Displaying drugs 726 - 750 of 11600 in total
Ulmus americana pollen
Ulmus americana pollen is the pollen of the Ulmus americana plant. Ulmus americana pollen is mainly used in allergenic testing.
Approved
Tilia americana pollen
Tilia americana pollen is the pollen of the Tilia americana plant. Tilia americana pollen is mainly used in allergenic testing.
Approved
Microsporum audouinii
Microsporum audouinii is a fungus which can provoke allergic reactions. Microsporum audouinii extract is used in allergenic testing.
Approved
Matched Description: … Microsporum audouinii is a fungus which can provoke allergic reactions. …
Melilotus albus pollen
Melilotus albus pollen is the pollen of the Melilotus albus plant. Melilotus albus pollen is mainly used in allergenic testing.
Approved
Aripiprazole lauroxil
Aripiprazole lauroxil is a long-acting injectable atypical antipsychotic drug used in the treatment of schizophrenia in adult patients. It is a prodrug of aripiprazole, which acts as a partial agonist at the D2 and 5-HT1A receptors, and as an antagonist at the 5-HT2A receptors .
Affecting about 1% of the...
Approved
Investigational
Matched Description: … It is a prodrug of [aripiprazole], which acts as a partial agonist at the D2 and 5-HT1A receptors, and ... Aripiprazole lauroxil is a long-acting injectable atypical antipsychotic drug used in the treatment of ... adult population in the United States and approximately 26 million people worldwide, schizophrenia is a …
Oxytetracycline
A tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety of clinical conditions.
Approved
Investigational
Vet approved
Matched Description: … A tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety …
Daprodustat
Daprodustat is a small-molecule hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor that was developed by GSK.[A254167,A254162] Patients with CKD cannot induce erythropoietin (EPO) production in response to hypoxia or anemia. As a potent inhibitor of PHD1, PHD2 and PHD3 (≥ 1000-fold selectivity), daprodustat stabilizes cellular HIF1α and HIF2α and the induces...
Approved
Investigational
Matched Description: … Daprodustat is a small-molecule hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor that ... As a potent inhibitor of PHD1, PHD2 and PHD3 (≥ 1000-fold selectivity), daprodustat stabilizes cellular ... [A254157] A phase 3 clinical trial (NCT02879305) found that in patients with CKD undergoing dialysis, …
Cilgavimab
SARS-CoV-2, the causative agent of COVID-19, enters cells via the interaction between the trimeric spike (S) glycoprotein and host cell angiotensin-converting enzyme 2 (ACE2). Blocking the interaction between the receptor-binding domain (RBD) of the S1 subunit and ACE2 inhibits viral host cell entry; animal studies indicate that antibodies capable of...
Approved
Investigational
Matched Description: … hamster ovary (CHO) cells derived from a neutralizing antibody isolated from a patient with a natural ... [A243356, A243361] Cilgavimab (formerly AZD1061) is a recombinant monoclonal antibody produced in Chinese …
Tixagevimab
SARS-CoV-2, the causative agent of COVID-19, enters cells via the interaction between the trimeric spike (S) glycoprotein and host cell angiotensin-converting enzyme 2 (ACE2). Blocking the interaction between the receptor-binding domain (RBD) of the S1 subunit and ACE2 inhibits viral host cell entry; animal studies indicate that antibodies capable of...
Approved
Investigational
Matched Description: … hamster ovary (CHO) cells derived from a neutralizing antibody isolated from a patient with a natural ... [A243356, A243361] Tixagevimab (formerly AZD8895) is a recombinant monoclonal antibody produced in Chinese …
Amaranthus hybridus pollen
Amaranthus hybridus pollen allergenic extract is used in allergenic testing.
Approved
Potassium perchlorate
Potassium perchlorate is an inorganic salt with the chemical formula KClO4. It is a strong oxidizer with the lowest solubility of the alkali metal perchlorates. Potassium is most commonly used in flares and automobile airbags . The use of potassium perchlorate as a component in sealing gaskets for food containers...
Approved
Investigational
Matched Description: … It is a strong oxidizer with the lowest solubility of the alkali metal perchlorates. ... The use of potassium perchlorate as a component in sealing gaskets for food containers has been revoked ... The therapeutic use of potassium perchlorate in thyroid disorders has been ceased due to a high risk …
Topiramate
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with phentermine for chronic weight management therapy...
Approved
Matched Description: … Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. ... chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. ... [A175249] Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel …
Nabilone
Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, however it is considered to be twice as...
Approved
Investigational
Matched Description: … for such a wide variety of medical conditions. ... Nabilone is a racemate consisting of the (S,S) and the (R,R) isomers. ... (THCA-A) and cannabidiolic acid (CBDA), through decarboxylation reactions. …
Protokylol
Protokylol is a β-adrenergic receptor agonist used as a bronchodilator in Europe and the United States.
Approved
Vet approved
Matched Description: … Protokylol is a β-adrenergic receptor agonist used as a bronchodilator in Europe and the United States …
Kappadione
Kappadione is a Vitamin K derivative (chemically, it is menadiol sodium diphosphate), previously approved by FDA prior to 1982 and marketed by Lilly Marketing for this drug has been discontinued and is not available in North America . It has been found to have carcinogenic potential in mammalian cells as...
Approved
Matched Description: … Kappadione is a Vitamin K derivative (chemically, it is menadiol sodium diphosphate), previously approved ... Studies involving the active metabolite of this formulation, menadione, showed oocyte toxicity in a study …
Glimepiride
First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in accordance with progressive...
Approved
Matched Description: … First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class ... Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by ... Compared to [glipizide], another second SU drug, glimepiride has a longer duration of action. …
Resmetirom
Resmetirom is a thyroid hormone receptor-beta (THR-beta) agonist. On March 14, 2024, it was approved by the FDA as the first treatment of liver fibrosis due to noncirrhotic non-alcoholic steatohepatitis (NASH), which is a form of non-alcoholic fatty liver disease (NAFLD). Thyroid hormones directly regulate lipid metabolism in the liver;...
Approved
Investigational
Matched Description: … Resmetirom is a thyroid hormone receptor-beta (THR-beta) agonist. ... first treatment of liver fibrosis due to noncirrhotic non-alcoholic steatohepatitis (NASH), which is a …
Infigratinib
Infigratinib is a pan-fibroblast growth factor receptor (FGFR) kinase inhibitor. By inhibiting the FGFR pathway, which is often aberrated in cancers such as cholangiocarcinoma, infigratinib suppresses tumour growth. Cholangiocarcinoma is the most common primary malignancy affecting the biliary tract and the second most common primary hepatic malignancy. Infitratinib is a...
Approved
Investigational
Matched Description: … Infigratinib is a pan-fibroblast growth factor receptor (FGFR) kinase inhibitor. ... [A198963] Infitratinib is a pan-FGFR inhibitor, as it is an ATP-competitive inhibitor of all four FGFR ... of previously treated, unresectable locally advanced or metastatic cholangiocarcinoma in adults with a …
Upadacitinib
Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by synovial inflammation and hyperplasia, autoantibody production, cartilage damage...
Approved
Investigational
Matched Description: … Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic ... Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. ... [A189165] Despite a variety of therapeutic agents available for treatment, up to 40% of the patients …
Palovarotene
Fibrodysplasia Ossificans Progressiva (FOP), with an estimated worldwide prevalence of one in 2 million individuals, is an exceptionally rare genetic disorder. FOP is caused by a gain-of-function mutation in the ACVR1/ALK2 gene which results in progressive heterotopic ossification, a process wherein connective tissues (e.g. skeletal muscle, ligaments, tendons) are replaced...
Approved
Investigational
Matched Description: … It first garnered interest as a potential treatment for emphysema but was eventually recognized as a ... ], which are derivatives of [vitamin A]. ... [A244920] FOP is caused by a gain-of-function mutation in the ACVR1/ALK2 gene which results in progressive …
Azadirachta indica leaf
Azadirachta indica leaf is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Approved
Experimental
Matched Description: … Azadirachta indica leaf is a plant/plant extract used in some OTC (over-the-counter) products. …
Rumex acetosella pollen
Rumex acetosella pollen is the pollen of the Rumex acetosella plant. Rumex acetosella pollen is mainly used in allergenic testing.
Approved
Rumex altissimus pollen
Rumex altissimus pollen is the pollen of the Rumex altissimus plant. Rumex altissimus pollen is mainly used in allergenic testing.
Approved
Displaying drugs 726 - 750 of 11600 in total