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Displaying drugs 276 - 300 of 13657 in total

Ecamsule

Ecamsule is an organic compound which is added to many sunscreens to filter out UVA rays. It is a benzylidene camphor derivative, many of which are known for their excellent photostability. Ecamsule has been approved for use in the U.S. since 2006, but only at a specific concentration and only...
Approved
Matched Description: … Ecamsule has been approved for use in the U.S. since 2006, but only at a specific concentration and only ... in a few products manufactured by L'Oreal. ... The company got approval for those products through a new drug application process. …
Matched Mixtures name: … Kiehls Activated Sun Protector Sunscreen SPF 50 For Face and Body For All Skin Types ... Kiehls Activated Sun Protector Sunscreen SPF 30 For Face and Body For All Skin Types ... Anthelios XL Melt-IN Cream …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Benzatropine

Benztropine, with the chemical formula 3alpha-diphenylmethoxytropane, is a tropane-based dopamine inhibitor used for the symptomatic treatment of Parkinson's disease. It is a combination molecule between a tropane ring, similar to cocaine, and a diphenyl ether from the dialkylpiperazines determined to be a dopamine uptake inhibitor since 1970. The generation of...
Approved
Matched Description: … chlorine substituent in the para position in one of the phenyl rings produces an increased potency for ... used for the symptomatic treatment of Parkinson's disease. ... It is a combination molecule between a tropane ring, similar to cocaine, and a diphenyl ether from the …
Matched Products: … BENZATROPINE PHEBRA SOLUTION FOR INJECTION 2 MG/2 ML …

Aripiprazole lauroxil

Aripiprazole lauroxil is a long-acting injectable atypical antipsychotic drug used in the treatment of schizophrenia in adult patients. It is a prodrug of aripiprazole, which acts as a partial agonist at the D2 and 5-HT1A receptors, and as an antagonist at the 5-HT2A receptors . Affecting about 1% of the...
Approved
Investigational
Matched Description: … to achieve appropriate levels of aripiprazole more rapidly. ... D2 receptors have been the most common target for antipsychotic agents used in the treatment of schizophrenia ... for the treatment of schizophrenia. …

Acetic acid

Acetic acid is a product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed) Acetic acid otic (for the ear) is an antibiotic that treats infections caused by bacteria or...
Approved
Matched Description: … (Stedman, 26th ed) Acetic acid otic (for the ear) is an antibiotic that treats infections caused by bacteria ... It is used locally, occasionally internally, as a counterirritant and also as a reagent. ... Acetic acid is a product of the oxidation of ethanol and of the destructive distillation of wood. …
Matched Mixtures name: … POLYLAB T-EUSOL (SOLUTION A & B) ... POLYLAB T-EUSOL( SOLUTION A & B) ... SC Pharma Eusol Solution Max A & B …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Nintedanib

Nintedanib is a small molecule kinase inhibitor used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC).[L8453,L8459] It was first approved for use in the United States in 2014. Within the spectrum of idiopathic pulmonary fibrosis treatment options, nintedanib is currently one...
Approved
Matched Description: … [A185237] As a chemotherapeutic agent for NSCLC, nintedanib, in combination with [Docetaxel], is reserved ... [L8453,L8459] It was first approved for use in the United States in 2014. ... Nintedanib is a small molecule kinase inhibitor used in the treatment of pulmonary fibrosis, systemic …

Morphine

Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength...
Approved
Investigational
Matched Description: … Morphine was granted FDA approval in 1941.[L12114] ... Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. ... [A176035] It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk …
Matched Products: … MORPH 1 A PHARMA 10MG ... MORPH 1 A PHARMA 30MG ... MORPH 1 A PHARMA 60MG …

Ruxolitinib

Ruxolitinib, formerly known as INCB018424 or INC424, is an anticancer drug and a Janus kinase (JAK) inhibitor. It is a potent and selective inhibitor of JAK1 and JAK2, which are tyrosine kinases involved in cytokine signalling and hematopoiesis. Myeloproliferative neoplasms, such as myelofibrosis and polycythemia vera, are often characterized by...
Approved
Matched Description: … [A229708] In 2014, it was approved for the treatment of polycythemia vera in adults who have an inadequate ... response to or are intolerant of [hydroxyurea] and in 2019, ruxolitinib was approved for use in steroid-refractory ... treatment for COVID-19. …
Matched Categories: … Agents for Dermatitis, Excluding Corticosteroids ... Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Osilodrostat

Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiologically elevated. Cushing's...
Approved
Investigational
Matched Description: … [L12123] It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder ... in which cortisol levels are chronically and supraphysiologically elevated. ... [A191850] Osilodrostat was approved for use in the EU in January 2020 for the treatment of endogenous …

Tivozanib

Renal cell carcinoma (RCC) is responsible for 3% of cancer cases and is one of the 10 most common cancers in adults. The average age of diagnosis is between age 65 to 74. Tivozanib, also known as FOTIVDA, is a kinase inhibitor developed to treat adult patients with relapsed or...
Approved
Investigational
Matched Description: … cancers in adults. ... Marketed by Aveo Oncology, tivozanib is a promising therapy for individuals with RCC who have not been ... Renal cell carcinoma (RCC) is responsible for 3% of cancer cases[A231314] and is one of the 10 most common …

Gestrinone

Gestrinone, also known as ethylnorgestrienone, is a synthetic steroid of the 19-nortestosterone group that is marketed in Europe, Australia, and Latin America, though not the United States or Canada, and is used primarily in the treatment of endometriosis. Gestrinone was developed in the early 1970s and was tested clinically as...
Approved
Matched Iupac: … (1R,3aS,3bS,11aS)-11a-ethyl-1-ethynyl-1-hydroxy-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,11aH-cyclopenta[a]phenanthren …
Matched Description: … Gestrinone was developed in the early 1970s and was tested clinically as a weekly oral contraceptive ... Gestrinone, also known as ethylnorgestrienone, is a synthetic steroid of the 19-nortestosterone group ... in Europe and North America. …
Matched Categories: … Hormonal Contraceptives for Systemic Use …

Ursodeoxycholic acid

Ursodeoxycholic acid (UDCA), also known as ursodiol, is a naturally-occurring bile acid that constitutes a minor fraction of the human bile acid pool.[A256272,A256277] UDCA has been used to treat liver disease for decades: its first use in traditional medicine dates back more than a hundred years.[A256267,A256463] UDCA was first characterized...
Approved
Investigational
Matched Iupac: … 4R)-4-[(1R,3aS,3bR,4S,5aS,7R,9aS,9bS,11aR)-4,7-dihydroxy-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a] …
Matched Description: … [A256272] UDCA was first approved by the FDA in 1987 for dissolution of gallstones and for primary ... [A256272,A256277] UDCA has been used to treat liver disease for decades: its first use in traditional ... biliary cirrhosis in 1996. …

Nirsevimab

Nirsevimab (MEDI8897) is a recombinant human immunoglobulin G1 kappa (IgG1ĸ) monoclonal antibody used to prevent respiratory syncytial virus (RSV) lower respiratory tract disease in neonates and infants. It binds to the prefusion conformation of the RSV F protein, a glycoprotein involved in the membrane fusion step of the viral entry...
Approved
Investigational
Matched Description: … In addition, nirsevimab was developed as a single-dose treatment for all infants experiencing their first ... [A254691] This is due to a modification in the Fc region of nirsevimab that grants it a longer half-time ... for the same indication. …
Matched Categories: … Antiinfectives for Systemic Use …

Antithrombin III human

A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.
Approved
Matched Description: … A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and ... It is a member of the serpin superfamily. …
Matched Products: … Anbinex Powder For Injection 500 I.U. ... Anbinex Powder For Injection 1000 I.U. …

Norepinephrine

Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is...
Approved
Matched Description: … It is also found in plants and is used pharmacologically as a sympathomimetic. ... Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic ... principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in …
Matched Products: … Norepinephrine Bitartrate In Sodium Chloride ... Norepinephrine Bitartrate In 5% Dextrose Injection ... N-EPI® 1mg/ml Concentrate for Solution for Infusion …

Methadone

Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain transmission. It also has a...
Approved
Matched Description: … These effects make methadone a good option for the treatment of severe pain and addiction as fewer doses ... ; in particular, methadone has a lower risk of neuropsychiatric toxicity compared to other opioids (due ... It also has a number of unique characteristics that have led to its increased use in the last two decades …
Matched Categories: … Drugs Used in Opioid Dependence ... Drugs Used in Addictive Disorders …

Almotriptan

Almotriptan is a triptan drug for the treatment of migraine headaches. Almotriptan is in a class of medications called selective serotonin receptor agonists. It works by narrowing blood vessels in the brain, stopping pain signals from being sent to the brain, and stopping the release of certain natural substances that...
Approved
Investigational
Matched Description: … Almotriptan is a triptan drug for the treatment of migraine headaches. ... Almotriptan is in a class of medications called selective serotonin receptor agonists. ... It works by narrowing blood vessels in the brain, stopping pain signals from being sent to the brain, …
Matched Categories: … Monoamine Oxidase A Substrates …

Dexibuprofen

Dexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID). It is a pharmacologically effective enantiomer of racemic ibuprofen that differs in physicochemical properties. It is proposed to be more pharmacologically active and tolerable with a better safety profile than ibuprofen due to higher concentration of active S enantiomer. Dexibuprofen has a...
Approved
Investigational
Matched Description: … Dexibuprofen has a slower dissolution rate in the simulated gastric and enteric juices compared with ... It is a pharmacologically effective enantiomer of racemic ibuprofen that differs in physicochemical properties ... For Metabolism, Enzymes, Carriers, Transporters Sections, refer to [Ibuprofen]. …

Sofosbuvir

Sofosbuvir (tradename Sovaldi) is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the...
Approved
Matched Description: … In a joint recommendation published in 2016, the American Association for the Study of Liver Diseases ... Both Canadian and American guidelines list Epclusa as a first line recommendation for all genotypes of ... combination with other antivirals for all six genotypes of Hepatitis C [L852]. …
Matched Mixtures name: … MYHEP ALL …
Matched Categories: … Antivirals for Systemic Use ... Antiinfectives for Systemic Use ... Treatments for Hepatitis C ... Antivirals for treatment of HCV infections …

Alfacalcidol

Alfacalcidol, or 1-alpha-hydroxycholecalciferol or 1-alpha-hydroxyvitamin D3, is a non-endogenous analogue of vitamin D. It plays an essential function in calcium homeostasis and bone metabolism. Alfacaldisol is activated by the enzyme 25-hydroxylase in the liver to mediate its effects in the body, or most importantly, the kidneys and bones. The pharmacological...
Approved
Nutraceutical
Matched Description: … [L33284] In approving European countries, alfacalcidol is also indicated for managing nutritional and ... Alfacalcidol, or 1-alpha-hydroxycholecalciferol or 1-alpha-hydroxyvitamin D3, is a non-endogenous analogue ... The pharmacological actions of alfacalcidol are prolonged than vitamin D because a negative feedback …
Matched Categories: … Drugs for Treatment of Bone Diseases …

Anthrax vaccine

Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to Bacillus anthracis. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsulated strain of Bacillus anthracis...
Approved
Matched Description: … Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high ... [L47526] It is considered one of the most likely agents to be used in a biological attack. ... for an Anthrax terrorist attack or for pre-exposure prophylaxis of personnel going to specific arenas …
Matched Products: … BioThrax (Anthrax Vaccine Adsorbed) Supension for Injection 50?g/dose (nominal) …

Guselkumab

Guselkumab is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody that selectively blocks interleukin-23. IL-23 is an inflammatory cytokine that activates the CD4+ T-helper (Th17) cell pathway to mediate the inflammatory cascade that induces psoriatic plaque formation . In clinical trials, guselkumab demonstrated improved skin clearance and symptomatic improvements in...
Approved
Investigational
Matched Description: … Guselkumab is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody that selectively blocks interleukin ... market name Tremfya for the treatment of adult patients with moderate-to-severe plaque psoriasis. ... In clinical trials, guselkumab demonstrated improved skin clearance and symptomatic improvements in dermatological …
Matched Products: … TREMFYA SOLUTION FOR INJECTION IN PRE-FILLED PEN 100MG/ML ... TREMFYA SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 100MG/1ML ... TREMFYA 100MG/ML SOLUTION FOR INJECTION …

Phenazopyridine

Phenazopyridine, also known as Pyridium, is a urinary tract analgesic used for the short-term management of urinary tract irritation and its associated unpleasant symptoms such as burning and pain during urination. In the USA, this drug was previously marked by Roche but has been discontinued by the FDA. It is...
Approved
Matched Description: … Phenazopyridine, also known as Pyridium, is a urinary tract analgesic used for the short-term management ... [L7832] It is still used in various parts of the world. ... In the USA, this drug was previously marked by Roche but has been discontinued by the FDA. …
Matched Mixtures name: … All-In-One UTI Emergency Kit …

Larotrectinib

Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby preventing neurotrophin-Trk interaction and...
Approved
Investigational
Matched Iupac: … (3S)-N-{5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl}-3-hydroxypyrrolidine …
Matched Description: … kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important ... [L49821] Larotrectinib was granted accelerated approval by the FDA in November 2018 for the treatment ... Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine …

Aminocaproic acid

An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.
Approved
Investigational
Matched Mixtures name: … LACSIAN new perfect all care tooth …

Tetracycline

Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some extent to the...
Approved
Vet approved
Withdrawn
Matched Description: … The FDA withdrew its approval for the use of all liquid oral drug products formulated for pediatric use ... containing tetracycline in a concentration greater than 25 mg/ml. ... Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria …
Matched Categories: … Medications that reduce magnesium levels ... Antibiotics for Topical Use ... Antibacterials for Systemic Use ... Antiinfectives for Systemic Use ... Drugs for Acid Related Disorders …
Matched Products: … Tetracycline 3 percent a First Aid Antibiotic …
Displaying drugs 276 - 300 of 13657 in total