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  1. Pathway

    Simvastatin Predicted Metabolism Pathway

    smpdb.ca/view/SMP0174691
    Metabolic

    Metabolites of Simvastatin are predicted with biotransformer.

    Drugs: Simvastatin · Mesoheme
  2. Pathway

    Simvastatin Action Pathway

    smpdb.ca/view/SMP0000082
    Drug action

    Simvastatin, the methylated form of lovastatin, is an inactive lactone that is metabolized in vivo to β,δ-dihydroxy acid, its most potent metabolite. … The simvastatin hydroxy acid inhibits cholesterol synthesis via the mevalonate pathway by competitively inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase.

    Drugs: Cholecalciferol · ATP · Simvastatin · Magnesium cation · Iron · Dimethylallyl Diphosphate +9 more
  3. Pathway

    Simvastatin Action Pathway (New)

    smpdb.ca/view/SMP0124578
    Drug action

    Reported side effects of Simvastatin include constipation, flatulence, dyspepsia (indigestion), abdominal pain, headache, and myalgia (muscle pain). … Simvastatin is a well-tolerated orally-administered synthetic statin that reduces total cholesterol levels, low-density lipoprotein (LDL)-cholesterol, triglyceride, and very-low-density lipoprotein (VLDL

    Drugs: Simvastatin · Calcium · Zinc · Cholesterol