Displaying drugs 10301 - 10325 of 12422 in total
VX-765
VX-765 is the orally available prodrug of a potent and selective competitive inhibitor of ICE/caspase-1 (VRT-043198). VX-765 is currently under clinical development for the treatment of inflammatory and autoimmune conditions, as it blocks the hypersensitive response to an inflammatory stimulus.
Investigational
Matched Description: … VX-765 is the orally available prodrug of a potent and selective competitive inhibitor of ICE/caspase ... VX-765 is currently under clinical development for the treatment of inflammatory and autoimmune conditions …
ALT-2074
An organoselenium drug previously studied by Oxis International in Phase-II clinical trials for ulcerative colitis patients. Some indications of efficacy were demonstrated. BXT-51072 has enthusiastic endorsement for treatment in cardiovascular indications, primarily because of its ability to mimic the function of glutathione peroxidase.
Investigational
Matched Description: … Some indications of efficacy were demonstrated. ... its ability to mimic the function of glutathione peroxidase. ... BXT-51072 has enthusiastic endorsement for treatment in cardiovascular indications, primarily because of …
AVE-1625
AVE-1625 is an oral selective and potent antagonist of cannabinoid 1 (CB1) receptors having the same mechanism of action as rimonabant. It is currently developed in obesity and its associated comorbidities. AVE-1625 is also being developed for the treatment of Alzheimer disease.
Investigational
Matched Description: … mechanism of action as rimonabant. ... AVE-1625 is also being developed for the treatment of Alzheimer disease. ... AVE-1625 is an oral selective and potent antagonist of cannabinoid 1 (CB1) receptors having the same …
Probiorinse
Probiorinse is an intranasal probiotic treatment composed of a pre-mixed and buffered sinus irrigation solution that contains the probiotic bacteria Lactococcus lactis W136. This strain of bacteria is said to have salubrious effects on the microbiome of the nasal cavity and sinuses.
Investigational
Matched Description: … [L16368] This strain of bacteria is said to have salubrious effects on the microbiome of the nasal cavity ... Probiorinse is an intranasal probiotic treatment composed of a pre-mixed and buffered sinus irrigation …
PI-0824
Pemphigus vulgaris (PV) is an autoimmune disease affecting approximately 40,000 people worldwide. People with PV produce antibodies that attack the cells of the skin, resulting in blisters which, if left untreated, can lead to devastating infections and discomfort. Currently, most doctors who treat patients with PV will prescribe high-dose steroids...
Investigational
Matched Description: … The goal of this therapy is to reduce the production of antibodies that cause PV blisters by acting only ... on the disease causing components of the immune system. ... Peptimmune, Inc. has developed a new therapy for the treatment of PV, PI-0824. …
VLTS-589
VLTS-589 consists of plasmid encoding the angiomatrix protein Del-1 in conjunction with poloxamer 188 for the treatment of peripheral vascular disease.
Investigational
Matched Description: … for the treatment of peripheral vascular disease. ... VLTS-589 consists of plasmid encoding the angiomatrix protein Del-1 in conjunction with poloxamer 188 …
Aviscumine
Cy 503 is under investigation in clinical trial NCT00658437 (Aviscumine for the Treatment of Malignant Melanoma Stage IV After Failure of Prior Therapy).
Investigational
Matched Description: … Melanoma Stage IV After Failure of Prior Therapy). ... Cy 503 is under investigation in clinical trial NCT00658437 (Aviscumine for the Treatment of Malignant …
Monalizumab
Monalizumab has been used in trials studying the treatment of Gynecologic Cancer, Chronic Lymphocytic Leukemia, and Squamous Cell Carcinoma of the Oral Cavity.
Investigational
Matched Description: … Leukemia, and Squamous Cell Carcinoma of the Oral Cavity. ... Monalizumab has been used in trials studying the treatment of Gynecologic Cancer, Chronic Lymphocytic …
Adafosbuvir
Adafosbuvir is under investigation in clinical trial NCT02894905 (A Study to Evaluate the Effect of Renal Impairment on the Pharmacokinetics of AL-335).
Investigational
Matched Description: … Impairment on the Pharmacokinetics of AL-335). ... Adafosbuvir is under investigation in clinical trial NCT02894905 (A Study to Evaluate the Effect of Renal …
Bixalomer
Bixalomer is under investigation in clinical trial NCT01115985 (A Study to Assess the Effect of ASP1585 on Pharmacokinetics of Atorvastatin in Healthy Volunteers).
Investigational
Matched Description: … on Pharmacokinetics of Atorvastatin in Healthy Volunteers). ... Bixalomer is under investigation in clinical trial NCT01115985 (A Study to Assess the Effect of ASP1585 …
Ribaxamase
Ribaxamase is under investigation in clinical trial NCT02563106 (A Study of SYN-004 for the Prevention of c.diff in Patients With a LRTI).
Investigational
Matched Description: … of c.diff in Patients With a LRTI). ... Ribaxamase is under investigation in clinical trial NCT02563106 (A Study of SYN-004 for the Prevention …
Lactoferrin
Lactoferrin is under investigation in clinical trial NCT03748043 (The Effectiveness of Lactoferrin in Treatment of Iron Deficiency Anemia in Children With Chronic Tonsillitis).
Investigational
Matched Description: … Treatment of Iron Deficiency Anemia in Children With Chronic Tonsillitis). ... Lactoferrin is under investigation in clinical trial NCT03748043 (The Effectiveness of Lactoferrin in …
Imolamine
Imolamine is a compound with a molecular weight of 260.33 g/mol with the formula diethyl[2-{5-imino-3-phenyl-4,5-dihydro-1,2,3-oxadiazol,-4-yl)ethyl]amine. It is developed under the brand name Coremax by Novartis consumer health SA.
Investigational
Matched Description: … Imolamine is a compound with a molecular weight of 260.33 g/mol with the formula diethyl[2-{5-imino-3 …
Cellobiose
A disaccharide consisting of two glucose units in beta (1-4) glycosidic linkage. Obtained from the partial hydrolysis of cellulose. [PubChem]
Experimental
Matched Description: … Obtained from the partial hydrolysis of cellulose. [PubChem] ... A disaccharide consisting of two glucose units in beta (1-4) glycosidic linkage. …
Molidustat
Molidustat is under investigation in clinical trial NCT03350321 (A Study of Molidustat for Correction of Renal Anemia in Non-dialysis Subjects).
Investigational
Matched Description: … of Renal Anemia in Non-dialysis Subjects). ... Molidustat is under investigation in clinical trial NCT03350321 (A Study of Molidustat for Correction …
GFT14
GFT14 is a new class of medicaction for treatment of cardiometabolic disease. GFT14 aims to target mixed dyslipidemia of type IIb (high levels of triglycerides and LDL-C) as one of the major indications of cardiometabolic disease.
GFT14 is destined to improve the condition of patients at risk from cardiovascular disease...
Investigational
Matched Description: … GFT14 aims to target mixed dyslipidemia of type IIb (high levels of triglycerides and LDL-C) as one of ... GFT14 is a new class of medicaction for treatment of cardiometabolic disease. ... and favorable action on the plasmatic lipids (rise of HDL- cholesterol et lowering of triglycerides) …
IN01
The IN01 Vaccine, sponsored by the Instituto Oncologico Dr Rosell, IN3BIO, and PANGAEA, is a compound containing recombinant bacteria . These cultures contain EGF-4-EGF with the cholera toxin B-subunit domain G33D sequence . Administration of the vaccine stimulates the production of anti-epidermal growth factor (anti-EGF) neutralizing antibodies . Of note,...
Investigational
Matched Description: … The study will explore the effect of this vaccine on pulmonary function, oxygen saturation, quality of ... Administration of the vaccine stimulates the production of anti-epidermal growth factor (anti-EGF) neutralizing ... life, and fibrosing status in addition to biomarkers and molecular markers of the vaccine. …
DTX-101
DTX-101 is an investigational gene therapy consisting of an adeno-associated virus serotype Rh10 vector encoding the human Factor Ix gene. It was previously investigated for the treatment of hemophilia B; however, the clinical development of DTX-101 was discontinued.
Investigational
Matched Description: … It was previously investigated for the treatment of hemophilia B; however, the clinical development of ... DTX-101 is an investigational gene therapy consisting of an adeno-associated virus serotype Rh10 vector …
Felypressin
A synthetic nonapeptide comprising cysteinyl, phenylalanyl, phenylalanyl, glutaminyl, asparaginyl, cysteinyl, prolyl, lysyl, and glycinamide residues in sequence, with a disulfide bridge joining the two cysteine residues. Its antidiuretic effects are less than those of vasopressin. It is a non-catecholamine vasoconstrictor used in local anaesthetic injections for dental use, and is...
Experimental
Matched Description: … preparations that have been used for treatment of pain and inflammation of the mouth. ... Its antidiuretic effects are less than those of vasopressin. ... non-catecholamine vasoconstrictor used in local anaesthetic injections for dental use, and is an ingredient of …
Celivarone
Celivarone is under investigation in clinical trial NCT00233441 (Placebo Controlled Double-blind Dose Ranging Study of the Efficacy and Safety of SSR149744C 50, 100, 200 or 300 Mg OD With Amiodarone as Calibrator for the Maintenance of Sinus Rhythm in Patients With Recent Atrial Fibrillation/flutter).
Investigational
Matched Description: … Maintenance of Sinus Rhythm in Patients With Recent Atrial Fibrillation/flutter). ... under investigation in clinical trial NCT00233441 (Placebo Controlled Double-blind Dose Ranging Study of ... the Efficacy and Safety of SSR149744C 50, 100, 200 or 300 Mg OD With Amiodarone as Calibrator for the …
XL784
XL784 is a potent inhibitor of the ADAM-10 metalloprotease enzyme, a target of significant interest because of its important role in blood vessel formation and cell proliferation. XL784 was specifically optimized to be MMP-1 sparing, thus potentially enhancing its safety profile and enabling higher dosing compared with other previously studied...
Investigational
Matched Description: … XL784 is a potent inhibitor of the ADAM-10 metalloprotease enzyme, a target of significant interest because ... Results of single dose Phase I clinical trials of XL784 administered orally to 96 healthy volunteers ... of its important role in blood vessel formation and cell proliferation. …
ARC183
ARC183 is a DNA aptamer, which is a single-stranded DNA molecule consisting of 15 deoxynucleotides that forms well-defined three-dimensional configuration, allowing it to bind to thrombin with high affinity and specificity. The key
advantage of ARC183 compared to other thrombin inhibitors is its rapid onset of action and short half-life,...
Investigational
Matched Description: … The key
advantage of ARC183 compared to other thrombin inhibitors is its rapid onset of action and short ... ARC183 is a DNA aptamer, which is a single-stranded DNA molecule consisting of 15 deoxynucleotides that ... , giving it the potential to be an ideal agent for medical procedures that require rapid resolution of …
PF-05180999
PF-05180999 is under investigation in clinical trial NCT01530529 (A Study to Assess the Relative Bioavailability of a Modified-Release Formulation of PF-05180999).
Investigational
Matched Description: … a Modified-Release Formulation of PF-05180999). ... is under investigation in clinical trial NCT01530529 (A Study to Assess the Relative Bioavailability of …
D-3082-L
D-3082-L is one of the components of the human papilloma virus (HPV) type 16 E6/E7 synthetic long peptide (SLP) vaccine ISA101b.
Investigational
Matched Description: … D-3082-L is one of the components of the human papilloma virus (HPV) type 16 E6/E7 synthetic long peptide …
LX201
LX201 is a silicone matrix ocular implant that provides sustained release of cyclosporine A (CsA) locally to the eye over the course of one year. LX201 is implanted subconjunctivally (beneath the transparent membrane covering the white of the eye) in a minimally invasive procedure. The implant is being developed clinically...
Investigational
Matched Description: … to the eye over the course of one year. ... LX201 is a silicone matrix ocular implant that provides sustained release of cyclosporine A (CsA) locally ... LX201 is implanted subconjunctivally (beneath the transparent membrane covering the white of the eye) …
Displaying drugs 10301 - 10325 of 12422 in total