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Displaying all 6 results
  1. Pathway

    Relaxin IV Signaling Pathway

    smpdb.ca/view/SMP0688465
    Signaling

    The RXFP4 signaling pathway is initiated when the insulin-like peptide INSL5 binds to the RXFP4 receptor, a G protein-coupled receptor (GPCR) predominantly expressed in the human colon and hypothalamus

    Drugs: Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Insulin-like peptide INSL5
  2. Pathway

    Fructose and Mannose Degradation

    smpdb.ca/view/SMP0000064
    Metabolic

    Fructose causes less of an insulin response compared to glucose and thus may be a preferred sugar for diabetics. … However, mannose can be detrimental to humans by causing diabetic complications.

    Drugs: NADH · ATP · Magnesium cation · Zinc · Sorbitol · D-glyceraldehyde 3-phosphate +5 more
  3. Pathway

    GABA

    smpdb.ca/view/SMP0127038
    Physiological

    GABA is found throughout the human body, though the role that it plays in many regions remains an area of active research. … The insulin-producing beta-cells of the pancreas produce GABA. It functions to inhibit pancreatic alpha cells, stimulate beta-cell growth, and convert alpha-cells to beta cells.

    Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate +2 more
  4. Pathway

    Autophagy

    smpdb.ca/view/SMP0578913
    Signaling

    Dysregulation of autophagy has been implicated in a spectrum of human diseases, including metabolic disorders (insulin resistance, diabetes, obesity), cancer (where it can act as both a tumor suppressor

    Drugs: Adenosine phosphate · Calcium
  5. Pathway

    Famotidine H2 Anti-Histamine Action Pathway

    smpdb.ca/view/SMP0126789
    Drug action

    Famotidine inhibits both basal and nocturnal gastric acid secretion, as well as acid secretion stimulated by food, caffeine, insulin, and pentagastrin.

    Drugs: ATP · Famotidine · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate
  6. Pathway

    Clotrimazole Action Pathway

    smpdb.ca/view/SMP0125104
    Drug action

    Adiponectin is a fat-derived hormone that causes insulin resistance in the liver and skeletal muscles, therefore Clotrimazole causes a partial inhibition of the insulin pathway. … The Hydroxycarboxylic acid receptor has a high affinity for (D)-beta-hydroxybutyrate and nicotinic acid, but only in high enough doses that are not present in the human body.

    Drugs: ATP · Clotrimazole · Magnesium cation · Formic acid · Cyclic adenosine monophosphate · Mesoheme +1 more