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Displaying drugs 10726 - 10750 of 12998 in total

Buparlisib

Buparlisib has been used in trials studying the treatment and basic science of Lymphoma, Metastases, Lung Cancer, Solid Tumors, and Breast Cancer, among others.
Investigational
Matched Iupac: … 5-[2,6-bis(morpholin-4-yl)pyrimidin-4-yl]-4-(trifluoromethyl)pyridin-2-amine …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Pevonedistat

Pevonedistat has been used in trials studying the treatment of Lymphoma, Solid Tumors, Multiple Myeloma, Hodgkin Lymphoma, and Metastatic Melanoma, among others.
Investigational
Matched Iupac: … [(1S,2S,4R)-4-(4-{[(1S)-2,3-dihydro-1H-inden-1-yl]amino}-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Ralimetinib

Ralimetinib has been used in trials studying the treatment of Postmenopausal, Advanced Cancer, Adult Glioblastoma, Fallopian Tube Cancer, and Metastatic Breast Cancer, among others.
Investigational
Matched Iupac: … 5-[2-tert-butyl-5-(4-fluorophenyl)-1H-imidazol-4-yl]-3-(2,2-dimethylpropyl)-3H-imidazo[4,5-b]pyridin- …
Matched Salts cas: … 862507-23-1 …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Tegobuvir

Tegobuvir has been investigated for the treatment of Hepatitis C, Chronic.
Investigational
Matched Categories: … Heterocyclic Compounds, 1-Ring …

AZD-3839

AZD3839 has been used in trials studying the basic science of Safety, Tolerability, Alzheimer's Disease, and Blood Concentration.
Investigational
Matched Iupac: … (1S)-1-[2-(difluoromethyl)pyridin-4-yl]-4-fluoro-1-[3-(pyrimidin-5-yl)phenyl]-1H-isoindol-3-amine …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Nelivaptan

Nelivaptan has been used in trials studying the treatment of Anxiety Disorders, Depressive Disorder, and Major Depressive Disorder.
Investigational
Matched Iupac: … -3-yl]-4-hydroxy-N,N-dimethylpyrrolidine-2-carboxamide ... (2S,4R)-1-[(3R)-5-chloro-1-(2,4-dimethoxybenzenesulfonyl)-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Nerispirdine

Nerispirdine has been used in trials studying the treatment of Neuritis, Optic Nerve, and Multiple Sclerosis.
Investigational
Matched Iupac: … N-(3-fluoropyridin-4-yl)-3-methyl-N-propyl-1H-indol-1-amine …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Turofexorate isopropyl

Fxr 450 is under investigation in clinical trial NCT00509756 (Study Evaluating Turofexorate isopropyl in Healthy Japanese Men).
Investigational
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Milademetan

Milademetan is under investigation in clinical trial NCT02319369 (Safety, Tolerability and Pharmacokinetics of Milademetan Alone and With 5-Azacitidine (AZA) in Acute Myelogenous Leukemia (AML) or High-Risk Myelodysplastic Syndrome (MDS)).
Investigational
Matched Iupac: … (3'R,4'S,5'R)-N-[(3R,6S)-6-carbamoyloxan-3-yl]-6''-chloro-4'-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl ... -2''-oxo-1'',2''-dihydrodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indole]-5'-carboxamide …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Ravoxertinib

Ravoxertinib is under investigation in clinical trial NCT01875705 (A Dose-Escalation Study of GDC-0994 in Patients With Locally Advanced or Metastatic Solid Tumors).
Investigational
Matched Iupac: … 1-[(1S)-1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl]-4-{2-[(1-methyl-1H-pyrazol-5-yl)amino]pyrimidin-4 …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Tesetaxel

Tesetaxel has been used in trials studying the treatment of Cancer, Melanoma, Prostate Cancer, Gastric Carcinoma, and Advanced Melanoma, among others.
Investigational
Matched Iupac: … -3,5,11-trioxapentacyclo[14.3.1.0^{2,6}.0^{7,14}.0^{10,13}]icos-1(19)-en-15-yl benzoate ... (2R,4S,6S,7R,10R,13S,14R,15S,16S,18S)-13-(acetyloxy)-18-{[(2R,3S)-3-{[(tert-butoxy)carbonyl]amino}-3- ... (3-fluoropyridin-2-yl)-2-hydroxypropanoyl]oxy}-4-[(dimethylamino)methyl]-16-hydroxy-7,19,20,20-tetramethyl …

Ranirestat

Ranirestat is a structurally novel and stereospecifically potent aldose reductase (AKR1B; EC 1.1.1.21) inhibitor, which contains a succinimide ring that undergoes ring-opening at physiological pH levels. It has been used in trials studying the treatment of Mild to Moderate Diabetic Sensorimotor Polyneuropathy.
Investigational
Matched Iupac: … (3R)-2'-[(4-bromo-2-fluorophenyl)methyl]-2',3'-dihydro-1'H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine ... ]-1',2,3',5-tetrone …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Fevipiprant

Fevipiprant has been used in trials studying the treatment of Asthma, Atopic Dermatitis, and Allergic Rhinitis.
Investigational
Matched Iupac: … 2-(1-{[4-methanesulfonyl-2-(trifluoromethyl)phenyl]methyl}-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

CH-5132799

CH5132799 has been used in trials studying the treatment of Solid Tumors.
Investigational
Matched Iupac: … 5-[7-methanesulfonyl-2-(morpholin-4-yl)-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

ABP-700

ABP-700 is under investigation in clinical trial NCT02800590 (Study to Investigate the Safety and Efficacy of 3 Dosing Regimens of ABP-700 for Procedural Sedation in Adult Participants Undergoing Colonoscopy).
Investigational
Matched Iupac: … 1-(methoxycarbonyl)cyclopropyl 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylate …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Cambinol

Cambinol is a beta-naphtol derivative that inhibits NAD-dependant deacetylases to reduce cell survival under stress. This activity is currently being investigated for its use as a cancer treatment.
Experimental
Matched Iupac: … 5-[(2-hydroxynaphthalen-1-yl)methyl]-6-phenyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidin-4-one …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Pexmetinib

Pexmetinib is under investigation in clinical trial NCT04074967 (Study of ARRY-614 Plus Either Nivolumab or Ipilimumab).
Investigational
Matched Iupac: … 3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-[(5-fluoro-2-{[1-(2-hydroxyethyl)-1H-indazol-5- …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Beclamide

Beclamide (N-benzyl-B-chloropropionamide) is a no longer used drug that possesses anticonvulsant and sedative activity. It was studied in the 1950s for generalised tonic-clonic seizures but was not effective for absence seizures.
Experimental

Vatalanib

Vatalanib (PTK787/ZK-222584) is a new oral antiangiogenic molecule that inhibits all known vascular endothelial growth factor receptors. Vatalanib is under investigation for the treatment of solid tumors.
Investigational
Matched Iupac: … N-(4-chlorophenyl)-4-[(pyridin-4-yl)methyl]phthalazin-1-amine …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Cloperastine

Cloperastine is a cough suppressant that acts on the central nervous system.
Experimental
Matched Iupac: … 1-{2-[(4-chlorophenyl)(phenyl)methoxy]ethyl}piperidine …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Dasolampanel etibutil

Dasolampanel etibutil has been used in trials studying the treatment of Diabetic Neuropathy, Painful.
Investigational
Matched Categories: … Heterocyclic Compounds, 1-Ring …

AZD-9164

AZD9164 has been used in trials studying the basic science and treatment of Chronic Obstructive Pulmonary Disease.
Investigational
Matched Iupac: … (3R)-1-[2-(4-fluorophenyl)ethyl]-3-{[(2S)-2-phenyl-2-(piperidin-1-yl)propanoyl]oxy}-1-azabicyclo[2.2.2 ... ]octan-1-ium …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Cinepazide

Cinepazide has been used in trials studying the treatment of Ischemic Stroke.
Investigational
Matched Iupac: … (2E)-1-{4-[2-oxo-2-(pyrrolidin-1-yl)ethyl]piperazin-1-yl}-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one …
Matched Salts cas: … 26328-04-1 …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Apitolisib

Apitolisib has been used in trials studying the treatment of Solid Cancers, Breast Cancer, Prostate Cancer, Renal Cell Carcinoma, and Endometrial Carcinoma, among others.
Investigational
Matched Iupac: … (2S)-1-(4-{[2-(2-aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl}piperazin ... -1-yl)-2-hydroxypropan-1-one …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

LY-2584702

LY2584702 has been used in trials studying the treatment of Cancer, Advanced Cancer, Renal Cell Carcinoma, Metastases, Neoplasm, and Neuroendocrine Tumors, among others.
Investigational
Matched Iupac: … 4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl}-1-{1H-pyrazolo[3,4-d]pyrimidin-4 …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Displaying drugs 10726 - 10750 of 12998 in total