Displaying drugs 51 - 75 of 1579 in total
rsPSMA Vaccine
Prostate-specific membrane antigen (PSMA) is an ∼100 kDa transmembrane glycoprotein that is abundantly and preferentially expressed in prostate cancer, including recurrent and hormone-refractory cases. rsPSMA Vaccine is a subunit vaccine based on a novel rsPSMA protein that represents the entire extracellular domain of PSMA (Schulke et al., PNAS 100:12590, 2003)....
Approved
Investigational
Matched Synonyms: … Recombinant soluble prostate-specific membrane antigen (rsPSMA) vaccine …
Matched Description: … The vaccine comprises purified rsPSMA protein formulated with Alhydrogel® adjuvant. ... recurrent and hormone-refractory cases. rsPSMA Vaccine is a subunit vaccine based on a novel rsPSMA protein …
Matched Description: … The vaccine comprises purified rsPSMA protein formulated with Alhydrogel® adjuvant. ... recurrent and hormone-refractory cases. rsPSMA Vaccine is a subunit vaccine based on a novel rsPSMA protein …
Sargramostim
Sargramostim is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed in yeast. It is a glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein.
Approved
Investigational
Matched Synonyms: … Recombinant human granulocyte-macrophage colony stimulating factor …
Matched Description: … Substitution of Leu23 leads to a difference from native protein. ... Sargramostim is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed …
Matched Description: … Substitution of Leu23 leads to a difference from native protein. ... Sargramostim is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed …
Parathyroid hormone
Parathyroid hormone (PTH) is a single-chain polypeptide composed of 84 amino acids. Available as Preotact, it is an identical form of human recombinant hormome which produced as a fusion protein undergoeing post-translational processing involving the cleavage of the OmpA leader sequence, leaving the mature protein as a single-chain 84 amino-acids...
Approved
Investigational
Matched Synonyms: … Parathormone (human recombinant) ... Parathyroid hormone (1-84) human recombinant …
Matched Description: … Available as Preotact, it is an identical form of human recombinant hormome which produced as a fusion ... , leaving the mature protein as a single-chain 84 amino-acids polypeptide (9.4 kDa). ... protein undergoeing post-translational processing involving the cleavage of the OmpA leader sequence …
Matched Description: … Available as Preotact, it is an identical form of human recombinant hormome which produced as a fusion ... , leaving the mature protein as a single-chain 84 amino-acids polypeptide (9.4 kDa). ... protein undergoeing post-translational processing involving the cleavage of the OmpA leader sequence …
Avalglucosidase alfa
Avalglucosidase alfa, or NeoGAA, is a drug for enzyme replacement therapy specifically designed for Pompe disease, a rare inherited neuromuscular disorder caused by the deficiency of the alpha-glucosidase (GAA) enzyme. GAA is an essential enzyme that hydrolyzes glycogen into free glucose for use in cellular functions. In Pompe disease, the...
Approved
Investigational
Matched Synonyms: … Neo-recombinant human acid alpha-glucosidase …
Matched Description: … [A232955] Avalglucosidase alfa is a recombinant form of GAA that restores deficient enzyme levels. …
Matched Description: … [A232955] Avalglucosidase alfa is a recombinant form of GAA that restores deficient enzyme levels. …
Turoctocog alfa pegol
Turoctocog alfa pegol is a pegylated version of turoctocog alfa. Novo Nordisk's brand name Esperoct (turoctocog alfa pegol, N8-GP) was approved by the US FDA on February 19, 2019.
Fundamentally, the N8-GP moiety is identical to turoctocog alfa, a recombinant human clotting factor VIII (rFVIII) with a truncated B-domain made...
Approved
Matched Synonyms: … Antihemophilic factor (recombinant), glycopegylated-exei …
Matched Description: … Fundamentally, the N8-GP moiety is identical to [turoctocog alfa], a recombinant human clotting factor …
Matched Categories: … Recombinant Proteins …
Matched Description: … Fundamentally, the N8-GP moiety is identical to [turoctocog alfa], a recombinant human clotting factor …
Matched Categories: … Recombinant Proteins …
Asparaginase Erwinia chrysanthemi
Asparaginase Erwinia chrysanthemi is an asparaginase-specific enzyme derived from Erwinia chrysanthemi used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-asparaginase was first identified in...
Approved
Investigational
Matched Synonyms: … Asparaginase Erwinia chrysanthemi (recombinant) ... asparaginase erwinia chrysanthemi (recombinant)-rywn …
Matched Description: … [L149] In June 2021, the recombinant form of asparaginase _Erwinia chrysanthemi_ was approved by the …
Matched Categories: … Narrow Therapeutic Index Drugs …
Matched Description: … [L149] In June 2021, the recombinant form of asparaginase _Erwinia chrysanthemi_ was approved by the …
Matched Categories: … Narrow Therapeutic Index Drugs …
Etanercept
Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of IgG1....
Approved
Investigational
Matched Synonyms: … Recombinant human TNF …
Matched Description: … Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton ... Etanercept is produced by recombinant DNA technology in a Chinese hamster ovary (CHO) mammalian cell …
Matched Description: … Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton ... Etanercept is produced by recombinant DNA technology in a Chinese hamster ovary (CHO) mammalian cell …
Becaplermin
Becaplermin is produced by recombinant DNA technology by insertion of the gene for the B chain of platelet derived growth factor (PDGF) into the yeast, Saccharomyces cerevisiae. Becaplermin has a molecular weight of approximately 25 KD and is a homodimer composed of two identical polypeptide chains that are bound together...
Approved
Investigational
Matched Synonyms: … Platelet-derived growth factor BB, recombinant ... Recombinant platelet-derived growth factor BB …
Matched Description: … Becaplermin is produced by recombinant DNA technology by insertion of the gene for the B chain of platelet …
Matched Description: … Becaplermin is produced by recombinant DNA technology by insertion of the gene for the B chain of platelet …
Casein
Casein allergenic extract is used in allergenic testing.
Approved
Matched Synonyms: … Milk protein …
Lenograstim
Lenograstim is a recombinant granulocyte colony-stimulating factor used as an immunostimulating agent.
Approved
Investigational
Matched Synonyms: … Glycosylated recombinant G-CSF ... Glycosylated recombinant granulocyte colony stimulating factor …
Matched Description: … Lenograstim is a recombinant granulocyte colony-stimulating factor used as an immunostimulating agent …
Matched Description: … Lenograstim is a recombinant granulocyte colony-stimulating factor used as an immunostimulating agent …
Insulin aspart
Insulin aspart is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the...
Approved
Matched Synonyms: … Insulin aspart recombinant ... Insulin aspart protamine recombinant …
Matched Description: … Insulin aspart is a recombinant, biosynthetic, fast-acting insulin analogue. ... Insulin also inhibits hepatic glucose production, enhances protein synthesis, and inhibits lipolysis …
Matched Description: … Insulin aspart is a recombinant, biosynthetic, fast-acting insulin analogue. ... Insulin also inhibits hepatic glucose production, enhances protein synthesis, and inhibits lipolysis …
Cipaglucosidase alfa
Cipaglucosidase alfa (ATB200) is a novel recombinant human acid alpha-glucosidase (GAA) investigated for the treatment of patients with Pompe disease, a rare inherited metabolic disorder characterized by a deficiency in GAA. Other types of enzyme replacement therapy for the treatment of Pompe disease include alglucosidase alfa and avalglucosidase alfa. Cipaglucosidase...
Approved
Investigational
Matched Synonyms: … Recombinant human acid alpha-glucosidase optimized for high expression of mannose 6-phosphate …
Matched Description: … Cipaglucosidase alfa (ATB200) is a novel recombinant human acid alpha-glucosidase (GAA) investigated …
Matched Description: … Cipaglucosidase alfa (ATB200) is a novel recombinant human acid alpha-glucosidase (GAA) investigated …
Human interferon beta
Human interferon beta is a polypeptide used in the management of relapsing forms of Multiple Sclerosis (MS), and was initially approved by the FDA in 1992. Multiple Sclerosis is a devastating neurodegenerative disease that is usually progressive and significantly debilitating with a profound impact on the quality of life. Interferon...
Approved
Investigational
Matched Synonyms: … Interferon beta (recombinant) …
Elotuzumab
Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family member 7, a cell surface glycoprotein. Elotuzumab...
Approved
Matched Synonyms: … Immunoglobulin G1, anti-(human protein CS1) (human-mouse HuLuc63 heavy chain), disulfide with human-mouse …
Matched Description: … Elotuzumab is produced in NS0 cells by recombinant DNA technology. …
Matched Categories: … Narrow Therapeutic Index Drugs …
Matched Description: … Elotuzumab is produced in NS0 cells by recombinant DNA technology. …
Matched Categories: … Narrow Therapeutic Index Drugs …
Nirsevimab
Nirsevimab (MEDI8897) is a recombinant human immunoglobulin G1 kappa (IgG1ĸ) monoclonal antibody used to prevent respiratory syncytial virus (RSV) lower respiratory tract disease in neonates and infants. It binds to the prefusion conformation of the RSV F protein, a glycoprotein involved in the membrane fusion step of the viral entry...
Approved
Investigational
Matched Synonyms: … Immunoglobulin g1-kappa, anti-(human respiratory syncytial virus fusion glycoprotein f0 (protein f))human ... Immunoglobulin g1, anti-(human respiratory syncytial virus fusion protein)(human monoclonal med18897 …
Matched Description: … Nirsevimab (MEDI8897) is a recombinant human immunoglobulin G1 kappa (IgG1ĸ) monoclonal antibody used ... [L44146] It binds to the prefusion conformation of the RSV F protein, a glycoprotein involved in the …
Matched Categories: … Respiratory Syncytial Virus Anti-F Protein Monoclonal Antibody …
Matched Description: … Nirsevimab (MEDI8897) is a recombinant human immunoglobulin G1 kappa (IgG1ĸ) monoclonal antibody used ... [L44146] It binds to the prefusion conformation of the RSV F protein, a glycoprotein involved in the …
Matched Categories: … Respiratory Syncytial Virus Anti-F Protein Monoclonal Antibody …
Agalsidase alfa
Agalsidase alfa is a recombinant human α-galactosidase A similar to agalsidase beta. While patients generally do not experience a clinically significant difference in outcomes between the two drugs, some patients may experience greater benefit with agalsidase beta.[A220228,A220233] Use of agalsidase beta has decreased in Europe, in favor of agalsidase alfa,...
Approved
Matched Synonyms: … Recombinant alpha-galactosidase A …
Matched Description: … Agalsidase alfa is a recombinant human α-galactosidase A similar to [agalsidase beta]. …
Matched Categories: … Protein Isoforms …
Matched Description: … Agalsidase alfa is a recombinant human α-galactosidase A similar to [agalsidase beta]. …
Matched Categories: … Protein Isoforms …
Beremagene geperpavec
Beremagene geperpavec is a live, replication-defective herpes simplex virus type 1 (HSV-1)-based vector therapy. Developed by Krystal Biotech, it was first approved by the FDA on May 19, 2023, for the treatment of wounds associated with dystrophic epidermolysis bullosa (DEB). DEB is caused by mutations in the COL7A1 gene that...
Approved
Matched Synonyms: … Dna (recombinant herpes simplex virus type 1 strain kos plasmid vector kb103 human collagen col7a1-specifying …
Matched Description: … Beremagene geperpavec is genetically modified to deliver _COL7A1_, thereby restoring the levels of the COL7 protein …
Matched Description: … Beremagene geperpavec is genetically modified to deliver _COL7A1_, thereby restoring the levels of the COL7 protein …
Dostarlimab
Dostarlimab is an IgG4 humanized monoclonal antibody targeted against the human programmed death receptor-1 (PD-1). PD-1 receptors are found on T-cells and, when activated, serve to inhibit immune responses - some cancers leverage this system by overexpressing PD-1 ligands, thereby effectively inhibiting the anti-tumor immune response that would typically attempt...
Approved
Investigational
Matched Synonyms: … Immunoglobulin G4, anti-programmed cell death protein 1 (PDCD1) (humanized clone ABT1 gamma4-chain), …
Matched Categories: … PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) inhibitors …
Matched Categories: … PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) inhibitors …
Factor XIII (human)
Factor XIII (human) is a heat-treated, lyophilized concentrate of coagulation factor XIII, an endogenous enzyme responsible for the crosslinking of fibrin and an essential component of the coagulation cascade [FDA Label]. For people with congenital deficiency or mutation of Factor XIII, a rare bleeding disorder, exogenous replacement of this key...
Approved
Investigational
Matched Synonyms: … Coagulation factor XIII, recombinant …
Matched Description: … DNA technology where the target protein is grown in yeast and then isolated [FDA Label]. ... drug products with similar structure and function to Factor XIII (human) include [DB09310], which is a recombinant ... Compared to Factor XIII (human), which is purified from pooled human plasma, [DB09310] is produced through recombinant …
Matched Categories: … Protein Precursors …
Matched Description: … DNA technology where the target protein is grown in yeast and then isolated [FDA Label]. ... drug products with similar structure and function to Factor XIII (human) include [DB09310], which is a recombinant ... Compared to Factor XIII (human), which is purified from pooled human plasma, [DB09310] is produced through recombinant …
Matched Categories: … Protein Precursors …
Exagamglogene autotemcel
Sickle cell disease (SCD) is a genetic disorder characterized by the production of abnormal sickle-shaped red blood cells (called hemoglobin S, HbS) that initiate a pathophysiology resulting in severe pain, progressive multi-organ damage, and premature death. Treatment options for SCD are largely focused on preventing the production and circulation of...
Approved
Investigational
Matched Synonyms: … modified by CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein …
Ebola Zaire vaccine (live, attenuated)
Ebola virus vaccine is a vaccine used to prevent Ebola virus disease caused by Zaire ebolavirus in adults, prevent outbreaks, and reduce the extent of the virus spreading in case of outbreaks. Ebola virus disease, formerly known as Ebola hemorrhagic fever, is a rare but severe and often deadly disease....
Approved
Matched Synonyms: … Recombinant Vesicular Stomatitis Virus (rVSV) strain Indiana with a deletion of the VSV envelope glycoprotein …
Matched Description: … [L10854] By introducing the relatively inactive viral protein to the patient, the patient’s immune system …
Matched Description: … [L10854] By introducing the relatively inactive viral protein to the patient, the patient’s immune system …
Elapegademase
Elapegademase is a PEGylated recombinant adenosine deaminase. It can be defined molecularly as a genetically modified bovine adenosine deaminase with a modification in cysteine 74 for serine and with about 13 methoxy polyethylene glycol chains bound via carbonyl group in alanine and lysine residues. Elapegademase is generated in E. coli,...
Approved
Matched Synonyms: … monomethoxypolyethylene glycol recombinant adenosine deaminase …
Matched Description: … Elapegademase is a PEGylated recombinant adenosine deaminase. …
Matched Categories: … Recombinant Proteins ... Recombinant Adenosine Deaminases …
Matched Description: … Elapegademase is a PEGylated recombinant adenosine deaminase. …
Matched Categories: … Recombinant Proteins ... Recombinant Adenosine Deaminases …
Pegunigalsidase alfa
Pegunigalsidase alfa (PRX-102) is a recombinant form of human α-galactosidase-A indicated for long-term enzyme replacement therapy in patients with Fabry disease, a rare genetic disorder characterized by the deficiency of alpha-galactosidase A.[A259352,L46342] Unlike other forms of recombinant alpha-galactosidase A, such as agalsidase alfa and agalsidase beta, pegunigalsidase alfa uses a...
Approved
Investigational
Matched Description: … [agalsidase beta], pegunigalsidase alfa uses a plant cell-based protein expression system, leading to ... Pegunigalsidase alfa (PRX-102) is a recombinant form of human α-galactosidase-A indicated for long-term ... [A259352,L46342] Unlike other forms of recombinant alpha-galactosidase A, such as [agalsidase alfa] and …
Matched Categories: … Recombinant Proteins …
Matched Categories: … Recombinant Proteins …
Valoctocogene roxaparvovec
Valoctocogene roxaparvovec is an adeno-associated virus serotype 5 (AAV5) based gene therapy vector that expresses the B-domain deleted SQ form of human coagulation factor VIII (hFVIII-SQ). The expression of hFVIII-SQ is driven by a liver-specific promoter, which enables hepatocytes to produce factor VIII protein and increase the levels of active...
Approved
Investigational
Matched Description: … hFVIII-SQ is driven by a liver-specific promoter, which enables hepatocytes to produce factor VIII protein …
Matched Categories: … Protein Precursors ... Recombinant Proteins …
Matched Categories: … Protein Precursors ... Recombinant Proteins …
Trolamine salicylate
Trolamine salicylate is an organic compound or a salt formed between triethanolamine and salicylic acid. Triethanolamine neutralizes the acidity of the salicylic acid. It is a topical analgesic used for temporary relief of minor pain associated with arthritis, simple backache, muscle strains, sprains, and bruises. Unlike other topical analgesics, trolamine...
Approved
Matched Products: … Real Time Pain Relief Therapeutic Hand Cream …
Displaying drugs 51 - 75 of 1579 in total