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Displaying drugs 676 - 700 of 14400 in total

Ancrod

Ancrod, marketed as Viprinex, is a defibrinogenating agent derived from Malayan pit viper venom. The defribrinogenation of blood results in an anticoagulant effect. Currently, Viprinex®/ancrod is not approved or marketed in any country, but is being investigated as a stroke treatment in worldwide clinical trials. In January 2005, the U.S....
Approved
Investigational
Matched Description: … ischemic stroke, a life threatening condition caused by the blockage of blood vessels supplying blood and …
Matched Categories: … Enzymes and Coenzymes ... Blood and Blood Forming Organs …

Cemiplimab

Cemiplimab is a fully human monoclonal antibody that works against programmed death receptor-1 (PD-1), which is a negative regulator of T cell function. By blocking PD-1, cemiplimab works to enhance T cell-mediated antitumour responses. Cemiplimab was first approved by the FDA on September 28, 2018, as the first FDA-approved treatment...
Approved
Investigational
Matched Description: … [A39201,A254177,L4615] It was later approved to be used in basal cell carcinoma and non-small non-small …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …

Deucravacitinib

Deucravacitinib is a novel oral selective tyrosine kinase 2 (TYK2) inhibitor. Unlike other Janus kinase 1/2/3 inhibitors that bind to the conserved active domain of these non-receptor tyrosine kinases, deucravacitinib binds to the regulatory domain of TYK2 with high selectivity to this therapeutic target.[A246938, A246943] This selectivity towards TYK2 may...
Approved
Investigational
Matched Description: … triglyceride levels and liver and kidney dysfunction. ... [L43150] It was later approved by Health Canada in November 2022 [L44216] and by the European Medicines ... nonselective JAK inhibitors are associated with a range of adverse effects such as altered cholesterol and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Ecallantide

Ecallantide is a potent and selective human plasma kallikrein inhibitor that is indicated for the symptomatic treatment of hereditary angioedema. Ecallantide is a recombinant 60-amino-acid protein produced in Pichia pastoris yeast cells that contains three intramolecular disulfide bonds [FDA Label]. It was discovered by phage display technology . It shares...
Approved
Investigational
Matched Description: … activity of kallikrein and excessive bradykinin production [FDA Label]. ... Ecallantide is a potent and selective human plasma kallikrein inhibitor that is indicated for the symptomatic ... Ecallantide is marketed by FDA and EMA under the trade name Kalbitor for subcutaneous injection. …
Matched Categories: … Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …

Spiramycin

Spiramycin is a primarily bacteriostatic macrolide antimicrobial agent with activity against Gram-positive cocci and rods, Gram-negative cocci and also Legionellae, mycoplasmas, chlamydiae, some types of spirochetes, Toxoplasma gondii and Cryptosporidium. Spiramycin is a 16-membered ring macrolide discovered in 1952 as a product of Streptomyces ambofaciens that has been available in...
Approved
Matched Description: … Toxoplasma gondii and Cryptosporidium. ... Resistant organisms include Enterobacteria, pseudomonads, and moulds. ... a primarily bacteriostatic macrolide antimicrobial agent with activity against Gram-positive cocci and …
Matched Categories: … spiramycin and metronidazole ... Macrolides, Lincosamides and Streptogramins …

Normethadone

Normethadone is used as an opioid antitussive in combination with DB11610. It is marketed in Canada by Valeant under the tradename Cophylac.
Approved
Illicit
Matched Categories: … Cough and Cold Preparations ... Opium Alkaloids and Derivatives …

Colestilan chloride

Colestilan is an ingredient in the EMA-withdrawn product BindRen.
Approved
Investigational
Withdrawn
Matched Categories: … Drugs for Treatment of Hyperkalemia and Hyperphosphatemia …

Benznidazole

Benznidazole was granted accelerated approval for the treatment of Chagas disease in children 2-12 years of age by the FDA on August 29, 2017. It is the first treatment made available in the United States for Chagas disease.
Approved
Investigational
Matched Categories: … Agents Against Leishmaniasis and Trypanosomiasis ... Antiparasitic Products, Insecticides and Repellents …

Odevixibat

Odevixibat, or A4250, is an ileal sodium/bile acid cotransporter inhibitor indicated for the treatment of pruritus in patients older than 3 months, with progressive familial intrahepatic cholestasis (PFIC).[A236808,L34793] Odevixibat is the first approved non-surgical treatment option for PFIC. Previous therapies for PFIC included a bile acid sequestrant such as ursodeoxycholic...
Approved
Investigational
Matched Description: … [A236808] Odevixibat was granted FDA and Health Canada approval on 20 July 2021 and 13 November 2023 …
Matched Categories: … Bile and Liver Therapy ... Alimentary Tract and Metabolism …

Casimersen

Duchenne muscular dystrophy (DMD) is an X-linked recessive allelic disorder characterized by a lack of functional dystrophin protein, which leads to progressive impairment of ambulatory, pulmonary, and cardiac function and is invariably fatal. A related, albeit a less severe, form of muscular dystrophy known as Becker muscular dystrophy (BMD) is...
Approved
Investigational
Matched Description: … [A218186, L32118] In this manner, PMOs are much less susceptible to endo- and exonucleases and exhibit ... cardiac function and is invariably fatal. ... lack of functional dystrophin protein, which leads to progressive impairment of ambulatory, pulmonary, and …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …

Neratinib

Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer.
Approved
Investigational
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Sodium aurotiosulfate

Approved
Experimental
Matched Categories: … Antiinflammatory and Antirheumatic Products …

Anthrax immune globulin human

Anthrax immune globulin is a human antibody given with antibiotics for the treatment of anthrax. It is derived from the plasma of humans immunized with BioThrax (adsorbed anthrax vaccine), which is then further purified. Available as the product Anthrasil (FDA), the result is a solution for slow IV infusion containing...
Approved
Matched Description: … polyclonal antibodies that bind the protective antigen (PA) component of Bacillus anthracis lethal and ... to have direct antibacterial activity against anthrax bacteria, which otherwise may continue to grow and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Garlic

Garlic allergenic extract is used in allergenic testing.
Approved
Nutraceutical
Matched Categories: … Herbs and Natural Products …

Papaya

Papaya allergenic extract is used in allergenic testing.
Approved
Matched Categories: … Herbs and Natural Products …

Pegaspargase

Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagine through the action of asparagine synthetase. However, leukemia...
Approved
Investigational
Matched Description: … reducing immune detection, and it also increases the half-life of L-asparaginase. ... However, leukemia cells have low levels of this enzyme and depend on exogenous sources. ... Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine …
Matched Categories: … Enzymes and Coenzymes ... Antineoplastic and Immunomodulating Agents …

Peginesatide

Peginesatide is a synthetic peptide attached to polyethylene glycol for the treatment of anemia. The polyethylene glycol moiety helps make the drug less immunogenic and prolongs its plasma half-life. Chemically, peginesatide is designed to mimic the pharmacological activity of erythropoietin, but is not a replica of the structure itself. Peginesatide...
Approved
Investigational
Matched Description: … The polyethylene glycol moiety helps make the drug less immunogenic and prolongs its plasma half-life ... of two 21-amino acid chains that are covalently bonded by a linker derived from iminodiacetic acid and …
Matched Categories: … Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …

Diphemanil

Approved
Vet approved
Withdrawn
Matched Categories: … Alimentary Tract and Metabolism ... diphemanil and psycholeptics …

Danicopan

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired hematologic disease characterized by hemolysis, thrombophilia, and bone marrow dysfunction.[A263501,L50417] Both hemolysis and thrombophilia are mediated primarily by the complement system. Standard therapy for PNH involves the use of complement C5 inhibitors (e.g. eculizumab, ravulizumab) which are effective in mitigating complement-mediated intravascular...
Approved
Investigational
Matched Description: … [A263501,L50417] Both hemolysis and thrombophilia are mediated primarily by the complement system. ... hemoglobinuria (PNH) is a rare acquired hematologic disease characterized by hemolysis, thrombophilia, and ... Japan for patients with PNH,[A263506,L50416] shortly after which the EMA adopted a positive opinion and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …

Serdexmethylphenidate

Attention Deficit Hyperactivity Disorder (ADHD) is an early-onset neurodevelopmental disorder that often extends into adulthood and is characterized by developmentally inappropriate and impaired attention, impulsivity, and motor hyperactivity.[A230698, A230703] The underlying cause of ADHD is unclear but likely involves dysfunction in dopaminergic and noradrenergic neurotransmission, as evidenced by the clear...
Approved
Matched Description: … is characterized by developmentally inappropriate and impaired attention, impulsivity, and motor hyperactivity ... [amphetamine] that increase extracellular dopamine and norepinephrine levels. ... Hyperactivity Disorder (ADHD) is an early-onset neurodevelopmental disorder that often extends into adulthood and …
Matched Categories: … dexmethylphenidate and serdexmethylphenidate ... Psychostimulants, Agents Used for ADHD and Nootropics …

Choline C 11

Choline C 11 is a marker for cellular proliferation as its main molecule is a precursor for the biosynthesis of phospholipids which are essential components of all cell membranes. It was developed by MCPRF and FDA first approved in September 2012.
Approved
Investigational
Matched Description: … [A32041] It was developed by MCPRF and FDA first approved in September 2012. …

Dexmethylphenidate

Dexmethylphenidate is the dextrorotary form of methylphenidate introduced in 2002 . It is a norepinephrine-dopamine reuptake inhibitor (NDRI) and thus a psychostimulant . It is used for treatment of Attention Deficit Hyperactivity Disorder (ADHD)[Label,A177181]. The d-isomer is thought to have greater effect with fewer side effects than the l-isomer or...
Approved
Investigational
Matched Description: … It is a norepinephrine-dopamine reuptake inhibitor (NDRI) and thus a psychostimulant[A177193]. …
Matched Categories: … Methylphenidate and isomer ... dexmethylphenidate and serdexmethylphenidate ... Psychostimulants, Agents Used for ADHD and Nootropics …

Ferrous glycine sulfate

Approved
Matched Categories: … Blood and Blood Forming Organs …

Potassium aspartate

Approved
Experimental
Matched Categories: … Amino Acids, Peptides, and Proteins …

Temazepam

Temazepam, like many other similar and related benzodiazepines, acts as a gamma-aminobutyric acid (GABA) modulator and is capable of eliciting a variety of actions including sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action [A175207, A175210, F3718, F3721]. Although the chemical synthesis of temazepam was established by 1965 ,...
Approved
Investigational
Matched Description: … capable of developing drug tolerance, physical dependence, and addiction in users. ... Temazepam, like many other similar and related benzodiazepines, acts as a gamma-aminobutyric acid (GABA ... relaxation, anticonvulsant activity, and anxiolytic action [A175207, A175210, F3718, F3721]. …
Matched Categories: … Hypnotics and Sedatives ... Benzodiazepine hypnotics and sedatives ... Benzodiazepines and benzodiazepine derivatives …
Displaying drugs 676 - 700 of 14400 in total