Displaying drugs 11001 - 11025 of 12071 in total
Ertiprotafib
Ertiprotafib belongs to a novel class of insulin sensitizers developed for treatment of type 2 diabetes. In insulin-resistant rodent models, ertiprotafib and a close analog lowered both fasting blood glucose and insulin levels and improved glycemic excursion during an oral glucose tolerance test.
Investigational
Matched Description: … Ertiprotafib belongs to a novel class of insulin sensitizers developed for treatment of type 2 diabetes ... In insulin-resistant rodent models, ertiprotafib and a close analog lowered both fasting blood glucose …
Gemogenovatucel-T
Gemogenovatucel-T is a bi-shRNA furin/Granulocyte Macrophage Colony Stimulating Factor (GMCSF) Augmented autologous tumour cell vaccine. Furin is a convertase involved in the activation of TGFβ-1 and TGFβ-2. Gemogenovatucel-T is being investigated in the treatment of various cancers.
Investigational
Matched Description: … Furin is a convertase involved in the activation of TGFβ-1 and TGFβ-2. ... Gemogenovatucel-T is a bi-shRNA furin/Granulocyte Macrophage Colony Stimulating Factor (GMCSF) Augmented …
EP-2104R
EP-2104R is an imaging pharmaceutical under development for the detection of blood clots. It is the first targeted high-resolution technique designed to visualize blood clots directly. It is being developed by EPIX Pharmaceuticals, Inc.
Investigational
PH94B
PH94B is being developed by Pherin Pharmaceuticals, Inc. for the treatment of social phobias (generalized anxiety disorder). It is a member of a new family of pharmaceutical compounds called vomeropherins.
Investigational
Matched Description: … It is a member of a new family of pharmaceutical compounds called vomeropherins. …
Nequinate
Nequinate is an antiprotozoan used as a coccidiostat for poultry and rabbits. Nequinate belongs to the family of Hydroquinolones. These are compounds containing an hydrogenated quinoline bearing a ketone group.
Vet approved
Matched Description: … Nequinate is an antiprotozoan used as a coccidiostat for poultry and rabbits. ... These are compounds containing an hydrogenated quinoline bearing a ketone group. …
Mitoquinone
Mitoquinone is based on a novel technology, targeted lipophilic cations, that transport and concentrate antioxidants into the mitochondria -- organelles inside cells that provide energy for life processes -- where they accumulate up to a thousand fold. In 2004, a genomic study of hereditary early-onset Parkinson's disease demonstrated a direct...
Investigational
Matched Description: … In 2004, a genomic study of hereditary early-onset Parkinson's disease demonstrated a direct molecular ... Mitoquinone is based on a novel technology, targeted lipophilic cations, that transport and concentrate ... mitochondria -- organelles inside cells that provide energy for life processes -- where they accumulate up to a …
Garenoxacin
Garenoxacin, a quinolone antibiotic, is being investigated for the treatment of gram-positive and gram-negative bacterial infections.
Investigational
Matched Description: … Garenoxacin, a quinolone antibiotic, is being investigated for the treatment of gram-positive and gram-negative …
Chlorproguanil
Chlorproguanil has been used in trials studying the treatment of MALARIA. It is a dichloro-derivative of chloroguanide.
Investigational
Matched Description: … It is a dichloro-derivative of chloroguanide. …
Hispidulin
Hispidulin (4',5,7-trihydroxy-6-methoxyflavone) is a potent benzodiazepine (BZD) receptor ligand with positive allosteric properties .
Experimental
Matched Description: … Hispidulin (4',5,7-trihydroxy-6-methoxyflavone) is a potent benzodiazepine (BZD) receptor ligand with …
TOL2
TOL2 is a modified form of the acetylcholine receptor being investigated for the treatment of myasthenia gravis.
Investigational
Matched Description: … TOL2 is a modified form of the acetylcholine receptor being investigated for the treatment of myasthenia …
INT41
INT41 (also known as rAAV6-INT41) is a recombinant adeno-associated virus vector containing DNA encoding INT41 intrabody.
Investigational
Matched Description: … INT41 (also known as rAAV6-INT41) is a recombinant adeno-associated virus vector containing DNA encoding …
GMI-1359
GMI-1359 is a small molecule, glycomimetic compound with dual inhibitory activity against E-selectin and CXCR4.
Investigational
Matched Description: … GMI-1359 is a small molecule, glycomimetic compound with dual inhibitory activity against E-selectin …
MRT5005
MRT5005 is a human cystic fibrosis transmembrane conductance regulator (hCFTR) messenger RNA (mRNA) complexed with branched polyethyleneimine (bPEI).
Investigational
Matched Description: … MRT5005 is a human cystic fibrosis transmembrane conductance regulator (hCFTR) messenger RNA (mRNA) complexed …
C134
C134 is a genetically engineered oncolytic herpes simplex virus expressing human cytomegalovirus (HCMV) internal repeat short 1 (IRS1).
Investigational
Matched Description: … C134 is a genetically engineered oncolytic herpes simplex virus expressing human cytomegalovirus (HCMV …
SLN500
SLN500 is a synthetic double-strand small interfering ribonucleic acid (siRNA) oligonucleotide drug directed against C3 messenger RNA
Investigational
Matched Description: … SLN500 is a synthetic double-strand small interfering ribonucleic acid (siRNA) oligonucleotide drug directed …
S-Hydroxycysteine
S-hydroxycysteine is a solid. This compound belongs to the alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof. It targets the proteins subtilisin BPN', glutathione S-transferase A1,...
Experimental
Matched Description: … S-hydroxycysteine is a solid. This compound belongs to the alpha amino acids and derivatives. ... group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a …
Posizolid
Posizolid (AZD2563) is an oxazolidinone antibiotic. In July 2002, after completion of phase I trials in December 2001, AstraZeneca announced that they were no longer pursuing the development of Posizolid, presumably due to negative trial results (though no results were reported).
Investigational
CYP-001
CYP-001 is a mesenchymoangioblast (MCA)-derived mesenchymal stem cell (MSC) therapy that originates from the mesoderm. When activated with fibroblast growth factor-2 (FGF-2), MCAs create colonies with specific phenotypes. These cells are then able to differentiate into bone, cartilage, and adipose tissue.
The MCA-derived MSCs can be obtained from induced pluripotent...
Investigational
Matched Description: … These cells have advantage over other MSCs because a large amount can be obtained from a single healthy ... CYP-001 is a mesenchymoangioblast (MCA)-derived mesenchymal stem cell (MSC) therapy that originates from …
MK-0731
MK-0731 is a kinesin spindle protein inhibitor and antineoplastic agent.
Experimental
Matched Description: … MK-0731 is a kinesin spindle protein inhibitor and antineoplastic agent. …
CA-170
CA-170 is a selective, small molecule inhibitor of PD-L1.
Investigational
Matched Description: … CA-170 is a selective, small molecule inhibitor of PD-L1. …
LAVA-051
LAVA-051 is a humanized Vγ9Vδ2-T cell-engaging bispecific antibody.
Investigational
Matched Description: … LAVA-051 is a humanized Vγ9Vδ2-T cell-engaging bispecific antibody. …
TMV-083
TMV-083 is an attenuated live virus COVID-19 vaccine candidate which employs the measles vaccine as a vector . It expresses a spike protein antigen from SARS-CoV-2 .
Investigational
Matched Description: … It expresses a spike protein antigen from SARS-CoV-2[L30433]. ... TMV-083 is an attenuated live virus COVID-19 vaccine candidate which employs the measles vaccine as a …
Pozanicline
ABT-089 is a neuronal nicotinic acetylcholine receptor agonist that may have therapeutic utility for the treatment of several neurological disorders including Alzheimer, Attention Deficit Hyperactivity Disorder and Schizophrenia/Schizoaffective disorders. In radioligand binding studies, ABT-089 has shown selectivity toward the alpha4beta2 nAChR subtype as compared to the alpha7 and alpha1beta1deltagamma nAChR...
Investigational
Matched Description: … ABT-089 is a neuronal nicotinic acetylcholine receptor agonist that may have therapeutic utility for …
CG0070
CG0070 is investigated in clinical trials for treating bladder cancer. CG0070 is a solid. CG0070 can potentially destroy cancer cells by two different mechanisms: direct cell killing by the virus and immune-mediated cell killing stimulated by GM-CSF. CG0070, an oncolytic virus therapy with specificity for multiple cancers, has been evaluated...
Investigational
Matched Description: … CG0070 is a solid. …
Repinotan
Repinotan is a high-affinity, selective, full agonist of the 5HT1A-receptor subtype with neuroprotective properties.
Investigational
Matched Description: … Repinotan is a high-affinity, selective, full agonist of the 5HT1A-receptor subtype with neuroprotective …
Displaying drugs 11001 - 11025 of 12071 in total