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Displaying drugs 851 - 875 of 14877 in total

Maftivimab

Ebola virus (EBOV) remains an important human pathogen within the Ebolavirus genus, having been responsible for at least 17 known outbreaks with an average case fatality rate of 43.92%. Immune therapy using monoclonal antibodies (mAbs) is becoming an increasingly attractive therapeutic method to combat infectious diseases due to its rapid...
Approved
Matched Description: … neutralizing and Fc-mediated immune effector function against EBOV _in vitro_ and protection against ... INMAZEB™ is produced by Regeneron Pharmaceuticals and was granted FDA approval on October 14, 2020. ... attractive therapeutic method to combat infectious diseases due to its rapid development, low toxicity, and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Human immunoglobulin G

Intravenous immunoglobulin (IVIg) is a mixture of IgG1 and other antibodies derived from healthy human plasma via Cohn fractionation. The purification process includes cold alcohol fractionation, polyethylene glycol precipitation, and ion exchange chromatography. IVIg contains the same distribution of IgG antibody subclasses as is found in the general human population....
Approved
Investigational
Matched Description: … Intravenous immunoglobulin (IVIg) is a mixture of IgG1 and other antibodies derived from healthy human ... The purification process includes cold alcohol fractionation, polyethylene glycol precipitation, and ... IVIg is used in the treatment of immunodeficiencies, as well as autoimmune and inflammatory disorders …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Deferasirox

Deferasirox is an iron chelator and the first oral medication FDA approved for chronic iron overload in patients receiving long term blood transfusions.
Approved
Investigational
Matched Description: … Deferasirox is an iron chelator and the first oral medication FDA approved for chronic iron overload …

Daridorexant

Daridorexant, formerly known as nemorexant, is a selective dual orexin receptor antagonist used to treat insomnia. Insomnia is characterized by difficulties with sleep onset and/or sleep maintenance and impairment of daytime functioning. It chronically affects the person's daily functioning and long-term health effects, as insomnia is often associated with comorbidities...
Approved
Matched Description: … Insomnia is characterized by difficulties with sleep onset and/or sleep maintenance and impairment of ... associated with comorbidities such as hypertension, diabetes, and depression. ... are wake-promoting neuropeptides and endogenous ligands to these receptors. …
Matched Categories: … Hypnotics and Sedatives …

Botulinum toxin type B

Neurotoxin produced by fermentation of clostridium botulinum type B. The protein exists in noncovalent association with hemagglutinin and nonhemagglutinin proteins as a neurotoxin complex. The neurotoxin complex is recovered from the fermentation process and purified through a series of precipitation and chromatography steps.
Approved
Investigational
Matched Description: … and chromatography steps. ... The protein exists in noncovalent association with hemagglutinin and nonhemagglutinin proteins as a neurotoxin ... The neurotoxin complex is recovered from the fermentation process and purified through a series of precipitation …
Matched Categories: … Enzymes and Coenzymes ... Amino Acids, Peptides, and Proteins …

Eprosartan

Eprosartan is an angiotensin II receptor antagonist used to treat hypertension. It performs 2 actions on the renin angiotensin system. By preventing the binding of angiotensin II to AT1, vascular smooth muscle relaxes and vasodilation occurs. By inhibiting norepinephrine production, blood pressure is further reduced.
Approved
Matched Description: … By preventing the binding of angiotensin II to AT1, vascular smooth muscle relaxes and vasodilation occurs …
Matched Categories: … eprosartan and diuretics ... Angiotensin II receptor blockers (ARBs) and diuretics …

Tiaprofenic acid

Tiaprofenic acid is a non-steroidal anti-inflammatory drug employed in the treatment of pain, particularly arthritis pain. It belongs to the arylpropionic acid (profen) group of nonsteroidal anti-inflammatory drugs (NSAIDs).
Approved
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …

Benzyl alcohol

Approved
Matched Categories: … Scabicides, Insecticides and Repellents ... Antiparasitic Products, Insecticides and Repellents …

Buspirone

Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class, buspirone is a serotonin 5-HT1A receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic drugs. Unlike many drugs used to treat anxiety, buspirone does...
Approved
Investigational
Matched Description: … , such as generalized anxiety disorder (GAD), and relieve symptoms of anxiety. ... Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. ... receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and …
Matched Categories: … Miscellaneous Anxiolytics Sedatives and Hypnotics …

Lemborexant

Lemborexant is a novel dual orexin receptor antagonist used in the treatment of insomnia characterized by difficulties with sleep onset and/or sleep maintenance. Recent research in the field of sleep disorders has revealed that insomnia is likely driven not by the inability of the brain to "switch on" sleep-related circuits,...
Approved
Investigational
Matched Description: … receptors, lemborexant and other orexin antagonists (e.g. ... receptor antagonist used in the treatment of insomnia characterized by difficulties with sleep onset and ... potential advantages over classic hypnotic agents, including a more favorable adverse effect profile and …
Matched Categories: … Hypnotics and Sedatives ... Sleep Initiation and Maintenance Disorders …

Lumiracoxib

Lumiracoxib is a COX-2 selective non-steroidal anti-inflammatory drug (NSAID). On August 11, 2007, Australia's Therapeutic Goods Administration (TGA, the Australian equivalent of the FDA) cancelled the registration of lumiracoxib in Australia due to concerns that it may cause liver failure. New Zealand and Canada have also followed suit in recalling...
Approved
Investigational
Matched Description: … New Zealand and Canada have also followed suit in recalling the drug. …
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …

Tirbanibulin

Tirbanibulin (KX-O1 or KX2–391) is a dual inhibitor of Src Kinase and tubulin. On December 14, 2020, tirbanibulin was approved by the FDA for the topical treatment of actinic keratosis on the face or scalp. It is marketed under the brand name Klisyri. Actinic keratosis is a chronic condition characterized...
Approved
Investigational
Matched Description: … Tirbanibulin exhibits antitumour effects in vitro and in vivo [A225791] and has been investigated for ... Tirbanibulin (KX-O1 or KX2–391) is a dual inhibitor of Src Kinase and tubulin. ... its antitumor efficacy in the management of various cancers, such as prostate cancer and breast cancer …

Clobazam

Clobazam belongs to the 1,5-benzodiazepine class of drugs and is marketed under different names, Onfi, Frisium, Urbanyl, and others. . Clobazam was first synthesized in 1966 and first published in 1969, following the incidental synthesis and discovery of the first benzodiazepine chlordiazepoxide in the 1950s. Unlike older 1,4-benzodiazepines, clobazam has...
Approved
Illicit
Matched Description: … , Frisium, Urbanyl, and others. ... children aged two years and older. ... and discovery of the first benzodiazepine chlordiazepoxide in the 1950s. …
Matched Categories: … Benzodiazepines and benzodiazepine derivatives …

Sitaxentan

Sitaxentan was marketed under the trade name Thelin for the treatment of pulmonary arterial hypertension (PAH) by Encysive Pharmaceuticals until Pfizer purchased Encysive in February 2008. In 2010, Pfizer voluntarily removed sitaxentan from the market over concerns of hepatotoxicity.
Approved
Investigational
Withdrawn

Erenumab

Erenumab (AMG-334) (INN; trade name Aimovig) is a human monoclonal antibody designed specifically to bind and antagonize the calcitonin gene-related peptide receptor (CGRPR) as a means to prevent migraines. Aimovig, as released and marketed by Novartis and Amgen, is in fact a novel therapeutic approach as the first and only...
Approved
Investigational
Matched Description: … Aimovig, as released and marketed by Novartis and Amgen, is in fact a novel therapeutic approach as the ... Erenumab (AMG-334) (INN; trade name Aimovig) is a human monoclonal antibody designed specifically to bind and ... first and only FDA approved treatment specifically developed to prevent migraine by blocking the CGRP …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Armodafinil

Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA), narcolepsy, or shift work disorder (SWD). Research has shown that armodafinil significantly improves driving simulator performance in patients with SWD. Armodafinil consists...
Approved
Investigational
Matched Description: … Food and Drug Administration (FDA) in June 2007. ... Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated ... (a wholly owned subsidiary of Teva Pharmaceutical Industries Ltd.) and was approved by the U.S. …
Matched Categories: … Modafinil and isomer ... Metabolic Side Effects of Drugs and Substances ... Psychostimulants, Agents Used for ADHD and Nootropics …

Phosphoric acid

Phosphoric Acid is a colorless, odorless phosphorus-containing inorganic acid. Phosphoric acid is a sequestering agent which binds many divalent cations, including Fe++, Cu++, Ca++, and Mg++.
Approved
Matched Description: … Phosphoric acid is a sequestering agent which binds many divalent cations, including Fe++, Cu++, Ca++, and …

Epicriptine

Epicriptine is also known as beta-dihydroergocryptine presents a molecular formula of 9,10 alpha-dihydro-13'-epi-b-ergocryptine. Together with the alpha-dihydroergocryptine, it represents one-third of the ergoloid mesylate mixture. Epicriptine differs from the alpha form on the position of one methyl group. To know more about the mixture please visit DB01049
Approved

Nortriptyline

Nortriptyline hydrochloride, the active metabolite of amitriptyline, is a tricyclic antidepressant (TCA). It is used in the treatment of major depression and is also used off-label for chronic pain and other conditions.
Approved
Matched Description: … and other conditions. ... [L11878] It is used in the treatment of major depression and is also used off-label for chronic pain …
Matched Categories: … Tricyclics and Other Norepinephrine-reuptake Inhibitors …

Chloroquine

Chloroquine is an aminoquinolone derivative first developed in the 1940s for the treatment of malaria. It was the drug of choice to treat malaria until the development of newer antimalarials such as pyrimethamine, artemisinin, and mefloquine. Chloroquine and its derivative hydroxychloroquine have since been repurposed for the treatment of a...
Approved
Investigational
Vet approved
Matched Description: … treat malaria until the development of newer antimalarials such as [pyrimethamine], [artemisinin], and ... of a number of other conditions including HIV, systemic lupus erythematosus, and rheumatoid arthritis ... [A191787] Chloroquine and its derivative [hydroxychloroquine] have since been repurposed for the treatment …
Matched Categories: … chloroquine and proguanil ... Antiparasitic Products, Insecticides and Repellents …

Amlexanox

Amlexanox is an antiallergic drug, clinically effective for atopic diseases, especially allergic asthma and rhinitis. Amlexanox as a topical paste is a well tolerated treatment of recurrent aphthous ulcers. Recurrent aphthous ulcer (RAU) is the most prevalent oral mucosal disease in humans, estimated to affect between 5% and 50% of...
Approved
Investigational
Withdrawn
Matched Description: … Amlexanox is an antiallergic drug, clinically effective for atopic diseases, especially allergic asthma and ... aphthous ulcer (RAU) is the most prevalent oral mucosal disease in humans, estimated to affect between 5% and …
Matched Categories: … Alimentary Tract and Metabolism …

Teicoplanin

Teicoplanin is a glycopeptide antibiotic consisting of a mixture of several compounds, five major (named teicoplanin A2-1 through A2-5) and four minor (named teicoplanin RS-1 through RS-4). All teicoplanins share a same glycopeptide core, teicoplanin A3-1, but differ in the length and conformation of side chains attached to their β-D-glucosamine...
Approved
Investigational
Matched Description: … antibiotic consisting of a mixture of several compounds, five major (named teicoplanin A2-1 through A2-5) and ... All teicoplanins share a same glycopeptide core, teicoplanin A3-1, but differ in the length and conformation …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Idarucizumab

Idarucizumab is a humanized monoclonal antibody fragment (Fab) derived from an immunoglobulin G1 isotype molecule that binds to and inactivates the oral anticoagulant dabigatran, thereby reversing its anticoagulant effect. As a direct acting oral anticoagulant (DOAC), one of the risks associated with the use of dabigatran includes bleeding, espeically when...
Approved
Matched Description: … monoclonal antibody fragment (Fab) derived from an immunoglobulin G1 isotype molecule that binds to and ... Its use is associated with immediate, complete and sustained reversal of the anticoagulant effects of …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Bioallethrin

Bioallethrin refers to a mixture of two of the allethrin isomers (1R,trans;1R and 1R,trans;1S) in an approximate ratio of 1:1, where both isomers are active ingredients. A mixture of the two same stereoisomers, but in an approximate ratio of R:S in 1:3, is called esbiothrin. A mixture containing only S-forms...
Approved
Experimental
Matched Description: … Bioallethrin refers to a mixture of two of the allethrin isomers (1R,trans;1R and 1R,trans;1S) in an ... synthetic pyrethroid used as a pesticide against household pest insects such as mosquitoes, houseflies and …
Matched Categories: … Scabicides, Insecticides and Repellents ... Antiparasitic Products, Insecticides and Repellents …

Chromium nicotinate

Approved
Experimental
Displaying drugs 851 - 875 of 14877 in total