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Displaying drugs 4876 - 4900 of 10517 in total
Indalpine
Indalpine was one of the first selective serotonin reuptake inhibitors to reach the American market. It was initially marketed by Pharmuka. However, after the emergence of widespread concern regarding adverse effects caused by SSRIs, and reported hematological effects caused by Indalpine, it was abruptly withdrawn from the US market.
Investigational
Withdrawn
Matched Description: … Indalpine was one of the first selective serotonin reuptake inhibitors to reach the American market. ... However, after the emergence of widespread concern regarding adverse effects caused by SSRIs, and reported …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Pirlindole
This drug is classified as a reversible inhibitor of monoamine oxidase A enzyme (also known as a RIMA drug). It was developed and is currently used as an antidepressant in Russia. Its chemical structure is similar to metralindole, and it also shares pharmacological properties with this drug.
Pirlindole is a...
Experimental
Matched Description: … supported by many years of clinical experience in the treatment of depression. ... Pirlindole's efficacy and safety have also been shown in the treatment of fibromyalgia. ... This drug is classified as a reversible inhibitor of monoamine oxidase A enzyme (also known as a RIMA …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
SARS-CoV-2 Sclamp
The University of Queensland (UQ), in partnership with The Coalition for Epidemic Preparedeness Inovations (CEPI) and CSL has developed a COVID-19 candidate, SARS-CoV-2 Sclamp. The vaccine was developed using UQ’s rapid response ‘molecular clamp’ vaccine platform that locks surface proteins in a configuration that allows more robust immune responses, in...
Investigational
Matched Description: … The University of Queensland (UQ), in partnership with The Coalition for Epidemic Preparedeness Inovations ... Preclinical trials showed the vaccine candidate produced high levels of neutralizing antibodies, and ... As of July 13, 2020, the candidate is being tested for safety and immunogenicity in Phase 1 clinical …
Furazolidone
A nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone binds bacterial DNA which leads to the gradual inhibition of monoamine oxidase. (From Martindale, The Extra Pharmacopoeia, 30th ed, p514)
Experimental
Vet approved
Matched Description: … Furazolidone binds bacterial DNA which leads to the gradual inhibition of monoamine oxidase. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Ketobemidone
Ketobemidone is a powerful opioid analgesic. It also has some NMDA-antagonist properties. This makes it useful for some types of pain that don't respond well to other opioids. The most commonly cited equalisation ratio for analgesic doses is 25 mg of ketobemidone hydrobromide to 60 mg of morphine hydrochloride or...
Investigational
Matched Description: … to 60 mg of morphine hydrochloride or sulfate and circa 8 mg of ketobemidone by injection. ... This makes it useful for some types of pain that don't respond well to other opioids. ... The most commonly cited equalisation ratio for analgesic doses is 25 mg of ketobemidone hydrobromide …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
NKG2D-ACE2 CAR-NK Cell
These cells are prepared as universal off-the-shelf CAR-NK cells from cord blood with NKG2D-ACE2 proteins engineered as part of the CARs; the cell secretes IL-15 and GM-CSF. Chimeric antigen receptors (CARs) are artificial receptors consisting of an antibody-derived antigen binding domain and transmembrane and signaling domains from T-cell receptor signalling...
Investigational
Matched Description: … The ACE2 is a receptor for SARS-Cov-2, binding to the S-protein of the viral envelope and competitively ... inhibiting SARS-Cov-2 infection of type II alveolar epithelial cells. ... as universal off-the-shelf CAR-NK cells from cord blood with NKG2D-ACE2 proteins engineered as part of …
BNT162b1 SARS-CoV-2 Vaccine
BNT162b1 is one of four advanced mRNA-based vaccines being developed through "Project Lightspeed," a joint program between Pfizer and BioNTech.[L15002, L15007] BNT162b1 is a nucleoside modified mRNA (modRNA) vaccine encoding the receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) protein together with a "foldon" trimerization domain derived from T4 fibritin...
Investigational
Matched Description: … the SARS-CoV-2 spike (S) protein together with a "foldon" trimerization domain derived from T4 fibritin ... either 10 or 30μg of BNT162b1, with further improvements following a second dose. ... BNT162b1 is one of four advanced mRNA-based vaccines being developed through "Project Lightspeed," a …
Samarium Sm-153
Samarium 153 has been used in trials studying the supportive care of Pain, Lung Cancer, Breast Cancer, Prostate Cancer, and Metastatic Cancer.
Investigational
Matched Description: … Samarium 153 has been used in trials studying the supportive care of Pain, Lung Cancer, Breast Cancer …
Methacrylyl-Coenzyme A
Experimental
Oxidized coenzyme A
Experimental
Ceftiofur
Ceftiofur is a third generation cephalosporin antibiotic, first described in 1987, and now used in veterinary medicine. It is marketed by pharmaceutical company Zoetis as Excenel, and is the active ingredient in that company's Specramast LC (lactating cow formula) product. It is resistant to hydrolysis by beta-lactamase, and has activity...
Vet approved
Tianeptine
Tianeptine is a drug used primarily in the treatment of major depressive disorder and has been studied in the treatment of irritable bowel syndrome (IBS) . Structurally, it is classified as a tricyclic antidepressant (TCA), however, it possesses different pharmacological properties than typical tricyclic antidepressants .
Tianeptine was discovered and...
Investigational
Matched Description: … in the treatment of irritable bowel syndrome (IBS) [A31983]. ... Tianeptine is a drug used primarily in the treatment of major depressive disorder and has been studied ... Tianeptine was discovered and patented by The French Society of Medical Research in the 1960s [L2946] …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
3-thiaoctanoyl-CoA
Experimental
L-serine O-sulfate
Experimental
SN-38
7-ethyl-10-hydroxycamptothecin (SN 38) is a liposomal formulation of the active metabolite of Irinotecan DB00762, a chemotherapeutic pro-drug approved for the treatment of advanced colorectal cancer. SN 38 has been used in trials studying the treatment of Cancer, Advanced Solid Tumors, Small Cell Lung Cancer, Metastatic Colorectal Cancer, and Triple Negative...
Investigational
Matched Description: … 7-ethyl-10-hydroxycamptothecin (SN 38) is a liposomal formulation of the active metabolite of Irinotecan ... [DB00762], a chemotherapeutic pro-drug approved for the treatment of advanced colorectal cancer. ... SN 38 has been used in trials studying the treatment of Cancer, Advanced Solid Tumors, Small Cell Lung …
ST-36
ST-36 is a cell-penetrating dominant-negative form of activating transcription factor 5. In 2017, it received orphan drug designation by the FDA for the treatment of glioma.
Investigational
Matched Description: … ST-36 is a cell-penetrating dominant-negative form of activating transcription factor 5. ... In 2017, it received orphan drug designation by the FDA for the treatment of glioma.[L47341] …
Iproniazid
Withdrawn from the Canadian market in July 1964 due to interactions with food products containing tyrosine.
Withdrawn
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Dapoxetine
Dapoxetine is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation. In a phase II proof-of-concept study conducted by PPD, dapoxetine demonstrated a statistically significant increase in ejaculatory latency when compared to placebo. Alza submitted a NDA to the FDA for dapoxetine for the treatment of premature ejaculation...
Investigational
Matched Description: … Dapoxetine is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation. ... Alza submitted a NDA to the FDA for dapoxetine for the treatment of premature ejaculation in December ... In a phase II proof-of-concept study conducted by PPD, dapoxetine demonstrated a statistically significant …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
SGN-1
SGN-1 is a genetically modified strain of Salmonella enterica comprising methioninase.
Investigational
Matched Description: … SGN-1 is a genetically modified strain of _Salmonella enterica_ comprising methioninase. …
Siagoside
Siagoside (Sygen, AGF 2) has been investigated for the treatment of Parkinson Disease. It is a naturally occurring substance in the nerve cell’s membrane that is thought to play a role in cell growth, development, and repair. Siagoside completed phase 2 trials for parkinson's disease (PD) treatment. Sygen appears to...
Investigational
Matched Iupac: … N-[(2S,3R,4E)-1-{[(2R,3R,4R,5S,6R)-5-[(2S,4S,4'aR,5R,5'S,6R,7'R,8'S,8'aS)-5-acetamido-8'-{[(2S,3R,4R, …
Matched Description: … by permanent unilateral ligation of the common carotid artery. ... Siagoside (Sygen, AGF 2) has been investigated for the treatment of Parkinson Disease. ... Treatment results in a 52% decrease in mortality 48 hours after the induction of ischemia in gerbils …
Matched Description: … by permanent unilateral ligation of the common carotid artery. ... Siagoside (Sygen, AGF 2) has been investigated for the treatment of Parkinson Disease. ... Treatment results in a 52% decrease in mortality 48 hours after the induction of ischemia in gerbils …
Ephedra sinica stem
Experimental
SP-876
Experimental
Sp-722
Experimental
SGN-15
SGN-15 is studied in the treatment of cancer. It combines a monoclonal antibody with the anticancer drug doxorubicin. Monoclonal antibodies are substances that are made in the laboratory and that can locate and bind to cancer cells. Doxorubicin is a type of anthracycline antitumor antibiotic. When it is combined with...
Investigational
Matched Description: … SGN-15 is studied in the treatment of cancer. ... Doxorubicin is a type of anthracycline antitumor antibiotic. ... When it is combined with a monoclonal antibody, it forms a type of drug conjugate. …
SC-236
SC-236 is a potent, selective, orally active inhibitor of cyclooxygenase-2 (COX-2) that has been studied in cancer therapy , lower back pain , and inflammation , , , .
Experimental
Investigational
Matched Description: … SC-236 is a potent, selective, orally active inhibitor of cyclooxygenase-2 (COX-2) [L2964] that has been …
Displaying drugs 4876 - 4900 of 10517 in total