Displaying drugs 10501 - 10525 of 12589 in total
SEP-363856
SEP-363856 is a novel psychotropic drug being investigated for the treatment of schizophrenia. Unlike other drugs used for this condition, SEP-363856 does not bind to the dopamine D2 receptors, but exerts actions on the trace amine–associated receptor 1 (TAAR1) and 5-hydroxytryptamine type 1A (5-HT1A). SEP-363856 was developed by Sunovion pharmaceuticals....
Investigational
Matched Description: … Additional clinical trials of SEP-363856 are required to confirm the safety and efficacy of this drug ... SEP-363856 is a novel psychotropic drug being investigated for the treatment of schizophrenia. ... initial clinical study has shown this drug may be effective against both positive and negative symptoms of …
CHGN111
CHGN111 is an inhibitor of the mitochondrial enzyme CLK-1 which is a demethoxyubiquinone hydroxylase. Numerous parameters of mitochondrial function are altered when the activity of CLK-1 is reduced, which results in a decrease of ROS at critical cellular sites, as well as in a decrease of systemic oxidative stress. It...
Investigational
Matched Description: … Numerous parameters of mitochondrial function are altered when the activity of CLK-1 is reduced, which ... results in a decrease of ROS at critical cellular sites, as well as in a decrease of systemic oxidative ... CHGN111 is an inhibitor of the mitochondrial enzyme CLK-1 which is a demethoxyubiquinone hydroxylase. …
Zinc glycinate
Glycoprotein marker of gastrointestinal cancer.
Experimental
Matched Description: … Glycoprotein marker of gastrointestinal cancer. …
R1295
R1295 is an integrin antagonist currently in clinical trials for the treatment of rheumatoid arthritis. Integrins are associated to the pathology seen in some of the autoimmune diseases such as rheumatoid arthritis.
Investigational
Matched Description: … R1295 is an integrin antagonist currently in clinical trials for the treatment of rheumatoid arthritis ... Integrins are associated to the pathology seen in some of the autoimmune diseases such as rheumatoid …
OC-1012
OC-1012 is a compound which has emerged as a promising therapeutic agent for the treatment and prevention of mucositis, a serious side effect of chemotherapy and head and neck radiation therapy.
Investigational
Matched Description: … mucositis, a serious side effect of chemotherapy and head and neck radiation therapy. ... 1012 is a compound which has emerged as a promising therapeutic agent for the treatment and prevention of …
Debamestrocel
Debamestrocel consists of autologous mesenchymal stromal cells secreting neurotrophic factors. Debamestrocel is under clinical development by BrainStorm Cell Therapeutics and is being investigated for the treatment of Amyotrophic Lateral Sclerosis (ALS).
Investigational
Matched Description: … Debamestrocel consists of autologous mesenchymal stromal cells secreting neurotrophic factors. ... under clinical development by BrainStorm Cell Therapeutics and is being investigated for the treatment of …
Methaqualone
Methaqualone is a sedative-hypnotic drug that is similar in effect to barbiturates, a general central nervous system depressant. The sedative-hypnotic activity was first noted by Indian researchers in the 1950s and in 1962 methaqualone itself was patented in the US by Wallace and Tiernan. Its use peaked in the early...
Illicit
Withdrawn
PZM21
PZM21 is a novel μ-opioid receptor (MOPr) ligand that has been reported to induce minimal arrestin recruitment and be devoid of the respiratory depressant effects characteristic of classical μ-opioid ligands such as morphine.
Experimental
Matched Description: … receptor (MOPr) ligand that has been reported to induce minimal arrestin recruitment and be devoid of ... the respiratory depressant effects characteristic of classical μ-opioid ligands such as morphine. …
PTC299
PTC299 is a novel, orally administered small-molecule designed to inhibit the production of vascular endothelial growth factor (VEGF) in tumors. Overexpression of VEGF plays a key role in multiple diseases including cancer and macular degeneration. PTC299 was discovered through PTC's GEMS technology by targeting the post-transcriptional processes that regulate VEGF...
Investigational
Matched Description: … PTC299 is a novel, orally administered small-molecule designed to inhibit the production of vascular ... Overexpression of VEGF plays a key role in multiple diseases including cancer and macular degeneration ... post-transcriptional processes that regulate VEGF formation, and is currently being developed for the treatment of …
QS-21
QS-21 is an investigational adjuvant, which is a substance added to vaccines and other immunotherapies that is designed to enhance the body’s immune response to the antigen contained within the treatment. It is the leading member of the Stimulon family of adjuvants. As a vaccine additive, it is currently being...
Investigational
Matched Description: … It is the leading member of the Stimulon family of adjuvants. ... As a vaccine additive, it is currently being evaluated in clinical trials in a variety of disease areas …
R-851
R-851 is part of the family of immune response modifier (IRM) and it acts in a novel way to stimulate the human body's immnune system to attack virus-infected cells and tumor cells. It is expected to be topical treatment for cervical displasia and cervical high-risk human papillomavirus (HPV), the sexually...
Investigational
Matched Description: … R-851 is part of the family of immune response modifier (IRM) and it acts in a novel way to stimulate ... cervical high-risk human papillomavirus (HPV), the sexually transmitted virus that causes most cases of …
Evofosfamide
TH-302 is a novel cancer therapeutic specifically activated under the low oxygen or "hypoxic" conditions typical of solid tumor cancer cells. TH-302 is a nitroimidazole-linked prodrug of a brominated derivative of an isophosphoramide mustard previously used in cancer drugs such as ifosfamide, cyclophosphamide, and glufosfamide. TH-302 has been shown, in...
Investigational
Matched Description: … TH-302 is a nitroimidazole-linked prodrug of a brominated derivative of an isophosphoramide mustard previously ... novel cancer therapeutic specifically activated under the low oxygen or "hypoxic" conditions typical of …
Resveratrol
Resveratrol (3,5,4'-trihydroxystilbene) is a polyphenolic phytoalexin. It is a stilbenoid, a derivate of stilbene, and is produced in plants with the help of the enzyme stilbene synthase. It exists as cis-(Z) and trans-(E) isomers. The trans- form can undergo isomerisation to the cis- form when heated or exposed to ultraviolet...
Investigational
Matched Description: … In a 2004 issue of Science, Dr. ... It is a stilbenoid, a derivate of stilbene, and is produced in plants with the help of the enzyme stilbene ... Sinclair of Harvard University said resveratrol is not an easy molecule to protect from oxidation. …
SLV319
SLV319 belongs to a novel class of agents called CB1 antagonists, which work by blocking the cannabinoid type 1 (CB1) receptor. It is developed for the treatment of obesity and other metabolic disorders.
Investigational
Matched Description: … It is developed for the treatment of obesity and other metabolic disorders. ... SLV319 belongs to a novel class of agents called CB1 antagonists, which work by blocking the cannabinoid …
Octopamine
Octopamine is structurally similar to norepinephrine. It has been used as a nootropic, and therefore it and all of its enantiomer are prohibited by the World Anti-doping Agency (WADA) as of 2014.
Experimental
Matched Description: … Anti-doping Agency (WADA) as of 2014. ... It has been used as a nootropic, and therefore it and all of its enantiomer are prohibited by the World …
Zinpentraxin alfa
Zinpentraxin alfa is a recombinant form of PTX-2, a naturally circulating human protein. It is under investigation in clinical trial NCT01981850 (A Phase 2 Study Of PRM-151 In Subjects With Myelofibrosis).
Investigational
Matched Description: … Zinpentraxin alfa is a recombinant form of PTX-2, a naturally circulating human protein. ... It is under investigation in clinical trial NCT01981850 (A Phase 2 Study Of PRM-151 In Subjects With …
Rocapuldencel-T
Rocapuldencel-T is an autologous dendritic cell immunotherapy that was investigated in NCT02662634 (A Safety and Feasibility Study of AGS-003-LNG for the Treatment of Stage 3 Non Small Cell Lung Cancer).
Investigational
Matched Description: … AGS-003-LNG for the Treatment of Stage 3 Non Small Cell Lung Cancer). ... autologous dendritic cell immunotherapy that was investigated in NCT02662634 (A Safety and Feasibility Study of …
GBR-12783
A selective inhibitor of dopamine uptake.
Investigational
Matched Description: … A selective inhibitor of dopamine uptake.[A252997] …
AG-702
AG-702 is a recombinant human heat shock protein also known as stress protein. It is also known as HSPs, which are a group of proteins that are induced when a cell undergoes various types of environmental stresses like heat, cold and oxygen deprivation. HSPs are present in all cells in...
Investigational
Matched Description: … I of clinical trial. ... types of environmental stresses like heat, cold and oxygen deprivation. ... It is also known as HSPs, which are a group of proteins that are induced when a cell undergoes various …
Carphenazine
Carphenazine is an antipsychotic drug, used in hospitalized patients in the management of chronic schizophrenic psychoses.
Withdrawn
Matched Description: … Carphenazine is an antipsychotic drug, used in hospitalized patients in the management of chronic schizophrenic …
Bifeprunox
Bifeprunox is a novel atypical antipsychotic agent which, along with SLV313, aripiprazole and SSR-181507 combines minimal D2 receptor agonism with 5-HT receptor agonism.
Investigational
Lucanthone
One of the schistosomicides, it has been replaced largely by hycanthone and more recently praziquantel. (From Martindale The Extrapharmacopoeia, 30th ed., p46). It is currently being tested as a radiation sensitizer.
Investigational
Matched Description: … One of the schistosomicides, it has been replaced largely by hycanthone and more recently praziquantel …
Ad5-nCoV
Ad5-nCoV is a recombinant adenovirus type-5 vector (Ad5) vaccine currently being investigated for prophylaxis against SARS-CoV-2.[L12675,L12678] It is being developed by CanSino Biologics Inc., in partnership with the Beijing Institute of Biotechnology, who in March 2020 announced the approval of a phase I clinical trial (ChiCTR2000030906) with an expected completion...
Investigational
Matched Description: … of a phase I clinical trial (ChiCTR2000030906)[L12675] with an expected completion in December 2020. ... ., in partnership with the Beijing Institute of Biotechnology, who in March 2020 announced the approval ... The study will evaluate antibody response in healthy patients between the ages of 18 and 60 who will …
PH-284
PH-284 belongs to a new family of new chemical entities called vomeropherins. Vomeropherins are self-administered by the patient with a metered nasal spray, or nasal aerosol device so that they can bind to peripheral chemosensory receptors in the nasal passages. This binding produces neural impulses that are transmitted by specific...
Investigational
Matched Description: … PH-284 is under investigation by Pherin and Organon for the treatment of anorexia nervosa, and loss of ... PH-284 belongs to a new family of new chemical entities called vomeropherins. …
Odronextamab
Odronextamab is a hinge-stabilized, fully human immunoglobulin G4 (IgG4)-based CD20×CD3 bispecific antibody currently evaluated for the treatment of relapsed/refractory (R/R) B-Cell non-Hodgkin lymphoma (NHL).[A254187,A254197] Preliminary studies have shown that in patients with R/R NHL, the use of odronextamab does not lead to the development of neurologic toxicity; however, it can...
Investigational
Matched Description: … does not lead to the development of neurologic toxicity; however, it can lead to the development of ... cytokine release syndrome (CRS), a serious condition associated with the use of immunotherapy. ... human immunoglobulin G4 (IgG4)-based CD20×CD3 bispecific antibody currently evaluated for the treatment of …
Displaying drugs 10501 - 10525 of 12589 in total