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Displaying drugs 1176 - 1200 of 1781 in total
Investigational
Selective inhibitor of SIRT1 that does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC50 values are 98, 19600, 48700, > 100000 and > 100000 nM for SIRT1, SIRT2, SIRT3, HDAC and NADase respectively). Enhances p53 acetylation in response to DNA damaging agents.
Experimental
Experimental
Investigational
XR5944 is a DNA bis-intercalating anticancer drug. It has both intercalating and antineoplastic activities.
Investigational
Matched Iupac: … 9-methyl-N-(2-{[2-({2-[(9-methylphenazin-1-yl)formamido]ethyl}amino)ethyl]amino}ethyl)phenazine-1-carboxamide …
Experimental
Matched Iupac: … (9Z)-octadec-9-en-1-amine hydrofluoride …
Investigational
Experimental
Matched Iupac: … 4-(9H-carbazol-9-yl)butanoic acid …
Investigational
Matched Iupac: … (9Z)-N-(2-hydroxyethyl)octadec-9-enamide …
Irosustat has been investigated for the treatment of Metastatic Breast Cancer and Locally Advanced Breast Cancer.
Investigational
A macrocyclic peptide (BMS-986189) with activity in binding and functional assays comparable to a PD-L1 antibody.
Investigational
GDC-0084 is under investigation in clinical trial NCT03696355 (Study of GDC-0084 in Pediatric Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma or Diffuse Midline Gliomas).
Investigational
Experimental
Matched Iupac: … 7-ethoxy-9-imino-9,10-dihydroacridin-3-amine …
Matched Salts cas: … 6402-23-9
Experimental
Matched Iupac: … -9-ylium ... (6S)-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-hydroxy-6,7-dihydro-3H-9lambda5-purin …
Investigational
Matched Iupac: … 2-{4-[(9R)-9-hydroxy-2-(3-hydroxy-3-methylbutoxy)-9-(trifluoromethyl)-9H-fluoren-4-yl]-1H-pyrazol-1-yl …
Investigational
Ziltivekimab is under investigation in clinical trial NCT06200207 (A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation).
Investigational
First-in-class potent and selective inhibitor of the BRD4 signaling pathway.
Investigational
Matched Iupac: … chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9- …
Displaying drugs 1176 - 1200 of 1781 in total