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Displaying drugs 726 - 746 of 746 in total
Cerulenin
Cerulenin is an antifungal agent whose activity interferes with or otherwise acts to prevent the formation of fatty acids and sterols. In fatty acid synthesis, reported to bind in equimolar ratio to b-keto-acyl-ACP synthase. In sterol synthesis, inhibits HMG-CoA synthetase activity. It is also shown to inhibit feeding and induce...
Experimental
Matched Description: … In fatty acid synthesis, reported to bind in equimolar ratio to b-keto-acyl-ACP synthase. ... It is also shown to inhibit feeding and induce dramatic weight loss in mice. ... antifungal agent whose activity interferes with or otherwise acts to prevent the formation of fatty acids and …
VPM1002
The bacille Calmette-Guérin (BCG) vaccine protects against severe extrapulmonary forms of tuberculosis (TB) but does not adequately protect against pulmonary TB -- the most prevalent form of TB. This recombinant BCG, VPM1002, has been created in response and investigated for preventing pulmonary TB in newborns and TB recurrence in adults...
Investigational
Matched Description: … As of August 2020, this vaccine is being tested for prophylaxis against COVID-19 in human clinical trials ... TB in newborns and TB recurrence in adults through post-exposure immunization. ... This recombinant BCG, VPM1002, has been created in response and investigated for preventing pulmonary …
Bavituximab
Bavituximab is a chimeric Anti-PS monoclonal antibody analog which is used to potentially treat cancers and viral infections. It binds to phosphatidylserine and other exposed host cell lipids when induced by cellular stress. Additional analogs in the class include 3G4, 2aG4, 9d2 and Hu3g4.
Investigational
Matched Description: … Additional analogs in the class include 3G4, 2aG4, 9d2 and Hu3g4. ... It binds to phosphatidylserine and other exposed host cell lipids when induced by cellular stress. ... Bavituximab is a chimeric Anti-PS monoclonal antibody analog which is used to potentially treat cancers and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Thiocolchicoside
Thiocolchicoside is a semi-synthetic derivative of the colchicine, a natural anti-inflammatory glycoside which originates from the flower seeds of Superba gloriosa. It is a muscle relaxant with anti-inflammatory and analgesic effects. It has potent convulsant activity and should not be administered to individuals prone to seizures.
Experimental
Matched Iupac: … oxo-5-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}tricyclo[9.5.0.0²,⁷]hexadeca-1( …
Matched Description: … It is a muscle relaxant with anti-inflammatory and analgesic effects. ... It has potent convulsant activity and should not be administered to individuals prone to seizures. …
Matched Mixtures name: … ETNA COMBO %1 / %0.25 JEL ... VETEXINE COMBO %1/%0.25 JEL, 50 G ... DEKSİT 25 MG/4 MG TABLET …
Matched Products: … MUSCOMED MERHEM ,1 TÜP; ... REUTRID 4 MG ... HEXOFEN®TABLETA 4 MG …
Matched Description: … It is a muscle relaxant with anti-inflammatory and analgesic effects. ... It has potent convulsant activity and should not be administered to individuals prone to seizures. …
Matched Mixtures name: … ETNA COMBO %1 / %0.25 JEL ... VETEXINE COMBO %1/%0.25 JEL, 50 G ... DEKSİT 25 MG/4 MG TABLET …
Matched Products: … MUSCOMED MERHEM ,1 TÜP; ... REUTRID 4 MG ... HEXOFEN®TABLETA 4 MG …
N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine
25CN-NBOH (N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine) is a newly developed selective 5-HT2A agonist. It has been tested with regard to the head-twitch-response (HTR) model of 5-HT2A activity and effects on locomotion . It was discovered in 2014 at the University of Copenhagen.
Experimental
Matched Name: … N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine …
Matched Iupac: … 4-(2-{[(2-hydroxyphenyl)methyl]amino}ethyl)-2,5-dimethoxybenzonitrile …
Matched Description: … 25CN-NBOH (N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine) is a newly developed selective ... It has been tested with regard to the head-twitch-response (HTR) model of 5-HT2A activity and effects …
Matched Iupac: … 4-(2-{[(2-hydroxyphenyl)methyl]amino}ethyl)-2,5-dimethoxybenzonitrile …
Matched Description: … 25CN-NBOH (N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine) is a newly developed selective ... It has been tested with regard to the head-twitch-response (HTR) model of 5-HT2A activity and effects …
Ceramide NP
Ceramide NP is a lipid molecule included in a group of lipid molecules called ceramides. Ceramides are major lipid components in the stratum corneum of the human skin. Ceramide 3 consists of a phytosphingosine backbone N-acylated with a saturated fatty acid (stearic acid) . It is widely used as a...
Experimental
Matched Synonyms: … N-oloeoyl-4-hydroxysphinganine ... N-(9Z-octadecenoyl)-4-hydroxysphinganine …
Matched Description: … Ceramides are major lipid components in the stratum corneum of the human skin. ... It is widely used as a moisturizer in various cosmetic and personal products. ... Together with ceramide 1, they synergistically improve the skin barrier function in humans [A27232, A27233 …
Matched Description: … Ceramides are major lipid components in the stratum corneum of the human skin. ... It is widely used as a moisturizer in various cosmetic and personal products. ... Together with ceramide 1, they synergistically improve the skin barrier function in humans [A27232, A27233 …
Cinalukast
Used in the treatment of asthma, cinalukast selectively antagonizes leukotriene D4 (LTD4) at the cysteinyl leukotriene receptor, CysLT1, in the human airway. Cinalukast inhibits the actions of LTD4 at the CysLT1 receptor, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus.
Experimental
Matched Synonyms: … 3'-((E)-2-(4-cyclobutyl-2-thiazolyl)vinyl)-2,2-diethylsuccinanilic acid …
Matched Iupac: … 3-({3-[(E)-2-(4-cyclobutyl-1,3-thiazol-2-yl)ethenyl]phenyl}carbamoyl)-2,2-diethylpropanoic acid …
Matched Description: … selectively antagonizes leukotriene D4 (LTD4) at the cysteinyl leukotriene receptor, CysLT1, in the human ... inhibits the actions of LTD4 at the CysLT1 receptor, preventing airway edema, smooth muscle contraction, and …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Iupac: … 3-({3-[(E)-2-(4-cyclobutyl-1,3-thiazol-2-yl)ethenyl]phenyl}carbamoyl)-2,2-diethylpropanoic acid …
Matched Description: … selectively antagonizes leukotriene D4 (LTD4) at the cysteinyl leukotriene receptor, CysLT1, in the human ... inhibits the actions of LTD4 at the CysLT1 receptor, preventing airway edema, smooth muscle contraction, and …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
NNZ-2591
NNZ-2591 (cyclo-L-glycyl-L-2-allylproline) is an investigational synthetic analog of cyclic glycine-proline (cGP), a breakdown product of human insulin-like growth factor 1 (IGF-1), that has been chemically modified to increase its half-life, stability, and oral bioavailability. It is currently under development by Neuren Pharmaceuticals for the symptomatic treatment of Angelman, Phelan-McDermid, and...
Investigational
Matched Iupac: … (8aR)-8a-(prop-2-en-1-yl)-octahydropyrrolo[1,2-a]pyrazine-1,4-dione …
Matched Description: … insulin-like growth factor 1 (IGF-1), that has been chemically modified to increase its half-life, stability ... A189390] is an investigational synthetic analog of cyclic glycine-proline (cGP), a breakdown product of human ... , and oral bioavailability. …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Amino Acids, Peptides, and Proteins …
Matched Description: … insulin-like growth factor 1 (IGF-1), that has been chemically modified to increase its half-life, stability ... A189390] is an investigational synthetic analog of cyclic glycine-proline (cGP), a breakdown product of human ... , and oral bioavailability. …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Amino Acids, Peptides, and Proteins …
Palmidrol
A cannabinoid receptor-inactive eCB-related molecule used as prophylactic in helping to prevent respiratory viral infection. Palmidrol is available for human use as a supplement (400 mg capsules) and as food for medical purposes In Italy and Spain (300 mg and 600 mg tablets).
Experimental
Nutraceutical
Matched Description: … Palmidrol is available for human use as a supplement (400 mg capsules) and as food for medical purposes ... In Italy and Spain (300 mg and 600 mg tablets). …
Matched Categories: … Cannabinoids and similars ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Categories: … Cannabinoids and similars ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Tegoprubart
Investigational
Zanidatamab
According to Zymeworks, "ZW25 is a bispecific antibody that can simultaneously bind two non-overlapping epitopes, known as biparatopic binding, of HER2 resulting in dual HER2 signal blockade, increased binding and removal of HER2 protein from the cell surface, and potent effector function. These combined mechanisms of action have led to...
Investigational
Matched Description: … removal of HER2 protein from the cell surface, and potent effector function. ... epitopes, known as biparatopic binding, of HER2 resulting in dual HER2 signal blockade, increased binding and ... combined mechanisms of action have led to significant anti-tumor activity in preclinical models of breast and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Protocatechualdehyde
Also known as protocatechuic aldehyde, protocatechualdehyde is a naturally-occuring phenolic aldehyde that is found in barley, green cavendish bananas, grapevine leaves and root of the herb S. miltiorrhiza . Protocatechualdehyde possesses antiproliferative and pro-apoptotic properties against human breast cancer cells and colorectal cancer cells by reducing the expression of pro-oncogenes...
Experimental
Matched Description: … Protocatechualdehyde possesses antiproliferative and pro-apoptotic properties against human breast cancer ... cells and colorectal cancer cells by reducing the expression of pro-oncogenes β-catenin and cyclin D1 ... naturally-occuring phenolic aldehyde that is found in barley, green cavendish bananas, grapevine leaves and …
Dapirolizumab pegol
Dapirolizumab pegol is under investigation in clinical trial NCT02804763 (A Phase 2 Efficacy and Safety Study of Dapirolizumab Pegol (DZP) in Systemic Lupus Erythematosus).
Investigational
Matched Description: … Dapirolizumab pegol is under investigation in clinical trial NCT02804763 (A Phase 2 Efficacy and Safety …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Umbilical Cord Blood Hematopoietic Stem Cells
The use of umbilical cord blood (UCB) for therapies is advantageous because of its ease of access, non-invasive collection procedures, and more plasticity for multi-differentiation. UCB contains a large source of hematopoietic stem cells (HSCs) that are capable of self-renewal, have increased sensitivity to various factors, and are able to...
Investigational
Matched Description: … , from red blood cells, to B-, T-, and Natural Killer Cells. ... Specifically, the proliferation capacity of human umbilical cord blood mononuclear progenitor cells ( ... Cord blood transplants have been used to treat conditions from aplastic anemia, B-thalassemia, X-linked …
Fenretinide
A synthetic retinoid that is used orally as a chemopreventive against prostate cancer and in women at risk of developing contralateral breast cancer. It is also effective as an antineoplastic agent.
Investigational
Matched Synonyms: … 4-HPR ... 4-hydroxy(phenyl)retinamide ... 4-hydroxyphenyl retinamide …
Matched Iupac: … (2E,4E,6E,8E)-N-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenamide …
Matched Description: … A synthetic retinoid that is used orally as a chemopreventive against prostate cancer and in women at …
Matched Iupac: … (2E,4E,6E,8E)-N-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenamide …
Matched Description: … A synthetic retinoid that is used orally as a chemopreventive against prostate cancer and in women at …
MMDA
MMDA, or 3-methoxy-4,5-methylenedioxyamphetamine, is a member of the amphetamine drug class with stimulant and psychedelic properties. It also acts as an entheogen and an entactogen. MMDA bears resemblance to the psychopharmacologically active essential oils elemicin and myristicin found in nutmeg. The effects of MMDA includes feelings of euphoria and warmth,...
Experimental
Illicit
Matched Iupac: … 1-(7-methoxy-2H-1,3-benzodioxol-5-yl)propan-2-amine …
Matched Description: … It also acts as an entheogen and an entactogen. ... or 3-methoxy-4,5-methylenedioxyamphetamine, is a member of the amphetamine drug class with stimulant and ... The effects of MMDA includes feelings of euphoria and warmth, as well as realistic closed-eye visuals …
Matched Description: … It also acts as an entheogen and an entactogen. ... or 3-methoxy-4,5-methylenedioxyamphetamine, is a member of the amphetamine drug class with stimulant and ... The effects of MMDA includes feelings of euphoria and warmth, as well as realistic closed-eye visuals …
Tomaralimab
Tomaralimab is under investigation in clinical trial NCT01794663 (Placebo-Controlled Study to Evaluate the Safety and Efficacy of OPN-305 in Preventing Delayed Renal Graft Function).
Investigational
Matched Description: … under investigation in clinical trial NCT01794663 (Placebo-Controlled Study to Evaluate the Safety and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
INO-4800
INO-4800 is a DNA vaccine containing the full sequence for the SARS-CoV-2 Spike (S) protein in development for immunization against COVID-19. Early in vitro studies using HEK-293T cells demonstrated that the transfection of INO-4800 results in the expression of S protein by human cells.[A214475, A214478] Follow up studies in both...
Investigational
Matched Description: … on June 4, 2020, and expected to start later in the month. ... 293T cells demonstrated that the transfection of INO-4800 results in the expression of S protein by human ... [A214475]
A Phase 1 clinical trial for INO-4800 in the U.S. …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Ezatiostat
Ezatiostat is investigated in clinical trials for treating myelodysplastic syndrome. This compound belongs to the peptides. These are compounds containing an amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen...
Investigational
Matched Iupac: … ethyl (2S)-2-amino-4-{[(1R)-2-(benzylsulfanyl)-1-{[(1R)-2-ethoxy-2-oxo-1-phenylethyl]carbamoyl}ethyl] …
Matched Description: … Ezatiostat has myelostimulant activity in preclinical rodent models and human bone marrow cultures, and ... Ezatiostat is a small molecule drug that is an analog inhibitor of glutathione S-transferase P1-1. ... differentiates granulocytes and monocytes in HL60 cells. …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … Ezatiostat has myelostimulant activity in preclinical rodent models and human bone marrow cultures, and ... Ezatiostat is a small molecule drug that is an analog inhibitor of glutathione S-transferase P1-1. ... differentiates granulocytes and monocytes in HL60 cells. …
Matched Categories: … Amino Acids, Peptides, and Proteins …
GTS-21
GTS-21 (also known as DMBX-A), is a novel, small-molecule, orally active and selective alpha-7 nicotinic acetylcholine (nACh) receptor agonist that has demonstrated memory and cognition enhancement activity in human clinical trials. Athenagen licensed the exclusive rights to the compound and a related library of analogs as part of the acquisition...
Investigational
Matched Description: … in human clinical trials. ... GTS-21 (also known as DMBX-A), is a novel, small-molecule, orally active and selective alpha-7 nicotinic ... acetylcholine (nACh) receptor agonist that has demonstrated memory and cognition enhancement activity …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Displaying drugs 726 - 746 of 746 in total