Displaying drugs 701 - 725 of 6317 in total
Biguanide
Biguanide has been investigated for the treatment of Diabetes Mellitus.
Approved
Investigational
Avapritinib
Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis.[A189339,L40363] It is one of the first medications available for the treatment of multidrug resistant cancers. Avapritinib shares a...
Approved
Investigational
Matched Iupac: … (1S)-1-(4-fluorophenyl)-1-(2-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin ... -1-yl}pyrimidin-5-yl)ethan-1-amine …
Matched Description: … [A189327] Avapritinib shares a similar mechanism with [ripretinib]. ... Avapritinib, or BLU-285,[A189327] is a selective tyrosine kinase inhibitor of KIT and platelet derived …
Matched Categories: … MATE 1 Inhibitors ... MATE 2 Inhibitors ... MATE 2-K Inhibitors ... Heterocyclic Compounds, 1-Ring …
Matched Description: … [A189327] Avapritinib shares a similar mechanism with [ripretinib]. ... Avapritinib, or BLU-285,[A189327] is a selective tyrosine kinase inhibitor of KIT and platelet derived …
Matched Categories: … MATE 1 Inhibitors ... MATE 2 Inhibitors ... MATE 2-K Inhibitors ... Heterocyclic Compounds, 1-Ring …
Levomenol
Bisabolol, or more formally α-(−)-bisabolol or also known as levomenol, (-)-alpha-Bisabolol is found in fats and oils. (-)-alpha-Bisabolol is isolated from essential oil of Matricaria chamomilla (German chamomile) (-)-alpha-Bisabolol belongs to the family of Sesquiterpenes. These are terpenes with three consecutive isoprene units.
Approved
Experimental
Matched Iupac: … (2S)-6-methyl-2-[(1S)-4-methylcyclohex-3-en-1-yl]hept-5-en-2-ol …
Ertugliflozin
Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018.
Approved
Investigational
Matched Synonyms: … 1,6-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-5-C-(hydroxymethyl)-β-L-idopyranose ... (1S,2S,3S,4R,5S)-5-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane ... β-L-Idopyranose, 1,6-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-5-C-(hydroxymethyl)- …
Matched Iupac: … (1S,2S,3S,4R,5S)-5-{4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl}-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1 …
Matched Description: … Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes ... [A261951, L1132] It was also approved by the European Commission in March 2018.[L48621] …
Matched Categories: … Sodium-Glucose Transporter 2 Inhibitors ... Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors …
Matched Iupac: … (1S,2S,3S,4R,5S)-5-{4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl}-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1 …
Matched Description: … Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes ... [A261951, L1132] It was also approved by the European Commission in March 2018.[L48621] …
Matched Categories: … Sodium-Glucose Transporter 2 Inhibitors ... Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors …
Flavoxate
A drug that has been used in various urinary syndromes and as an antispasmodic. Its therapeutic usefulness and its mechanism of action are not clear. It may have local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a muscarinic antagonist. [PubChem]
Approved
Matched Synonyms: … 2-(1-piperidinyl)ethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylate ... 2-piperidinoethyl 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylate ... 2-piperidinoethyl 3-methylflavone-8-carboxylate …
Matched Iupac: … 2-(piperidin-1-yl)ethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylate …
Matched Description: … A drug that has been used in various urinary syndromes and as an antispasmodic. ... local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a …
Matched Salts cas: … 3717-88-2 …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Heterocyclic Compounds, 2-Ring …
Matched Iupac: … 2-(piperidin-1-yl)ethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylate …
Matched Description: … A drug that has been used in various urinary syndromes and as an antispasmodic. ... local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a …
Matched Salts cas: … 3717-88-2 …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Heterocyclic Compounds, 2-Ring …
Tyropanoic acid
Tyropanoic acid is a radiocontrast agent used in cholecystography, the X-ray diagnosis of gallstones under the trade names include Bilopaque, Lumopaque, Tyropaque, and Bilopac. The molecule contains three heavy iodine atoms which obstruct X-rays in the same way as the calcium in bones, which results in a visible image .
Approved
Matched Iupac: … 2-[(3-butanamido-2,4,6-triiodophenyl)methyl]butanoic acid …
Matched Description: … Tyropanoic acid is a radiocontrast agent used in cholecystography, the X-ray diagnosis of gallstones ... heavy iodine atoms which obstruct X-rays in the same way as the calcium in bones, which results in a …
Matched Salts cas: … 7246-21-1 …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Description: … Tyropanoic acid is a radiocontrast agent used in cholecystography, the X-ray diagnosis of gallstones ... heavy iodine atoms which obstruct X-rays in the same way as the calcium in bones, which results in a …
Matched Salts cas: … 7246-21-1 …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Miltefosine
Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid drug that was originally developed in the 1980s as an anti-cancer agent. It is currently the only recognized oral agent used to treat visceral, cutaneous, and mucosal forms of leishmaniasis, a neglected tropical disease. It can be administered topically or orally and...
Approved
Investigational
Matched Synonyms: … hexadecyl 2-(trimethylazaniumyl)ethyl phosphate …
Matched Iupac: … hexadecyl 2-(trimethylazaniumyl)ethyl phosphate …
Matched Description: … Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid drug that was originally ... the only recognized oral agent used to treat visceral, cutaneous, and mucosal forms of leishmaniasis, a ... The CDC has also recommended it as a first line treatment for free-living amebae (FLA) infections such …
Matched Iupac: … hexadecyl 2-(trimethylazaniumyl)ethyl phosphate …
Matched Description: … Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid drug that was originally ... the only recognized oral agent used to treat visceral, cutaneous, and mucosal forms of leishmaniasis, a ... The CDC has also recommended it as a first line treatment for free-living amebae (FLA) infections such …
Fosdenopterin
Molybdenum cofactor deficiency (MoCD) is an exceptionally rare autosomal recessive disorder resulting in a deficiency of three molybdenum-dependent enzymes: sulfite oxidase (SOX), xanthine dehydrogenase, and aldehyde oxidase. Signs and symptoms begin shortly after birth and are caused by a build-up of toxic sulfites resulting from a lack of SOX activity.[A230088,L32163]...
Approved
Matched Description: … resulting from a lack of SOX activity. ... the first therapeutic option for patients with MoCD type A. ... Molybdenum cofactor deficiency (MoCD) is an exceptionally rare autosomal recessive disorder resulting in a …
Matched Categories: … MATE 1 Substrates ... MATE 2 Inhibitors ... Heterocyclic Compounds, 2-Ring …
Matched Categories: … MATE 1 Substrates ... MATE 2 Inhibitors ... Heterocyclic Compounds, 2-Ring …
Carpinus caroliniana pollen
Carpinus caroliniana pollen is the pollen of the Carpinus caroliniana plant. Carpinus caroliniana pollen is mainly used in allergenic testing.
Approved
Pholcodine
Pholcodine formula is 3-o-morpholinoethylmorphine and it is classified as an antitussive which is defined as an opioid cough suppressant. It belongs to the opioid family of compounds and it is widely used. Pholcodine activity is the suppression of unproductive cough and it also has a mild sedative effect with little...
Approved
Illicit
Matched Iupac: … (1S,5R,13R,14S,17R)-4-methyl-10-[2-(morpholin-4-yl)ethoxy]-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17 …
Matched Description: … Pholcodine formula is 3-o-morpholinoethylmorphine and it is classified as an antitussive which is defined ... It is categorized as Class B drug in the UK and officially taken out of the shelves in 2008. ... [A31738] Pholcodine activity is the suppression of unproductive cough and it also has a mild sedative …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Description: … Pholcodine formula is 3-o-morpholinoethylmorphine and it is classified as an antitussive which is defined ... It is categorized as Class B drug in the UK and officially taken out of the shelves in 2008. ... [A31738] Pholcodine activity is the suppression of unproductive cough and it also has a mild sedative …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Telmisartan
Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. Generally, angiotensin II receptor blockers (ARBs) such as telmisartan bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle, ultimately leading to...
Approved
Investigational
Matched Synonyms: … 4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl]biphenyl-2-carboxylic acid ... 4'-((4-methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl)methyl)-2-biphenylcarboxylic acid ... 4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)-(1,1'-biphenyl)-2-carboxylic acid …
Matched Iupac: … 4'-{[4-methyl-6-(1-methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazol-1-yl]methyl}-[1,1'-biphenyl ... ]-2-carboxylic acid …
Matched Description: … Generally, angiotensin II receptor blockers (ARBs) such as telmisartan bind to the angiotensin II type 1 ... causing inhibition of the action of angiotensin II on vascular smooth muscle, ultimately leading to a …
Matched Salts cas: … 515815-47-1 …
Matched Mixtures name: … CARDIOCAP A 80/5 ... CARDIOCAP A 80/5 ... XIFEN A®80 /10 MG …
Matched Categories: … Angiotensin II Type 1 Receptor Blockers ... Angiotensin 2 Receptor Blocker ... Heterocyclic Compounds, 2-Ring ... Angiotensin II Type 2 Receptor Blockers …
Matched Iupac: … 4'-{[4-methyl-6-(1-methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazol-1-yl]methyl}-[1,1'-biphenyl ... ]-2-carboxylic acid …
Matched Description: … Generally, angiotensin II receptor blockers (ARBs) such as telmisartan bind to the angiotensin II type 1 ... causing inhibition of the action of angiotensin II on vascular smooth muscle, ultimately leading to a …
Matched Salts cas: … 515815-47-1 …
Matched Mixtures name: … CARDIOCAP A 80/5 ... CARDIOCAP A 80/5 ... XIFEN A®80 /10 MG …
Matched Categories: … Angiotensin II Type 1 Receptor Blockers ... Angiotensin 2 Receptor Blocker ... Heterocyclic Compounds, 2-Ring ... Angiotensin II Type 2 Receptor Blockers …
Nisoldipine
Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. Nisoldipine may be used in alone...
Approved
Matched Synonyms: … isobutyl methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate …
Matched Iupac: … 3-methyl 5-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate …
Matched Description: … Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Iupac: … 3-methyl 5-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate …
Matched Description: … Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Bioallethrin
Bioallethrin refers to a mixture of two of the allethrin isomers (1R,trans;1R and 1R,trans;1S) in an approximate ratio of 1:1, where both isomers are active ingredients. A mixture of the two same stereoisomers, but in an approximate ratio of R:S in 1:3, is called esbiothrin. A mixture containing only S-forms...
Approved
Experimental
Matched Iupac: … 2-methyl-4-oxo-3-(prop-2-en-1-yl)cyclopent-2-en-1-yl 2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropane ... -1-carboxylate …
Matched Description: … A mixture of the two same stereoisomers, but in an approximate ratio of R:S in 1:3, is called esbiothrin ... approximate ratio of 1:1, where both isomers are active ingredients. ... Bioallethrin is a synthetic pyrethroid used as a pesticide against household pest insects such as mosquitoes …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Description: … A mixture of the two same stereoisomers, but in an approximate ratio of R:S in 1:3, is called esbiothrin ... approximate ratio of 1:1, where both isomers are active ingredients. ... Bioallethrin is a synthetic pyrethroid used as a pesticide against household pest insects such as mosquitoes …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Febuxostat
Febuxostat is a non-purine xanthine oxidase (XO) inhibitor. In early 2008, febuxostat was granted marketing authorization by the European Commission for the treatment of chronic hyperuricemia and gout. In the following year, the FDA for approved febuxostat for use in the chronic management of hyperuricemia in adult patients with gout...
Approved
Matched Synonyms: … 2-(3-cyano-4-isobutoxyphenyl)-4-methyl- 1,3-thiazole-5-carboxylic acid …
Matched Iupac: … 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid …
Matched Description: … [A230548] In February 2019, a black box warning for febuxostat was added, based on the findings of ... Febuxostat is a non-purine xanthine oxidase (XO) inhibitor. ... a post-market clinical study (the CARES trial) where there was an increased risk of cardiovascular ( …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Iupac: … 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid …
Matched Description: … [A230548] In February 2019, a black box warning for febuxostat was added, based on the findings of ... Febuxostat is a non-purine xanthine oxidase (XO) inhibitor. ... a post-market clinical study (the CARES trial) where there was an increased risk of cardiovascular ( …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Upadacitinib
Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by synovial inflammation and hyperplasia, autoantibody production, cartilage damage...
Approved
Investigational
Matched Iupac: … (3S,4R)-3-ethyl-4-{1,5,7,10-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-12-yl}-N-(2,2,2 ... -trifluoroethyl)pyrrolidine-1-carboxamide …
Matched Description: … Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic ... [A189165] The FDA approved upadacitinib in August 2019 and it is used for the treatment of active ... [L10896] In December 2019, it was additionally approved by the European Commission and Health Canada. …
Matched Description: … Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic ... [A189165] The FDA approved upadacitinib in August 2019 and it is used for the treatment of active ... [L10896] In December 2019, it was additionally approved by the European Commission and Health Canada. …
Meticillin
One of the penicillins which is resistant to penicillinase but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.
Approved
Investigational
Matched Synonyms: … (2S,5R,6R)-6-[(2,6-dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic …
Matched Iupac: … (2S,5R,6R)-6-(2,6-dimethoxybenzamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic …
Matched Description: … It is inactivated by gastric acid so administered by injection. ... One of the penicillins which is resistant to penicillinase but susceptible to a penicillin-binding protein …
Matched Salts cas: … 7246-14-2 …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Iupac: … (2S,5R,6R)-6-(2,6-dimethoxybenzamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic …
Matched Description: … It is inactivated by gastric acid so administered by injection. ... One of the penicillins which is resistant to penicillinase but susceptible to a penicillin-binding protein …
Matched Salts cas: … 7246-14-2 …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Sarecycline
Sarecycline is a semi-synthetic derivative of tetracycline that was initially discovered by Paratek Pharmaceuticals from Boston, MA but then licensed to Warner Chilcott of Rockaway, NJ in July of 2007 . After completing various phase-II and phase-III trials demonstrating its effectiveness in treating moderate to severe facial acne vulgaris [A39993,...
Approved
Investigational
Matched Iupac: … 3,10,12,12a-tetrahydroxy-7-{[methoxy(methyl)amino]methyl}-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2- …
Matched Description: … Allergan's US Medical Dermatology portfolio, before Almirall acquired the portfolio in the second half of 2018 ... s Seysara (sarecylcine) as a new first in class narrow spectrum tetracycline derived oral antibiotic ... Sarecycline is a semi-synthetic derivative of tetracycline that was initially discovered by Paratek Pharmaceuticals …
Matched Salts cas: … 1035979-44-2 …
Matched Description: … Allergan's US Medical Dermatology portfolio, before Almirall acquired the portfolio in the second half of 2018 ... s Seysara (sarecylcine) as a new first in class narrow spectrum tetracycline derived oral antibiotic ... Sarecycline is a semi-synthetic derivative of tetracycline that was initially discovered by Paratek Pharmaceuticals …
Matched Salts cas: … 1035979-44-2 …
Troglitazone
Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by pioglitazone and rosiglitazone.
Approved
Investigational
Withdrawn
Matched Iupac: … 5-({4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-yl)methoxy]phenyl}methyl)-1,3-thiazolidine …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Heterocyclic Compounds, 2-Ring …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Heterocyclic Compounds, 2-Ring …
Penicillamine
Penicillamine is a pharmaceutical of the chelator class. The pharmaceutical form is D-penicillamine, as L-penicillamine is toxic (it inhibits the action of pyridoxine). It is an α-amino acid metabolite of penicillin, although it has no antibiotic properties.
Approved
Matched Synonyms: … (S)-2-amino-3-mercapto-3-methylbutanoic acid ... 3-mercapto-D-valine …
Matched Iupac: … (2S)-2-amino-3-methyl-3-sulfanylbutanoic acid …
Matched Description: … Penicillamine is a pharmaceutical of the chelator class. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Iupac: … (2S)-2-amino-3-methyl-3-sulfanylbutanoic acid …
Matched Description: … Penicillamine is a pharmaceutical of the chelator class. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Motixafortide
Motixafortide is a cyclic peptide hematopoietic stem cell mobilizer used to improve stem cell collection prior to autologous transplantation. Hematopoietic stem cell transplantation (HSCT) is commonly employed in the context of hematologic cancers - high-dose chemotherapy regimens destroy cancerous blood cells, which are then replaced via infusion of the patient's...
Approved
Investigational
Matched Description: … Motixafortide is a cyclic peptide hematopoietic stem cell mobilizer used to improve stem cell collection ... previously approved [plerixafor], motixafortide is an inhibitor of C-X-C Motif Chemokine Receptor 4 (CXCR4), a …
Displaying drugs 701 - 725 of 6317 in total