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Displaying drugs 451 - 475 of 9508 in total

Etanercept

Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of IgG1....
Approved
Investigational
Matched Description: … Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton ... It consists of 934 amino acids. ... , but not the CH1 domain of IgG1. …

Bacitracin

Bacitracin is a combination of at least 9 bacitracins.[A955,A181952] 60-80% of commercially prepared bacitracin is bacitracin A. The bacillus that produces bacitracin was first isolated from a knee scrape in 1945 from the knee wound of a child named Margaret Tracy. Bacitracin was granted FDA approval on 29 July 1948.[A181997,L7748]
Approved
Vet approved
Matched Description: … Bacitracin is a combination of at least 9 bacitracins. ... [A955,A181952] 60-80% of commercially prepared bacitracin is bacitracin A. ... bacillus that produces bacitracin was first isolated from a knee scrape in 1945 from the knee wound of …

Aclidinium

Aclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease (COPD). It has a much higher propensity to bind to muscarinic receptors than nicotinic receptors. FDA approved on July 24, 2012.
Approved
Matched Description: … Aclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease …

Mifamurtide

Mifamurtide is an immunomodulator with antitumor activity via activation of macrophages and monocytes. Also called L-MTP-PE, mifamurtide may be a liposomal form of of the active ingredient MTP-PE, which is a synthetic, less pyrogenic, and longer-acting derivative of muramyl dipeptide (MDP). MDP is a motif present in all gram-positive and...
Approved
Experimental
Matched Description: … Also called L-MTP-PE, mifamurtide may be a liposomal form of of the active ingredient MTP-PE, which is ... The overall result of MDP recognition leads to the production of proinflammatory cytokines and promotion ... of bactericidal and tumoricidal effects [A31745]. …

Febuxostat

Febuxostat is a non-purine xanthine oxidase (XO) inhibitor. In early 2008, febuxostat was granted marketing authorization by the European Commission for the treatment of chronic hyperuricemia and gout. In the following year, the FDA for approved febuxostat for use in the chronic management of hyperuricemia in adult patients with gout...
Approved
Matched Description: … [L32238] Gout is a form of arthritis that is caused by the accumulation of uric acid crystal in or around ... Febuxostat works by inhibiting the activity of an enzyme that is responsible for the synthesis of uric ... [A230548] In the following year, the FDA for approved febuxostat for use in the chronic management of …

Fluconazole

Fluconazole, commonly known as Diflucan, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an azole antifungal, in the same drug family as ketoconazole and itraconazole. Fluconazole...
Approved
Investigational
Matched Description: … The side effect profile of this drug is minimal. ... and superficial fungal infections in a variety of tissues. ... Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic …

Palovarotene

Fibrodysplasia Ossificans Progressiva (FOP), with an estimated worldwide prevalence of one in 2 million individuals, is an exceptionally rare genetic disorder. FOP is caused by a gain-of-function mutation in the ACVR1/ALK2 gene which results in progressive heterotopic ossification, a process wherein connective tissues (e.g. skeletal muscle, ligaments, tendons) are replaced...
Approved
Investigational
Matched Description: … ], which are derivatives of [vitamin A]. ... Fibrodysplasia Ossificans Progressiva (FOP), with an estimated worldwide prevalence of one in 2 million ... [A244920] FOP is caused by a gain-of-function mutation in the ACVR1/ALK2 gene which results in progressive …

Pepsin

Pepsin is a potent enzyme in gastric juice that digests proteins such as those in meat, eggs, seeds, and dairy products . Studies on gastric digestion from 1820-1840 led to the discovery of pepsin as the substance which, in the presence of stomach acid, causes nutrients including meat or coagulated...
Approved
Experimental
Investigational
Matched Description: … Stimulation of the pancreas and therefore enzymatic digestion of food is a tightly controlled and is ... Studies on gastric digestion from 1820-1840 led to the discovery of pepsin as the substance which, in ... the presence of stomach acid, causes nutrients including meat or coagulated egg whites to dissolve. …

Peanut oil

Peanut oil is derived from Arachis hypogaea which can be found in South America, Mexico, and Centro America. The kernels are consumed roasted but a large percentage is used for the production of vegetable oil. The peanut oil represents about 45-52% of the kernel content and it is mainly formed...
Approved
Matched Description: … The kernels are consumed roasted but a large percentage is used for the production of vegetable oil. ... The peanut oil represents about 45-52% of the kernel content and it is mainly formed from monounsaturated …

Avacincaptad pegol

Avacincaptad pegol is an RNA aptamer covalently bound to a branched polyethylene glycol (PEG) molecule. It was developed to treat an advanced form of age-related macular degeneration (AMD) called geographic atrophy (GA). AMD is the leading cause of vision loss in developed countries for people over 50 years old, with...
Approved
Investigational
Matched Description: … with a global estimate of 170 million individuals affected. ... the non-neovascular (dry) or the neovascular (wet) form of AMD. ... It was developed to treat an advanced form of age-related macular degeneration (AMD) called geographic …

Nisoldipine

Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. Nisoldipine may be used in alone...
Approved
Matched Description: … Nisoldipine may be used in alone or in combination with other agents in the management of hypertension ... By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth …

Carglumic acid

Carglumic acid is a drug used for the treatment of hyperammonemia in patients with a deficiency in N-acetyl glutamate synthase. This rare genetic disorder results in elevated blood levels of ammonia, which can eventually cross the blood–brain barrier and cause neurologic problems, cerebral edema, coma, and death. Carglumic acid was...
Approved
Matched Description: … Carglumic acid is a drug used for the treatment of hyperammonemia in patients with a deficiency in N-acetyl ... This rare genetic disorder results in elevated blood levels of ammonia, which can eventually cross the …

SARS-CoV-2 virus recombinant spike (S) protein receptor binding domain (RBD) fusion heterodimer (B.1.351-B.1.1.7 strains)

Bimervax is an adjuvanted non-mRNA COVID-19 vaccine utilizing a SARS-CoV-2 recombinant spike (S) protein receptor binding domain (RBD) fusion heterodimer. It is intended to elicit protection against Omicron XBB.1.5, one of the dominant circulating SARS-CoV-2 subvariants in 2023. It is produced using recombinant DNA technology in CHO cell lines and...
Approved
Matched Description: … [L48902] It is intended to elicit protection against Omicron XBB.1.5, one of the dominant circulating …

Oxytocin

Sir Henry H. Dale first identified oxytocin and its uterine contractile properties in 1906.[A229008,A228593,A229108] Like all other neurohypophysial hormones, oxytocin is composed of nine amino acids with a disulfide bridge between the Cys 1 and 6 residues.[A229008,A228593] In the mid-1950s, synthetic oxytocin was successfully synthesized by a biochemist named Vincent...
Approved
Vet approved
Matched Description: … [A229008,A228593,A229108] Like all other neurohypophysial hormones, oxytocin is composed of nine amino ... [A229108,A229113] It is estimated that labor induction with oxytocin is used in almost 10% of deliveries …

Pyrantel

Pyrantel is a pyrimidine-derivative anthelmintic agent for the oral treatment of various parasitic worm infections including ascariasis, hookworm infections, enterobiasis (pinworm infection), trichostrongyliasis, and trichinellosis . Pyrantel was initially described in 1965 by researchers from Pfizer who sought cyclic amidines with suitable pharmacokinetic properties (specifically, duration of action) for use...
Approved
Vet approved
Matched Description: … Pyrantel is a pyrimidine-derivative anthelmintic agent for the oral treatment of various parasitic worm ... Pfizer who sought cyclic amidines with suitable pharmacokinetic properties (specifically, duration of ... Pyrantel is on the World Health Organization's List of Essential Medicines, which are the safest and …

Daprodustat

Daprodustat is a small-molecule hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor that was developed by GSK.[A254167,A254162] Patients with CKD cannot induce erythropoietin (EPO) production in response to hypoxia or anemia. As a potent inhibitor of PHD1, PHD2 and PHD3 (≥ 1000-fold selectivity), daprodustat stabilizes cellular HIF1α and HIF2α and the induces...
Approved
Investigational
Matched Description: … for non-dialysis patients with anemia of CKD. ... As a potent inhibitor of PHD1, PHD2 and PHD3 (≥ 1000-fold selectivity), daprodustat stabilizes cellular ... [A254172] In June 2020, daprodustat was first approved in Japan for the treatment of renal anemia. …

Chromium nicotinate

Approved
Experimental

Edetic acid

A chelating agent (chelating agents) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive.
Approved
Vet approved
Matched Description: … A chelating agent (chelating agents) that sequesters a variety of polyvalent cations. …

Ziprasidone

Disorders such as schizophrenia and bipolar disorder can significantly impair mood, cognition, and behavior. These mental illnesses can often be accompanied by comorbidities such as depression and substance abuse, and can significantly impact the quality of life of patients and caregivers. Luckily, several treatment options for psychotic disorders have been...
Approved
Matched Description: … life of patients and caregivers. ... treat manic episodes in bipolar disorder although the mechanism of action is unknown. ... several treatment options for psychotic disorders have been introduced to market since the realization of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Trazodone

Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and serotonin-norepinephrine receptor inhibitor (SNRIs) in the...
Approved
Investigational
Matched Description: … triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of ... [T646] A unique feature of this drug is that it does not promote the anxiety symptoms, sexual symptoms ... reuptake inhibitors (SSRIs), and serotonin-norepinephrine receptor inhibitor (SNRIs) in the treatment of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Upadacitinib

Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by synovial inflammation and hyperplasia, autoantibody production, cartilage damage...
Approved
Investigational
Matched Description: … [A189171] The etiology of the disease is mostly unknown; however, the role of JAK as a driver of immune-mediated ... [A189165] Despite a variety of therapeutic agents available for treatment, up to 40% of the patients ... (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of …

Memantine

Initially approved by the FDA in 2013, memantine is an N-methyl-D-aspartate (NMDA) receptor antagonist used in the management of Alzheimer's Disease (AD). It is different from many other Alzheimer's Disease medications, as it works by a different mechanism than the cholinesterase enzyme inhibitors normally employed in the management of Alzheimer's...
Approved
Investigational
Matched Description: … FDA in 2013, memantine is an N-methyl-D-aspartate (NMDA) receptor antagonist used in the management of ... a different mechanism than the cholinesterase enzyme inhibitors normally employed in the management of ... Almost doubling every 20 years, the prevalence of Alzheimer's Disease is predicted to reach 66 million …
Matched Products: … MEMDRIVE (R) 10 TABLETAS RECUBIERTAS …

Apadamtase alfa

Thrombotic thrombocytopenic purpura (TTP) is a rare blood clotting disorder characterized by thrombocytopenia, microangiopathic hemolytic anemia, and various degrees of organ damage. It may be inherited (congenital TTP; cTTP) or acquired due to autoantibodies (immune-mediated TTP; iTTP), although cTTP accounts for <5% of all cases of TTP. Patients with cTTP...
Approved
Investigational
Matched Description: … all cases of TTP. ... disorder characterized by thrombocytopenia, microangiopathic hemolytic anemia, and various degrees of ... cTTP) or acquired due to autoantibodies (immune-mediated TTP; iTTP), although cTTP accounts for <5% of …

Vildagliptin

Vildagliptin (LAF237) is an orally active antihyperglycemic agent that selectively inhibits the dipeptidyl peptidase-4 (DPP-4) enzyme. It is used to manage type II diabetes mellitus, where GLP-1 secretion and insulinotropic effects are impaired. By inhibiting DPP-4, vildagliptin prevents the degradation of glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP),...
Approved
Investigational
Matched Description: … Elevated levels of GLP-1 and GIP consequently results in improved glycemic control. ... [L32803] In clinical trials, vildagliptin has a relatively low risk of hypoglycemia. ... [A232488] By inhibiting DPP-4, vildagliptin prevents the degradation of glucagon-like peptide 1 (GLP- …

Degarelix

Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH) which ultimately causes testosterone suppression. Reduction in...
Approved
Matched Description: … Degarelix is used for the treatment of advanced prostate cancer. ... Chemically, it is a synthetic linear decapeptide amide with seven unnatural amino acids, five of which …
Displaying drugs 451 - 475 of 9508 in total