Displaying drugs 10676 - 10700 of 12589 in total
alpha-Hydroxy glycineamide
Alpha-hydroxy glycineamide (αHGA) is the active antiviral metabolite of tri-peptide glycyl-prolyl-glycine-amide (GPG-NH2). αHGA inhibits the replication of HIV-1 in vitro by interfering with the capsid formation. It also has an effect on viral gp160 envelope protein.
Investigational
Matched Description: … (GPG-NH2). αHGA inhibits the replication of HIV-1 in vitro by interfering with the capsid formation. ... Alpha-hydroxy glycineamide (αHGA) is the active antiviral metabolite of tri-peptide glycyl-prolyl-glycine-amide …
Ferric oxide
Iron(III) oxide or ferric oxide is the inorganic compound with the formula Fe2O3. It is one of the three main oxides of iron, the other two being iron(II) oxide (FeO) the rarer form, and iron(II,III) oxide (Fe3O4) which naturally as magnetite.
Experimental
Matched Description: … It is one of the three main oxides of iron, the other two being iron(II) oxide (FeO) the rarer form, …
CK0802
CK0802 is an off-the-shelf product composed of allogeneic umbilical cord blood derived regulatory T-cells (T-Reg cells), which can be used intravenously and without HLA matching. On the surface of these T-Reg cells, T-cell lung homing markers are expressed.
Investigational
Matched Description: … [L16358] On the surface of these T-Reg cells, T-cell lung homing markers are expressed. ... CK0802 is an off-the-shelf product composed of allogeneic umbilical cord blood derived regulatory T-cells …
Saposin C
Saposin C is a lysosomal protein. Recombinant, non-glycosylated Saposin C is an active ingredient of BXQ-350, which is a novel, investigational anti-neoplastic therapy. BXQ-350 consists of Saposin C and the phospholipid dioleoylphosphatidyl-serine (DOPS), a phospholipid located on cell membranes.
Investigational
Matched Description: … BXQ-350 consists of Saposin C and the phospholipid dioleoylphosphatidyl-serine (DOPS), a phospholipid ... Recombinant, non-glycosylated Saposin C is an active ingredient of BXQ-350, which is a novel, investigational …
Gemogenovatucel-T
Gemogenovatucel-T is a bi-shRNA furin/Granulocyte Macrophage Colony Stimulating Factor (GMCSF) Augmented autologous tumour cell vaccine. Furin is a convertase involved in the activation of TGFβ-1 and TGFβ-2. Gemogenovatucel-T is being investigated in the treatment of various cancers.
Investigational
Matched Description: … Furin is a convertase involved in the activation of TGFβ-1 and TGFβ-2. ... [A255163] Gemogenovatucel-T is being investigated in the treatment of various cancers. …
ETC-588
ETC-588, or LUV (large unilamellar vesicles), is made of naturally occurring lipids that circulate through arteries to facilitate the role of high-density lipoprotein (HDL) in removing accumulated cholesterol and other lipids from cells including those in the arterial wall. LUV are capable of transporting excess cholesterol from the vasculature to...
Investigational
Matched Description: … of atherosclerosis. ... as part of the reverse lipid transport (RLT) pathway. ... ETC-588, or LUV (large unilamellar vesicles), is made of naturally occurring lipids that circulate through …
Deoxyribonuclease I
Deoxyribonuclease I (DNase I) is a human enzyme responsible for the digestion of extracellular DNA7 . It is normally found in saliva, urine, pancreatic secretions, and blood . Because of the hypothesis that increased concentrations of high-molecular-weight DNA is a factor for airway obstruction, abnormal viscoelastic properties of the sputum,...
Investigational
Matched Description: … Because of the hypothesis that increased concentrations of high-molecular-weight DNA is a factor for ... airway obstruction, abnormal viscoelastic properties of the sputum, and recurrent exacerbations of respiratory ... Deoxyribonuclease I (DNase I) is a human enzyme responsible for the digestion of extracellular DNA7[A227723 …
Custirsen
Custirsen is a benzopyran with potential antineoplastic activity. Custirsen acts as a selective estrogen receptor modulator (SERM), inhibiting the proliferation of estrogen-sensitive breast cancer cells. This agent also inhibits growth and induces apoptosis of glioblastoma cells via a mechanism independent of estrogen receptor-related mechanisms. Custirsen is also being investigated in...
Investigational
Matched Description: … of estrogen receptor-related mechanisms. ... Custirsen is also being investigated in the treatment of primary brain tumors. ... This agent also inhibits growth and induces apoptosis of glioblastoma cells via a mechanism independent …
R450
R450 is an alpha 1 antagonist that acts to tighten the muscle tone in the bladder. It is being considered for treatment of stress-related urinary incontinence. Phase IIa data for the drug show it reduced the number of incontinent episodes compared to placebo with minimal cardiovascular effects.
Investigational
Matched Description: … It is being considered for treatment of stress-related urinary incontinence. ... Phase IIa data for the drug show it reduced the number of incontinent episodes compared to placebo with …
GPI-0100
GPI-0100 is Avantogen’s lead adjuvanat-immunopotentiator, a key component of vaccines for boosting the immune response.
The GPI-0100 adjuvant, which has been shown to significantly enhance the immune response with a variety of vaccines, has been shown to have good overall performance characteristics on safety and efficacy.
Investigational
Matched Description: … GPI-0100 is Avantogen’s lead adjuvanat-immunopotentiator, a key component of vaccines for boosting the ... GPI-0100 adjuvant, which has been shown to significantly enhance the immune response with a variety of …
Mitometh
Mitometh is under investigation for the treatment of Adenocarcinoma, Oropharyngeal Neoplasms, Nasopharyngeal Carcinoma, Non-small Cell Lung Cancer, and Stage IV Non-small Cell Lung Cancer, among others. Mitometh has been investigated for the treatment of Lung Neoplasms, Untreated Childhood Medulloblastoma, and Untreated Childhood Supratentorial Primitive Neuroectodermal Tumor.
Investigational
Matched Description: … Mitometh is under investigation for the treatment of Adenocarcinoma, Oropharyngeal Neoplasms, Nasopharyngeal ... Mitometh has been investigated for the treatment of Lung Neoplasms, Untreated Childhood Medulloblastoma …
Devafidugene civaparvovec
Devafidugene civaparvovec is an investigational in vivo genome editing product. It uses proprietary zinc finger nucleases (ZFN) that insert a functional copy of the alpha-L-iduronidase (IDUA) enzyme. Developed by Sangamo Therapeutics, Inc., devafidugene civaparvovec is being investigated for the treatment of mucopolysaccharidosis Type I (MPS I).
Experimental
Matched Description: … It uses proprietary zinc finger nucleases (ZFN) that insert a functional copy of the alpha-L-iduronidase ... Developed by Sangamo Therapeutics, Inc., devafidugene civaparvovec is being investigated for the treatment of …
Vonapanitase
Vonapanitase is under investigation for the treatment of Chronic Kidney Disease.
Investigational
Matched Description: … Vonapanitase is under investigation for the treatment of Chronic Kidney Disease. …
PF-04447943
PF-04447943 has been investigated for the treatment of Alzheimer's Disease.
Investigational
Matched Description: … PF-04447943 has been investigated for the treatment of Alzheimer's Disease. …
VP-14637
MDT-637 has been investigated for the treatment of Drug Safety.
Investigational
Matched Description: … MDT-637 has been investigated for the treatment of Drug Safety. …
Tozadenant
Tozadenant has been investigated for the basic science of Cocaine Dependence.
Investigational
Matched Description: … Tozadenant has been investigated for the basic science of Cocaine Dependence. …
BIIB021
BIIB021 has been investigated for the treatment of Tumors and Lymphoma.
Investigational
Matched Description: … BIIB021 has been investigated for the treatment of Tumors and Lymphoma. …
Forigerimod
Forigerimod is under investigation for the treatment of Lupus Erythematosus, Systemic.
Investigational
Matched Description: … Forigerimod is under investigation for the treatment of Lupus Erythematosus, Systemic. …
Combretastatin
Combretastatin has been investigated for the treatment of Anaplastic Thyroid Cancer.
Investigational
Matched Description: … Combretastatin has been investigated for the treatment of Anaplastic Thyroid Cancer. …
Sisomicin
Sisomicin has been used in trials studying the treatment of Pyoderma.
Investigational
Matched Description: … Sisomicin has been used in trials studying the treatment of Pyoderma. …
Methyl isocyanate
Methyl isocyanate has been investigated for the treatment of Nosocomial Pneumonia.
Investigational
Matched Description: … Methyl isocyanate has been investigated for the treatment of Nosocomial Pneumonia. …
ZSTK-474
ZSTK474 has been used in trials studying the treatment of Neoplasms.
Investigational
Matched Description: … ZSTK474 has been used in trials studying the treatment of Neoplasms. …
Gallopamil
Gallopamil has been used in trials studying the treatment of Asthma.
Investigational
Matched Description: … Gallopamil has been used in trials studying the treatment of Asthma. …
Triethylhexanoin
Triethylhexanoin is an ingredient of cosmetic products as a fragrant solvent.
Experimental
Matched Description: … Triethylhexanoin is an ingredient of cosmetic products as a fragrant solvent. …
CA-170
CA-170 is a selective, small molecule inhibitor of PD-L1.
Investigational
Matched Description: … CA-170 is a selective, small molecule inhibitor of PD-L1. …
Displaying drugs 10676 - 10700 of 12589 in total