhibitor) used for the management of moderate to severe pain in adults.

    Drugs: ATP · Tramadol · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +2 more