Displaying drugs 3426 - 3450 of 11857 in total
Ticlopidine
Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who cannot...
Approved
Matched Description: … It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved ... and is indicated for patients who cannot take aspirin or in whom aspirin has not worked to prevent a ... The FDA label includes a black-box warning of neutropenia, aplastic anemia, thrombotic thrombocytopenia …
Xanthinol
Xanthinol is a very potent water-soluble derivative of niacin that can be found in diet supplements. It is also known as xanthinol nicotinate. Xaninthol is known to be a potent vasodilator that can easily pass through the cell membrane and once inside the cell it causes an increase in glucose...
Approved
Withdrawn
Matched Description: … Xanthinol is a very potent water-soluble derivative of niacin that can be found in diet supplements. ... [L1079] Xaninthol is known to be a potent vasodilator that can easily pass through the cell membrane ... [L1080] It was approved as a drug in 1998 in Canada and nowadays its status is cancelled post marketing …
Oxymetazoline
Oxymetazoline is an imidazole derivative and a potent, direct-acting alpha (α)-adrenergic agonist with affinity to both α1- and α2-adrenoceptors. Oxymetazoline is available in various formulations with a wide variety of clinical implications. The topical formulation of the drug is used to treat persistent facial redness in adults. As an effective...
Approved
Investigational
Matched Description: … Oxymetazoline is an imidazole derivative and a potent, direct-acting alpha (α)-adrenergic agonist with ... [A215542] Oxymetazoline is available in various formulations with a wide variety of clinical implications ... available in over-the-counter intranasal sprays used to relieve nasal and sinus congestion caused by a …
Moxetumomab pasudotox
CD22 is a lineage-restricted B-cell antigen that is expressed solely in on B-chronic lymphocytic leukemia, hairy cell leukemia, acute lymphocytic leukemiathe and Burkitt's lymphoma. The predecessor of Moxetumab pasudotox (MxP), named BL22, was first created based on the antibody RFB4 which specifically binds to CD22. This antibody was used to...
Approved
Investigational
Matched Description: … This antibody was used to generate a recombinant immunotoxin in which a stabilized Fv segment by a disulfide ... CD22 is a lineage-restricted B-cell antigen that is expressed solely in on B-chronic lymphocytic leukemia ... bond is fused to the _Pseudomonas_ exotoxin A (PE38) which does not have the cell-binding portion. …
Dasiglucagon
Dasiglucagon is a glucagon analog that acts to increase blood sugar levels. It consists of 29 amino acids similar to endogenous glucagon; however, it contains seven substituted amino acids for improved physical and chemical stability in its drug formulation. In March 2021, the FDA approved dasiglucagon to treat severe hypoglycemia...
Approved
Investigational
Matched Description: … Dasiglucagon is a glucagon analog that acts to increase blood sugar levels. ... It is available as a subcutaneous injection marketed as ZEGALOGUE. ... Hypoglycemia is a common side effect of antidiabetic treatments, most notably insulin and sulfonylureas …
Oteseconazole
Oteseconazole is an azole metalloenzyme inhibitor that targets fungal CYP51. CYP51, also known as 14α demethylase, participates in the formation of ergosterol, a compound that plays a vital role in the integrity of cell membranes.[L41635,A247020] By binding and inhibiting CYP51, oteseconazole is active against most microorganisms associated with recurrent vulvovaginal...
Approved
Investigational
Matched Description: … that plays a vital role in the integrity of cell membranes. ... [L41635] CYP51, also known as 14α demethylase, participates in the formation of ergosterol, a compound ... [L41635]
Unlike previous-generation azole antifungals, oteseconazole has a high selectivity for CYP51 …
Succinic acid
A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of...
Approved
Nutraceutical
Matched Description: … It is also used in foods as a sequestrant, buffer, and a neutralizing agent. ... A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine …
Streptococcus pneumoniae type 1 capsular polysaccharide antigen
Streptococcus pneumoniae type 1 capsular polysaccharide antigen is a vaccine that contains highly purified capsular polysaccharides from the invasive pneumococcal type 1 of Streptococcus pneumoniae. It is an active immunization for intramuscular or subcutaneous injection against pneumococcal disease such as pneumococcal pneumonia and pneumococcal bacteremia.
Approved
Matched Description: … Streptococcus pneumoniae type 1 capsular polysaccharide antigen is a vaccine that contains highly purified …
Streptococcus pneumoniae type 3 capsular polysaccharide antigen
Streptococcus pneumoniae type 3 capsular polysaccharide antigen is a vaccine that contains highly purified capsular polysaccharides from the invasive pneumococcal type 3 of Streptococcus pneumoniae. It is an active immunization for intramuscular or subcutaneous injection against pneumococcal disease such as pneumococcal pneumonia and pneumococcal bacteremia.
Approved
Investigational
Matched Description: … Streptococcus pneumoniae type 3 capsular polysaccharide antigen is a vaccine that contains highly purified …
Streptococcus pneumoniae type 4 capsular polysaccharide antigen
Streptococcus pneumoniae type 4 capsular polysaccharide antigen is a vaccine that contains highly purified capsular polysaccharides from the invasive pneumococcal type 4 of Streptococcus pneumoniae. It is an active immunization for intramuscular or subcutaneous injection against pneumococcal disease such as pneumococcal pneumonia and pneumococcal bacteremia.
Approved
Investigational
Matched Description: … Streptococcus pneumoniae type 4 capsular polysaccharide antigen is a vaccine that contains highly purified …
Streptococcus pneumoniae type 5 capsular polysaccharide antigen
Streptococcus pneumoniae type 5 capsular polysaccharide antigen is a vaccine that contains highly purified capsular polysaccharides from the invasive pneumococcal type 5 of Streptococcus pneumoniae. It is an active immunization for intramuscular or subcutaneous injection against pneumococcal disease such as pneumococcal pneumonia and pneumococcal bacteremia.
Approved
Investigational
Matched Description: … Streptococcus pneumoniae type 5 capsular polysaccharide antigen is a vaccine that contains highly purified …
Streptococcus pneumoniae type 8 capsular polysaccharide antigen
Streptococcus pneumoniae type 8 capsular polysaccharide antigen is a vaccine that contains highly purified capsular polysaccharides from the invasive pneumococcal type 8 of Streptococcus pneumoniae. It is an active immunization for intramuscular or subcutaneous injection against pneumococcal disease such as pneumococcal pneumonia and pneumococcal bacteremia.
Approved
Investigational
Matched Description: … Streptococcus pneumoniae type 8 capsular polysaccharide antigen is a vaccine that contains highly purified …
Streptococcus pneumoniae type 14 capsular polysaccharide antigen
Streptococcus pneumoniae type 14 capsular polysaccharide antigen is a vaccine that contains highly purified capsular polysaccharides from the invasive pneumococcal type 14 of Streptococcus pneumoniae. It is an active immunization for intramuscular or subcutaneous injection against pneumococcal disease such as pneumococcal pneumonia and pneumococcal bacteremia.
Approved
Investigational
Matched Description: … Streptococcus pneumoniae type 14 capsular polysaccharide antigen is a vaccine that contains highly purified …
Thrombin alfa
Thrombin Alfa is a human coagulation protein produced via recombinant DNA technology from a genetically modified CHO cell line. Thrombin Alfa is identical in amino acid sequence and structurally similar to naturally occurring human thrombin. Thrombin Alfa precursor is secreted to culture medium as single chain form that is proteolytically...
Approved
Matched Description: … Thrombin Alfa is a human coagulation protein produced via recombinant DNA technology from a genetically ... two-chain active form (using a protein derived from snakes) and is purified by a chromatographic process ... that yields a product having hemostatic activities similar to native human thrombin. …
Mandelic acid
Mandelic acid is an approved aromatic, alpha hydroxy acid . Mandelic acid is used as an ingredient in cosmetics and drug products applied topically.
Approved
Aprocitentan
Aprocitentan is a dual antagonist of endothelin receptors A and B used for treatment-resistant hypertension. It is the active metabolite of macitentan.
Approximately 10-15% of patients with hypertension have resistant hypertension, defined as uncontrolled high blood pressure despite the combined use of a renin-angiotensin system blocker, a calcium channel blocker,...
Approved
Investigational
Matched Description: … Aprocitentan is a dual antagonist of endothelin receptors A and B used for treatment-resistant hypertension ... renin-angiotensin system blocker, a calcium channel blocker, and a diuretic at maximally tolerated doses ... have resistant hypertension, defined as uncontrolled high blood pressure despite the combined use of a …
Belantamab mafodotin
Belantamab mafodotin, or GSK2857916, is an afucosylated monoclonal antibody that targets B cell maturation antigen conjugated to the microtubule disrupter monomethyl auristatin-F (MMAF). Belantamab mafodotin was granted FDA accelerated approval on 5 August 2020 for the treatment of multiple myeloma; however, its manufacturer began the process for withdrawal of the...
Approved
Matched Description: … available for patients in the Risk Evaluation and Mitigation Strategy (REMS) program who can enrol in a …
Rilpivirine
Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients. It is a diarylpyrimidine derivative. The internal conformational flexibility of rilpivirine and the plasticity of it interacting binding site gives it a very high potency and reduces the chance of resistance...
Approved
Matched Description: … [A31328] It is a diarylpyrimidine derivative. ... conformational flexibility of rilpivirine and the plasticity of it interacting binding site gives it a …
Mipomersen
Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. Mipomersen is indicated in...
Approved
Investigational
Matched Description: … Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic ... It is marketed under the brand name Kynamro in the United States, and the FDA label includes a black ... Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Inclisiran
Inclisiran is a long-acting, synthetic small interfering RNA (siRNA) directed against proprotein convertase subtilisin-kexin type 9 (PCSK9), which is a serine protease that regulates plasma low-density lipoprotein cholesterol (LDL-C) levels. By binding to PCSK9 messenger RNA, inclisiran prevents protein translation of PCSK9, leading to decreased concentrations of PCSK9 and plasma...
Approved
Investigational
Matched Description: … Inclisiran is a long-acting, synthetic small interfering RNA (siRNA) directed against proprotein convertase ... subtilisin-kexin type 9 (PCSK9), which is a serine protease that regulates plasma low-density lipoprotein ... risk of cardiovascular disease (CVD) and improving cardiovascular outcomes, as hypercholesterolemia is a …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Mercaptopurine
An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
Approved
Matched Categories: … OAT3/SLC22A8 Substrates with a Narrow Therapeutic Index …
Pyridoxal phosphate
This is the active form of vitamin B6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (pyridoxamine).
Approved
Investigational
Nutraceutical
Matched Description: … This is the active form of vitamin B6 serving as a coenzyme for synthesis of amino acids, neurotransmitters …
Prenylamine
Prenylamine was withdrawn from the Canadian, US, and UK markets in 1988 due to concerns regarding cardiac arrhythmias.
Approved
Withdrawn
Displaying drugs 3426 - 3450 of 11857 in total