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Displaying results 1 - 10 of 332 in total
  1. Drug

    Naltrexone

    go.drugbank.com/drugs/DB00704
    ApprovedInvestigationalVet approved

    The FDA has approved naltrexone for the treatment of alcohol dependence.

    Synonyms: Naltrexone, NaltrexonSalts: Naltrexone hydrochloride
  2. Drug

    CYNK-101

    go.drugbank.com/drugs/DB18637
    Investigational

    CYNK-101 is an allogeneic human placental hematopoietic stem cell-derived natural killer (NK) cell therapy product that is genetically modified to express a variant of CD16 (CD16VP).

    Synonyms: allogeneic human placental hematopoietic stem cell derived natural killer (NK) cell therapy product that is genetically modified to express a variant of CD16 (CD16VP)
  3. Drug

    AB-201

    go.drugbank.com/drugs/DB18629
    Investigational

    AB-201 is a CAR-NK cell therapy targeted against HER2. It is under investigation for the treatment of HER2-positive cancers, including breast and gastric carcinomas.

    Synonyms: Ex vivo expanded allogeneic cord blood-derived NK cells that have been genetically modified to express a HER2-directed CAR and secrete IL-15
  4. Drug

    KITE-222

    go.drugbank.com/drugs/DB17195
    Investigational

    Synonyms: An autologous chimeric antigen receptor (CAR) T-cell therapy engineered to express an antibody-derived single-chain variable fragment that recognizes C-type lectin-like molecule-1 (CLL-1)
  5. Drug

    PRGN-3006

    go.drugbank.com/drugs/DB17229
    Investigational

    PRGN-3006 are autologous CD3+ T cells genetically modified using a non-viral system to express a CD33 CAR, membrane-bound interleukin-15, and a truncated form of human HER1T (kill switch) on the cell surface

    Synonyms: Autologous CD3+ T cells genetically modified using a non-viral system to express a CD33 CAR, membrane bound Interleukin-15, and a truncated form of human HER1t (kill switch) on the cell surface
  6. Drug

    B7-H3-specific chimeric antigen receptor T cells

    go.drugbank.com/drugs/DB18567
    Experimental

    Synonyms: allogeneic T cells genetically modified to express anti-B7-H3 chimeric antigen receptor (CAR)
  7. Pathway

    Naltrexone Metabolism

    smpdb.ca/view/SMP0125328
    Metabolic

    Only 2% of naltrexone remains as the original naltrexone while the remainder is metabolized into 6-beta-naltrexol and other minor metabolites. … In the liver naltrexone is metabolized into 6-beta-naltrexol. It was predicted by biotransformer that Cytochrome P450 2C9 metabolizes naltrexone into 6-beta-naltrexol.

    Drugs: Naltrexone · Mesoheme
  8. Pathway

    Naltrexone Action Pathway

    smpdb.ca/view/SMP0000687
    Drug action

    Naltrexone is also a type of medication that are used for manage opioid or alcohol dependence. … Naltrexone (also known as ReVia and Vivitrol) is a competitive antagonist of mu-type opioid receptor in the central nervous system (CNS).

    Drugs: ATP · Norepinephrine · Naltrexone · Dopamine · Potassium cation · Calcium
  9. Drug

    Olea europaea pollen

    go.drugbank.com/drugs/DB10378
    Approved

    Olea europaea pollen is the pollen of the Olea europaea plant. Olea europaea pollen is mainly used in allergenic testing.

    Synonyms: Olea europaea pollen, european olive pollen extractProducts: European Olive Pollen, Olea Europaea Pollen
  10. Pathway

    Naltrexone Opioid Antagonist Action Pathway

    smpdb.ca/view/SMP0125274
    Drug action

    Naltrexone inhibits Mu, Kappa, and Delta opioid receptors, with the highest affinity for the mu-type opioid receptors. … The major metabolite, 6-β-naltrexol is also a opioid antagonist that may contribute to the effects of naltrexone.

    Drugs: ATP · Naltrexone · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +1 more