Displaying drugs 301 - 325 of 8033 in total
Ranitidine
Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as cimetidine and famotidine. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.[A176759,L10818] Ranitidine is often referred to as...
Approved
Withdrawn
Matched Description: … [L10818,F4253]
The prevalence of GERD is thought to be 10-20% in western countries. ... This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of ... [A176843] Ranitidine has proven to be an effective treatment for relieving uncomfortable symptoms of …
Phenytoin
Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for several other indications such as...
Approved
Vet approved
Matched Description: … Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of ... [A189219,A35884] Both parenteral and oral formulations of phenytoin are available on the market. …
Matched Categories: … Inducers of Drug Clearance ... Metabolic Side Effects of Drugs and Substances …
Matched Categories: … Inducers of Drug Clearance ... Metabolic Side Effects of Drugs and Substances …
Desirudin
Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three disulfide...
Approved
Matched Description: … Desirudin has a chemical formula of C287H440N80O110S6 with a molecular weight of 6963.52. ... Desirudin is a direct inhibitor of human thrombin. ... It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant …
Enasidenib
Enasidenib is an orally available treatment for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with specific mutations in the isocitrate dehydrogenase 2 (IDH2) gene, which is a recurrent mutation detected in 12-20% of adult patients with AML [A20344, A20345]. Patients eligible for this treatment...
Approved
Investigational
Matched Description: … Enasidenib is an orally available treatment for the treatment of adult patients with relapsed or refractory ... This small molecule acts as an allosteric inhibitor of mutant IDH2 enzyme to prevent cell growth, and ... Patients eligible for this treatment are selected by testing the presence of IDH2 mutations in the blood …
Angiotensin II
Angiotensin II is under investigation for the treatment of Sepsis, Septic Shock, Diabetes Mellitus, and Acute Renal Failure. Angiotensin II has been investigated for the treatment, basic science, and diagnostic of Hypertension, Renin Angiotensin System, and Idiopathic Membranous Nephropathy.
As of December 21, 2017 the FDA approved La Jolla Pharmaceutical's...
Approved
Investigational
Matched Description: … The novelty of the medication lies in the fact that it is the first and only use of synthetic human angiotensin ... Angiotensin II is under investigation for the treatment of Sepsis, Septic Shock, Diabetes Mellitus, and ... Angiotensin II has been investigated for the treatment, basic science, and diagnostic of Hypertension …
Donepezil
In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and in some...
Approved
Matched Description: … the dementia of Alzheimer's Disease, and in some cases, is used to manage other types of dementia. ... the symptoms of its associated dementia. ... increase from a global prevalence of 20.2 million in 1990. …
Dinoprostone
Dinoprostone is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour. It also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts. As a prescription drug it is used as a vaginal suppository, to prepare the cervix for labour and to induce labour.
Approved
Acetylsalicylic acid
Also known as Aspirin, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial infarction...
Approved
Vet approved
Matched Description: … Interestingly, the results of various studies have demonstrated that long-term use of acetylsalicylic ... It should be kept out of reach from young children, toddlers, and infants [FDA label]. ... Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain …
Formestane
Formestane was the first selective, type I, steroidal aromatase inhibitor used in the treatment of estrogen-receptor positive breast cancer in post-menopausal women. Formestane suppresses estrogen production from anabolic steroids or prohormones. Formestane is also a prohormone of 4-hydroxytestosterone, an active steroid with weak androgenic activity and mild aromatase inhibitor activity....
Approved
Investigational
Withdrawn
Matched Description: … Some clinical data has suggested that the clinically recommended dose of 250mg was too low. ... Formestane is also a prohormone of 4-hydroxytestosterone, an active steroid with weak androgenic activity ... Formestane was the first selective, type I, steroidal aromatase inhibitor used in the treatment of estrogen-receptor …
Oxazepam
Oxazepam is an intermediate-acting, 3-hydroxybenzodiazepine used in the treatment of alcohol withdrawal and anxiety disorders. Oxazepam, like related 3-hydroxybenzodiazepine lorazepam, is considered less susceptible to pharmacokinetic variability based on patient-specific factors (e.g. age, liver disease) - this feature is advantageous as compared to other benzodiazepines, and is likely owing in...
Approved
Matched Description: … Oxazepam is an intermediate-acting, 3-hydroxybenzodiazepine used in the treatment of alcohol withdrawal ... [A203516] It is an active metabolite of both [diazepam] and [temazepam][A39486] and undergoes very little …
Mifepristone
Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary cushing syndrome....
Approved
Investigational
Matched Description: … Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing ... The two marketed forms of mifepristone are Mifeprex® (mifepristone 200mg) and Korlym™ (mifepristone 300mg …
Matched Categories: … Sex Hormones and Modulators of the Genital System …
Matched Categories: … Sex Hormones and Modulators of the Genital System …
Triazolam
Withdrawn in the United Kingdom due to risk of psychiatric adverse drug reactions. This drug continues to be available in the U.S. Internationally, triazolam is a Schedule IV drug under the Convention on Psychotropic Substances.
Approved
Investigational
Matched Description: … Withdrawn in the United Kingdom due to risk of psychiatric adverse drug reactions. …
Arsenic trioxide
Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of dangerous...
Approved
Investigational
Matched Description: … In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of dangerous ... Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive …
Trimebutine
Trimebutine is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu opioid agonist effects. It is marketed for the treatment of irritable bowel syndrome (IBS) and lower gastrointestinal tract motility disorders, with IBS being one of the most common multifactorial GI...
Approved
Matched Description: … disorders, with IBS being one of the most common multifactorial GI disorders [A19691]. ... It is marketed for the treatment of irritable bowel syndrome (IBS) and lower gastrointestinal tract motility …
Ganirelix
Ganirelix is a synthetic decapeptide and a competitive gonadotropin-releasing hormone (GnRH) antagonist. Derived from endogenous GnRH, ganirelix has amino acid substitutions. Ganirelix is indicated for controlled ovarian hyperstimulation in assisted reproduction techniques. The first case of pregnancy achieved after the use of ganirelix in an assisted reproduction program was reported...
Approved
Matched Description: … [L43045] The first case of pregnancy achieved after the use of ganirelix in an assisted reproduction …
Chloramphenicol succinate
Chloramphenicol succinate is an ester prodrug of chloramphenicol. Chloramphenicol is a bacteriostatic antibiotic. Use of chloramphenicol succinate and chloramphenicol has decreased due to the risk of potentially fatal blood dyscrasias. Chloramphenicol succinate was granted FDA approval on 20 February 1959.
Approved
Matched Description: … [A204065] Use of chloramphenicol succinate and chloramphenicol has decreased due to the risk of potentially ... Chloramphenicol succinate is an ester prodrug of [chloramphenicol]. …
Abrocitinib
Abrocitinib is an oral small-molecule inhibitor of Janus kinase 1 (JAK1). Janus kinases are intracellular enzymes involved in transduction pathways that regulate hematopoiesis and immune cell function. The Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signalling pathway plays a central role in the pathogenesis of a variety of...
Approved
Investigational
Matched Description: … plays a central role in the pathogenesis of a variety of autoimmune and inflammatory diseases, including ... Abrocitinib is an oral small-molecule inhibitor of Janus kinase 1 (JAK1). ... [L39774] The Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signalling pathway …
Apremilast
Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of symptoms resulting from certain inflammatory autoimmune diseases. It belongs to the same drug class as Roflumilast and Crisaborole.[A181244,L7495] Initially approved in 2014, it is marketed by Celgene. In July 2019, apremilast was granted...
Approved
Investigational
Matched Description: … Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of ... [L7501] In July 2019, apremilast was granted a new FDA approval for the treatment of oral ulcers associated …
Enzacamene
Commonly known as 4-methylbenzylidene-camphor (4-MBC), enzacamene is a camphor derivative and an organic chemical UV-B filter. It is used in cosmetic products such as sunscreen to provide skin protection against UV rays. While its effects on the human reproductive system as an endocrine disruptor are being investigated, its use in...
Approved
Ximelagatran
Ximelagatran is an anticoagulant intended to become a replacement for warfarin by overcoming the dietary restrictions, drug interaction, and monitoring issues associated with the former. In 2006, its manufacturer AstraZeneca announced that it would not attempt to market ximelagatran after reports of hepatotoxicity (liver damage) during trials, and to discontinue...
Approved
Investigational
Withdrawn
Matched Description: … its manufacturer AstraZeneca announced that it would not attempt to market ximelagatran after reports of …
Avacopan
Anti-neutrophil cytoplasmic (auto)antibody (ANCA)-associated vasculitis (AAV) is a rare (estimated incidence of 3 cases per 100,000 per year) form of "pauci-immune" systemic small-vessel vasculitis typified by the presence of ANCAs in the serum.[A240249, A240254, A227003] The full spectrum of AAV includes granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), eosinophilic granulomatosis...
Approved
Investigational
Matched Description: … presence of ANCAs in the serum. ... 3 cases per 100,000 per year) form of "pauci-immune" systemic small-vessel vasculitis typified by the ... [A240249, A240254, A227003] The full spectrum of AAV includes granulomatosis with polyangiitis (GPA), …
Carbocisteine
Dyspnea and cough are common symptoms of chronic obstructive pulmonary disease (COPD) and other respiratory conditions characterized by increased mucus production. Individuals with COPD have a greater risk of pulmonary infection due to the growth and accumulation of viruses and bacteria in thick bronchial mucus. Carbocisteine is a mucolytic drug...
Approved
Investigational
Matched Description: … Individuals with COPD have a greater risk of pulmonary infection due to the growth and accumulation of ... Dyspnea and cough are common symptoms of chronic obstructive pulmonary disease (COPD)[A231169] and other ... Carbocisteine is a mucolytic drug that alleviates respiratory symptoms and infections by reducing the viscosity of …
Ardeparin
Ardeparin, marketed under the US trade name Normiflo, is a low molecular weight heparin (LMWH) anticoagulant used for the prevention of postoperative venous thrombosis. Ardeparin is derived via peroxide degradation of heparin extracted from porcine intestinal mucosa. Its molecular weight ranges from 2000 to 15,000 with an average molecular weight...
Approved
Investigational
Withdrawn
Matched Description: … trade name Normiflo, is a low molecular weight heparin (LMWH) anticoagulant used for the prevention of ... Ardeparin is derived via peroxide degradation of heparin extracted from porcine intestinal mucosa. ... Its molecular weight ranges from 2000 to 15,000 with an average molecular weight of 5500 to 6500. …
Letermovir
Letermovir recieved approval from the FDA on November 8th, 2017 for use in prophylaxis of cytomegalovirus (CMV) infection in allogeneic hematopoietic stem cell transplant patients. It is the first of a new class of CMV anti-infectives called DNA terminase complex inhibitors. Letermovir has recieved both priority and orphan drug status...
Approved
Investigational
Matched Description: … [L1021] It is the first of a new class of CMV anti-infectives called DNA terminase complex inhibitors ... Letermovir recieved approval from the FDA on November 8th, 2017 for use in prophylaxis of cytomegalovirus …
Dexketoprofen
Dexketoprofen is a non-steroidal anti-inflammatory drug. It is available in the various countries in Europe, Asia and Latin America. It has analgesic, antipyretic and anti-inflammatory properties .
Approved
Investigational
Displaying drugs 301 - 325 of 8033 in total