Displaying drugs 3676 - 3700 of 4636 in total
Glycyl-L-alpha-amino-epsilon-pimelyl-D-alanine
Experimental
Matched Name: … Glycyl-L-alpha-amino-epsilon-pimelyl-D-alanine …
Matched Iupac: … (2S)-2-(2-aminoacetamido)-6-{[(1R)-1-carboxyethyl]carbamoyl}hexanoic acid …
Matched Iupac: … (2S)-2-(2-aminoacetamido)-6-{[(1R)-1-carboxyethyl]carbamoyl}hexanoic acid …
MMDA
MMDA, or 3-methoxy-4,5-methylenedioxyamphetamine, is a member of the amphetamine drug class with stimulant and psychedelic properties. It also acts as an entheogen and an entactogen. MMDA bears resemblance to the psychopharmacologically active essential oils elemicin and myristicin found in nutmeg. The effects of MMDA includes feelings of euphoria and warmth,...
Experimental
Illicit
Matched Synonyms: … 3-Methoxy-alpha-methyl-4,5-methylenedioxyphenethylamine …
Matched Iupac: … 1-(7-methoxy-2H-1,3-benzodioxol-5-yl)propan-2-amine …
Matched Description: … It also acts as an entheogen and an entactogen. ... or 3-methoxy-4,5-methylenedioxyamphetamine, is a member of the amphetamine drug class with stimulant and ... MMDA bears resemblance to the psychopharmacologically active essential oils elemicin and myristicin found …
Matched Iupac: … 1-(7-methoxy-2H-1,3-benzodioxol-5-yl)propan-2-amine …
Matched Description: … It also acts as an entheogen and an entactogen. ... or 3-methoxy-4,5-methylenedioxyamphetamine, is a member of the amphetamine drug class with stimulant and ... MMDA bears resemblance to the psychopharmacologically active essential oils elemicin and myristicin found …
ONO-7579
Investigational
Matched Synonyms: … 1-[2-[4-(2-amino-5-chloropyridin-3-yl)phenoxy]pyrimidin-5-yl]-3-[2-methylsulfonyl-5-(trifluoromethyl) …
Beremagene geperpavec
Beremagene geperpavec is a live, replication-defective herpes simplex virus type 1 (HSV-1)-based vector therapy. Developed by Krystal Biotech, it was first approved by the FDA on May 19, 2023, for the treatment of wounds associated with dystrophic epidermolysis bullosa (DEB). DEB is caused by mutations in the COL7A1 gene that...
Approved
Matched Synonyms: … Dna (recombinant herpes simplex virus type 1 strain kos plasmid vector kb103 human collagen col7a1-specifying …
Matched Description: … Beremagene geperpavec is a live, replication-defective herpes simplex virus type 1 (HSV-1)-based vector ... Developed by Krystal Biotech, it was first approved by the FDA on May 19, 2023, for the treatment of …
Matched Categories: … Cellular and Gene Therapy ... Preparations for Treatment of Wounds and Ulcers …
Matched Description: … Beremagene geperpavec is a live, replication-defective herpes simplex virus type 1 (HSV-1)-based vector ... Developed by Krystal Biotech, it was first approved by the FDA on May 19, 2023, for the treatment of …
Matched Categories: … Cellular and Gene Therapy ... Preparations for Treatment of Wounds and Ulcers …
BMS-741672
BMS-741672 is under investigation in clinical trial NCT00699790 (Proof of Confidence Study of CCR2 Antagonist (BMS-741672) in Insulin Resistance).
Investigational
Matched Synonyms: … N-(5-(ISOPROPYL(METHYL)AMINO)-2-(2-OXO-3-((6-(TRIFLUOROMETHYL)QUINAZOLIN-4-YL)AMINO)PYRROLIDIN-1-YL)CYCLOHEXYL …
Elimusertib
Elimusertib is under investigation in clinical trial NCT05071209 (Elimusertib for the Treatment of Relapsed or Refractory Solid Tumors).
Investigational
Matched Synonyms: … 1,7-naphthyridine, 2-((3r)-3-methyl-4-morpholinyl)-4-(1-methyl-1h-pyrazol-5-yl)-8-(1h-pyrazol-3-yl)- …
Raloxifene
Raloxifene is a second generation selective estrogen receptor modulator (SERM) that mediates anti-estrogenic effects on breast and uterine tissues, and estrogenic effects on bone, lipid metabolism, and blood coagulation.[A4979,T28] Exhibiting tissue-specific effects distinct from estradiol, raloxifene is the first of the benzothiophene group of antiestrogens to be labelled a SERM....
Approved
Investigational
Matched Synonyms: … (2-(4-Hydroxyphenyl)-6-hydroxybenzo(b)thien-3-yl)(4-(2-(1-piperidinyl)ethoxy)phenyl)methanone …
Matched Iupac: … 2-(4-hydroxyphenyl)-3-{4-[2-(piperidin-1-yl)ethoxy]benzoyl}-1-benzothiophen-6-ol …
Matched Description: … Raloxifene is a second generation selective estrogen receptor modulator (SERM) that mediates anti-estrogenic ... effects on breast and uterine tissues, and estrogenic effects on bone, lipid metabolism, and blood coagulation ... and it does not cause endometrial proliferation. …
Matched Categories: … Genito Urinary System and Sex Hormones ... Hormones, Hormone Substitutes, and Hormone Antagonists ... Sex Hormones and Modulators of the Genital System …
Matched Iupac: … 2-(4-hydroxyphenyl)-3-{4-[2-(piperidin-1-yl)ethoxy]benzoyl}-1-benzothiophen-6-ol …
Matched Description: … Raloxifene is a second generation selective estrogen receptor modulator (SERM) that mediates anti-estrogenic ... effects on breast and uterine tissues, and estrogenic effects on bone, lipid metabolism, and blood coagulation ... and it does not cause endometrial proliferation. …
Matched Categories: … Genito Urinary System and Sex Hormones ... Hormones, Hormone Substitutes, and Hormone Antagonists ... Sex Hormones and Modulators of the Genital System …
Crozbaciclib
Investigational
Matched Synonyms: … 2-PYRIMIDINAMINE, 5-FLUORO-4-(7'-FLUORO-2'-METHYLSPIRO(CYCLOPENTANE-1,3'-(3H)INDOL)-5'-YL)-N-(5-(1-METHYL ... 5-fluoro-4-(7'-fluoro-2'-methylspiro[cyclopentane-1,3'- indol]-5'-yl)-N-[5-(1-methylpiperidin-4-yl)pyridin …
Matched Iupac: … 5-fluoro-4-{7'-fluoro-2'-methylspiro[cyclopentane-1,3'-indol]-5'-yl}-N-[5-(1-methylpiperidin-4-yl)pyridin …
Matched Iupac: … 5-fluoro-4-{7'-fluoro-2'-methylspiro[cyclopentane-1,3'-indol]-5'-yl}-N-[5-(1-methylpiperidin-4-yl)pyridin …
Butabarbital
Butabarbital, or Butisol, is a fast onset barbiturate with short duration of action compared to other barbiturates.[A201977,L13613] This makes butabarbital a useful drug for treating severe insomnia and pre-operative anxiety.[A201977,L13613] Butabarbital is less commonly used in recent years, as more patients are typically prescribed benzodiazepines. Its short duration of action...
Approved
Illicit
Matched Synonyms: … 5-ethyl-5-(1-methylpropyl)-2,4,6(1H,3H,5H)-pyrimidinetrione ... 5-ethyl-5-(1-methylpropyl)barbituric acid ... 5-sec-butyl-5-ethyl-2,4,6(1H,3H,5H)-pyrimidinetrione …
Matched Iupac: … 5-(butan-2-yl)-5-ethyl-1,3-diazinane-2,4,6-trione …
Matched Description: … [A201977,L13613] This makes butabarbital a useful drug for treating severe insomnia and pre-operative …
Matched Salts cas: … 143-81-7 …
Matched Mixtures name: … Phenazopyridine Hydrochloride, Hyoscyamine Hydrobromide, and Butabarbital …
Matched Categories: … Hypnotics and Sedatives ... Heterocyclic Compounds, 1-Ring …
Matched Iupac: … 5-(butan-2-yl)-5-ethyl-1,3-diazinane-2,4,6-trione …
Matched Description: … [A201977,L13613] This makes butabarbital a useful drug for treating severe insomnia and pre-operative …
Matched Salts cas: … 143-81-7 …
Matched Mixtures name: … Phenazopyridine Hydrochloride, Hyoscyamine Hydrobromide, and Butabarbital …
Matched Categories: … Hypnotics and Sedatives ... Heterocyclic Compounds, 1-Ring …
Tuspetinib
Tuspetinib (HM-43239) is under investigation in clinical trial NCT03850574 (Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HM43239 in Patients With Relapsed or Refractory Acute Myeloid Leukemia).
Investigational
Matched Synonyms: … 6-methyl-1H-indol-3-yl)-, rel- ... 2-Pyrimidinamine, 5-chloro-N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethyl-1-piperazinyl)methyl)phenyl)-4-( ... 5-Chloro-N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethylpiperazine-1-yl) methyl) phenyl)-4-(6-methyl-1hindol …
Matched Iupac: … 5-chloro-N-(3-cyclopropyl-5-{[(3R,5S)-3,5-dimethylpiperazin-1-yl]methyl}phenyl)-4-(6-methyl-1H-indol- …
Matched Description: … in clinical trial NCT03850574 (Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and …
Matched Iupac: … 5-chloro-N-(3-cyclopropyl-5-{[(3R,5S)-3,5-dimethylpiperazin-1-yl]methyl}phenyl)-4-(6-methyl-1H-indol- …
Matched Description: … in clinical trial NCT03850574 (Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and …
Methopterin
Methopterin is thought to have effects on osteoclasts and to inhibit inflammatory bone destruction.
Investigational
Matched Synonyms: … alpha-Methopterin ... 10-methylfolic acid ... 10-methylpteroylglutamic acid …
Matched Description: … Methopterin is thought to have effects on osteoclasts and to inhibit inflammatory bone destruction. …
Matched Description: … Methopterin is thought to have effects on osteoclasts and to inhibit inflammatory bone destruction. …
Selonsertib
Selonsertib is under investigation in clinical trial NCT03053050 (Safety and Efficacy of Selonsertib in Adults With Nonalcoholic Steatohepatitis (NASH) and Bridging (F3) Fibrosis).
Investigational
Matched Synonyms: … BENZAMIDE, 5-(4-CYCLOPROPYL-1H-IMIDAZOL-1-YL)-2-FLUORO-4-METHYL-N-(6-(4-(1-METHYLETHYL)-4H-1,2,4-TRIAZOL ... 5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-{6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin ... 5-(4-Cyclopropyl-1H-imidazol-l-yl)-2-fluoro-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-methylbenzamide …
Matched Iupac: … 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-{6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin …
Matched Description: … Selonsertib is under investigation in clinical trial NCT03053050 (Safety and Efficacy of Selonsertib ... in Adults With Nonalcoholic Steatohepatitis (NASH) and Bridging (F3) Fibrosis). …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Iupac: … 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-{6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin …
Matched Description: … Selonsertib is under investigation in clinical trial NCT03053050 (Safety and Efficacy of Selonsertib ... in Adults With Nonalcoholic Steatohepatitis (NASH) and Bridging (F3) Fibrosis). …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Hydroxychloroquine
Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like chloroquine. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxychloroquine is also used for the prophylaxis of malaria in...
Approved
Matched Synonyms: … 7-chloro-4-(4-(ethyl(2-hydroxyethyl)amino)-1-methylbutylamino)quinoline ... 7-chloro-4-(4-(N-ethyl-N-β-hydroxyethylamino)-1-methylbutylamino)quinoline ... 7-chloro-4-[4-(N-ethyl-N-β-hydroxyethylamino)-1-methylbutylamino]quinoline …
Matched Iupac: … 2-({4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino)ethan-1-ol …
Matched Description: … Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. ... the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and ... [A183092] Chloroquine and hydroxychloroquine are both being investigated for the treatment of SARS-CoV …
Matched Categories: … Antiparasitic Products, Insecticides and Repellents ... Anti-Infective Agents …
Matched Products: … HALOXIN TABLET 100 mg ... PLAQUENIL 200 MG FILM KAPLI TABLET, 100 ADET …
Matched Iupac: … 2-({4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino)ethan-1-ol …
Matched Description: … Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. ... the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and ... [A183092] Chloroquine and hydroxychloroquine are both being investigated for the treatment of SARS-CoV …
Matched Categories: … Antiparasitic Products, Insecticides and Repellents ... Anti-Infective Agents …
Matched Products: … HALOXIN TABLET 100 mg ... PLAQUENIL 200 MG FILM KAPLI TABLET, 100 ADET …
Obiltoxaximab
Obiltoxaximab, an affinity-enhanced monoclonal antibody (Mab), is used for prevention and treatment of infection and death caused by anthrax toxin. Obiltoxaximab is a chimeric IgG1 kappa monoclonal antibody (mAb) that binds the PA component of B. anthracis toxin. It has an approximate molecular weight of 148 kDa.
Approved
Matched Description: … infection and death caused by anthrax toxin. ... Obiltoxaximab, an affinity-enhanced monoclonal antibody (Mab), is used for prevention and treatment of ... It has an approximate molecular weight of 148 kDa. …
Matched Categories: … Immune Sera and Immunoglobulins ... Amino Acids, Peptides, and Proteins ... Immunoglobulins ... Specific Immunoglobulins …
Matched Products: … Anthim …
Matched Categories: … Immune Sera and Immunoglobulins ... Amino Acids, Peptides, and Proteins ... Immunoglobulins ... Specific Immunoglobulins …
Matched Products: … Anthim …
Trihexyphenidyl
Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced extrapyramidal disorders.[L31773,L31778] Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity. Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is not a first line treatment due to significant...
Approved
Matched Iupac: … 1-cyclohexyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol …
Matched Description: … Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced ... [A229103] Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is not a first line treatment ... [L31843] Trihexyphenidyl was granted FDA approval on 13 May 1949.[L31768] …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Anti-Parkinson Drugs ... Anti-Dyskinesia Agents …
Matched Products: … TRIHEXYPHENIDYL (PYR) G …
Matched Description: … Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced ... [A229103] Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is not a first line treatment ... [L31843] Trihexyphenidyl was granted FDA approval on 13 May 1949.[L31768] …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Anti-Parkinson Drugs ... Anti-Dyskinesia Agents …
Matched Products: … TRIHEXYPHENIDYL (PYR) G …
Lerodalcibep
Lerodalcibep is under investigation in clinical trial NCT05004675 (Trial to Evaluate Efficacy and Safety of LIB003 and Inclisiran in High-risk CVD Patients).
Investigational
Matched Synonyms: … Engineered binding protein (1-96) anti-(human proprotein convertase subtilisin/kexin type 9), derived ... tenth fibronectin type iii domain, fused via peptidyl linker (97gsgsgs102) to human serum albumin (103 …
Matched Description: … of LIB003 and Inclisiran in High-risk CVD Patients). ... Lerodalcibep is under investigation in clinical trial NCT05004675 (Trial to Evaluate Efficacy and Safety …
Matched Description: … of LIB003 and Inclisiran in High-risk CVD Patients). ... Lerodalcibep is under investigation in clinical trial NCT05004675 (Trial to Evaluate Efficacy and Safety …
Osugacestat
Osugacestat (BMS-906024) has been used in trials studying the treatment of Cancer, Lymphoblastic Leukemia, Acute T-cell, and Precursor T-Cell Lymphoblastic Lymphoma.
Investigational
Matched Synonyms: … (2R,3S)-N1-((S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl ... Butanediamide, N1-((3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3- …
Matched Iupac: … (2R,3S)-N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl …
Matched Description: … , Acute T-cell, and Precursor T-Cell Lymphoblastic Lymphoma. ... Osugacestat (BMS-906024) has been used in trials studying the treatment of Cancer, Lymphoblastic Leukemia …
Matched Iupac: … (2R,3S)-N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl …
Matched Description: … , Acute T-cell, and Precursor T-Cell Lymphoblastic Lymphoma. ... Osugacestat (BMS-906024) has been used in trials studying the treatment of Cancer, Lymphoblastic Leukemia …
Resmetirom
Resmetirom is a thyroid hormone receptor-beta (THR-beta) agonist. On March 14, 2024, it was approved by the FDA as the first treatment of liver fibrosis due to noncirrhotic non-alcoholic steatohepatitis (NASH), which is a form of non-alcoholic fatty liver disease (NAFLD). Thyroid hormones directly regulate lipid metabolism in the liver;...
Approved
Investigational
Matched Synonyms: … 1,2,4-Triazine-6-carbonitrile, 2-[3,5-dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl] ... 2-[3,5-Dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy]phenyl]-2,3,4,5-tetrahydro- …
Matched Iupac: … 2-(3,5-dichloro-4-{[6-oxo-5-(propan-2-yl)-1,6-dihydropyridazin-3-yl]oxy}phenyl)-3,5-dioxo-2,3,4,5-tetrahydro …
Matched Description: … [A263461] Resmetirom works to reduce liver fat by stimulating fatty acid degradation and oxidation. ... On March 14, 2024, it was approved by the FDA as the first treatment of liver fibrosis due to noncirrhotic ... Resmetirom is a thyroid hormone receptor-beta (THR-beta) agonist. …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Thyroid hormone receptor-beta (THR-beta) agonist …
Matched Iupac: … 2-(3,5-dichloro-4-{[6-oxo-5-(propan-2-yl)-1,6-dihydropyridazin-3-yl]oxy}phenyl)-3,5-dioxo-2,3,4,5-tetrahydro …
Matched Description: … [A263461] Resmetirom works to reduce liver fat by stimulating fatty acid degradation and oxidation. ... On March 14, 2024, it was approved by the FDA as the first treatment of liver fibrosis due to noncirrhotic ... Resmetirom is a thyroid hormone receptor-beta (THR-beta) agonist. …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Thyroid hormone receptor-beta (THR-beta) agonist …
PF-4136309
Investigational
Matched Synonyms: … Benzamide, n-(2-((3s)-3-((trans-4-hydroxy-4-(5-(2-pyrimidinyl)- 2-pyridinyl)cyclohexyl)amino)-1-pyrrolidinyl ... N-(2-((3s)-3-((trans-4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2- yl)cyclohexyl)amino)pyrrolidin-1-yl)-2 …
Matched Iupac: … 1-yl]ethyl}-3-(trifluoromethyl)benzamide ... N-{2-oxo-2-[(3S)-3-{[(1r,4r)-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino}pyrrolidin- …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Iupac: … 1-yl]ethyl}-3-(trifluoromethyl)benzamide ... N-{2-oxo-2-[(3S)-3-{[(1r,4r)-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino}pyrrolidin- …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
LAS-191954
Investigational
Matched Synonyms: … 2-((1s)-1-((6-amino-5-cyano-4-pyrimidinyl)amino)ethyl)-3,4-dihydro-4-oxo-3-phenylpyrrolo(2,1-f)(1,2,4 ... Pyrrolo(2,1-f)(1,2,4)triazine-5-carbonitrile, 2-((1s)-1-((6-amino-5-cyano-4-pyrimidinyl)amino)ethyl)- …
Matched Iupac: … 4-amino-6-{[(1S)-1-{5-cyano-4-oxo-3-phenyl-3H,4H-pyrrolo[2,1-f][1,2,4]triazin-2-yl}ethyl]amino}pyrimidine …
Matched Iupac: … 4-amino-6-{[(1S)-1-{5-cyano-4-oxo-3-phenyl-3H,4H-pyrrolo[2,1-f][1,2,4]triazin-2-yl}ethyl]amino}pyrimidine …
Drotrecogin alfa
Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated...
Approved
Investigational
Withdrawn
Matched Synonyms: … Blood coagulation factor XIV (human) …
Matched Description: … It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and …
Matched Categories: … Anti-Infective Agents ... Amino Acids, Peptides, and Proteins ... Blood and Blood Forming Organs ... Enzymes and Coenzymes ... Biological Factors …
Matched Description: … It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and …
Matched Categories: … Anti-Infective Agents ... Amino Acids, Peptides, and Proteins ... Blood and Blood Forming Organs ... Enzymes and Coenzymes ... Biological Factors …
Nadofaragene firadenovec
Nadofaragene firadenovec (nadofaragene firadenovec-vncg) is a recombinant non-replicating adenovirus serotype 5 vector containing a transgene encoding human interferon alfa-2b (IFNα2b). It was approved by the FDA on December 2022 for the treatment of high-risk Bacillus Calmette-Guérin (BCG)-unresponsive non-muscle invasive bladder cancer (NMIBC) with carcinoma in situ (CIS) with or without...
Approved
Investigational
Matched Synonyms: … alpha-2b) gene under the control of the cytomegalovirus (cmv) immediate-early enhancer/promoter ... Replication-deficient adenovirus type 5 (ad5) vector encoding the human interferon alpha 2 (ifna2, interferon …
Matched Description: … [L44381,L44431] BCG-unresponsive NMIBC has a high recurrence and is notably difficult to treat. ... firadenovec is formulated with an excipient (Syn-3) that facilitates gene transfer across the urothelium and ... The localized expression of this gene induces anti-tumor effects. …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Cellular and Gene Therapy ... Antineoplastic cell and gene therapy …
Matched Description: … [L44381,L44431] BCG-unresponsive NMIBC has a high recurrence and is notably difficult to treat. ... firadenovec is formulated with an excipient (Syn-3) that facilitates gene transfer across the urothelium and ... The localized expression of this gene induces anti-tumor effects. …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Cellular and Gene Therapy ... Antineoplastic cell and gene therapy …
LPT-99
Investigational
Matched Synonyms: … -1-(2-(2-thienyl)ethyl)- ... 2-(4-(2,4-dichlorophenethyl)-3,6-dioxo-1-(2-(thiophen-2-yl)ethyl)piperazin-2-yl)-n-(2-(5-methoxy-1h-indol ... 2-(4-(2,4-dichlorophenethyl)-3,6-dioxo-1-(2-(thiophen-2-yl)ethyl)piperazin-2-yl)-n-(2-(5-methoxy-1h-indol …
Matched Iupac: … -1H-indol-3-yl)ethyl]acetamide ... 2-{4-[2-(2,4-dichlorophenyl)ethyl]-3,6-dioxo-1-[2-(thiophen-2-yl)ethyl]piperazin-2-yl}-N-[2-(5-methoxy …
Matched Iupac: … -1H-indol-3-yl)ethyl]acetamide ... 2-{4-[2-(2,4-dichlorophenyl)ethyl]-3,6-dioxo-1-[2-(thiophen-2-yl)ethyl]piperazin-2-yl}-N-[2-(5-methoxy …
Rodatristat
Investigational
Matched Synonyms: … (3s)-8-(2-amino-6-((1r)-1-(5-chloro(1,1'-biphenyl)-2-yl)-2,2,2-trifluoroethoxy)-4-pyrimidinyl)-2,8-diazaspiro ... (3s)-8-(2-amino-6-((1r)-1-(5-chloro(1,1'-biphenyl)-2-yl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)-2,8-diazaspiro ... 2,8-diazaspiro(4.5)decane-3-carboxylic acid, 8-(2-amino-6-((1r)-1-(5-chloro(1,1'-biphenyl)-2-yl)-2,2,2 …
Matched Iupac: … (3S)-8-{2-amino-6-[(1R)-1-{5-chloro-[1,1'-biphenyl]-2-yl}-2,2,2-trifluoroethoxy]pyrimidin-4-yl}-2,8-diazaspiro …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Iupac: … (3S)-8-{2-amino-6-[(1R)-1-{5-chloro-[1,1'-biphenyl]-2-yl}-2,2,2-trifluoroethoxy]pyrimidin-4-yl}-2,8-diazaspiro …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Displaying drugs 3676 - 3700 of 4636 in total