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Displaying drugs 426 - 450 of 15377 in total

Taurine

Taurine, whose chemical name is 2-aminoethanesulfonic acid, is one of the most abundant amino acids in several organs. It plays important role in essential biological processes. This conditional amino acid can be either be manufactured by the body or obtained in the diet mainly by the consumption of fish and...
Approved
Nutraceutical
Matched Description: … can be either be manufactured by the body or obtained in the diet mainly by the consumption of fish and ... [L1058] The supplements containing taurine were FDA approved by 1984 and they are hypertonic injections …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Poliovirus type 1 antigen (formaldehyde inactivated)

Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were...
Approved
Investigational
Matched Description: … Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and ... The vaccine contains purified and inactivated poliovirus type 1 that were grown from a continuous line …

Poliovirus type 2 antigen (formaldehyde inactivated)

Poliovirus type 2 antigen is a suspension of poliovirus Type 2 (MEF-1) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 2. The vaccine contains purified and inactivated poliovirus type 2 that were...
Approved
Investigational
Matched Description: … The vaccine contains purified and inactivated poliovirus type 2 that were grown from a continuous line ... poliovirus Type 2 (MEF-1) used in the active immunization of infants (as young as 6 weeks of age), children, and …

Poliovirus type 3 antigen (formaldehyde inactivated)

Poliovirus type 3 antigen is a suspension of poliovirus Type 3 (Saukett) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 3. The vaccine contains purified and inactivated poliovirus type 3 that were...
Approved
Investigational
Matched Description: … Type 3 (Saukett) used in the active immunization of infants (as young as 6 weeks of age), children, and ... The vaccine contains purified and inactivated poliovirus type 3 that were grown from a continuous line …

Kappadione

Kappadione is a Vitamin K derivative (chemically, it is menadiol sodium diphosphate), previously approved by FDA prior to 1982 and marketed by Lilly Marketing for this drug has been discontinued and is not available in North America . It has been found to have carcinogenic potential in mammalian cells as...
Approved
Matched Iupac: … tetrasodium 3-methyl-4-(phosphonatooxy)naphthalen-1-yl phosphate …
Matched Description: … derivative (chemically, it is menadiol sodium diphosphate), previously approved by FDA prior to 1982 and ... marketed by Lilly Marketing for this drug has been discontinued and is not available in North America …

Remdesivir

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends on an RNA-dependent RNA polymerase...
Approved
Investigational
Matched Description: … the related SARS-CoV and MERS-CoV,[A222398] and has been investigated in multiple COVID-19 clinical ... disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and ... , A222393] Broad antiviral activity of remdesivir is suggested by its mechanism of action,[A222398] and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Nucleosides and Nucleotides ... Nucleic Acids, Nucleotides, and Nucleosides ... Nucleosides and Nucleotides Excl. Reverse Transcriptase Inhibitors …

Difenoxin

Difenoxin is a 4-phenylpiperidine which is closely related to the opioid analgesic meperidine. Difenoxin alone is a USA Schedule I controlled drug, as it may be habit forming. However, it is listed as a Schedule IV controlled drug if combined with atropine, which is added to decrease deliberate misuse. Motofen(R)...
Approved
Illicit
Matched Description: … It is approved by the FDA to treat acute and chronic diarrhea. ... Motofen(R) is a brand mixture which combines atropine sulfate and difenoxin hydrochloride. ... It works mostly in the periphery and activates opioid receptors in the intestine rather than the central …
Matched Categories: … Alimentary Tract and Metabolism …

Indacaterol

Indacaterol is a novel, ultra-long-acting, rapid onset β(2)-adrenoceptor agonist developed for Novartis for the once-daily management of asthma and chronic obstructive pulmonary disease. It was approved by the European Medicines Agency (EMA) on 30 November 2009 and by the FDA on 1 July 2011. It is marketed in Europe as...
Approved
Matched Description: … Indacaterol is provided as its maleate salt form. ... It is marketed in Europe as Onbrez and in America as Arcapta Neohaler. ... rapid onset β(2)-adrenoceptor agonist developed for Novartis for the once-daily management of asthma and …
Matched Categories: … indacaterol and mometasone ... indacaterol and glycopyrronium bromide ... indacaterol, glycopyrronium bromide and mometasone …

Asparaginase Erwinia chrysanthemi

Asparaginase Erwinia chrysanthemi is an asparaginase-specific enzyme derived from Erwinia chrysanthemi used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-asparaginase was first identified in...
Approved
Investigational
Matched Description: … L-asparaginase, including [Asparaginase Escherichia coli] and a pegylated form of this enzyme, [Pegaspargase ... [L149] In June 2021, the recombinant form of asparaginase _Erwinia chrysanthemi_ was approved by the ... [L1448] L-asparaginase was first identified in 1963,[A236344] and there are different formulations of …
Matched Categories: … Enzymes and Coenzymes …

Tacrolimus

Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis...
Approved
Investigational
Matched Description: … drug whose main use is after organ transplant to reduce the activity of the patient's immune system and ... the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and ... This FKBP12-FK506 complex inhibits calcineurin which inhibits T-lymphocyte signal transduction and IL …
Matched Categories: … Skin and Mucous Membrane Agents ... Antineoplastic and Immunomodulating Agents …

Buclizine

Buclizine is an antihistamine medication with both antiemetic and anticholinergic effects , belonging to the piperazine derivative family of drugs. It was manufactured by Stuart Pharms and initially approved by the FDA in 1957. Following this, it was touted to be effective as an appetite stimulant in children when administered...
Approved
Matched Iupac: … 1-[(4-tert-butylphenyl)methyl]-4-[(4-chlorophenyl)(phenyl)methyl]piperazine …
Matched Description: … , it was touted to be effective as an appetite stimulant in children when administered in the syrup form ... in the treatment of nausea and vomiting during pregnancy. ... It was manufactured by Stuart Pharms and initially approved by the FDA in 1957. …

Testosterone undecanoate

Testosterone undecanoate is the ester prodrug of testosterone and has a mid-chain fatty acid at the carbon 17β position. It was developed via fatty acid esterification of testosterone in order to achieve orally administer testosterone. There are oral and intramuscular formulations available for testosterone undecanoate: both formulations are indicated for...
Approved
Investigational
Matched Description: … of testosterone deficiency, such as decreased libido, erectile dysfunction, and loss of muscle and bone ... Testosterone undecanoate is the ester prodrug of [testosterone] and has a mid-chain fatty acid at the ... development of the male sex organs and for the maintenance of secondary sex characteristics. …
Matched Categories: … Testosterone and derivatives ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Luspatercept

Luspatercept is a recombinant fusion protein comprised of a modified extracellular domain of activin receptor type IIB fused to the FC domain of human IgG1.[A187829,L42455] It was first approved for use in the United States in November 2019 under the brand name Reblozyl® for the treatment of anemia in patients...
Approved
Investigational
Matched Description: … the treatment of conditions in which late-stage erythropoiesis is defective, such as beta thalassemia and ... erythropoiesis, in contrast to typical erythropoiesis-stimulating agents (ESAs), such as [darbepoetin alfa] and …
Matched Categories: … Enzymes and Coenzymes ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins ... Intracellular Signaling Peptides and Proteins …

Dichlorobenzyl alcohol

Dichlorobenzyl alcohol is a mild antiseptic with a broad spectrum for bacterial and virus associated with mouth and throat infections. Dichlorobenzyl alcohol is considered as an active ingredient found in several marketed OTC products by Health Canada which has categorized this agent as an anatomical therapeutic chemical. On the other...
Approved
Matched Description: … with mouth and throat infections. ... Dichlorobenzyl alcohol is a mild antiseptic with a broad spectrum for bacterial and virus associated …
Matched Mixtures name: … STREPSILS HONEY AND LEMON ... STREPSILS SORE THROAT AND BLOCKED NOSE LOZENGE ... Difflam plus ANAESTHETIC Sore Throat Lozenges (Sugar Free) Menthol and Eucalyptus Flavour …

Flurazepam

A benzodiazepine derivative used mainly as a hypnotic.
Approved
Illicit
Investigational
Matched Categories: … Hypnotics and Sedatives ... Benzodiazepines and benzodiazepine derivatives …

Benzoic acid

A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid. As the sodium salt form, sodium benzoate is used as a treatment for urea cycle disorders due to its ability to bind amino acids. This leads...
Approved
Investigational
Matched Description: … As the sodium salt form, sodium benzoate is used as a treatment for urea cycle disorders due to its ability ... It is conjugated to GLYCINE in the liver and excreted as hippuric acid. ... This leads to excretion of these amino acids and a decrease in ammonia levels. …
Matched Mixtures name: … Sodium Phenylacetate and Sodium Benzoate ... Sodium Phenylacetate and Sodium Benzoate ... Sodium Phenylacetate and Sodium Benzoate …
Matched Categories: … Diet, Food, and Nutrition ... Alimentary Tract and Metabolism ... caffeine and sodium benzoate ... sodium benzoate and sodium phenylacetate ... Various Alimentary Tract and Metabolism Products …

Amlexanox

Amlexanox is an antiallergic drug, clinically effective for atopic diseases, especially allergic asthma and rhinitis. Amlexanox as a topical paste is a well tolerated treatment of recurrent aphthous ulcers. Recurrent aphthous ulcer (RAU) is the most prevalent oral mucosal disease in humans, estimated to affect between 5% and 50% of...
Approved
Investigational
Withdrawn
Matched Description: … Amlexanox is an antiallergic drug, clinically effective for atopic diseases, especially allergic asthma and ... aphthous ulcer (RAU) is the most prevalent oral mucosal disease in humans, estimated to affect between 5% and …
Matched Categories: … Alimentary Tract and Metabolism …

Sofosbuvir

Sofosbuvir (tradename Sovaldi) is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the...
Approved
Matched Description: … As a prodrug nucleotide analog, Sofosbuvir is metabolized into its active form as the antiviral agent ... count, and neuropsychiatric effects [A19635]. ... for its high replicative rate and genetic diversity [A19594]. …
Matched Mixtures name: … Ledipasvir and Sofosbuvir ... Sofosbuvir and Velpatasvir …
Matched Categories: … sofosbuvir and ledipasvir ... sofosbuvir and velpatasvir ... sofosbuvir, velpatasvir and voxilaprevir ... Nucleic Acids, Nucleotides, and Nucleosides …

Larotrectinib

Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby preventing neurotrophin-Trk interaction and...
Approved
Investigational
Matched Description: … plays an important role in tumor cell growth and survival. ... receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and ... Trk activation, which results in both the induction of cellular apoptosis and the inhibition of cell …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Lutropin alfa

Lutropin alfa is a recombinant human luteinizing hormone produced in yeast with 2 subunits, alpha = 92 residues, beta = 121 residues. It is a heterodimeric glycoprotein made up of monomeric units. Lutropin alfa was the first and only recombinant human form of luteinizing hormone (LH) developed for use in...
Approved
Matched Description: … Lutropin alfa was the first and only recombinant human form of luteinizing hormone (LH) developed for ... biological activity of endogenous LH; an acute rise of LH, or LH surge, in females triggers ovulation and …
Matched Mixtures name: … Pergoveris 150IU/75IU powder and solvent for solution for injection ... Pergoveris Powder and Solvent for Solution for Injection 150iu/75iu …
Matched Categories: … Gonadotropins and Antigonadotropins ... Genito Urinary System and Sex Hormones ... Sex Hormones and Modulators of the Genital System …

Gadobenic acid

Gadobenic acid, usually available in the salt form gadobenate dimeglumine, is a linear MRI gadolinium-based contrast agent (GBCA) used primarily for MR imaging of the liver. It differs from other GBCAs due to the benzene ring that confers weak protein binding, thus leading to an increased R1 and R2 relaxivity....
Approved
Investigational
Matched Description: … Gadobenic acid, usually available in the salt form gadobenate dimeglumine, is a linear MRI gadolinium-based ... [A263166] As gadobenate dimeglumine is specifically taken up by hepatocytes and excreted through the ... other GBCAs due to the benzene ring that confers weak protein binding, thus leading to an increased R1 and …

Famciclovir

Famciclovir, marketed as Famvir by Novartis, is a guanine analogue used to treat herpes virus infections. It is most commonly used to treat herpes zoster (shingles). Famciclovir is a prodrug of penciclovir with higher oral bioavailability.
Approved
Investigational
Matched Iupac: … 2-[(acetyloxy)methyl]-4-(2-amino-9H-purin-9-yl)butyl acetate …
Matched Categories: … Nucleosides and Nucleotides ... Nucleosides and Nucleotides Excl. Reverse Transcriptase Inhibitors …

Sodium acetate

Sodium Acetate is chemically designated CH3COONa, a hygroscopic powder very soluble in water. Sodium acetate could be used as additives in food, industry, concrete manufacture, heating pads and in buffer solutions. Medically, sodium acetate is important component as an electrolyte replenisher when given intravenously. It is mainly indicated to correct...
Approved
Investigational
Matched Description: … It can be used also in metabolic acidosis and for urine alkalinization. ... Sodium acetate could be used as additives in food, industry, concrete manufacture, heating pads and in …
Matched Mixtures name: … Plasma-Lyte 148 and dextrose ... Normosol-R and Dextrose ... Plasma-Lyte M and Dextrose …
Matched Categories: … Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions …

Gilteritinib

Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression observed in other...
Approved
Investigational
Matched Description: … [A40044] Gilteritinib was developed by Astellas Pharma and FDA approved on November 28, 2018. ... is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and ... This drug was approved after being designed as an orphan drug with a fast track and priority review status …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Resmetirom

Resmetirom is a thyroid hormone receptor-beta (THR-beta) agonist. On March 14, 2024, it was approved by the FDA as the first treatment of liver fibrosis due to noncirrhotic non-alcoholic steatohepatitis (NASH), which is a form of non-alcoholic fatty liver disease (NAFLD). Thyroid hormones directly regulate lipid metabolism in the liver;...
Approved
Investigational
Matched Description: … [A263461] Resmetirom works to reduce liver fat by stimulating fatty acid degradation and oxidation. ... first treatment of liver fibrosis due to noncirrhotic non-alcoholic steatohepatitis (NASH), which is a form …
Displaying drugs 426 - 450 of 15377 in total