Displaying drugs 2701 - 2725 of 2939 in total
Ciglitazone
Developed by Takeda Pharmaceuticals in the early 1980s, it is considered the prototypical compound for the thiazolidinedione class.
Ciglitazone was never used as a medication, but it sparked interest in the effects of thiazolidinediones. Several analogues were later developed, some of which—such as pioglitazone and troglitazone—made it to the market....
Experimental
Matched Description: … endothelial cell (HUVEC), and osteoblastogenesis in human mesenchymal stem cells. ... Ciglitazone significantly decreases VEGF production by human granulosa cells in an in vitro study, and ... Ciglitazone increases adipogenesis, decreases differentiation and angiogenesis in human umbilical vein …
Entinostat
Entinostat is under investigation for the treatment and other of Volunteers, Breast Cancer, Human Volunteers, and Normal Volunteers. Entinostat has been investigated for the treatment of Non-Small Lung Cancer, Epigenetic Therapy.
Investigational
Matched Description: … Entinostat is under investigation for the treatment and other of Volunteers, Breast Cancer, Human Volunteers …
NTLA-2001
NTLA-2001 is a clustered regularly interspaced short palindromic repeats CRISPR/ Cas9-based gene therapy consisting of a single guide RNA targeting the human TTR gene and a messenger RNA encoding Cas9.
Investigational
Matched Description: … palindromic repeats CRISPR/ Cas9-based gene therapy consisting of a single guide RNA targeting the human …
Elafin
Elafin is a human protein that is produced naturally in the skin, lung and breast, protecting the respective tissue from destruction by the immune system. Elafin’s ability to block the activity of destructive enzymes that are involved in inflammatory reactions makes it a highly promising active compound for the treatment...
Investigational
Matched Description: … Elafin is a human protein that is produced naturally in the skin, lung and breast, protecting the respective ... The excellent tolerability of Elafin in human subjects was demonstrated in a Phase I clinical single …
SAR421869
SAR421869 is a Lentiviral Vector Containing The Human My07A Gene currently being investigated for the treatment of retinitis pigmentosa associated with Usher syndrome 1B gene defect.
Investigational
Matched Description: … SAR421869 is a Lentiviral Vector Containing The Human My07A Gene currently being investigated for the …
GS-100
GS-100 is an adeno-associated virus serotype 9 virus particle containing viral DNA that includes an expression cassette containing the human NGLY1 gene coding sequence
Investigational
Matched Description: … serotype 9 virus particle containing viral DNA that includes an expression cassette containing the human …
ABX-PTH
ABX-PTH is a fully human monoclonal antibody generated by Abgenix's technology platform. This drug targets and neutralizes the action of parathyroid hormone (PTH) for the treatment of a secondary hyperparathyroidism.
Investigational
Matched Description: … ABX-PTH is a fully human monoclonal antibody generated by Abgenix's technology platform. …
AMG-553
AMG-553 is an adoptive, anti-FLT3 chimeric antigen receptor T-cell therapy generated through transduction of autologous T-cells with a self-inactivating human immunodeficiency virus-1 based lentiviral vector.
Investigational
Matched Description: … receptor T-cell therapy generated through transduction of autologous T-cells with a self-inactivating human …
AMP-101
AMP-101 is a gene therapy comprising an adeno-associated virus type 9 (AAV9) vector encoding the human Dok-7 protein. It is under investigation for the treatment of Dok-7-associated myasthenia.
Investigational
Matched Description: … AMP-101 is a gene therapy comprising an adeno-associated virus type 9 (AAV9) vector encoding the human …
RVT-3101
RVT-3101 is a fully human monoclonal antibody targeting vascular endothelial growth inhibitor, also known as TNF-like ligand 1A (TL1A) and TNF superfamily member 15. It is being investigated for ulcerative colitis.
Investigational
Matched Description: … RVT-3101 is a fully human monoclonal antibody targeting vascular endothelial growth inhibitor, also known …
Labetuzumab
Labetuzumab is a humanized monoclonal antibody to carcinoembryonic antigen that inhibits tumor growth. It is used in radioimmunotherapy.
Investigational
BB-1701
BB-1701 is a humanized IgG1 kappa monoclonal antibody (anti-HER2 antibody) conjugated to eribulin developed by Bliss Biopharmaceutical.
Investigational
Picrotoxin
A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the gamma-aminobutyric acid-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates. [PubChem]
Experimental
Matched Categories: … Complex Mixtures …
TA-CIN
TA-CIN is a subunit vaccine comprising L2/E6/E7 proteins from Human Papillomavirus (HPV16), designed to generate a strong cellular immune response against HPV-infected cells.
Investigational
Matched Description: … TA-CIN is a subunit vaccine comprising L2/E6/E7 proteins from Human Papillomavirus (HPV16), designed …
CYNK-001
CYNK-001 is a novel allogenic off-the-shelf natural killer (NK) cell therapy originating from human placental CD34+ hematopoietic stem cells and enriched with CD56+/CD3-.
Investigational
Matched Description: … CYNK-001 is a novel allogenic off-the-shelf natural killer (NK) cell therapy originating from human placental …
N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine
25CN-NBOH (N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine) is a newly developed selective 5-HT2A agonist. It has been tested with regard to the head-twitch-response (HTR) model of 5-HT2A activity and effects on locomotion . It was discovered in 2014 at the University of Copenhagen.
Experimental
Lysergic acid diethylamide
Debate continues over the nature and causes of chronic flashbacks. Explanations in terms of LSD physically remaining in the body for months or years after consumption have been discounted by experimental evidence. Some say HPPD is a manifestation of post-traumatic stress disorder, not related to the direct action of LSD...
Illicit
Investigational
Withdrawn
EGEN-001
EGEN-001 is a novel non-viral vector consisting of a plasmid DNA encoding the human gene for interleukin 12 (IL-12) and a biocompatible, biodegradable delivery polymer with potential antineoplastic activity.
Investigational
Matched Description: … EGEN-001 is a novel non-viral vector consisting of a plasmid DNA encoding the human gene for interleukin …
MW33
MW33 is a recombinant fully human antibody to SARS-CoV-2. This antibody injection is currently being investigated against COVID-19 in the clinical trial NCT04533048 (A Clinical Study to Evaluate MW33 Injection).
Investigational
Matched Description: … MW33 is a recombinant fully human antibody to SARS-CoV-2. …
Andrographolide
Andrographolide (HMPL-004) is a botanical product extracted from a herb that occurs naturally in China. The herb has an extensive history of use in TCM for the treatment of upper respiratory tract infections and other inflammatory and infectious diseases.
Investigational
Matched Categories: … Complex Mixtures …
Neosaxitoxin
Neosaxitoxin is under investigation in clinical trial NCT01786655 (Safety Study of Long-Acting Local Anesthetic).
Investigational
Matched Categories: … Complex Mixtures …
Molnupiravir
Molnupiravir (EIDD-2801, MK-4482) is the isopropylester prodrug of N4-hydroxycytidine.[A193014,A193026] With improved oral bioavailability in non-human primates, it is hydrolyzed in vivo, and distributes into tissues where it becomes the active 5’-triphosphate form. The active drug incorporates into the genome of RNA viruses, leading to an accumulation of mutations known as...
Investigational
Matched Description: … including SARS-CoV-2, in mice and human airway epithelial cells. ... [A193014,A193026] With improved oral bioavailability in non-human primates, it is hydrolyzed _in vivo ... [A193029] Recent studies have shown molnupiravir inhibits replication of human and bat coronaviruses, …
Foliglurax
Foliglurax is under investigation in clinical trial NCT02639221 (A Phase I, Double Blind, Placebo Controlled, First in Human, Single and Multiple Ascending Oral Dose, Safety, Tolerability and Pharmacokinetic Study in Healthy Male and Female Subjects).
Investigational
Matched Description: … investigation in clinical trial NCT02639221 (A Phase I, Double Blind, Placebo Controlled, First in Human …
Inodiftagene vixteplasmid
Inodiftagene vixteplasmid is a plasmid DNA vector encoding the diphtheria toxin A (dT-a) gene under transcriptional regulation of the promoter region of the human H19 gene (an imprinted maternally expressed non-protein coding gene).
Investigational
Matched Description: … encoding the diphtheria toxin A (dT-a) gene under transcriptional regulation of the promoter region of the human …
Displaying drugs 2701 - 2725 of 2939 in total