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Displaying drugs 451 - 475 of 13909 in total

Cimetidine

A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy.
Approved
Investigational
Matched Description: … It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... Cimetidine has a range of pharmacological actions. ... A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. …
Matched Categories: … Medications that reduce magnesium levels ... Drugs for Acid Related Disorders ... Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord) …
Matched Products: … Cimetidine in Sodium Chloride ... Gaviscon All-night …

Sodium aurothiomalate

Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in active progressive rheumatoid arthritis and of little or no value in...
Approved
Investigational
Matched Description: … Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects ... Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold ... It is most effective in active progressive rheumatoid arthritis and of little or no value in the presence …

Tavaborole

Tavaborale is a novel, boron-based topical antifungal medication for the treatment of onychomycosis, a fungal infection of the nail and nail bed due to Trichophyton rubrum or Trichophyton mentagrophytes infection. Tavaborole functions by inhibiting Leucyl-tRNA synthetase, or LeuRS, an essential fungal enzyme required for protein synthesis and for the catalysis...
Approved
Investigational
Matched Description: … Tavaborale is a novel, boron-based topical antifungal medication for the treatment of onychomycosis, ... a fungal infection of the nail and nail bed due to *Trichophyton rubrum* or *Trichophyton mentagrophytes ... protein synthesis and for the catalysis of ATP-dependent ligation of L-leucine to tRNA(Leu). …
Matched Categories: … Antifungals for Topical Use ... Antifungals for Dermatological Use …

Carglumic acid

Carglumic acid is a drug used for the treatment of hyperammonemia in patients with a deficiency in N-acetyl glutamate synthase. This rare genetic disorder results in elevated blood levels of ammonia, which can eventually cross the blood–brain barrier and cause neurologic problems, cerebral edema, coma, and death. Carglumic acid was...
Approved
Matched Description: … Carglumic acid is a drug used for the treatment of hyperammonemia in patients with a deficiency in N-acetyl ... This rare genetic disorder results in elevated blood levels of ammonia, which can eventually cross the …

Bioallethrin

Bioallethrin refers to a mixture of two of the allethrin isomers (1R,trans;1R and 1R,trans;1S) in an approximate ratio of 1:1, where both isomers are active ingredients. A mixture of the two same stereoisomers, but in an approximate ratio of R:S in 1:3, is called esbiothrin. A mixture containing only S-forms...
Approved
Experimental
Matched Description: … A mixture of the two same stereoisomers, but in an approximate ratio of R:S in 1:3, is called esbiothrin ... Bioallethrin refers to a mixture of two of the allethrin isomers (1R,trans;1R and 1R,trans;1S) in an ... Bioallethrin is a synthetic pyrethroid used as a pesticide against household pest insects such as mosquitoes …
Matched Mixtures name: … Para Special Shampoo for Lice & Nits …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Phenoxyethanol

Phenoxyethanol is a colorless liquid with a pleasant odor. It is a glycol ether used as a perfume fixative, insect repellent, antiseptic, solvent, preservative, and also as an anesthetic in fish aquaculture. Phenoxyethanol is an ether alcohol with aromatic properties. It is both naturally found and manufactured synthetically. Demonstrating antimicrobial...
Approved
Matched Description: … preservative in cosmetic formulations at a maximum concentration of 1.0% [L2625]. ... Phenoxyethanol is a colorless liquid with a pleasant odor. ... and also as an anesthetic in fish aquaculture. …

Plasminogen

Plasminogen is a pro-enzyme (i.e. a zymogen) which is cleaved to form plasmin - also known as fibrinolysin - as part of the fibrinolytic pathway that breaks down fibrin blood clots. This pathway is activated when a clot is no longer needed or to prevent a clot from extending beyond...
Approved
Matched Description: … [L34635] In June 2021, the FDA approved a plasma-derived plasminogen (Ryplazim, human plasminogen-tvmh ... Plasminogen is a pro-enzyme (i.e. a zymogen) which is cleaved to form plasmin - also known as [fibrinolysin ... )[L34620] for the treatment of type 1 plasminogen deficiency (hypoplasminogenemia). …

Methimazole

Methimazole is a thionamide antithyroid agent that inhibits the synthesis of thyroid hormones.[A184559,A184733,A184694] It was first introduced as an antithyroid agent in 1949 and is now commonly used in the management of hyperthyroidism, particularly in those for whom more aggressive options such as surgery or radioactive iodine therapy are inappropriate.[L8336,L8339]...
Approved
Matched Description: … commonly used in the management of hyperthyroidism, particularly in those for whom more aggressive options ... pregnancy due to a perceived lower risk of teratogenic effects. ... Methimazole is a thionamide antithyroid agent that inhibits the synthesis of thyroid hormones. …

Nebivolol

Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than atenolol, propranolol, or pindolol. Nebivolol and other beta...
Approved
Investigational
Matched Description: … [A182579] Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure ... Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other ... acts as a cardiac stimulant without beta adrenergic activity. …
Matched Categories: … Antihypertensive Agents Indicated for Hypertension …

Methocarbamol

Methocarbamol was developed in the early 1950s as a treatment for muscle spasticity and the associated pain.[A178441,A178450] It is a guaiacol glyceryl ether. Methocarbamol tablets and intramuscular injections are prescription medicines indicated in the United States as an adjunct to rest, physical therapy, and other measures for the relief of...
Approved
Vet approved
Matched Description: … Methocarbamol was developed in the early 1950s as a treatment for muscle spasticity and the associated ... [Label,L6268] In Canada, methocarbamol can be sold as an over the counter oral medicine at a lower dose ... [L6295] A combination product with [acetylsalicylic acid] and [codeine] is available in Canada by prescription …
Matched Mixtures name: … SINAXAR ® A TABLETAS ... SINAXAR ® A TABLETAS …

Memantine

Initially approved by the FDA in 2013, memantine is an N-methyl-D-aspartate (NMDA) receptor antagonist used in the management of Alzheimer's Disease (AD). It is different from many other Alzheimer's Disease medications, as it works by a different mechanism than the cholinesterase enzyme inhibitors normally employed in the management of Alzheimer's...
Approved
Investigational
Matched Description: … In December 2013, the G8 dementia summit concluded that dementia should be considered a global priority ... Memantine blocks the effects of glutamate, a neurotransmitter in the brain that leads to neuronal excitability ... with the objective of developing a cure or a disease-modifying therapy by the year 2025 [L5953, F4366 …

Gallium Ga-68 gozetotide

Gallium (Ga) 68 prostate-specific membrane antigen (PSMA)-11, or Ga-68 gozetotide, is a radiopharmaceutical agent used to identify and assess prostate-specific membrane antigen (PSMA)-positive lesions in adult men with prostate cancer during positron emission tomography (PET). Prostate cancer is one of the most commonly diagnosed cancers among men in Western countries...
Approved
Matched Description: … [A225396] In nearly all prostate cancers, malignant cells express a transmembrane protein called prostate-specific ... In October 2022, the EMA's Committee for Medicinal Products for Human Use (CHMP) recommended Ga-68 gozetotide ... [L44682] In Octer 2022, Ga-68 PSMA-11 was approved by Health Canada for diagnostic use in men with prostate …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Bordetella pertussis toxoid antigen (formaldehyde inactivated)

Bordetella pertussis toxoid antigen (formaldehyde inactivated) is a vaccine.
Approved
Matched Description: … Bordetella pertussis toxoid antigen (formaldehyde inactivated) is a vaccine. …
Matched Mixtures name: … -POLIO SUSPENSION FOR INJECTION IN PRE-FILLED SYRINGE ... , Suspension for Injection ... Repevax Injektionssuspension in einer Fertigspritze …

Thalidomide

A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating the release of inflammatory mediators like tumor necrosis factor-alpha...
Approved
Investigational
Withdrawn
Matched Description: … It has been reintroduced and used for a number of inflammatory disorders and cancers. ... severe teratogenicity, pregnancy must be excluded before the start of treatment and patients must enrol in ... A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn …

Taurine

Taurine, whose chemical name is 2-aminoethanesulfonic acid, is one of the most abundant amino acids in several organs. It plays important role in essential biological processes. This conditional amino acid can be either be manufactured by the body or obtained in the diet mainly by the consumption of fish and...
Approved
Nutraceutical
Matched Description: … It plays important role in essential biological processes. ... Taurine, whose chemical name is 2-aminoethanesulfonic acid, is one of the most abundant amino acids in ... [A31396] This conditional amino acid can be either be manufactured by the body or obtained in the diet …
Matched Mixtures name: … AMINOVEN SOLUTION FOR INFUSION 5% ... SmofKabiven Emulsion for Infusion ... AMINOVEN SOLUTION FOR INFUSION 10% …

Omadacycline

Omadacycline has been used in trials studying the treatment of Bacterial Pneumonia, Bacterial Infections, Community-Acquired Infections, and Skin Structures and Soft Tissue Infections. Omadacycline represents a significant advance over the well-known tetracycline family, and has been shown to be highly effective in animal models at treating increasingly problematic, clinically prevalent...
Approved
Investigational
Matched Description: … Omadacycline represents a significant advance over the well-known tetracycline family, and has been shown ... Omadacycline has been used in trials studying the treatment of Bacterial Pneumonia, Bacterial Infections ... cause diseases such as pneumonias, urinary tract infections, skin diseases and blood-borne infections in …
Matched Categories: … Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …

Rotigotine

Rotigotine (Neupro) is a non-ergoline dopamine agonist indicated for the treatment of Parkinson's disease (PD) and restless legs syndrome (RLS) in Europe and the United States. It is formulated as a once-daily transdermal patch which provides a slow and constant supply of the drug over the course of 24 hours....
Approved
Matched Description: … Rotigotine has been authorized as a treatment for RLS since August 2008. ... However, all Neupro patches in the United States and some of Europe were recalled in 2008 due to delivery ... Rotigotine (Neupro) is a non-ergoline dopamine agonist indicated for the treatment of Parkinson's disease …

Kappadione

Kappadione is a Vitamin K derivative (chemically, it is menadiol sodium diphosphate), previously approved by FDA prior to 1982 and marketed by Lilly Marketing for this drug has been discontinued and is not available in North America . It has been found to have carcinogenic potential in mammalian cells as...
Approved
Matched Description: … Studies involving the active metabolite of this formulation, menadione, showed oocyte toxicity in a study ... by FDA prior to 1982 and marketed by Lilly Marketing for this drug has been discontinued and is not ... available in North America [L1543]. …

Dactinomycin

A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin...
Approved
Investigational
Matched Description: … A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces ... As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index …
Matched Products: … DACTINOMYCIN FOR INJECTION 0.5 mg/vial …

Bismuth subgallate

Bismuth subgallate is a yellow colored substance that presents as an odorless powder that undergoes discoloration when exposed to sunlight. It is a heavy metal salt of gallic acid that is highly insoluble and poorly absorbed. Possessing protective effects on the gastric mucosa, strong astringent effects, and not as yet...
Approved
Matched Description: … It is a heavy metal salt of gallic acid that is highly insoluble and poorly absorbed. ... Bismuth subgallate is a yellow colored substance that presents as an odorless powder that undergoes discoloration …

Icodextrin

Icodextrin is an iso-osmotic peritoneal dialysis solution containing glucose polymers. It is used primarily for ambulatory peritoneal dialysis (CAPD) of diabetic patients and automated peritoneal dialysis (APD) for patients with end-stage renal disease. It is injected as a solution into the peritoneal cavity. The drug is absorbed via convective transport...
Approved
Investigational
Matched Description: … It is injected as a solution into the peritoneal cavity. ... dialysis (APD) for patients with end-stage renal disease. ... It is used primarily for ambulatory peritoneal dialysis (CAPD) of diabetic patients and automated peritoneal …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Reslizumab

Reslizumab is a humanized interleukin-5 (IL-5) antagonist monoclonal antibody (IgG4 kappa) that is produced by recombinant DNA technology in murine myeloma non-secreting 0 (NS0) cells. IL-5 is a pro-inflammatory cytokine that is responsible for the growth and differentiation, recruitment, activation, and survival of eosinophils [FDA Label]. Elevated levels of eosinophils...
Approved
Investigational
Matched Description: … Elevated levels of eosinophils increase the risk for asthma exacerbations, including both allergic forms ... IL-5 is a pro-inflammatory cytokine that is responsible for the growth and differentiation, recruitment ... It is approved for patients who have a history of severe asthma attacks (exacerbations) despite receiving …
Matched Categories: … Drugs for Obstructive Airway Diseases …

Latanoprostene bunod

Latanoprostene Bunod has been used in trials studying the treatment of Glaucoma, Ocular Hypertension, Open-Angle Glaucoma, Open Angle Glaucoma, and Intraocular Pressure. As of November 2, 2017 the FDA approved Bausch + Lomb's Vyzulta (latanoprostene bunod opthalmic solution), 0.024% for the indication of reducing intraocular pressure in patients with open-angle...
Approved
Investigational
Matched Description: … In comparison, both latanoprost and latanoprostene bunod contain a latanoprost acid backbone. ... 2, 2017 the FDA approved Bausch + Lomb's Vyzulta (latanoprostene bunod opthalmic solution), 0.024% for ... both its prostaglandin F2-alpha analog latanoprost acid metabolite and its ability to donate NO for proposed …

Tapentadol

Tapentadol is a centrally-acting synthetic analgesic with a dual mechanism of action. It is a mu-opioid receptor agonist that also inhibits norepinephrine reuptake.[A260721, A36596] Tapentadol was first approved by the FDA on November 20, 2008. The extended-release formulation of tapentadol was also approved by the FDA on August 26, 2011....
Approved
Matched Description: … [L47291] Used in the management of pain, tapentadol is typically reserved for patients who have limited ... Tapentadol is a centrally-acting synthetic analgesic with a dual mechanism of action. ... It is a mu-opioid receptor agonist that also inhibits norepinephrine reuptake. …

Cilazapril

Cilazapril is an ACE inhibtor class drug used in the treatment of hypertension and heart failure. It belongs to the angiotensin-converting enzyme inhibitors (ACE inhibitors) class of drugs. It is a prodrug that is hydrolyzed after absorption to its main metabolite cilazaprilat. It is branded as Inhibace in Canada and...
Approved
Matched Iupac: … (1S,9S)-9-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-10-oxo-octahydro-1H-pyridazino[1,2-a][1,2]diazepine …
Matched Description: … It is branded as Inhibace in Canada and other countries, Vascace and Dynorm in a number of European countries ... It is a prodrug that is hydrolyzed after absorption to its main metabolite cilazaprilat. ... None of these varieties are available in the United States. …
Matched Categories: … Antihypertensive Agents Indicated for Hypertension …
Displaying drugs 451 - 475 of 13909 in total