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Displaying drugs 2676 - 2700 of 9613 in total

Tramadol

Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to codeine and morphine. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatment of moderate to severe pain. It is considered...
Approved
Investigational
Matched Description: … the potency of [morphine]. ... a lower-risk opioid option for the treatment of moderate to severe pain. ... Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered …
Matched Categories: … Combined Inhibitors of Serotonin/Norepinephrine Reuptake ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Products: … ADOLONTA (R) CAPSULAS …

Avanafil

Avanafil is a phosphodiesterase-5 (PDE5) inhibitor used in the treatment of erectile dysfunction. In comparison with other drugs of the same class, it shows greater selectivity for PDE5 over PDE6 than both sildenafil and vardenafil but less selectivity than tadalafil, suggesting a relatively lower risk of visual disturbances associated with...
Approved
Matched Description: … Avanafil is a phosphodiesterase-5 (PDE5) inhibitor used in the treatment of erectile dysfunction. ... In comparison with other drugs of the same class, it shows greater selectivity for PDE5 over PDE6 than ... sildenafil] and [vardenafil] but less selectivity than [tadalafil], suggesting a relatively lower risk of …

Oxacillin

An antibiotic similar to flucloxacillin used in resistant staphylococci infections.
Approved
Investigational
Matched Categories: … combinations of penicillins …

Azlocillin

Azlocillin is a semisynthetic ampicillin-derived acylureido penicillin.
Approved
Matched Categories: … combinations of penicillins …

Diazoxide

Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release....
Approved
Matched Description: … Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention ... [A190372] Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability ... In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension …
Matched Categories: … combinations of sulfonamides …

Tibolone

Tibolone is a synthetic steroid hormone drug, which is mainly non-selective in its binding profile, acting as an agonist primarily at estrogen receptors (ER), with a preference for ER alpha . Tibolone (Livial, Org OD 14), produced by Organon (West Orange, NJ), is a synthetic steroid that possesses estrogenic, androgenic...
Approved
Investigational
Matched Description: … and the treatment of post-menopausal symptoms [L1720]. ... In June 2006, Organon Pharmaceuticals announced the receipt of a Not Approvable Letter from the U.S. ... approved in 90 countries to manage menopausal symptoms and in 45 countries to prevent the development of …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Gadoteric acid

Gadoteric acid, commonly used in the salt form gadoterate meglumine, is a macrocyclic, ionic gadolinium-based contrast agent (GBCA). It is composed of the organic acid DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) used for its chelating properties, and gadolinium (Gd3+). Gadoterate meglumine has one of the highest thermodynamic stability, apparent stability, and kinetic stability,...
Approved
Matched Description: … [A263131] It is composed of the organic acid DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic ... [A263136] Gadoterate meglumine has one of the highest thermodynamic stability, apparent stability, and ... its macrocyclic structure, and thus has a more favorable safety profile due to a decreased tendency of …
Matched Categories: … Diagnostic Uses of Chemicals …

Antihemophilic factor (recombinant), PEGylated

Antihemophilic Factor (Recombinant), PEGylated, was approved by the FDA in December 2016 as the product Adynovate [FDA label]. Antihemophilic Factor (Recombinant), PEGylated, is a recombinant full-length human coagulation factor VIII (2,332 amino acids with a molecular weight (MW) of approximately 280 kDa) covalently conjugated with at least one molecule of...
Approved
Investigational
Matched Description: … the occurrence of bleeding events [A32067], [A32069], [FDA label]. ... approximately 280 kDa) covalently conjugated with at least one molecule of polyethylene glycol (MW 20 ... recombinant full-length human coagulation factor VIII (2,332 amino acids with a molecular weight (MW) of …

Magnesium chloride

Magnesium chloride salts are highly soluble in water and the hydrated form of magnesium chloride can be extracted from brine or sea water.
Approved
Matched Description: … Magnesium chloride salts are highly soluble in water and the hydrated form of magnesium chloride can …
Matched Salts cas: … 7791-18-6 …
Matched Mixtures name: … Plasma-Lyte R ... Normosol-R ... Normosol-R …

Amoxicillin

Amoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972. Amoxicillin has similar activity to penicillin and ampicillin, but leads to higher serum concentrations than ampicillin. Amoxicillin was granted FDA approval on 18 January 1974.
Approved
Vet approved
Matched Description: … [A190648] Amoxicillin was granted FDA approval on 18 January 1974.[L11644] …
Matched Mixtures name: … AMOXICILLIN R C875MG/125MG ... AMOXICILLIN R C875MG/125MG …
Matched Categories: … combinations of penicillins …
Matched Products: … โคอะมอกซ์ (R) 500 ... AMOXICILINA 500 MG CAPSULAS CALOX(R) ... AMOXICILINA250 MG / 5 ML POLVO PARA RECONSTITUIR A SUSPENSION ORAL CALOX(R) …

Diphenoxylate

A meperidine congener used as an antidiarrheal, usually in combination with atropine. At high doses, it acts like morphine. Its unesterified metabolite difenoxin has similar properties and is used similarly. It has little or no analgesic activity. This medication is classified as a Schedule V under the Controlled Substances Act...
Approved
Illicit
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Daratumumab

Daratumumab is an immunoglobulin G1 kappa monoclonal antibody developed by Janssen and Genmab. It was first described in the literature in 2010 as a monoclonal antibody that targets CD38+ multiple myeloma cells; the first of its kind. Daratumumab was granted FDA approval on 16 November 2015. It is approved for...
Approved
Matched Description: … the literature in 2010 as a monoclonal antibody that targets CD38+ multiple myeloma cells; the first of ... [L13290] It is approved for the treatment of multiple myeloma as monotherapy or combination therapy and …
Matched Categories: … CD38 (Clusters of Differentiation 38) inhibitors …

Janssen COVID-19 Vaccine

The Janssen COVID-19 vaccine (Ad26.COV2.S) is a recombinant vaccine that contains an adenovirus serotype 26 (Ad26) vector expressing a stabilized SARS-CoV-2 spike protein. The vaccine was created in collaboration with Johnson and Johnson (J&J), Janssen Pharmaceutical, and the Beth Israel Deaconess Medical Center. A preclinical study in hamsters infected with...
Approved
Investigational
Matched Description: … , and efficacy of the ad26.COV.S vaccine in 1045 healthy adults between the ages of 18-55 (NCT04436276 ... As of June 2020, a Phase 1/2 clinical trial in adult humans was announced to evaluate the safety, immunogenicity …

Furosemide

Furosemide is a potent loop diuretic that acts on the kidneys to ultimately increase water loss from the body. It is an anthranilic acid derivative. Furosemide is used for edema secondary to various clinical conditions, such as congestive heart failure exacerbation, liver failure, renal failure, and high blood pressure. It...
Approved
Vet approved
Matched Description: … It mainly works by inhibiting electrolyte reabsorption from the kidneys and enhancing the excretion of ... Furosemide has a fast onset and short duration of action and has been used safely and effectively in ... [A182495] The use of furosemide is particularly beneficial in clinical settings that require a drug with …
Matched Categories: … combinations of sulfonamides ... Increased Diuresis at Loop of Henle …

Adagrasib

Adagrasib (MRTX849) is an oral, small-molecule KRAS inhibitor developed by Mirati Therapeutics. KRAS mutations are highly common in cancer and account for approximately 85% of all RAS family mutations. However, the development of KRAS inhibitors has been challenging due to their high affinity for guanosine triphosphate (GTP) and guanosine diphosphate...
Approved
Investigational
Matched Description: … [A254941] However, the development of KRAS inhibitors has been challenging due to their high affinity ... KRAS mutations are highly common in cancer and account for approximately 85% of all RAS family mutations ... [A187559] Adagrasib targets KRASG12C, one of the most common KRAS mutations, at the cysteine …

Warfarin

Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be noted when used medicinally,...
Approved
Matched Description: … biologically active forms of various clotting factors in addition to several regulatory factors. ... Warfarin does not actually affect blood viscosity, rather, it inhibits vitamin-k dependent synthesis of …

Gadodiamide

Gadodiamide is a linear, non-ionic gadolinium-based contrast agent (GBCA) that is used in magnetic resonance imaging (MRI) procedures to assist in the visualization of blood vessels.[A263086,A263091] GBCAs constitute the largest group of MR agents, and they are thought to be safer than nonionic iodinated contrast agents. Approved by the FDA...
Approved
Investigational
Matched Description: … agent (GBCA) that is used in magnetic resonance imaging (MRI) procedures to assist in the visualization of ... [A263086,A263091] GBCAs constitute the largest group of MR agents, and they are thought to be safer than …
Matched Categories: … Diagnostic Uses of Chemicals …

Gadopentetic acid

A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see pentetic acid), that is given to enhance the image in cranial and spinal MRIs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706)
Approved
Matched Description: … A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see pentetic …
Matched Categories: … Diagnostic Uses of Chemicals …

Iodipamide

Iodipamide is a water-soluble radiographic contrast media for cholecystography and intravenous cholangiography.
Approved
Matched Categories: … Diagnostic Uses of Chemicals …

Gadofosveset trisodium

Gadofosveset trisodium is an intravenous contrast agent used with magnetic resonance angiography(MRA), which is a non-invasive way of imaging blood vessels. The agent allows for the vascular system to be imaged more clearly by the MRA. In this way, gadofosveset trisodium is used to help diagnose certain disorders of the...
Approved
Matched Description: … intravenous contrast agent used with magnetic resonance angiography(MRA), which is a non-invasive way of ... In this way, gadofosveset trisodium is used to help diagnose certain disorders of the heart and blood …
Matched Categories: … Diagnostic Uses of Chemicals …

Bedaquiline

Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affect DNA gyrase; instead, bedaquiline inhibits the c subunit of ATP...
Approved
Matched Description: … [L48506] Although the current standard of TB treatment of anti-TB drugs for 2 months, including 2 key ... Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. ... fluoroquinolones, bedaquiline does not affect DNA gyrase; instead, bedaquiline inhibits the c subunit of …
Matched Categories: … Drugs for Treatment of Tuberculosis …

Moxetumomab pasudotox

CD22 is a lineage-restricted B-cell antigen that is expressed solely in on B-chronic lymphocytic leukemia, hairy cell leukemia, acute lymphocytic leukemiathe and Burkitt's lymphoma. The predecessor of Moxetumab pasudotox (MxP), named BL22, was first created based on the antibody RFB4 which specifically binds to CD22. This antibody was used to...
Approved
Investigational
Matched Description: … [A38864] MxP appears as an improved form of BL22 by the mutation of the Fv region and the antibody ... The predecessor of Moxetumab pasudotox (MxP), named BL22, was first created based on the antibody RFB4 ... was developed by Astra Zeneca and FDA approved on September 13, 2018, after being granted the status of …
Matched Categories: … CD22 (Clusters of Differentiation 22) inhibitors …

Gelatin

Gelatin is a multifunctional ingredient that is used in foods, pharmaceuticals, cosmetics, and photographic films as a gelling agent, stabilizer, thickener, emulsifier, as well as film former. As a thermoreversible hydrocolloid with a small gap between its melting and gelling temperatures, gelatin provides unique advantages over carbohydrate-based gelling agents. Gelatin...
Approved
Vet approved
Withdrawn
Matched Description: … [L2121] Fish skins from a number of fish species a type of substance that has been comprehensively ... Gelatin continues to be approved for other routes of administration.[L43942] ... An increasing number of novel applications have been found for collagen and gelatin. …

Methazolamide

A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.
Approved
Matched Description: … A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma. …
Matched Categories: … combinations of sulfonamides …

Nialamide

Withdrawn from the Canadian, US, and UK markets in 1963 due to interactions with food products containing tyrosine.
Approved
Withdrawn
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Displaying drugs 2676 - 2700 of 9613 in total