Displaying drugs 11026 - 11050 of 12071 in total
XL784
XL784 is a potent inhibitor of the ADAM-10 metalloprotease enzyme, a target of significant interest because of its important role in blood vessel formation and cell proliferation. XL784 was specifically optimized to be MMP-1 sparing, thus potentially enhancing its safety profile and enabling higher dosing compared with other previously studied...
Investigational
Matched Description: … XL784 is a potent inhibitor of the ADAM-10 metalloprotease enzyme, a target of significant interest because …
G207
G207 is cancer-killing viruses, so-called oncolytic viruses, for the treatment of various forms of cancer developed by MediGene AG. These viruses are specific herpes simplex viruses, or HSVs, generally known as the cause of cold sores. MediGene uses these viruses, however, in a modified and "disarmed" form in order to...
Investigational
Matched Description: … as a therapeutic agent in humans. ... MediGene uses these viruses, however, in a modified and "disarmed" form in order to make them utilizable …
Vasomera
Investigational
IDD-1
Lipids promote the fusion of liposomes to cells. Eladem (IDD-1) is a therapeutic vaccine consisting of dendritophages that are loaded in vitro with tumor antigens and then reinjected into the subject. As with other monoclonal antibodies, this process stimulates an immune response to a particular disease-related antigen.
Investigational
Matched Description: … Eladem (IDD-1) is a therapeutic vaccine consisting of dendritophages that are loaded in vitro with tumor ... As with other monoclonal antibodies, this process stimulates an immune response to a particular disease-related …
OSI-7904L
OSI-7904L is a liposome encapsulated thymidylate synthase inhibitor, which is indicated for use in advanced gastric and/or gastroesophageal adenocarcinoma (A-G/GEJA). Current treatments also inhibit thymidylate synthase but the innovative lipid coating of OSI-7904L allows for more enduring results with administration of the TS inhibitor.
Investigational
Matched Description: … gastric and/or gastroesophageal adenocarcinoma (A-G/GEJA). ... OSI-7904L is a liposome encapsulated thymidylate synthase inhibitor, which is indicated for use in advanced …
Nisoxetine
Nisoxetine is a selective norepinephrine reuptake inhibitor (SNRI) developed in the 1970s. It was originally investigated as an antidepressant but has no current clinical applications aside from being a research standard SNRI. It has been used to research obesity and energy balance, and exerts some local analgesia effects.
Experimental
Matched Description: … Nisoxetine is a selective norepinephrine reuptake inhibitor (SNRI) developed in the 1970s. ... originally investigated as an antidepressant but has no current clinical applications aside from being a …
Tipapkinogene sovacivec
Investigational
SD118
SD118 was previously under investigation in Japan for a different indication and now, following re-profiling and evaluation in experimental animal models, has demonstrated its potential as a new oral therapy for neuropathic pain.
Investigational
Matched Description: … SD118 was previously under investigation in Japan for a different indication and now, following re-profiling ... and evaluation in experimental animal models, has demonstrated its potential as a new oral therapy for …
CTCE-0214
CTCE-0214 is a stable peptide agonist of stromal cell-derived factor-1 (SDF-1), a key signaling molecule in the proliferation, homing, engraftment and expansion of hematopoietic stem cells and white blood cells.
Investigational
Matched Description: … CTCE-0214 is a stable peptide agonist of stromal cell-derived factor-1 (SDF-1), a key signaling molecule …
MW33
MW33 is a recombinant fully human antibody to SARS-CoV-2. This antibody injection is currently being investigated against COVID-19 in the clinical trial NCT04533048 (A Clinical Study to Evaluate MW33 Injection).
Investigational
Matched Description: … MW33 is a recombinant fully human antibody to SARS-CoV-2. ... antibody injection is currently being investigated against COVID-19 in the clinical trial NCT04533048 (A …
Zofin
Zofin, previously known as Organicell Flow, is a nanoparticle-based therapeutic derived from perinatal sources which is manufactured in a way that retains the naturally occurring microRNAs without the addition of other substances .
Investigational
Matched Description: … Zofin, previously known as Organicell Flow, is a nanoparticle-based therapeutic derived from perinatal ... sources which is manufactured in a way that retains the naturally occurring microRNAs without the addition …
KAI-1455
KAI-1455 is a selective epsilon protein kinase C (εPKC) activator designed to reduce ischemic organ injury during procedures where blood supply may be compromised, such as coronary artery bypass grafting (CABG), congenital cardiac defect repair, and hip replacement and may protect against renal injury associated with contrast media. Several studies...
Investigational
Matched Description: … KAI-1455 is a selective epsilon protein kinase C (εPKC) activator designed to reduce ischemic organ injury ... Several studies have demonstrated that epsilon PKC plays a key role in cytoprotection during periods ... In preclinical studies, KAI-1455 showed a dramatic reduction in infarct size when delivered prior to …
Rosemary
Rosemary is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Experimental
Matched Description: … Rosemary is a plant/plant extract used in some OTC (over-the-counter) products. …
Ipafricept
Ipafricept is under investigation in clinical trial NCT01608867 (A Dose Escalation Study of OMP-54F28 in Subjects With Solid Tumors).
Investigational
Matched Description: … Ipafricept is under investigation in clinical trial NCT01608867 (A Dose Escalation Study of OMP-54F28 …
Hemoporfin
Hemoporfin is under investigation in clinical trial NCT03125057 (A Pilot Study of Hemoporfin PDT in Children With Port-wine Stain).
Investigational
Matched Description: … Hemoporfin is under investigation in clinical trial NCT03125057 (A Pilot Study of Hemoporfin PDT in Children …
Orelabrutinib
Orelabrutinib is under investigation in clinical trial NCT04305197 (A Study of ICP-022 in Patients With Systemic Lupus Erythematosus (SLE)).
Investigational
Matched Description: … Orelabrutinib is under investigation in clinical trial NCT04305197 (A Study of ICP-022 in Patients With …
DCVax-L
DCVax-L is a personalized immunotherapy comprising an autologous vaccine with dendritic cells loaded in vitro with autologous tumour lysate.
Investigational
Matched Description: … DCVax-L is a personalized immunotherapy comprising an autologous vaccine with dendritic cells loaded …
DTx-1252
DTx-1252 is a siRNA therapeutic under investigation for the treatment of Charcot-Marie-Tooth Disease type 1A (CMTD1A).
Investigational
Matched Description: … DTx-1252 is a siRNA therapeutic under investigation for the treatment of Charcot-Marie-Tooth Disease …
Etavopivat
Etavopivat is a small molecule activator of erythrocyte pyruvate kinase (PKR) under investigation for the treatment of sickle cell disease.
Investigational
Matched Description: … Etavopivat is a small molecule activator of erythrocyte pyruvate kinase (PKR) under investigation for …
CLBS12
CLBS12 is a GCSF-mobilized autologous cell therapy derived from CD34+ cells being investigated for the treatment of Buerger’s disease.
Investigational
Matched Description: … CLBS12 is a GCSF-mobilized autologous cell therapy derived from CD34+ cells being investigated for the …
UV1
UV1 is a cancer vaccine consisting of p719-20, p728, and p725 synthetic peptides representing fragments of the hTERT subunit
Investigational
Matched Description: … UV1 is a cancer vaccine consisting of p719-20, p728, and p725 synthetic peptides representing fragments …
mRNA-3745
mRNA-3745 is a lipid nanoparticle (LNP) encapsulated with nucleoside-modified, codon-optimized mRNAs encoding human glucose 6-phosphatase (G6Pase).
Investigational
Matched Description: … mRNA-3745 is a lipid nanoparticle (LNP) encapsulated with nucleoside-modified, codon-optimized mRNAs …
JNJ-55308942
JNJ-55308942 is under investigation in clinical trial NCT05328297 (A Study of JNJ-55308942 in the Treatment of Bipolar Depression).
Investigational
Matched Description: … JNJ-55308942 is under investigation in clinical trial NCT05328297 (A Study of JNJ-55308942 in the Treatment …
Thioproperazine
Thioproperazine is a potent neuroleptic with antipsychotic properties. Thioproperazine has a marked cataleptic and antiapomorphine activity associated with relatively slight sedative, hypothermic and spasmolytic effects. It is virtually without antiserotonin and hypotensive action and has no antihistaminic property. It is used for the treatment of all types of acute and...
Experimental
Matched Description: … Thioproperazine is a potent neuroleptic with antipsychotic properties. ... Thioproperazine has a marked cataleptic and antiapomorphine activity associated with relatively slight …
V1003
V1003 is an intranasal formulation of buprenorphine, an opiate analgesic, for the management of post-operative pain in hospital and home settings. Buprenorphine is a well-known analgesic and the intranasal formulation has the potential to provide a convenient alternative to other treatments, allowing patients to manage their post-operative pain both prior...
Investigational
Matched Description: … Buprenorphine is a well-known analgesic and the intranasal formulation has the potential to provide a …
Displaying drugs 11026 - 11050 of 12071 in total