Displaying drugs 6351 - 6375 of 8178 in total
AMG-131
AMG-131 (T131), an orally-administered therapy, is expected to lower blood glucose in type II diabetic patients by improving the body’s ability to respond to insulin. T131 is a selective modulator of PPARg (peroxisome proliferator activated receptor gamma), a receptor involved in regulating the body’s ability to respond to insulin. T131...
Investigational
Matched Description: … T131 is a selective modulator of PPARg (peroxisome proliferator activated receptor gamma), a receptor ... T131 is not structurally related to the thiazolidinedione class of PPARg agonists, which includes Actos …
Lactobacillus plantarum
Lactobacillus plantarum is a member of Lactobacillus, or lactic acid bacteria, that it is widely used in the food industry as a microbial starter and probiotic microorganism. It is considered to be one of versatile species that carry out fermentative and metabolic processes, while exhibiting an antagonistic activity against pathogenic...
Investigational
Matched Description: … *Lactobacillus plantarum* is a member of Lactobacillus, or lactic acid bacteria, that it is widely used ... It is considered to be one of versatile species that carry out fermentative and metabolic processes, …
H3B-8800
H3B-8800 is a novel spliceosome inhibitor developed by H3 Biomedicine . It offers the benefit of preferentially killing spliceosome-mutant cancer cells whereas other splicesome inhibitors, such as the pladienolide analogue E7107, show no such preferential targeting . H3B-8800 was granted orphan drug status by the FDA in August 2017 and...
Investigational
Matched Description: … It offers the benefit of preferentially killing spliceosome-mutant cancer cells whereas other splicesome ... was granted orphan drug status by the FDA in August 2017 and is in clinical trials for the treatment of …
SCB-2019
SCB-2019 is a recombinant trimeric S protein subunit vaccine candidate being investigated against COVID-19. This vaccine candidate resembles the native trimeric viral spike and is produced through mammalian cell-culture.
The vaccine was developed and tested by Clover Biopharmaceuticals AUS Pty Ltd.. As of June 2020, the company is pursuing a...
Investigational
Matched Description: … ) to test the safety and immunogenicity of the vaccine. ... As of June 2020, the company is pursuing a randomized, double blind, placebo controlled study (NCT04405908 …
CoVac-1
Sponsored by the University Hospital Tuebingen in Germany, CoVac-1 is a multi-peptide COVID-19 vaccine candidate created from HLA class I and HLA-DR T-cell epitopes of the S-protein . It is being investigated in the clinical trial NCT04546841 (Safety and Immunogenicity Trial of Multi-peptide Vaccination to Prevent COVID-19 Infection in Adults...
Investigational
Matched Description: … 1 is a multi-peptide COVID-19 vaccine candidate created from HLA class I and HLA-DR T-cell epitopes of ... It is being investigated in the clinical trial NCT04546841 (Safety and Immunogenicity Trial of Multi-peptide …
MVA-SARS-2-S
MVA-SARS-2-S is a COVID-19 vaccine candidate that contains a Modified Vaccinia Virus Ankara (MVA) vector expressing the SARS-CoV-2 spike protein . MVA is a highly attenuated poxvirus vector that has a high-level of biological safety due to its quality of being a non-replicating virus in mammalian hosts and is used...
Investigational
Matched Description: … MVA is a highly attenuated poxvirus vector[A226603] that has a high-level of biological safety due to ... its quality of being a non-replicating virus in mammalian hosts[L30458] and is used to develop vaccines …
Phosphocreatine
Phosphocreatine - or creatine phosphate - is the phosphorylated form of creatine. It is primarily found endogenously in the skeletal muscles of vertebrates where it serves a critical role as a rapidly acting energy buffer for muscle cell actions like contractions via its ability to regenerate adenosine triphosphate (ATP) from...
Nutraceutical
Matched Description: … Phosphocreatine - or creatine phosphate - is the phosphorylated form of creatine. ... It is primarily found endogenously in the skeletal muscles of vertebrates where it serves a critical …
Human Umbilical Cord Mesenchymal Stem Cells
Stem cells obtained from amniotic fluid, the umbilical cord (UC), and placenta are gaining in popularity. Stem cells from the umbilical cord offer several advantages, including: non-invasive collection procedures, more hearty and steady growth than bone-marrow derived stem cells (they can maintain a steady doubling time (DT) over up to...
Investigational
Matched Description: … of extracted MSCs. ... The cord lining of the UC is generally isolated with the explant method -- resulting in two kinds of ... Currently many companies are creating their own version of these stem cells, one of which is by Aspire …
Olokizumab
Interleukin-6 (IL-6) is an important cytokine with roles in immune cell proliferation/differentiation, energy and bone metabolism, and the acute phase response of the innate immune system. IL-6 pathway dysregulation is associated with chronic inflammation and lymphoproliferation, including in autoimmune conditions such as rheumatoid arthritis, Castleman disease, and cytokine release syndrome....
Investigational
Matched Description: … immune cell proliferation/differentiation, energy and bone metabolism, and the acute phase response of …
Willardiine
Willardiine is a compound isolated from seeds of Acacia willariana.
Experimental
Matched Description: … Willardiine is a compound isolated from seeds of _Acacia willariana_. …
Thenoyltrifluoroacetone
Thenoyltrifluoroacetone is a chelating agent and inhibitor of cellular respiration.
Experimental
Matched Description: … Thenoyltrifluoroacetone is a chelating agent and inhibitor of cellular respiration. …
PH-797804
PH-797804 has been investigated for the treatment of Osteoarthritis.
Investigational
Matched Description: … PH-797804 has been investigated for the treatment of Osteoarthritis. …
Bapineuzumab
Bapineuzumab has been investigated for the treatment of Alzheimer's Disease.
Investigational
Matched Description: … Bapineuzumab has been investigated for the treatment of Alzheimer's Disease. …
Orteronel
Orteronel has been investigated for the treatment of Prostate Cancer.
Investigational
Matched Description: … Orteronel has been investigated for the treatment of Prostate Cancer. …
Piclozotan
Piclozotan has been investigated for the treatment of Parkinson's Disease.
Investigational
Matched Description: … Piclozotan has been investigated for the treatment of Parkinson's Disease. …
Fanapanel
Fanapanel has been investigated for the treatment of Visual Acuity.
Investigational
Matched Description: … Fanapanel has been investigated for the treatment of Visual Acuity. …
Cannabinol
Cannabinol (CBN) is a physiologically inactive constituent of Cannabis sativa.
Experimental
Investigational
Matched Description: … Cannabinol (CBN) is a physiologically inactive constituent of Cannabis sativa. …
LY-2183240
LY-2183240 is an inhibitor of endocannabinoid reuptake/breakdown.
Investigational
Matched Description: … LY-2183240 is an inhibitor of endocannabinoid reuptake/breakdown.[A253037] …
BBP-671
BBP-671 is a small molecule activator of pantothenate kinases.
Investigational
Matched Description: … BBP-671 is a small molecule activator of pantothenate kinases. …
Bi104
Bi104 is being investigated for the treatment of Angelman syndrome.
Investigational
Matched Description: … Bi104 is being investigated for the treatment of Angelman syndrome. …
Methylmalonic Acid
A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA. [PubChem]
Experimental
Matched Description: … A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. ... This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl …
Virginiamycin S1
One of the components of virginiamycin, a cyclic polypeptide antibiotic complex from streptomyces virginiae, s. Loidensis, s. Mitakaensis, s. Pristina-spiralis, s. Ostreogriseus, and others. It is used to treat infections with gram-positive organisms and as a growth promoter in cattle, swine, and poultry.
Experimental
Matched Description: … One of the components of virginiamycin, a cyclic polypeptide antibiotic complex from streptomyces virginiae …
rhIGFBP-3
rhIGFBP-3 (recombinant human insulin-like growth factor binding protein-3) is Insmed’s proprietary anti-cancer compound that has demonstrated significant decreases in cancerous growth in several models of human. It is developed by Insmed and is currently under phase I of the clinical trial.
Investigational
Matched Description: … It is developed by Insmed and is currently under phase I of the clinical trial. ... anti-cancer compound that has demonstrated significant decreases in cancerous growth in several models of …
Vicriviroc
Vicriviroc, also known as SCH 417690 and SCH-D, is currently in clinical trials for the management of HIV-1. This pyrimidine based drug inhibits the interaction of HIV-1 with CCR5, preventing viral entry into cells. This drug was developed by Schering-Plough.
Investigational
Matched Description: … Vicriviroc, also known as SCH 417690 and SCH-D, is currently in clinical trials for the management of ... This pyrimidine based drug inhibits the interaction of HIV-1 with CCR5, preventing viral entry into cells …
Roxarsone
Roxarsone is an organoarsenic molecule added to poultry feed. The addition of this compound to poultry feed improves weight gain and feed efficiency as well as prevent the growth of coccidian parasites. The drug is also approved in the United States for use in pigs.
Vet approved
Matched Description: … the growth of coccidian parasites. ... The addition of this compound to poultry feed improves weight gain and feed efficiency as well as prevent …
Displaying drugs 6351 - 6375 of 8178 in total