Displaying drugs 401 - 425 of 14019 in total
Sofosbuvir
Sofosbuvir (tradename Sovaldi) is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the...
Approved
Matched Synonyms: … -methyltetrahydrofuran-2-yl)methoxy)- (phenoxy)phosphorylamino)propanoate ... S)-Isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4 …
Matched Iupac: … propan-2-yl (2S)-2-{[(S)-{[(2R,3R,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-4-fluoro-3-hydroxy ... -4-methyloxolan-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate …
Matched Description: … and 6 with or without [DB00811] depending on the level of liver damage or cirrhosis [FDA Label]. ... In a joint recommendation published in 2016, the American Association for the Study of Liver Diseases ... Its use has also proven successful in the treatment of HCV in patients co-infected with HIV [A19627]. …
Matched Categories: … Antivirals for treatment of HCV infections …
Matched Iupac: … propan-2-yl (2S)-2-{[(S)-{[(2R,3R,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-4-fluoro-3-hydroxy ... -4-methyloxolan-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate …
Matched Description: … and 6 with or without [DB00811] depending on the level of liver damage or cirrhosis [FDA Label]. ... In a joint recommendation published in 2016, the American Association for the Study of Liver Diseases ... Its use has also proven successful in the treatment of HCV in patients co-infected with HIV [A19627]. …
Matched Categories: … Antivirals for treatment of HCV infections …
Influenza A virus A/Switzerland/9715293/2013 (H3N2) recombinant hemagglutinin antigen
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …
Apalutamide
Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Resistant Prostate Cancer, and Prostatic...
Approved
Investigational
Matched Iupac: … 4-{7-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-5-yl}-2 …
Matched Description: … AR gene targets in prostate tumors [A31846]. ... In a phase-2 multicenter open-label study, 89% of patients with non-metastatic, castration-resistant ... It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms …
Matched Categories: … MATE 2 Inhibitors …
Matched Description: … AR gene targets in prostate tumors [A31846]. ... In a phase-2 multicenter open-label study, 89% of patients with non-metastatic, castration-resistant ... It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms …
Matched Categories: … MATE 2 Inhibitors …
Influenza B virus B/Phuket/3073/2013 hemagglutinin antigen (propiolactone inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …
Influenza B virus B/Brisbane/9/2014 hemagglutinin antigen (formaldehyde inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …
Influenza B virus B/Phuket/3073/2013 hemagglutinin antigen (formaldehyde inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …
Matched Mixtures name: … Efluelda Injektionssuspension in einer Fertigspritze …
Matched Mixtures name: … Efluelda Injektionssuspension in einer Fertigspritze …
Influenza B virus B/Brisbane/46/2015 hemagglutinin antigen (propiolactone inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …
Influenza B virus B/Hubei-Wujiagang/158/2009 BX-39 antigen (UV, formaldehyde inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …
Influenza B virus B/Iowa/06/2017 antigen (MDCK cell derived, propiolactone inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …
Indocyanine green
Approved
Experimental
Matched Iupac: … sodium 2-{7-[1,1-dimethyl-3-(4-sulfonatobutyl)-1H,2H,3H-benzo[e]indol-2-ylidene]hepta-1,3,5-trien-1-yl …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Compounds used in a research, industrial, or household setting …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Compounds used in a research, industrial, or household setting …
Gallium Ga-68 gozetotide
Gallium (Ga) 68 prostate-specific membrane antigen (PSMA)-11, or Ga-68 gozetotide, is a radiopharmaceutical agent used to identify and assess prostate-specific membrane antigen (PSMA)-positive lesions in adult men with prostate cancer during positron emission tomography (PET). Prostate cancer is one of the most commonly diagnosed cancers among men in Western countries...
Approved
Matched Iupac: … (68Ga)gallium(3+) 3-(3-{[(2-{[(5-{2-[(5-{[(5S)-5-carboxy-5-({[(1S)-1,3-dicarboxypropyl]carbamoyl}amino ... )pentyl]carbamoyl}pentyl)carbamoyl]ethyl}-2-hydroxyphenyl)methyl](carboxylatomethyl)amino}ethyl)(carboxylatomethyl …
Matched Description: … [L43542] In December of the same year, the drug was fully authorized by the EMA. ... [L26981] Prostate cancer is one of the most commonly diagnosed cancers among men in Western countries ... be granted marketing authorization for the diagnosis of prostate cancer. …
Matched Categories: … Diagnostic Uses of Chemicals ... Compounds used in a research, industrial, or household setting …
Matched Description: … [L43542] In December of the same year, the drug was fully authorized by the EMA. ... [L26981] Prostate cancer is one of the most commonly diagnosed cancers among men in Western countries ... be granted marketing authorization for the diagnosis of prostate cancer. …
Matched Categories: … Diagnostic Uses of Chemicals ... Compounds used in a research, industrial, or household setting …
Perflutren
Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultrasound machine. The difference in density between the...
Approved
Matched Description: … level of contrast visible in the resulting ultrasound image. ... During echocardiography, activated Perflutren enhances images of the inner edges or borders of the heart ... The difference in density between the gas-filled bubbles and the blood around them creates an increased …
Matched Categories: … Diagnostic Uses of Chemicals ... Compounds used in a research, industrial, or household setting …
Matched Categories: … Diagnostic Uses of Chemicals ... Compounds used in a research, industrial, or household setting …
Interferon alfa-n3
Purified, natural (n is for natural) human interferon alpha proteins (consists of 3 forms or polymorphisms including 2a, 2b and 2c). 166 residues, some are glycosylated (MW range from 16 kD to 27 kD).
Approved
Investigational
Matched Description: … Purified, natural (n is for natural) human interferon alpha proteins (consists of 3 forms or polymorphisms …
Larotrectinib
Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby preventing neurotrophin-Trk interaction and...
Approved
Investigational
Matched Iupac: … (3S)-N-{5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl}-3-hydroxypyrrolidine …
Matched Description: … both the induction of cellular apoptosis and the inhibition of cell growth in tumors that overexpress ... kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important ... of Trk-positive solid tumors. …
Matched Description: … both the induction of cellular apoptosis and the inhibition of cell growth in tumors that overexpress ... kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important ... of Trk-positive solid tumors. …
Histamine
A depressor amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
Approved
Investigational
Matched Synonyms: … 2-(4-imidazolyl)ethylamine …
Matched Iupac: … 2-(1H-imidazol-4-yl)ethan-1-amine …
Matched Description: … It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator ... A depressor amine derived by enzymatic decarboxylation of histidine. …
Matched Mixtures name: … Histamine DHCl 0.10 Percent and Menthol 2 Percent …
Matched Iupac: … 2-(1H-imidazol-4-yl)ethan-1-amine …
Matched Description: … It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator ... A depressor amine derived by enzymatic decarboxylation of histidine. …
Matched Mixtures name: … Histamine DHCl 0.10 Percent and Menthol 2 Percent …
Amiloxate
Amiloxate is an EMA-approved chemical UV-filter found in over-the-counter sunscreen products at concentrations up to 10%m . It is often referred to as isoamyl 4-methoxycinnamate or isoamyl p-methoxycinnamate. Amiloxate is a cinnamic acid derivative with an anti-inflammatory activity .
Approved
Matched Synonyms: … 3-(4-Methoxyphenyl)-2-propenoic acid, 3-methylbutyl ester …
Matched Iupac: … 3-methylbutyl (2E)-3-(4-methoxyphenyl)prop-2-enoate …
Matched Description: … Amiloxate is an EMA-approved chemical UV-filter found in over-the-counter sunscreen products at concentrations …
Matched Mixtures name: … The History of Whoo Jin Hae Yoon Sun …
Matched Iupac: … 3-methylbutyl (2E)-3-(4-methoxyphenyl)prop-2-enoate …
Matched Description: … Amiloxate is an EMA-approved chemical UV-filter found in over-the-counter sunscreen products at concentrations …
Matched Mixtures name: … The History of Whoo Jin Hae Yoon Sun …
Influenza B virus B/Singapore/INFTT-16-0610/2016 hemagglutinin antigen (MDCK cell derived, propiolactone inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …
Collagenase clostridium histolyticum
Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum. It is beneficial in the breakdown of collagen plaques for the treatment of Dupuytren's contracture and Peyronie's disease. The topical formulation is used for the debridement of necrotic tissue due to burns or chronic ulcers. On July 6,...
Approved
Investigational
Matched Description: … for the treatment of cellulite in adult women. ... It is beneficial in the breakdown of collagen plaques for the treatment of Dupuytren's contracture and ... [L14912]
On July 6, 2020 a combination of injectable bacterial collagenases was approved by the FDA …
Matched Categories: … Preparations for Treatment of Wounds and Ulcers …
Matched Categories: … Preparations for Treatment of Wounds and Ulcers …
Sodium zirconium cyclosilicate
Sodium zirconium cyclosilicate is approved as the trade product Lokelma developed by AstraZeneca - an insoluble, non-absorbed sodium zirconium silicate, formulated as a powder for oral suspension that acts as a highly selective potassium removing agent. It is administered orally and is odorless, tasteless, and stable at room temperature. Approval...
Approved
Investigational
Matched Description: … time to achieving normal potassium levels in the blood was 2.2 hours, with 92% of patients achieving ... [L2933] Approval of the medication is supported by data from three double-blind, placebo-controlled trials ... and two open-label trials which showed that the onset of action was approximately 1.0 hour and the median …
Matched Categories: … Drugs for Treatment of Hyperkalemia and Hyperphosphatemia ... Compounds used in a research, industrial, or household setting …
Matched Categories: … Drugs for Treatment of Hyperkalemia and Hyperphosphatemia ... Compounds used in a research, industrial, or household setting …
Palovarotene
Fibrodysplasia Ossificans Progressiva (FOP), with an estimated worldwide prevalence of one in 2 million individuals, is an exceptionally rare genetic disorder. FOP is caused by a gain-of-function mutation in the ACVR1/ALK2 gene which results in progressive heterotopic ossification, a process wherein connective tissues (e.g. skeletal muscle, ligaments, tendons) are replaced...
Approved
Investigational
Matched Iupac: … 4-[(1E)-2-{5,5,8,8-tetramethyl-3-[(1H-pyrazol-1-yl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl}ethenyl] …
Matched Description: … [A244920] FOP is caused by a gain-of-function mutation in the ACVR1/ALK2 gene which results in progressive ... Fibrodysplasia Ossificans Progressiva (FOP), with an estimated worldwide prevalence of one in 2 million ... [A244920] Palovarotene was approved for use in Canada in January 2022 for the management of heterotopic …
Matched Description: … [A244920] FOP is caused by a gain-of-function mutation in the ACVR1/ALK2 gene which results in progressive ... Fibrodysplasia Ossificans Progressiva (FOP), with an estimated worldwide prevalence of one in 2 million ... [A244920] Palovarotene was approved for use in Canada in January 2022 for the management of heterotopic …
Agalsidase alfa
Agalsidase alfa is a recombinant human α-galactosidase A similar to agalsidase beta. While patients generally do not experience a clinically significant difference in outcomes between the two drugs, some patients may experience greater benefit with agalsidase beta.[A220228,A220233] Use of agalsidase beta has decreased in Europe, in favor of agalsidase alfa,...
Approved
Matched Description: … [A220228,A220233] Use of agalsidase beta has decreased in Europe, in favor of agalsidase alfa, after ... a contamination event in 2009. ... While patients generally do not experience a clinically significant difference in outcomes between the …
Streptococcus pneumoniae type 9n capsular polysaccharide antigen
Streptococcus pneumoniae type 9n capsular polysaccharide antigen is a vaccine that contains highly purified capsular polysaccharides from the invasive pneumococcal type 9n of Streptococcus pneumoniae. It is an active immunization for intramuscular or subcutaneous injection against pneumococcal disease such as pneumococcal pneumonia and pneumococcal bacteremia.
Approved
Investigational
Matched Description: … vaccine that contains highly purified capsular polysaccharides from the invasive pneumococcal type 9n of …
Matched Mixtures name: … PNEUMOVAX 23 Injektionslösung in einer Fertigspritze ... PNEUMOVAX 23 Injektionslösung in einer Durchstechflasche …
Matched Mixtures name: … PNEUMOVAX 23 Injektionslösung in einer Fertigspritze ... PNEUMOVAX 23 Injektionslösung in einer Durchstechflasche …
Influenza A virus A/California/7/2009 X-179A (H1N1) antigen (formaldehyde inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Investigational
Matched Description: … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …
Influenza B virus B/Wisconsin/1/2010) antigen (MDCK cell derived, propiolactone inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …
Influenza A virus A/Brisbane/02/2018 IVR-190 (H1N1) antigen (propiolactone inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …
Displaying drugs 401 - 425 of 14019 in total