Displaying drugs 10701 - 10725 of 12591 in total
XTL-6865
XTL-6865 is a combination of two fully human monoclonal antibodies (Ab68 and Ab65) against the hepatitis C virus E2 envelope protein. It is being developed to prevent HCV re-infection following a liver transplant and for the treatment of chronic HCV disease.
Investigational
Matched Description: … XTL-6865 is a combination of two fully human monoclonal antibodies (Ab68 and Ab65) against the hepatitis ... It is being developed to prevent HCV re-infection following a liver transplant and for the treatment of …
Dexpramipexole
Dexpramipexole is under investigation in clinical trial NCT01511029 (Study to Evaluate the QTC Interval in Healthy Volunteers Dosed With Dexpramipexole (QTC = Electrocardiogram (ECG) Interval Measured From the Onset of the QRS Complex to the End of the T Wave Corrected for Heart Rate)).
Investigational
Matched Description: … the QRS Complex to the End of the T Wave Corrected for Heart Rate)). ... Volunteers Dosed With Dexpramipexole (QTC = Electrocardiogram (ECG) Interval Measured From the Onset of …
Vercirnon
Vercirnon is a novel, orally active anti-inflammatory agent that targets a chemokine receptor protein implicated in both Crohn's disease and ulcerative colitis, the two principal forms of IBD. It is under investigation in clinical trial NCT01611805 (Japanese Phase I of GSK1605786).
Investigational
Matched Description: … It is under investigation in clinical trial NCT01611805 (Japanese Phase I of GSK1605786). ... receptor protein implicated in both Crohn's disease and ulcerative colitis, the two principal forms of …
Rexin G
Rexin-G is a tumor-targeted, injectable retroviral vector carrying a mutant form of the cyclin G1 gene. It is under development by Epeius Biotechnologies for the potential treatment of metastatic cancer. It is also being investigated for preventing SARSCOV-2 viral entry.
Investigational
Matched Description: … Rexin-G is a tumor-targeted, injectable retroviral vector carrying a mutant form of the cyclin G1 gene ... It is under development by Epeius Biotechnologies for the potential treatment of metastatic cancer. …
RGX-501
RGX-501 is an adeno-associated virus vector 8 (AAV8)-mediated gene therapy that delivers a functional copy of the human low-density lipoprotein receptor (LDLR) gene to liver cells. It is being investigated for the treatment of homozygous familial hypercholesterolemia.
Investigational
Matched Description: … is an adeno-associated virus vector 8 (AAV8)-mediated gene therapy that delivers a functional copy of ... It is being investigated for the treatment of homozygous familial hypercholesterolemia.[L46696] …
VTX-801
VTX-801 is a replication-deficient recombinant adeno-associated viral vector (rAAV) consisting of an AAV liver tropic capsid containing a single-stranded DNA genome carrying a shortened version of the ATP7B gene (ATP7B-minigene). It is being investigated in Wilson Disease.
Investigational
Matched Description: … VTX-801 is a replication-deficient recombinant adeno-associated viral vector (rAAV) consisting of an ... AAV liver tropic capsid containing a single-stranded DNA genome carrying a shortened version of the ATP7B …
Viralym-C
Viralym-C is an investigational T-cell immunotherapy developed by ViraCyte. It consists of Human Leukocyte Antigen (HLA)-matched cytomegalovirus (CMV)-specific T lymphocytes. It was granted FDA orphan designation in January 2017 and investigated for the treatment of CMV infection.[A260291, L47241]
Investigational
Matched Description: … It consists of Human Leukocyte Antigen (HLA)-matched cytomegalovirus (CMV)-specific T lymphocytes. ... It was granted FDA orphan designation in January 2017 and investigated for the treatment of CMV infection …
Natural Killer Cell
Natural Killer (NK) cells originate and differentiate from hematopoietic stem cells through various signalling pathways involving cytokines and interleukins. These cells arise from CD34+ lymphoid progenitors and comprise 10-15% of all lymphocytes in human peripheral blood. Once completely differentiated, NK cells lack B (CD19-) and T(CD3-) lymphocyte markers and carry...
Investigational
Matched Description: … Expansion involves the use of feeder cell line systems or bioreactors to enhance the number of NK cells ... The most standard and utilized source of NK cells is directly from the peripheral blood of a donor through ... of toxic chemicals and cytokine secretion, respectively. …
Aloe vera leaf
Aloe describes a genus including over 500 species of flowering succulent plants that grow in the Southern peninsula and various islands. Aloe vera, or Aloe barbadensis miller, is the most common species of Aloe that is cultivated for agricultural and medical purposes. It is a perennial succulent xerophyte with elongated...
Experimental
Matched Description: … Aloe describes a genus including over 500 species of flowering succulent plants that grow in the Southern ... While aloe vera has a long history of commercial uses, it is still widely used in cosmetic, food and ... The active constituents of aloe vera include polysaccharides with protective effects on skin, as they …
Umbilical Cord Blood Hematopoietic Stem Cells
The use of umbilical cord blood (UCB) for therapies is advantageous because of its ease of access, non-invasive collection procedures, and more plasticity for multi-differentiation. UCB contains a large source of hematopoietic stem cells (HSCs) that are capable of self-renewal, have increased sensitivity to various factors, and are able to...
Investigational
Matched Description: … The use of umbilical cord blood (UCB) for therapies is advantageous because of its ease of access, non-invasive ... UCB contains a large source of hematopoietic stem cells (HSCs) that are capable of self-renewal, have ... This highlights the adaptive nature of these cells. …
FP0011
FP0011 is a small molecule antiglutamatergic compound with symptomatic and disease modifying effects in a variety of neurological disorders (amyotrophic lateral sclerosis and Parkinson's disease). It acts on the presynaptic regulation of glutamate and shows strong neuroprotective properties.
Investigational
Matched Description: … It acts on the presynaptic regulation of glutamate and shows strong neuroprotective properties. ... small molecule antiglutamatergic compound with symptomatic and disease modifying effects in a variety of …
SBT-100
SBT-100 is an anti-signal transducer and activator of transcription 3 (STAT3) B VHH13 single-domain antibody (sdAb). It was granted orphan drug designation by the FDA for the treatment of pancreatic cancer and osteosarcoma.[L44131,L44136]
Investigational
Matched Description: … SBT-100 is an anti-signal transducer and activator of transcription 3 (STAT3) B VHH13 single-domain antibody ... It was granted orphan drug designation by the FDA for the treatment of pancreatic cancer and osteosarcoma …
SNS01-T
SNS01-T is a gene therapy nanoparticle. It is composed of three components: a B cell-specific plasmid expressing eIF5AK50R; an siRNA that targets the native eIF5A that promotes growth/anti-apoptosis of cancer cells; and polyethylenimine.
Investigational
Matched Description: … the native eIF5A that promotes growth/anti-apoptosis of cancer cells; and polyethylenimine. ... It is composed of three components: a B cell-specific plasmid expressing eIF5AK50R; an siRNA that targets …
BMN-351
BMN-351 is a fully modified 18-mer oligonucleotide with a TEG modification at its 5' end that binds to exon 51 of dystrophin pre-mRNA. It is under investigation for the treatment of Duchenne Muscular Dystrophy (DMD).
Investigational
Matched Description: … It is under investigation for the treatment of Duchenne Muscular Dystrophy (DMD). ... a fully modified 18-mer oligonucleotide with a TEG modification at its 5' end that binds to exon 51 of …
Donanemab
Donanemab (LY3002813) is a humanized IgG1 monoclonal antibody targeted against an epitope at the N-terminal of a specific type of amyloid beta (Aβ) - pyroglutamate Aβ - which is found only in the brain amyloid plaques associated with Alzheimer's Disease (AD). It works by inducing microglial-mediated clearance of existing Aβ...
Investigational
Matched Description: … [A232214] It works by inducing microglial-mediated clearance of existing Aβ plaques with the intent of ... the first trial with an expanded patient population in order to address some of the deficiencies of ... (LY3002813) is a humanized IgG1 monoclonal antibody targeted against an epitope at the N-terminal of …
NM-702
Nissan Chemical and Taisho have been jointly developing NM-702, a drug for the treatment of arteriosclerosis obliterans.
M-702 is an orally active inhibitor of phosphodiesterase and thromboxane synthetase. In Japan, Phase 2 studies are being conducted for intermittent claudication caused by arteriosclerosis obliterans, intermittent claudication caused by spinal canal stenosis,...
Investigational
Matched Description: … sclerosis of peripheral arteries. ... Intermittent claudication is a major symptom of arteriosclerosis obliterans. ... M-702 is an orally active inhibitor of phosphodiesterase and thromboxane synthetase. …
Ginsenoside Rb1
Ginsenosides are a class of steroid glycosides, and triterpene saponins, found exclusively in the plant genus Panax (ginseng). Ginsenosides have been the target of research, as they are viewed as the active compounds behind the claims of ginseng's efficacy. Because ginsenosides appear to affect multiple pathways, their effects are complex...
Nutraceutical
Matched Description: … claims of ginseng's efficacy. ... Ginsenosides are a class of steroid glycosides, and triterpene saponins, found exclusively in the plant ... Ginsenosides have been the target of research, as they are viewed as the active compounds behind the …
Otilimab
Investigated for the treatment of osteoarthritis and rheumatoid arthritis (RA).
Investigational
Matched Description: … Investigated for the treatment of osteoarthritis and rheumatoid arthritis (RA). …
Visilizumab
Visilizumab has been investigated for the treatment of Ulcerative Colitis.
Investigational
Matched Description: … Visilizumab has been investigated for the treatment of Ulcerative Colitis. …
Mavrilimumab
Mavrilimumab has been investigated for the treatment of Rheumatoid Arthritis.
Investigational
Matched Description: … Mavrilimumab has been investigated for the treatment of Rheumatoid Arthritis. …
Doxifluridine
Doxifluridine has been investigated for the treatment of Stomach Cancer.
Investigational
Matched Description: … Doxifluridine has been investigated for the treatment of Stomach Cancer. …
Serlopitant
Serlopitant has been investigated for the treatment of Prurigo Nodularis.
Investigational
Matched Description: … Serlopitant has been investigated for the treatment of Prurigo Nodularis. …
Diclofop-methyl
Herbicide for control of wild oat & foxtails in cereal crops.
Experimental
Matched Description: … Herbicide for control of wild oat & foxtails in cereal crops. …
GFH-925
GFH-925 is an irreversibly covalent inhibitor of KRAS G12C.
Investigational
Matched Description: … GFH-925 is an irreversibly covalent inhibitor of KRAS G12C. …
Human Embryonic Stem Cell-derived M Cell
CAStem is composed of immunity- and matrix-regulatory cells (IMRCs), also known as M cells, which can be administered through injection. These IMRCs are differentiated from human embryonic stem cells that are expanded and then harvested. These cells are currently being investigated against lung injury and fibrosis -- conditions which are...
Investigational
Matched Description: … CAStem is composed of immunity- and matrix-regulatory cells (IMRCs), also known as M cells, which can ... are currently being investigated against lung injury and fibrosis -- conditions which are outcomes of ... IMRCs are similar to MSCs in terms of their capacity for self-renewal and tri-lineage differentiation …
Displaying drugs 10701 - 10725 of 12591 in total