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Displaying drugs 426 - 450 of 797 in total

Lactic acid

A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed) Sodium lactate is the sodium salt of lactic acid, and has a mild saline taste. It is produced by fermentation of a sugar source, such as...
Approved
Vet approved
Matched Description: … active ingredients in Phexxi, a non-hormonal contraceptive agent that was approved by the FDA on May 2020 ... (From Stedman, 26th ed) Sodium lactate is the sodium salt of lactic acid, and has a mild saline taste ... It is produced by fermentation of a sugar source, such as corn or beets, and then, by neutralizing the …
Matched Mixtures name: … Ionosol B and Dextrose ... Dextrose and Electrolyte No. 75 ... Plasma-Lyte M and Dextrose …
Matched Categories: … Basic Ointments and Protectants ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Dulaglutide

Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and exercise in the management of 2 diabetes (T2DM). Dulaglutide was initially approved by the FDA in 2014, and...
Approved
Investigational
Matched Description: … [A236070] Dulaglutide was initially approved by the FDA in 2014, and in February 2020 was approved for ... agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and ... use in patients with T2DM and multiple cardiovascular risk factors for the prevention of cardiovascular …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Regdanvimab

Regdanvimab (CT-P59) is a recombinant human IgG1 monoclonal antibody directed at the receptor binding domain (RBD) of the SARS-CoV-2 spike protein. It blocks the interaction between viral spike proteins and angiotensin-converting enzyme 2 (ACE2) that allows for viral entry into the cell, thereby inhibiting the virus' ability to replicate. Trials...
Approved
Investigational
Matched Description: … [L39140] It blocks the interaction between viral spike proteins and angiotensin-converting enzyme 2 ( ... investigating the use of regdanvimab as a therapeutic candidate for the treatment of COVID-19 began in mid-2020 …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Immune Sera and Immunoglobulins …

Prasterone

Prasterone, also known as dehydroepiandrosterone (DHEA) is a major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. In...
Approved
Investigational
Nutraceutical
Matched Description: … It is also produced in small quantities in the testis and the ovary. ... Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone ... DHEA and DHEAS are readily available in the United States, where they are marketed as over-the-counter …
Matched Categories: … Androgens and Estrogens ... prasterone and estrogen ... Alimentary Tract and Metabolism ... Genito Urinary System and Sex Hormones ... Sex Hormones and Modulators of the Genital System …

Eurotium amstelodami

Eurotium amstelodami allergenic extract is used in allergenic testing.
Approved
Matched Synonyms: … Molds, rusts and smuts, aspergillus amsterdami …

Dexamethasone

Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone. Dexamethasone was granted FDA approval on 30 October 1958....
Approved
Investigational
Vet approved
Matched Description: … L10695] In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020 ... dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and ... L10701] Developed in 1957, it is structurally similar to other corticosteroids like [hydrocortisone] and …
Matched Mixtures name: … NETILDEX GOZ DAMLASI %0,1 DEKSAMETAZON + %0,3 NETILMISIN 0,3 ML × 20 ADET ... Neomycin and Polymyxin B Sulfates and Dexamethasone ... Neomycin and Polymyxin B Sulfates and Dexamethasone …
Matched Categories: … Alimentary Tract and Metabolism ... Sex Hormones and Insulins ... dexamethasone and antibiotics ... dexamethasone and antiinfectives ... dexamethasone and antiinfectives …
Matched Products: … DEKORT 4 MG TABLET, 20 ADET ... DEKORT 8 MG TABLET, 20 ADET ... KORDEXA 4 MG TABLET, 20 ADET …

Tarlatamab

Tarlatamab is a first-in-class T-cell engager used to treat extensive-stage small cell lung cancer. It is a bispecific monoclonal antibody that targets CD3 expressed on the surface of T-cells and delta-like ligand 3 (DLL3), an inhibitory ligand that suppresses Notch signaling and is highly expressed across various SCLC disease stages...
Approved
Investigational
Matched Synonyms: … Immunoglobulin scfv-scfv-scfc, anti-(homo sapiens dll3 (delta-like ligand 3)) and anti-(homo sapiens …
Matched Description: … across various SCLC disease stages and treatment statuses. ... L50748] It is a bispecific monoclonal antibody that targets CD3 expressed on the surface of T-cells and ... delta-like ligand 3 (DLL3), an inhibitory ligand that suppresses Notch signaling and is highly expressed …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Levonorgestrel

Levonorgestrel (LNG) is a synthetic progestogen similar to Progesterone used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of these devices...
Approved
Investigational
Matched Synonyms: … (-)-13-Ethyl-17-hydroxy-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one …
Matched Description: … Some of these devices are known as Jaydess, Kyleena, and Mirena. ... Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone ... [A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as …
Matched Mixtures name: … MODULOV 20 ... ASUMATE ®20 ... NORVETAL 20 …
Matched Categories: … levonorgestrel and estrogen ... levonorgestrel and estrogen ... levonorgestrel and ethinylestradiol ... levonorgestrel and ethinylestradiol ... Genito Urinary System and Sex Hormones …
Matched Products: … ONE-AND-ONE ... Mirena 20 Mikrogramm/24 Stunden Intrauterinpessar ... Mirena 20 Mikrogramm/24 Stunden - Intrauterinpessar …

Vibegron

Vibegron is a potent, selective beta-3 adrenergic receptor (β3) agonist that relaxes the detrusor smooth muscle of the bladder, thereby increasing bladder capacity. Vibegron was first approved in Japan in September 2018 for the treatment of overactive bladder, a condition associated with distressing symptoms of urge urinary incontinence, urgency, and...
Approved
Investigational
Matched Description: … On December 23, 2020, vibegron was approved for the same indication in adults. ... urinary frequency, and reduced quality of life of patients. ... bladder,[A226050] a condition associated with distressing symptoms of urge urinary incontinence, urgency, and …
Matched Categories: … Genito Urinary System and Sex Hormones ... Drugs for Urinary Frequency and Incontinence …

Hydroxychloroquine

Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like chloroquine. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxychloroquine is also used for the prophylaxis of malaria in...
Approved
Matched Description: … of COVID-19 was revoked on 15 June 2020. ... Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. ... the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and …
Matched Categories: … Antiparasitic Products, Insecticides and Repellents …

Mannitol

Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma. As a...
Approved
Investigational
Matched Description: … On October 30, 2020, mannitol was approved by the FDA as add-on maintenance therapy for the control of ... As a result, cerebral edema, elevated intracranial pressure, and cerebrospinal fluid volume and pressure ... or sugar alcohol, in fruits and vegetables. …
Matched Mixtures name: … OSMOFUNDIN INJECTION 20% ... INFUSOL M20S (Mannitol 17.5%w/v and Sorbitol 2.5%w/v Intravenous Infusion) ... TERUFLEX Blood Bag System with Blood Sampling Arm Anticoagulant Citrate Phosphate Dextrose (CPD) AND …
Matched Categories: … Diet, Food, and Nutrition ... Alimentary Tract and Metabolism ... Blood and Blood Forming Organs ... Cough and Cold Preparations ... Blood Substitutes and Perfusion Solutions …
Matched Products: … OSMOROL 20 ... BRAUN OSMOFUNDIN 20% ... Osmitrol Injection 20% …

Lorcaserin

Lorcaserin (previously APD-356), a highly selective 5HT2C receptor agonist, is used for the treatment of obesity. It has been shown to reduce body weight and food intake in animal models of obesity, and it is thought that targeting the 5HT2C receptor may alter body weight by regulating satiety. Lorcaserin is...
Approved
Withdrawn
Matched Description: … hydrochloride tablets, 10 mg) and Belviq XR (lorcaserin hydrochloride extended-release tablets, 20 mg ... In February 2020, the FDA issued a Drug Safety Communication requesting the manufacturer of Belviq (lorcaserin ... It has been shown to reduce body weight and food intake in animal models of obesity, and it is thought …
Matched Categories: … Alimentary Tract and Metabolism …

Clorazepic acid

Clorazepic acid (clorazepate) is a water-soluble benzodiazepine with muscle-relaxant and anticonvulsant actions effective in the treatment of anxiety.[A957,L44788] Following administration, clorazepate is rapidly converted to nordiazepam (N-desmethyldiazepam), its active metabolite, before entering systemic circulation. Similar to other benzodiazepines, the active metabolite of clorazepate enhances the binding of gamma-aminobutyric acid (GABA)...
Approved
Illicit
Matched Description: … In September 2020, a black box warning describing these risks was included on the product label of benzodiazepines ... depression, coma, and death. ... Also, the use of clorazepate exposes users to users to the risks of abuse, misuse, and addiction, and …
Matched Categories: … Benzodiazepines and benzodiazepine derivatives …
Matched Products: … TRANXILIUM 20 …

Oxymetazoline

Oxymetazoline is an imidazole derivative and a potent, direct-acting alpha (α)-adrenergic agonist with affinity to both α1- and α2-adrenoceptors. Oxymetazoline is available in various formulations with a wide variety of clinical implications. The topical formulation of the drug is used to treat persistent facial redness in adults. As an effective...
Approved
Investigational
Matched Description: … [L15057] In July 2020, the FDA approved the use of an ophthalmic formulation of oxymetazoline (Upneeq ... affinity to both α1- and α2-adrenoceptors. ... is used for regional anesthesia during dental procedures in children and adults. …
Matched Mixtures name: … Mucinex Sinus-Max Pressure, Pain and Cough and Mucinex Sinus-Max Severe Congestion Relief Clear and Cool …
Matched Categories: … Decongestants and Antiallergics …
Matched Products: … Up and Up nasal ... Up and up nasal ... Foster and Thrive Nasal …

Vibrio cholerae CVD 103-HgR strain live antigen

Vibrio cholerae CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against Vibrio cholerae serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by Vibrio cholerae, which is gram-negative bacteria. Two serogroups of V. cholerae, O1 and O139, are causative...
Approved
Investigational
Matched Description: … [A244494] Vaxchora was later approved by the European Commission in April 2020. ... [L39729] It is indicated for individuals aged two years and older.[L12801] ... Two serogroups of _V. cholerae_, O1 and O139, are causative agents of epidemic cholera. …
Matched Products: … Cholera Vaccine Strain 35a-and 41 8000m/cc …

Imdevimab

Imdevimab is a monoclonal antibody combined with casirivimab in Regeneron's antibody cocktail known as REGEN-COV2 for the treatment of COVID-19. This drug is a combination of antibodies derived from humanized VelocImmune® mice in addition to blood samples from patients who have recovered from COVID-19. These antibodies have been formulated to...
Approved
Experimental
Matched Description: … [A221495] On November 21, 2020, the FDA authorized emergency approval of REGN-COV2 to treat mild ... [L39130,L39135] Full safety and efficacy data on imdevimab are not yet available, and further evaluation ... to moderate COVID-19 in patients aged 12 years and older. …
Matched Mixtures name: … Casirivimab and Imdevimab ... Casirivimab and Imdevimab …
Matched Categories: … casirivimab and imdevimab ... Amino Acids, Peptides, and Proteins ... Immune Sera and Immunoglobulins …

Mepolizumab

Eosinophils are involved in inflammatory immune responses, and prolonged hypereosinophilia (typically defined as absolute eosinophil levels of 1500/mm3 or more) is associated with a spectrum of diseases, including severe asthma, eosinophilic granulomatosis with polyangiitis (EGPA), and hypereosinophilic syndrome (HES). The pathogenesis of eosinophilia is complex, but IL-5 is recognized as...
Approved
Investigational
Matched Description: … , 2020. ... Activated eosinophils further stimulate an inflammatory response and also induce tissue lesions and promote ... Eosinophils are involved in inflammatory immune responses, and prolonged hypereosinophilia (typically …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Opicapone

Opicapone is a potent, reversible, and peripherally-acting third-generation inhibitor of catechol-o-methyltransferase (COMT), an enzyme involved in the breakdown of various catecholamines including dopamine.[A36938, A203048] Many patients with Parkinson’s disease treated with levodopa plus a dopa decarboxylase (DDC) inhibitor (eg carbidopa) experience motor complications over time, which calls for the management...
Approved
Investigational
Matched Description: … Opicapone was approved for use by the European Commission in June 2016 [L2339] and the FDA in April 2020 ... disease and end-of-dose motor fluctuations. ... Opicapone is a potent, reversible, and peripherally-acting third-generation inhibitor of catechol-o-methyltransferase …

Inclisiran

Inclisiran is a long-acting, synthetic small interfering RNA (siRNA) directed against proprotein convertase subtilisin-kexin type 9 (PCSK9), which is a serine protease that regulates plasma low-density lipoprotein cholesterol (LDL-C) levels. By binding to PCSK9 messenger RNA, inclisiran prevents protein translation of PCSK9, leading to decreased concentrations of PCSK9 and plasma...
Approved
Investigational
Matched Description: … [A225953,A225958] On December 11, 2020, the European Commission (EC) granted authorization for marketing ... RNA, inclisiran prevents protein translation of PCSK9, leading to decreased concentrations of PCSK9 and ... plasma LDL-C levels offers an additional benefit of reducing the risk of cardiovascular disease (CVD) and …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …

Janssen COVID-19 Vaccine

The Janssen COVID-19 vaccine (Ad26.COV2.S) is a recombinant vaccine that contains an adenovirus serotype 26 (Ad26) vector expressing a stabilized SARS-CoV-2 spike protein. The vaccine was created in collaboration with Johnson and Johnson (J&J), Janssen Pharmaceutical, and the Beth Israel Deaconess Medical Center. A preclinical study in hamsters infected with...
Approved
Investigational
Matched Description: … As of June 2020, a Phase 1/2 clinical trial in adult humans was announced to evaluate the safety, immunogenicity ... The vaccine was created in collaboration with Johnson and Johnson (J&J), Janssen Pharmaceutical, and ... -2 infection[A220053] showed a single immunization with the vaccine-elicited neutralizing responses and …

Mucor circinelloides f. lusitanicus

Mucor circinelloides f. lusitanicus allergenic extract is used in allergenic testing.
Approved
Matched Synonyms: … Molds, rusts and smuts, mucor circinelloides f. lusitanicus …

Nogapendekin alfa

Nogapendekin alfa is a human IL-15N72D variant. It is one of the active ingredients in Anktiva, a combination product also containing inbakicept, where a single inbakicept is complexed with two nogapendekin alfa components. This combination product was approved by the FDA on April 22, 2024, for the treatment of BCG-unresponsive...
Approved
Investigational
Matched Synonyms: … Fusion protein consisting of il-15n72d and il-15rasu/fc …
Matched Description: … 75% of all bladder tumours, is commonly treated with transurethral resection of the bladder tumour and ... proliferation of natural killer cells and CD8+ memory T cells, which also synergistically enhance BCG ... Nogapendekin alfa, in combination with inbakicept, mimics the actions of IL-15, , stimulating the activation and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Lonafarnib

Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cutaneous effects, lipoatrophy, alopecia, and a severe failure to thrive; HGPS is uniformly fatal.[A224379, A224384,...
Approved
Investigational
Matched Description: … [L23414, L23544] Lonafarnib was granted FDA approval on November 20, 2020, and is the first FDA-approved ... progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 ... treatment for HGPS and other related progeroid laminopathies. …
Matched Categories: … Alimentary Tract and Metabolism ... Various Alimentary Tract and Metabolism Products …

Odesivimab

Ebola virus (EBOV) remains an important human pathogen within the Ebolavirus genus, having been responsible for at least 17 known outbreaks with an average case fatality rate of 43.92%. Immune therapy using monoclonal antibodies (mAbs) is becoming an increasingly attractive therapeutic method to combat infectious diseases due to its rapid...
Approved
Matched Description: … INMAZEB™ is produced by Regeneron Pharmaceuticals and was granted FDA approval on October 14, 2020. ... neutralizing and Fc-mediated immune effector function against EBOV _in vitro_ and protection against ... attractive therapeutic method to combat infectious diseases due to its rapid development, low toxicity, and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Anakinra

Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta. Anakinra is...
Approved
Investigational
Matched Description: … It was later approved for the treatment of NOMID and DIRA on December 21, 2012, and December 18, 2020 ... This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta ... drugs (DMARDs), as well as the treatment of neonatal-onset multisystem inflammatory disease (NOMID) and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Intercellular Signaling Peptides and Proteins …
Displaying drugs 426 - 450 of 797 in total