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Displaying drugs 576 - 600 of 12824 in total
Thiosulfuric acid
Thiosulfuric acid is available in its salt forms sodium thiosulfate and sodium thiosulfate pentahydrate. Sodium thiosulfate is part of the World Health Organization’s list of essential medicines, and it has a variety of industrial uses, including food preservative, water de-chlorinator and paper pulp bleaching agent. Sodium thiosulfate is rapidly degraded...
Approved
Investigational
Matched Description: … Thiosulfuric acid is available in its salt forms sodium thiosulfate and sodium thiosulfate pentahydrate ... [A252827] Sodium thiosulfate is rapidly degraded in the stomach; therefore, it is normally administered ... approved for the treatment of acute cyanide poisoning[L310,L43332,A252832] and it is frequently used in …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Aluminum chloride
Aluminum chloride is a chemical compound with the chemical formula AlCl3. When contaminated with iron chloride, it often displays a yellow color compared to the white pure compound. It is used in various chemical applications as a Lewis base, with anhydrous aluminium trichloride being the most commonly used Lewis acid....
Approved
Investigational
Matched Description: … , calculated on the hexahydrate form, in an aqueous solution nonaerosol dosage form [L2012]. ... It is used in various chemical applications as a Lewis base, with anhydrous aluminium trichloride being ... In antiperspirant products, FDA approves the use of aluminum chloride as an active ingredient up to 15% …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Linagliptin
Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding . Linagliptin was approved by...
Approved
Matched Description: … Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, …
Matched Categories: … Drugs Used in Diabetes ... Heterocyclic Compounds, 2-Ring ... Heterocyclic Compounds, Fused-Ring …
Matched Categories: … Drugs Used in Diabetes ... Heterocyclic Compounds, 2-Ring ... Heterocyclic Compounds, Fused-Ring …
Colletotrichum coccodes
Colletotrichum coccodes is a fungus which can provoke allergic reactions. Colletotrichum coccodes extract is used in allergenic testing.
Approved
Matched Description: … Colletotrichum coccodes extract is used in allergenic testing. …
Chlorphenesin carbamate
Approved
Vet approved
Withdrawn
Celiprolol
Celiprolol is indicated for the management of mild to moderate hypertension and effort-induced angina pectoris. It is simultaneously a selective β1 receptor antagonist, a β2 receptor partial agonist and a weak α2 receptor antagonist. In 2010 a clinical trial has suggested a use for this medication in the prevention of...
Approved
Investigational
Matched Description: … In 2010 a clinical trial has suggested a use for this medication in the prevention of vascular complications ... Celiprolol is not approved for use by the FDA in the treatment of vascular Ehlers–Danlos syndrome. ... demonstrated decreased incidence of arterial rupture or dissection (a specific type of arterial rupture in …
Chloroquine
Chloroquine is an aminoquinolone derivative first developed in the 1940s for the treatment of malaria. It was the drug of choice to treat malaria until the development of newer antimalarials such as pyrimethamine, artemisinin, and mefloquine. Chloroquine and its derivative hydroxychloroquine have since been repurposed for the treatment of a...
Approved
Investigational
Vet approved
Matched Description: … Chloroquine is an aminoquinolone derivative first developed in the 1940s for the treatment of malaria ... [A192432]
**The FDA emergency use authorization for [hydroxychloroquine] and chloroquine in the treatment …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Heterocyclic Compounds, Fused-Ring …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Heterocyclic Compounds, Fused-Ring …
Cilgavimab
SARS-CoV-2, the causative agent of COVID-19, enters cells via the interaction between the trimeric spike (S) glycoprotein and host cell angiotensin-converting enzyme 2 (ACE2). Blocking the interaction between the receptor-binding domain (RBD) of the S1 subunit and ACE2 inhibits viral host cell entry; animal studies indicate that antibodies capable of...
Approved
Investigational
Matched Description: … Cilgavimab, in combination with [tixagevimab], was issued an FDA emergency use authorization (EUA) on ... December 9, 2021, for the pre-exposure prophylaxis of COVID-19 in individuals at increased risk for ... [A243356, A243361] Cilgavimab (formerly AZD1061) is a recombinant monoclonal antibody produced in Chinese …
Tixagevimab
SARS-CoV-2, the causative agent of COVID-19, enters cells via the interaction between the trimeric spike (S) glycoprotein and host cell angiotensin-converting enzyme 2 (ACE2). Blocking the interaction between the receptor-binding domain (RBD) of the S1 subunit and ACE2 inhibits viral host cell entry; animal studies indicate that antibodies capable of...
Approved
Investigational
Matched Description: … Tixagevimab, in combination with [cilgavimab], was issued an FDA emergency use authorization (EUA) on ... December 9, 2021, for the pre-exposure prophylaxis of COVID-19 in individuals at increased risk for ... [L41549]
In October 2022, the FDA and Health Canada released safety alerts regarding the risk of …
Vardenafil
Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, activating the enzyme guanylate cyclase and increasing the...
Approved
Matched Description: … ] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in ... the corpus cavernosum, activating the enzyme guanylate cyclase and increasing the synthesis of cGMP in ... vardenafil, inhibit the degradation of cGMP and allow increased blood flow into the penis, resulting in …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Drugs Used in Erectile Dysfunction …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Drugs Used in Erectile Dysfunction …
Tecovirimat
The World Health Organization declared smallpox, a contagious and sometimes fatal infectious disease, eradicated in 1980. However, there have been longstanding concerns that smallpox may be used as a bioweapon.[A35133,L3614] Tecovirimat is an antiviral drug that was identified via a high-throughput screen in 2002. It is effective against all orthopoxviruses,...
Approved
Investigational
Matched Description: … the approval from the European Commission in January 2022. ... Health Organization declared smallpox, a contagious and sometimes fatal infectious disease, eradicated in ... [A35133,L3614] Tecovirimat is an antiviral drug that was identified via a high-throughput screen in 2002 …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Heterocyclic Compounds, Fused-Ring …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Heterocyclic Compounds, Fused-Ring …
Creatine
An amino acid derivative that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Creatine is excreted as creatinine in the urine.
Approved
Investigational
Nutraceutical
Matched Description: … An amino acid derivative that occurs in vertebrate tissues and in urine. ... Creatine is excreted as creatinine in the urine. ... In muscle tissue, creatine generally occurs as phosphocreatine. …
Chickpea
Chickpea allergenic extract is used in allergenic testing.
Approved
Matched Description: … Chickpea allergenic extract is used in allergenic testing. …
Cinoxate
Approved
Clobazam
Clobazam belongs to the 1,5-benzodiazepine class of drugs and is marketed under different names, Onfi, Frisium, Urbanyl, and others. . Clobazam was first synthesized in 1966 and first published in 1969, following the incidental synthesis and discovery of the first benzodiazepine chlordiazepoxide in the 1950s. Unlike older 1,4-benzodiazepines, clobazam has...
Approved
Illicit
Matched Description: … Clobazam was first synthesized in 1966 and first published in 1969, following the incidental synthesis ... and discovery of the first benzodiazepine chlordiazepoxide in the 1950s. ... with Lennox-Gastaut syndrome in adults and children aged two years and older. …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Heterocyclic Compounds, Fused-Ring …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Heterocyclic Compounds, Fused-Ring …
Sevelamer
Sevelamer is a phosphate binding drug used to prevent hyperphosphataemia in patients with chronic renal failure. It is marketed by Genzyme under the trade name Renagel.
Approved
Matched Description: … Sevelamer is a phosphate binding drug used to prevent hyperphosphataemia in patients with chronic renal …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Ethanolamine oleate
Ethanolamine oleate is a mild sclerosing agent. It is composed of ethanolamine, a basic substance, which when combined with oleic acid forms a clear, straw to pale yellow colored, deliquescent oleate.
Approved
Matched Categories: … Compounds used in a research, industrial, or household setting …
Eculizumab
Eculizumab is a monoclonal antibody that targets complement protein C5.[L6919,A2245] Binding to this protein prevents the activation of a complement terminal complex, which is used to treat a number of autoimmune conditions.[L6919,A2245,A2246]
Eculizumab was granted FDA approval on 16 March 2007. In Q1 2023, the EMA's Committee for Medicinal Products...
Approved
Investigational
Matched Description: … [L6919] In Q1 2023, the EMA's Committee for Medicinal Products for Human Use (CHMP) adopted a positive …
Dermatophagoides farinae
Dermatophagoides farinae extracts are sterile solutions used for intradermal testing or subcutaneous immunotherapy. This combination is approved for as a year-round, once-a-day tablet that's dissolved under the tongue as a treatment for dust mite allergies.
Approved
Tyropanoic acid
Tyropanoic acid is a radiocontrast agent used in cholecystography, the X-ray diagnosis of gallstones under the trade names include Bilopaque, Lumopaque, Tyropaque, and Bilopac. The molecule contains three heavy iodine atoms which obstruct X-rays in the same way as the calcium in bones, which results in a visible image .
Approved
Matched Description: … The molecule contains three heavy iodine atoms which obstruct X-rays in the same way as the calcium in ... bones, which results in a visible image [L1608]. ... Tyropanoic acid is a radiocontrast agent used in cholecystography, the X-ray diagnosis of gallstones …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Methylparaben
Methylparaben is used in allergenic testing.
Approved
Matched Description: … Methylparaben is used in allergenic testing. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Golodirsen
Golodirsen is a morpholino antisense oligomer designed to treat about 8% of patients with Duchenne Muscular Dystrophy (DMD). This is an X-linked condition leading to progressive muscle degeneration that begins in early childhood, rendering many patients wheelchair-bound by age 12. Often, patients succumb to this condition by age 30 or...
Approved
Matched Description: … This is an X-linked condition leading to progressive muscle degeneration that begins in early childhood ... [A188580,T756] A similar drug used in the treatment of other types of DMD is [eteplirsen], which targets ... Therapeutics and granted accelerated FDA approval on December 12, 2019 due to the urgent need for this drug in …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Niraparib
Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, fallopian tube, or...
Approved
Investigational
Matched Description: … By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Heterocyclic Compounds, 2-Ring ... Heterocyclic Compounds, Fused-Ring …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Heterocyclic Compounds, 2-Ring ... Heterocyclic Compounds, Fused-Ring …
Abaloparatide
Abaloparatide is an N-terminal analog of parathyroid hormone-related protein (PTHrP) and an agonist at the parathyroid hormone type 1 (PTH1) receptor. It is a synthetic 34 amino acid peptide with 41% homology to human parathyroid hormone 1-34 and human PTHrP 1-34. Abaloparatide and PTHrP share the first 21 amino acids...
Approved
Investigational
Matched Description: … postmenopausal women and is also used to increase bone density in men with osteoporosis. ... L740] It was first approved by the FDA on April 28, 2017,[A256748] for the treatment of osteoporosis in ... be granted marketing authorization in Europe [L43552] and the drug was fully authorized by the European …
Faricimab
Retinal vascular diseases (RVDs) such as diabetic macular edema (DME), age-related macular degeneration (AMD), and retinal vein occlusion (RVO) are typically caused by retinal ischemia and subsequent neovascularization (NV).[A225985, A225990, A225995] Vascular endothelial growth factor A (VEGF-A) is a well-known mediator of retinal NV, and many currently approved RVD therapies...
Approved
Investigational
Matched Description: … [L40026] It received subsequent approval for the same indications in Canada in May 2022. ... and depleting VEGF-A and Ang-2, which has been developed to improve therapeutic efficacy, especially in ... transmembrane Tie-2 receptor and its soluble ligands Ang-1 and Ang-2, has been shown to play critical roles in …
Displaying drugs 576 - 600 of 12824 in total