Displaying drugs 4201 - 4225 of 11590 in total
Cofirasersen
Cofirasersen is under investigation in clinical trial NCT04441788 (A Study to Assess the Safety, Tolerability, and Efficacy of ION-827359 in Participants With Mild to Moderate Chronic Obstructive Pulmonary Disease (COPD) With Chronic Bronchitis (CB)).
Investigational
Matched Synonyms: … -L-MANNOFURANO)M5C-G-A-T-A- ... 2'-o,4'-c-((s)-ethylidene))m5rc-(2'-o,4'-c-((s)-ethylidene))m5rc-(2'-o,4'-c-((s)-ethylidene))m5rc-g-a-t-a-g-m5c-t-g-g-t …
Matched Description: … Cofirasersen is under investigation in clinical trial NCT04441788 (A Study to Assess the Safety, Tolerability …
Matched Description: … Cofirasersen is under investigation in clinical trial NCT04441788 (A Study to Assess the Safety, Tolerability …
Vactosertib
Vactosertib is under investigation in clinical trial NCT03724851 (Vactosertib in Combination With Pembrolizumab in Metastatic Colorectal or Gastric Cancer).
Investigational
Matched Synonyms: … 2-fluoro-N-[[5-(6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-imidazol-2-yl]methyl] …
Matched Iupac: … 2-fluoro-N-{[5-(6-methylpyridin-2-yl)-4-{[1,2,4]triazolo[1,5-a]pyridin-6-yl}-1H-imidazol-2-yl]methyl} …
Matched Iupac: … 2-fluoro-N-{[5-(6-methylpyridin-2-yl)-4-{[1,2,4]triazolo[1,5-a]pyridin-6-yl}-1H-imidazol-2-yl]methyl} …
PEP0101
PEP0101 is a nanocomplex consisting of elastin-like polypeptides and a small interfering RNA (siRNA) designed to down-regulate the expression of EVI1 oncogene in cancer cells.
Investigational
Matched Synonyms: … Nanocomplex consisting of a small interfering RNA that targets the human EV11 oncogenic transcription …
Matched Description: … PEP0101 is a nanocomplex consisting of elastin-like polypeptides and a small interfering RNA (siRNA) …
Matched Description: … PEP0101 is a nanocomplex consisting of elastin-like polypeptides and a small interfering RNA (siRNA) …
WU-CART-007
WU-CART-007 consists of allogeneic, fratricide-resistant genetically modified T cells transduced with a 2nd generation 4-1BB-CD3z chimeric antigen receptor targeting human CD7.
Investigational
Matched Synonyms: … an allogeneic, fratricide-resistant genetically modified T cell transduced with a 2nd generation 4-1BB-CD3z …
Matched Description: … WU-CART-007 consists of allogeneic, fratricide-resistant genetically modified T cells transduced with a …
Matched Description: … WU-CART-007 consists of allogeneic, fratricide-resistant genetically modified T cells transduced with a …
Suratadenoturev
Suratadenoturev is a gene-modified oncolytic adenovirus expressing the telomerase reverse transcriptase gene.
Investigational
Matched Synonyms: … A replication-competent adenovirus type 5 in which the E1A and E1B genes are under the control of a human ... A recombinant replication-competent adenovirus type 5 (Ad-5) in which the E1 gene, including its normal …
Matched Description: … Suratadenoturev is a gene-modified oncolytic adenovirus expressing the telomerase reverse transcriptase …
Matched Description: … Suratadenoturev is a gene-modified oncolytic adenovirus expressing the telomerase reverse transcriptase …
N-acetyl-alpha-D-glucosamine
The N-acetyl derivative of glucosamine.
Experimental
Matched Synonyms: … 2-(acetylamino)-2-deoxy-A-D-glucopyranose …
OTL-203
OTL-203 is an autologous CD34+ enriched cell therapy that contains hematopoietic stem and progenitor cells transduced ex-vivo using a lentiviral vector encoding alpha-L-iduronidase gene.
Investigational
Matched Synonyms: … enriched cell population that contains hematopoietic stem and progenitor cells transduced ex-vivo using a …
Matched Description: … enriched cell therapy that contains hematopoietic stem and progenitor cells transduced ex-vivo using a …
Matched Description: … enriched cell therapy that contains hematopoietic stem and progenitor cells transduced ex-vivo using a …
Tuvusertib
Investigational
Matched Synonyms: … 2-amino-6-fluoro-N-[5-fluoro-4-(1-methyl-1H-imidazol-5-yl)pyridin-3-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide …
Xevinapant
Investigational
Matched Synonyms: … 10aR)-N-benzhydryl-5-((S)-2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a] ... PYRROLO(1,2-A)(1,5)DIAZOCINE-8-CARBOXAMIDE, N-(DIPHENYLMETHYL)DECAHYDRO-5-(((2S)-2-(METHYLAMINO)-1-OXOPROPYL …
Matched Iupac: … diphenylmethyl)-5-[(2S)-2-(methylamino)propanamido]-3-(3-methylbutanoyl)-6-oxo-decahydropyrrolo[1,2-a] …
Matched Iupac: … diphenylmethyl)-5-[(2S)-2-(methylamino)propanamido]-3-(3-methylbutanoyl)-6-oxo-decahydropyrrolo[1,2-a] …
Gartisertib
Investigational
Matched Synonyms: … fluoro-n-(5-fluoro-4-(4-((4-(oxetan-3-yl)piperazin-1-yl)carbonyl)-1-piperidyl)-3-pyridyl)pyrazolo(1,5-a) ... Pyrazolo(1,5-a)pyrimidine-3-carboxamide, 2-amino-6-fluoro-n-(5-fluoro-4-(4-((4-(3-oxetanyl)-1-piperazinyl …
Acazicolcept
Investigational
Matched Synonyms: … HUMAN IMMUNOGLOBULIN G1 FC FRAGMENT (133-363) VARIANT (C137>S, L151>A, L152>E, G154>A, ... Fc fusion protein of a human inducible T cell costimulator ligand variant immunoglobulin domain designed ... N-TERMINAL FRAGMENT (1-122) (VARIANT (N52>H, N57>Y, Q100>R), FUSED VIA PEPTIDYL LINKER 123GGGGSGGGGS132 TO A …
Ozanezumab
Ozanezumab has been used in trials studying the treatment of Multiple Sclerosis, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis, Relapsing-Remitting.
Investigational
Matched Synonyms: … IMMUNOGLOBULIN G1, ANTI-(PROTEIN NOGO-A) (HUMAN-MUS MUSCULUS MONOCLONAL HEAVY CHAIN), DISULFIDE WITH …
Ganaplacide
Ganaplacide is under investigation in clinical trial NCT03167242 (Efficacy and Safety of KAF156 in Combination With LUM-SDF in Adults and Children With Uncomplicated Plasmodium Falciparum Malaria).
Investigational
Matched Synonyms: … 2-Amino-1-[2-(4-fluorophenyl)-3-[(4-fluorophenyl)amino]-5,6-dihydro-8,8-dimethylimidazo[1,2-a]pyrazin …
Matched Iupac: … 2-amino-1-[2-(4-fluorophenyl)-3-[(4-fluorophenyl)amino]-8,8-dimethyl-5H,6H,7H,8H-imidazo[1,2-a]pyrazin …
Matched Iupac: … 2-amino-1-[2-(4-fluorophenyl)-3-[(4-fluorophenyl)amino]-8,8-dimethyl-5H,6H,7H,8H-imidazo[1,2-a]pyrazin …
Eltrapuldencel-T
Investigational
Matched Synonyms: … cells loaded with antigen from self-renewing, proliferating autologous irradiated tumour cells, in a …
ssCART-19 cells
ssCART-19 cells consist of autologous anti-CD19 Chimeric Antigen Receptors (CAR)-T cells expressing a short hairpin RNA (shRNA) against interleukin-6 (IL-6).
Investigational
Matched Synonyms: … autologous anti-CD19 Chimeric Antigen Receptors (CAR)-T cells expressing a short hairpin RNA (shRNA) …
Matched Description: … ssCART-19 cells consist of autologous anti-CD19 Chimeric Antigen Receptors (CAR)-T cells expressing a …
Matched Description: … ssCART-19 cells consist of autologous anti-CD19 Chimeric Antigen Receptors (CAR)-T cells expressing a …
Sanfetrinem cilexetil
Sanfetrinem cilexetil is under investigation in clinical trial NCT05388448 (EBA, Safety and Tolerability of Sanfetrinem Cilexetil).
Investigational
Matched Synonyms: … hydroxyethyl (1s,5s,8as,8br)-1,2,5,6,7,8,8a,8b-octahydro-1-((r)-1-hydroxyethyl)-5-methoxy-2-oxoazeto(2,1-a) …
ABT-341
ABT-341 is a potent and selective DPP-4 inhibitor with a structure very similar to sitagliptin (in 2D; the 3D structure is significantly different).
Experimental
Matched Synonyms: … (1S,6R)-3-{[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]CARBONYL}-6-(2,4,5- …
Matched Iupac: … (1S,6R)-3-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl]-6-(2,4,5-trifluorophenyl …
Matched Description: … ABT-341 is a potent and selective DPP-4 inhibitor with a structure very similar to sitagliptin (in 2D …
Matched Iupac: … (1S,6R)-3-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl]-6-(2,4,5-trifluorophenyl …
Matched Description: … ABT-341 is a potent and selective DPP-4 inhibitor with a structure very similar to sitagliptin (in 2D …
AB-201
AB-201 is a CAR-NK cell therapy targeted against HER2. It is under investigation for the treatment of HER2-positive cancers, including breast and gastric carcinomas.
Investigational
Matched Synonyms: … vivo expanded allogeneic cord blood-derived NK cells that have been genetically modified to express a …
Matched Description: … AB-201 is a CAR-NK cell therapy targeted against HER2. …
Matched Description: … AB-201 is a CAR-NK cell therapy targeted against HER2. …
OTL-102
OTL-102 consists of autologous CD34+ enriched cells that contain hematopoietic stem and progenitor cells transduced ex vivo using a lentiviral vector encoding the human gp91phox gene. It is being investigated for the treatment of X-linked chronic granulomatous disease.
Investigational
Matched Synonyms: … enriched cell population that contains hematopoietic stem and progenitor cells transduced ex vivo using a …
Matched Description: … CD34+ enriched cells that contain hematopoietic stem and progenitor cells transduced ex vivo using a …
Matched Description: … CD34+ enriched cells that contain hematopoietic stem and progenitor cells transduced ex vivo using a …
Elivaldogene tavalentivec
Investigational
Matched Synonyms: … A vsv-g*-pseudotyped self-inactivating hiv-1-derived lentiviral vector (plbp100 hald) encoding human ... adrenoleukodystrophy (ald) protein (abcd1 gene) under the control of a modified myeloproliferative sarcoma …
EB003
EB003 is a CRISPR-based sequence-specific antimicrobial (SSAM) targeted against shiga toxin-producing E. coli.
Investigational
Matched Synonyms: … Phage-derived, non-replicative delivery vector carrying a DNA payload encoding an RNA-guided nuclease …
Matched Description: … EB003 is a CRISPR-based sequence-specific antimicrobial (SSAM) targeted against shiga toxin-producing …
Matched Description: … EB003 is a CRISPR-based sequence-specific antimicrobial (SSAM) targeted against shiga toxin-producing …
Birabresib
Birabresib is under investigation in clinical trial NCT02698176 (A Dose Exploration Study With MK-8628 in Participants With Selected Advanced Solid Tumors (MK-8628-006)).
Investigational
Matched Synonyms: … 2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thienol[3,2,-f]-[1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl …
Matched Description: … Birabresib is under investigation in clinical trial NCT02698176 (A Dose Exploration Study With MK-8628 …
Matched Description: … Birabresib is under investigation in clinical trial NCT02698176 (A Dose Exploration Study With MK-8628 …
CYNK-101
CYNK-101 is an allogeneic human placental hematopoietic stem cell-derived natural killer (NK) cell therapy product that is genetically modified to express a variant of CD16 (CD16VP).
Investigational
Matched Synonyms: … stem cell derived natural killer (NK) cell therapy product that is genetically modified to express a …
Matched Description: … stem cell-derived natural killer (NK) cell therapy product that is genetically modified to express a …
Matched Description: … stem cell-derived natural killer (NK) cell therapy product that is genetically modified to express a …
Glumetinib
Glumetinib is under investigation in clinical trial NCT04270591 (Assess the Anti-tumor Activity and Safety of Glumetinib in Patient With Advanced C-met-positive Non-small Cell Lung Cancer).
Investigational
Matched Synonyms: … 6-(1-methyl-1h-pyrazol-4-yl)-1-((6-(1-methyl-1h-pyrazol-4-yl)imidazo(1,2-a)pyridin-3-yl)sulfonyl)-1h-pyrazolo …
Matched Iupac: … 1-methyl-4-(3-{[6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[4,3-b]pyridin-1-yl]sulfonyl}imidazo[1,2-a]pyridin …
Matched Iupac: … 1-methyl-4-(3-{[6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[4,3-b]pyridin-1-yl]sulfonyl}imidazo[1,2-a]pyridin …
Displaying drugs 4201 - 4225 of 11590 in total