Displaying drugs 476 - 500 of 1731 in total
Risperidone
Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. Paliperidone, another commonly used SGA, is the primary active metabolite of risperidone (i.e. 9-hydroxyrisperidone). Schizophrenia and...
Approved
Investigational
Matched Iupac: … 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-4H,6H,7H,8H,9H-pyrido[1,2-a]pyrimidin …
Tazemetostat
Tazemetostat is a methyltransferase inhibitor used to treat metastatic or locally advanced epithelioid sarcoma not eligible for complete resection. Tazemetostat was first named in literature as EPZ-6438. Tazemetaostat was granted FDA approval on 23 January 2020.
Approved
Investigational
Matched Iupac: … N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-5-[ethyl(oxan-4-yl)amino]-4-methyl-4'-[(morpholin …
Paliperidone
Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin...
Approved
Matched Iupac: … 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-4H,6H,7H,8H,9H-pyrido[ …
Nirmatrelvir
Nirmatrelvir (PF-07321332) is an orally bioavailable 3C-like protease (3CLPRO) inhibitor that is the subject of clinical trial NCT04756531. 3CLPRO is responsible for cleaving polyproteins 1a and 1ab of SARS-CoV-2. Without the activity of the SARS-CoV-2 3CLPRO, nonstructural proteins (including proteases) cannot be released to perform their functions, inhibiting viral replication.[A234224,A234229,A234234]...
Approved
Investigational
Matched Iupac: … (1R,2S,5S)-N-[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-3-[(2S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido …
Gallium-68 PSMA
Approved
Investigational
Matched Iupac: … ({[(1S)-1-carboxy-5-(6-{3-[3-({[2-({[5-(2-carboxyethyl)-2-hydroxyphenyl]methyl}(carboxymethyl)amino)ethyl …
Semaglutide
Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include Exenatide and Liraglutide. Semaglutide was developed by Novo Nordisk and approved by the FDA for subcutaneous injection...
Approved
Investigational
Matched Iupac: … }pentyl]carbamoyl}methoxy)ethoxy]ethyl}carbamoyl)methoxy]ethoxy}ethyl)carbamoyl]-1-carboxypropyl]carbamoyl ... ]carbamoyl}ethyl]carbamoyl}-2-methylbutyl]carbamoyl}-2-phenylethyl]carbamoyl}-3-carboxypropyl]carbamoyl ... methyl)carbamoyl]butyl]carbamoyl}-2-methylpropyl]carbamoyl}-3-methylbutyl]carbamoyl}-2-(1H-indol-3-yl)ethyl …
Isavuconazonium
Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it...
Approved
Investigational
Matched Iupac: … difluorophenyl)-2-hydroxybutyl]-4-[1-({methyl[3-({[2-(methylamino)acetyl]oxy}methyl)pyridin-2-yl]carbamoyl}oxy)ethyl …
Cyclosporine
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus Beauveria nivea. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products...
Approved
Investigational
Vet approved
Matched Iupac: … (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28 …
Pimecrolimus
Pimecrolimus is an immunomodulating agent that was first marketed by Novartis under the trade name Elidel. It is now promoted in Canada by Galderma since early 2007. It is currently available as a topic cream used in the treatment of atopic dermatitis (eczema).
Approved
Investigational
Matched Iupac: … 17R,18E,21S,23S,24R,25S,27R)-12-[(1E)-1-[(1R,3R,4S)-4-chloro-3-methoxycyclohexyl]prop-1-en-2-yl]-17-ethyl …
Cefiderocol
Cefiderocol is a cephalosporin antibacterial drug and exerts a mechanism of action similar to other β-lactam antibiotics.[FDA Label] Unlike other agents in this category, cefiderocol is a siderophore able to undergo active transport into the bacterial cell through iron channels. It represents a significant addition to antibacterial treatment option as...
Approved
Investigational
Matched Iupac: … 8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}-1-{2-[(2-chloro-3,4-dihydroxyphenyl)formamido]ethyl …
Anidulafungin
Anidulafungin or Eraxis is an anti-fungal drug manufactured by Pfizer that gained approval by the Food and Drug Administration (FDA) in February 21, 2006; it was previously known as LY303366. There is preliminary evidence that it has a similar safety profile to caspofungin.
Approved
Investigational
Matched Iupac: … N-[(3S,6S,9S,11R,15S,18S,20R,21R,24S,25S,26S)-6-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-11,20,21,25 …
Caspofungin
Caspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug class called the echinocandins, as coined by Merck & Co., Inc. It is typically administered intravenously. It shows activity against infections with Aspergillus and Candida, and works by inhibiting β(1,3)-D-Glucan of the fungal...
Approved
Matched Iupac: … [(1R)-3-amino-1-hydroxypropyl]-21-[(2-aminoethyl)amino]-6-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl …
Clarithromycin
Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug...
Approved
Matched Iupac: … 5S,6R,7R,9R,11R,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl …
Ziconotide
Ziconotide (also known as SNX-111) is a neurotoxic peptide derived from the cone snail Conus magus comprising 25 amino acids with three disulphide bonds.[A202835, L13389] Other such peptides, collectively termed conotoxins, exist, and some have shown efficacy in binding specific subsets of calcium channels; ziconotide is used in part because...
Approved
Matched Iupac: … tris(hydroxymethyl)-27-[(4-hydroxyphenyl)methyl]-48-methyl-33-(2-methylpropyl)-30-[2-(methylsulfanyl)ethyl …
Cyanocobalamin Co-57
Approved
Matched Iupac: … 1lambda4,3-benzodiazol-3-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl phosphonato]oxy}propyl]carbamoyl}ethyl …
Cyanocobalamin
Cyanocobalamin (commonly known as Vitamin B12) is a highly complex, essential vitamin, owing its name to the fact that it contains the mineral, cobalt. This vitamin is produced naturally by bacteria , and is necessary for DNA synthesis and cellular energy production. Vitamin B12 has many forms, including the cyano-,...
Approved
Nutraceutical
Matched Iupac: … dimethyl-1H-1,3-benzodiazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl phosphonato]oxy}propyl]carbamoyl}ethyl …
Bleomycin
A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin.
Approved
Investigational
Matched Iupac: … )oxan-2-yl)oxy]-3-(1H-imidazol-4-yl)propanamido]-3-hydroxy-2-methylpentanamido]-3-hydroxybutanamido]ethyl …
Estradiol hemisuccinate
Experimental
Matched Synonyms: … 17beta-Estradiol hemisuccinate ... beta-Estradiol-17-beta-hemisuccinate ... beta-Estradiol-17beta-hemisuccinate …
Matched Name: … Estradiol hemisuccinate …
Matched Name: … Estradiol hemisuccinate …
Estradiol sulfamate
Investigational
Matched Synonyms: … Estradiol 3-sulfamate ... Estradiol-3-O-Sulfamate …
Matched Name: … Estradiol sulfamate …
Matched Categories: … Estradiol Congeners …
Matched Name: … Estradiol sulfamate …
Matched Categories: … Estradiol Congeners …
Ethyl pyruvate
CTI-01 (ethyl pyruvate) is a novel anti-inflammatory agent for the treatment of critical inflammatory conditions. CTI-01 shows a potent anti-inflammatory and tissue protection activity in multiple animal models of disease including pancreatitis, ischemia-reperfusion injury, sepsis, renal injury and endotoxemia.
Investigational
Matched Synonyms: … Ethyl 2-oxopropanoate ... Ethyl 2-oxopropionate ... Ethyl methylglyoxylate …
Matched Name: … Ethyl pyruvate …
Matched Iupac: … ethyl 2-oxopropanoate …
Matched Description: … CTI-01 (ethyl pyruvate) is a novel anti-inflammatory agent for the treatment of critical inflammatory …
Matched Name: … Ethyl pyruvate …
Matched Iupac: … ethyl 2-oxopropanoate …
Matched Description: … CTI-01 (ethyl pyruvate) is a novel anti-inflammatory agent for the treatment of critical inflammatory …
Fenoxaprop-ethyl
Fenoxaprop-ethyl (organic nitrate combined with L-arginine), is an oral proprietary nitrate therapeutic shown to induce coronary vasodilation while overcoming the significant problem of drug tolerance. Fenoxaprop-ethyl has been investigated to treat chronic angina, the chest pain that occurs from inadequate blood flow to the coronary arteries around the heart.
Investigational
Matched Synonyms: … Fenoxaprop ethyl …
Matched Name: … Fenoxaprop-ethyl …
Matched Iupac: … ethyl 2-{4-[(6-chloro-1,3-benzoxazol-2-yl)oxy]phenoxy}propanoate …
Matched Description: … Fenoxaprop-ethyl (organic nitrate combined with L-arginine), is an oral proprietary nitrate therapeutic ... Fenoxaprop-ethyl has been investigated to treat chronic angina, the chest pain that occurs from inadequate …
Matched Name: … Fenoxaprop-ethyl …
Matched Iupac: … ethyl 2-{4-[(6-chloro-1,3-benzoxazol-2-yl)oxy]phenoxy}propanoate …
Matched Description: … Fenoxaprop-ethyl (organic nitrate combined with L-arginine), is an oral proprietary nitrate therapeutic ... Fenoxaprop-ethyl has been investigated to treat chronic angina, the chest pain that occurs from inadequate …
Ethyl methoxycinnamate
Experimental
Matched Synonyms: … Ethyl methoxycinnamate ... Ethyl (E)-4-methoxycinnamate ... Ethyl (E)-p-methoxycinnamate …
Matched Name: … Ethyl methoxycinnamate …
Matched Iupac: … ethyl (2E)-3-(4-methoxyphenyl)prop-2-enoate …
Matched Name: … Ethyl methoxycinnamate …
Matched Iupac: … ethyl (2E)-3-(4-methoxyphenyl)prop-2-enoate …
Ethyl loflazepate
Experimental
Illicit
Matched Synonyms: … Ethyl fluclozepate ... Ethyl loflazepate …
Matched Name: … Ethyl loflazepate …
Matched Iupac: … ethyl 7-chloro-5-(2-fluorophenyl)-2-oxo-2,3-dihydro-1H-1,4-benzodiazepine-3-carboxylate …
Matched Categories: … ethyl loflazepate …
Matched Name: … Ethyl loflazepate …
Matched Iupac: … ethyl 7-chloro-5-(2-fluorophenyl)-2-oxo-2,3-dihydro-1H-1,4-benzodiazepine-3-carboxylate …
Matched Categories: … ethyl loflazepate …
Ethyl piperidinoacetylaminobenzoate
Experimental
Matched Synonyms: … Ethyl piperidinoacetylaminobenzoate ... Ethyl p-(piperidinoacetylamino)benzoate …
Matched Name: … Ethyl piperidinoacetylaminobenzoate …
Matched Iupac: … ethyl 4-[2-(piperidin-1-yl)acetamido]benzoate …
Matched Name: … Ethyl piperidinoacetylaminobenzoate …
Matched Iupac: … ethyl 4-[2-(piperidin-1-yl)acetamido]benzoate …
Ethyl biscoumacetate
Ethyl biscoumacetate is a courmarin that is used as an anticoagulant. It has actions similar to those of Warfarin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p226)
Withdrawn
Matched Synonyms: … Ethyl biscoumacetate ... Ethyl bis(4-hydroxy-2-oxo-2h-1-benzopyran-3-yl)acetate …
Matched Name: … Ethyl biscoumacetate …
Matched Iupac: … ethyl 2,2-bis(4-hydroxy-2-oxo-2H-chromen-3-yl)acetate …
Matched Description: … Ethyl biscoumacetate is a courmarin that is used as an anticoagulant. …
Matched Categories: … ethyl biscoumacetate …
Matched Name: … Ethyl biscoumacetate …
Matched Iupac: … ethyl 2,2-bis(4-hydroxy-2-oxo-2H-chromen-3-yl)acetate …
Matched Description: … Ethyl biscoumacetate is a courmarin that is used as an anticoagulant. …
Matched Categories: … ethyl biscoumacetate …
Displaying drugs 476 - 500 of 1731 in total