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Displaying drugs 3051 - 3075 of 9644 in total
Synthetic camphor
Approved
Experimental
Alteplase
Alteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent. It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots. In the absence of fibrin, the alteplase-mediated conversion of plasminogen is limited, thanks to the high affinity between alteplase and fibrin.[A252330,L43125] Alteplase...
Approved
Investigational
Matched Description: … In the absence of fibrin, the alteplase-mediated conversion of plasminogen is limited, thanks to the ... [A252270] The use of alteplase to manage AMI has decreased thanks to the availability of safer treatments ... [L43125] It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots …
Methotrexate
Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division in neoplastic diseases such...
Approved
Matched Description: … [A180322] This inhibition leads to suppression of inflammation as well as prevention of cell division ... are intolerant of those treatments. ... of some forms of arthritis and severe psoriasis only if first line treatment has failed or patients …
Ethinylestradiol
Ethinylestradiol was first synthesized in 1938 by Hans Herloff Inhoffen and Walter Hohlweg at Schering. It was developed in an effort to create an estrogen with greater oral bioavailability. These properties were achieved by the substitution of an ethinyl group at carbon 17 of estradiol. Ethinylestradiol soon replaced mestranol in...
Approved
Matched Description: … [A191107] These properties were achieved by the substitution of an ethinyl group at carbon 17 of [estradiol …
Matched Mixtures name: … LILA(R) TABLETAS RECUBIERTAS …
Matched Categories: … Sex Hormones and Modulators of the Genital System …
Matched Mixtures name: … LILA(R) TABLETAS RECUBIERTAS …
Matched Categories: … Sex Hormones and Modulators of the Genital System …
Polistes annularis venom protein
Polistes annularis venom protein is an extract of Polistes annularis venom. Polistes annularis venom protein is used in allergenic testing.
Approved
Matched Description: … Polistes annularis venom protein is an extract of Polistes annularis venom. …
Acarbose
Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are responsible for the metabolism of complex starches and...
Approved
Investigational
Matched Description: … [L31633,A37868] By inhibiting the activity of these enzymes, acarbose limits the absorption of dietary ... breakdown of complex carbohydrates in the intestines. ... Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the …
Chromic chloride
Chromic chloride, for injection, is a sterile, nonpyrogenic solution intended for use as an additive to solutions for Total Parenteral Nutrition (TPN).
Approved
Alpelisib
Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metabolism. Alpelisib was designed to target...
Approved
Investigational
Matched Description: … [L6652] In April 2022, the FDA granted the use of alpelisib in the treatment of PIK3CA-Related Overgrowth ... It works by selectively inhibiting class I PI3K p110α [A179203], which is the catalytic subunit of PI3K ... Alpelisib was designed to target this enzyme that appears to be mutated at a rate of nearly 30% in human …
Ambrosia acanthicarpa pollen
Ambrosia acanthicarpa pollen is the pollen of the Ambrosia acanthicarpa plant. Ambrosia acanthicarpa pollen is mainly used in allergenic testing.
Approved
Matched Description: … Ambrosia acanthicarpa pollen is the pollen of the Ambrosia acanthicarpa plant. …
Ambrosia trifida pollen
Ambrosia trifida pollen is the pollen of the Ambrosia trifida plant. Ambrosia trifida pollen is mainly used in allergenic testing.
Approved
Matched Description: … Ambrosia trifida pollen is the pollen of the Ambrosia trifida plant. …
Leymus condensatus pollen
Leymus condensatus pollen is the pollen of the Leymus condensatus plant. Leymus condensatus pollen is mainly used in allergenic testing.
Approved
Matched Description: … Leymus condensatus pollen is the pollen of the Leymus condensatus plant. …
Alcaftadine
Alcaftadine is a H1 histamine receptor antagonist indicated for the prevention of itching associated with allergic conjunctivitis. This drug was approved in July 2010.
Approved
Matched Description: … Alcaftadine is a H1 histamine receptor antagonist indicated for the prevention of itching associated …
Sulfur hexafluoride
Sulfur hexafluoride is an ultrasound contrast agent indicated for use
•in echocardiography to opacify the left ventricular chamber and to improve the delineation of the left ventricular endocardial border in adult patients with suboptimal echocardiograms
•in ultrasonography of the liver for characterization of focal liver lesions in adult and pediatric...
Approved
Matched Description: … the liver for characterization of focal liver lesions in adult and pediatric patients ... for use
•in echocardiography to opacify the left ventricular chamber and to improve the delineation of ... ventricular endocardial border in adult patients with suboptimal echocardiograms
•in ultrasonography of …
Betibeglogene autotemcel
Betibeglogene autotemcel is an autologous gene therapy that adds functional copies of the β-globin gene (βA-T87Q-globin) to hematopoietic stem cells in order to treat β-thalassemia. β-thalassemia is a condition caused by mutations in the β-globin gene (HBB) that leads to a significant decrease in the production of β-globin. This affects...
Approved
Investigational
Matched Description: … transfusions are required for survival and the prevention of serious complications. ... Betibeglogene autotemcel is an autologous gene therapy that adds functional copies of the β-globin gene ... This affects hemoglobin levels, and in patients with severe forms of this disease, long-term red cell …
Vayarin
Vayarin is a prescription medical food for the clinical dietary management of certain lipid imbalances blamed to be associated with attention deficit hyperactivity disorder (ADHD) in children. Vayarin contains Lipirinen, a proprietary composition containing phosphatidylserine-omega 3, EPA (eicosapentaenoic acid), and docosahexaenoic acid (DHA) [L1500, L1510]. Vayarin is currently available only...
Approved
Investigational
Matched Description: … A slow response time of 12 weeks is an impediment to successful management of ADHD as only 41.6% of subjects ... Cost of the drug and patient aversion to the taste of Vayarin were significant reasons for therapy failure ... Approximately 60% of the users who completed 12 weeks of therapy reported subjective benefits from treatment …
VidPrevtyn Beta
VidPrevtyn Beta is an adjuvanted, recombinant COVID-19 vaccine developed collaboratively by GlaxoSmithKline (GSK) and Sanofi Pasteur. It comprises a recombinant SARS-CoV-2 spike protein (B.1.351 strain) - produced by recombinant DNA technology using a baculovirus expression system in an insect cell line that is
derived from Sf9 cells of the fall...
Approved
Investigational
Matched Description: … technology using a baculovirus expression system in an insect cell line that is
derived from Sf9 cells of …
Carfilzomib
Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combination therapy.
Approved
Investigational
Matched Description: … Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. ... FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple …
Iodide I-131
Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of...
Approved
Investigational
Matched Description: … this mechanism for localization of drug to the site of malignancy. ... As a result of beta decay, approximately 10% of its energy and radiation dose is via gamma radiation, ... Therapeutic solutions of Sodium Iodide-131 are indicated for the treatment of hyperthyroidism and thyroid …
Ixazomib
Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to...
Approved
Investigational
Matched Description: … myeloma growth and prevention of bone loss. ... similar efficacy to bortezomib (the first PI approved for multiple myeloma therapy) in the control of …
Ambrosia dumosa pollen
Ambrosia dumosa pollen is the pollen of the Ambrosia dumosa plant. Ambrosia dumosa pollen is mainly used in allergenic testing.
Approved
Matched Description: … Ambrosia dumosa pollen is the pollen of the Ambrosia dumosa plant. …
Ambrosia psilostachya pollen
Ambrosia psilostachya pollen is the pollen of the Ambrosia psilostachya plant. Ambrosia psilostachya pollen is mainly used in allergenic testing.
Approved
Matched Description: … Ambrosia psilostachya pollen is the pollen of the Ambrosia psilostachya plant. …
Eplontersen
Eplontersen is a transthyretin-directed antisense oligonucleotide with 3 covalently linked e N-acetyl galactosamine residues for hepatic delivery. It was previously investigated as a potential treatment for hereditary transthyretin-mediated amyloidosis. Hereditary transthyretin-mediated amyloidosis is caused primarily by pathogenic variants of the TTR gene, leading to the formation and thus accumulation of...
Approved
Investigational
Matched Description: … adult polyneuropathy of hereditary transthyretin-mediated amyloidosis. ... [A262975] Hereditary transthyretin-mediated amyloidosis is caused primarily by pathogenic variants of ... On December 21, 2023, the FDA approved eplontersen under the brand name WAINUA for the treatment of …
Coral snake (micrurus fulvius) immune globulin antivenin (equine)
North American Coral Snake Antivenin (Equine) is a horse-derived antivenin indicated for the treatment of envenomation caused by North American coral snake bites. It is intravenously administered so that the antivenin binds to and neutralizes coral snake venom.
The antivenin is a refined, concentrated, and lyophilized preparation of serum globulins...
Approved
Experimental
Matched Description: … North American Coral Snake Antivenin (Equine) is a horse-derived antivenin indicated for the treatment of ... The antivenin is a refined, concentrated, and lyophilized preparation of serum globulins obtained by …
Semaglutide
Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include Exenatide and Liraglutide. Semaglutide was developed by Novo Nordisk and approved by the FDA for subcutaneous injection...
Approved
Investigational
Matched Description: … The use of salt forms of semaglutide, including semaglutide sodium and semaglutide acetate, has not been ... [A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. ... [L34485] The use of semaglutide in weight management is also approved by Health Canada [L39347] and the …
Displaying drugs 3051 - 3075 of 9644 in total