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Displaying drugs 1476 - 1500 of 1920 in total

Riociguat

Riociguat is a soluble guanylate cyclase (sGC) agonist approved in the USA, Europe and several other regions for patients with group I PAH (pulmonary arterial hypertension) in WHO FC II or III; and for the treatment of patients with inoperable CTEPH (chronic thromboembolic pulmonary hypertension), or persistent/recurrent PH (pulmonary hypertension)...
Approved
Matched Description: … regions for patients with group I PAH (pulmonary arterial hypertension) in WHO FC II or III; and for ... Riociguat is a soluble guanylate cyclase (sGC) agonist approved in the USA, Europe and several other ... hypertension), or persistent/recurrent PH (pulmonary hypertension) after pulmonary endarterectomy in WHO …
Matched Products: … Adempas 0.5mg film-coated tablet ... Adempas 1.5mg film-coated tablet ... Adempas 1mg film-coated tablet …

Zinlirvimab

Zinlirvimab is under investigation in clinical trial NCT03707977 (Dual Bnab Treatment in Children).
Investigational
Matched Synonyms: … Anti-hiv-1 human monoclonal antibody targeting v3 glycan supersite on the hiv-1 envelope protein (10- …

Otilonium

Experimental
Investigational
Matched Mixtures name: … SIMFLAT 40MG/80 MG FİLM KAPLI TABLET, 90 ADET ... DOLOSPAS 40 MG/80 MG FİLM KAPLI TABLET, 90 ADET ... SIMFLAT 40MG/80 MG FİLM KAPLI TABLET, 30 ADET …
Matched Categories: … Calcium-Regulating Hormones and Agents ... Alimentary Tract and Metabolism ... otilonium bromide and psycholeptics ... Calcium Channel Blockers …
Matched Products: … EKSPAZ 40 MG FILM TABLET, 60 ADET ... EKSPAZ 40 MG FILM TABLET, 90 ADET ... PENSOTIL 40 MG FILM TABLET,90 ADET …

Pinaverium

Pinaverium is a spasmolytic agent used for functional gastrointestinal disorders. It is a quaternary ammonium compound that acts as an atypical calcium antagonist to restore normal bowel function. It is shown to relieve GI spasm and pain, transit disturbances and other symptoms related to motility disorders and may be considered...
Approved
Matched Description: … It is shown to relieve GI spasm and pain, transit disturbances and other symptoms related to motility ... disorders [A19697] and may be considered as effective first-lline therapy for patients with irritable ... It is a quaternary ammonium compound that acts as an atypical calcium antagonist to restore normal bowel …
Matched Categories: … Calcium-Regulating Hormones and Agents ... Alimentary Tract and Metabolism ... Calcium Channel Blockers …
Matched Products: … DICETEL 100MG FILM-COATED TABLET ... Dicetel 50mg Film-Coated Tablet ... PİNASPAZ 50 MG FİLM KAPLI TABLET, 40 ADET …

Pecan

Pecan allergenic extract is used in allergenic testing.
Approved
Matched Synonyms: … Carya illinoinensis seed …

Asunercept

Asunercept is under investigation in clinical trial NCT02853565 (A Study of CAN008 for Newly Diagnosed Glioblastoma Multiforme).
Investigational
Matched Synonyms: … FAS ANTIGEN (HUMAN EXTRACELLULAR DOMAIN FRAGMENT) FUSION PROTEIN WITH IMMUNOGLOBULIN G1 (HUMAN FC FRAGMENT …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Proteins ... Blood Proteins ... Membrane Proteins ... Recombinant Proteins …

Anti-CD4 CAR T-cell therapy

Investigational
Matched Synonyms: … chimeric antigen receptor directed against the target protein CD4 lentivirally transfected T cells …

Afatinib

Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label]. For oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal growth factor receptor (EGFR) mutations...
Approved
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Protein Kinase Inhibitors …
Matched Products: … GIOTRIF 20MG FILM-COATED TABLETS ... GIOTRIF 40MG FILM-COATED TABLETS ... GIOTRIF 30MG FILM-COATED TABLETS …

Cabozantinib

Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced renal...
Approved
Investigational
Matched Description: … Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. ... a capsule formulation (Cabometyx) was approved for the treatment of advanced renal cell carcinoma, and ... this same formulation gained additional approval in both the US and Canada in 2019 for the treatment …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Protein Kinase Inhibitors ... Receptor Protein-Tyrosine Kinases, antagonists & inhibitors …
Matched Products: … CABOMETYX FILM COATED TABLET 20MG ... CABOMETYX FILM COATED TABLET 40MG ... CABOMETYX FILM COATED TABLET 60MG …

Ticagrelor

Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y12 receptor antagonism. Unlike clopidogrel, ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU, . Ticagrelor was...
Approved
Matched Description: … [A2903] It is marketed by Astra Zeneca as Brilinta in the US[L14201] and Brilique or Possia in the EU …
Matched Categories: … Blood and Blood Forming Organs ... Nucleic Acids, Nucleotides, and Nucleosides …
Matched Products: … BRILINTA 90MG FILM-COATED TABLET ... ABRİLOR 60 MG FİLM KAPLI TABLET, 56 ADET ... ALMINDA (FILM-COATED TABLETS 90 MG) …

Idebenone

Idebenone is a synthetic analogue of ubiquinone (also known as Coenzyme Q10), a vital cell antioxidant and essential component of the Electron Transport Chain (ETC). It has been proposed that by interacting with the ETC, idebenone increases ATP production required for mitochondrial function, reduces free radicals, inhibits lipid peroxidation, and...
Approved
Investigational
Matched Description: … consequently protects the lipid membrane and mitochondria from oxidative damage [A19768]. ... Idebenone is a synthetic analogue of ubiquinone (also known as Coenzyme Q10), a vital cell antioxidant and ... production required for mitochondrial function, reduces free radicals, inhibits lipid peroxidation, and …
Matched Mixtures name: … BERMAXIN 90/10/5 MG FILM TABLET ,FILM TABLET, 28 ADET ... BERMAXIN 90/10/5 MG FILM TABLET ,FILM TABLET, 84 ADET ... EVERON 90/5 MG FILM KAPLI TABLET ,50 TABLET …
Matched Categories: … Enzymes and Coenzymes ... Psychostimulants, Agents Used for ADHD and Nootropics …
Matched Products: … IDEBEX 45 MG FILM KAPLI TABLET ,90 FILM KAPLI TABLET ... IDEBEX 90 MG FILM KAPLI TABLET ,90 FILM KAPLI TABLET ... IDEBEX 45 MG FILM KAPLI TABLET ,FILM KAPLI TABLET, 30 ADET …

Minnelide

Investigational
Matched Synonyms: … -one, 3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-8b-methyl-6a-(1-methylethyl)-6-((phosphonooxy)methoxy)-, sodium …
Matched Iupac: … tetraoxaheptacyclo[11.7.0.0^{2,4}.0^{2,9}.0^{5,7}.0^{9,11}.0^{14,18}]icos-14(18)-en-8-yl]oxy}methyl phosphate …

Dapoxetine

Dapoxetine is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation. In a phase II proof-of-concept study conducted by PPD, dapoxetine demonstrated a statistically significant increase in ejaculatory latency when compared to placebo. Alza submitted a NDA to the FDA for dapoxetine for the treatment of premature ejaculation...
Investigational
Matched Mixtures name: … DAPOXIL 30/50 MG FILM KAPLI TABLET,18 FILM KAPLI TABLET ... DAPOKSEL 30 MG/50 MG FILM TABLET ,3 FILM TABLET ... DAPOKSEL 30 MG/50 MG FILM TABLET ,6 FILM TABLET …
Matched Categories: … Genito Urinary System and Sex Hormones …
Matched Products: … DAPIGRA 30 MG FILM TABLET ,3 FILM TABLET ... DAPIGRA 30 MG FILM TABLET ,6 FILM TABLET ... DAPIGRA 60 MG FILM TABLET ,3 FILM TABLET …

Erdafitinib

In early April of 2019, the US FDA approved Janssen Pharmaceutical Companies' brand name Balversa (erdafitinib) as the first-ever fibroblast growth factor receptor (FGFR) kinase inhibitor indicated for patients with locally advanced or metastatic urothelial carcinoma, with susceptible FGFR3 or FGFR2 genetic alterations, that has progressed during or following platinum-containing...
Approved
Investigational
Matched Description: … for patients with metastatic bladder cancer, which demonstrates the development of more personalized and …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Protein Kinase Inhibitors ... Tumor Suppressor Proteins …
Matched Products: … BALVERSA FILM-COATED TABLETS 3MG ... BALVERSA FILM-COATED TABLETS 5MG ... BALVERSA FILM-COATED TABLETS 4MG …

Brivaracetam

Brivaracetam is a racetam derivative of levetiracetam used in the treatment of partial-onset seizures. Brivaracetam binds SV2A with 20 times higher affinity than levetiracetam . It is available under the brand name Briviact made by UCB. Briviact received FDA approval on February 19, 2016 .
Approved
Investigational
Matched Products: … BRIVIACT 10 MG FILM KAPLI TABLET ,14 FILM KAPLI TABLET ... BRIVIACT 10 MG FILM KAPLI TABLET ,168 FILM KAPLI TABLET ... BRIVIACT 10 MG FILM KAPLI TABLET ,56 FILM KAPLI TABLET …

Macitentan

Macitentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension (PAH). It was first approved by the FDA in 2013. Macitentan differs from its predecessor bosentan in part due to its lower risk of hepatotoxicity. A combination product (Opsynvi) comprising macitentan and tadalafil was approved...
Approved
Matched Description: … A combination product (Opsynvi) comprising macitentan and [tadalafil] was approved in Canada in October …
Matched Categories: … macitentan and tadalafil ... Sulfur Compounds …
Matched Products: … OPSUMIT FILM-COATED TABLET 10MG ... Opsumit 10mg Film-Coated Tablets ... Opsumit ® 10mg Film-Coated Tablets …

Selexipag

Selexipag was approved by the United States FDA on December 22, 2015 for the treatment of pulmonary arterial hypertension (PAH) to delay disease progression and reduce risk of hospitalization. PAH is a relatively rare disease with usually a poor prognosis requiring more treatment options to prolong long-term outcomes. Marketed by...
Approved
Matched Description: … December 22, 2015 for the treatment of pulmonary arterial hypertension (PAH) to delay disease progression and ... Marketed by Actelion Pharmaceuticals under brand name Uptravi, selexipag and its active metabolite, ACT ... act as agonists of the prostacyclin receptor to increase vasodilation in the pulmonary circulation and …
Matched Categories: … Blood and Blood Forming Organs …
Matched Products: … UPTRAVI FILM-COATED TABLET 200MCG ... UPTRAVI FILM-COATED TABLETS 400MCG ... UPTRAVI FILM-COATED TABLETS 600MCG …

Maraviroc

Maraviroc (brand-named Selzentry, or Celsentri outside the U.S.) is a chemokine receptor antagonist drug developed by the drug company Pfizer that is designed to act against HIV by interfering with the interaction between HIV and CCR5. It was originally labelled as UK-427857 during development but was assigned the Maraviroc name...
Approved
Investigational
Matched Description: … company Pfizer that is designed to act against HIV by interfering with the interaction between HIV and …
Matched Categories: … Viral Fusion Protein Inhibitors …
Matched Products: … Celsentri Film-Coated Tablet 300mg ... Celsentri Film-Coated Tablet 150mg ... CELSENTRI 150 MG FILM KAPLI TABLET ,180 ADET …

Erlotinib

Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)...
Approved
Investigational
Matched Description: … EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and ... , which is a mutant form of tyrosine kinase JAK2 found in most patients with polycythemia vera (PV) and ... This finding introduces the potential use of erlotinib in the treatment of JAK2V617F-positive PV and …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Protein Kinase Inhibitors …
Matched Products: … TARCEVA FILM-COATED TABLET 25 MG ... TARCEVA FILM-COATED TABLET 100 MG ... TARCEVA FILM-COATED TABLET 150 MG …

2-(acetylamino)-2-deoxy-4-O-sulfo-alpha-D-galactopyranose

Experimental
Matched Name: … 2-(acetylamino)-2-deoxy-4-O-sulfo-alpha-D-galactopyranose …

Edoxaban

Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated...
Approved
Matched Description: … of protein factors needed to form blood clots. ... INR testing, and numerous drug-drug and drug-food interactions. ... atrial fibrillation (NVAF) and for the treatment of deep vein thrombosis (DVT) and pulmonary embolism …
Matched Categories: … Blood and Blood Forming Organs ... Sulfur Compounds ... Protease Inhibitors ... Serine Protease Inhibitors …
Matched Products: … LIXIANA FILM-COATED TABLET 30 MG ... LIXIANA FILM-COATED TABLET 60 MG ... LIXIANA FILM-COATED TABLET 15 MG …

Favipiravir

Discovered by Toyama Chemical Co., Ltd. in Japan, favipiravir is a modified pyrazine analog that was initially approved for therapeutic use in resistant cases of influenza.[A191688,A191721] The antiviral targets RNA-dependent RNA polymerase (RdRp) enzymes, which are necessary for the transcription and replication of viral genomes.[A191688,A191772,A191775] Not only does favipiravir inhibit...
Approved
Investigational
Matched Description: … antiviral targets RNA-dependent RNA polymerase (RdRp) enzymes, which are necessary for the transcription and ... [A191688,A191772,A191775] Not only does favipiravir inhibit replication of influenza A and B, but ... the drug has shown promise in the treatment of avian influenza, and may be an alternative option for …
Matched Products: … AVIGAN Film-Coated Tablets 200mg (Favipiravir) ... KOVİPİR 200 MG FİLM KAPLI TABLET, 40 ADET ... FAVİRA 200 MG FİLM KAPLI TABLET, 40 ADET …

Escitalopram

Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic citalopram. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible for the vast majority of citalopram’s clinical activity, with...
Approved
Matched Description: … Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram ... [A185420] It is used to restore serotonergic function in the treatment of depression and anxiety. ... L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and …
Matched Products: … ANZYL 10 MG FILM TABLET ,56 FILM TABLET ... ANZYL 20 MG FILM TABLET ,56 FILM TABLET ... ANZYL 5 MG FILM TABLET ,FILM TABLET, 28 ADET …

Dornase alfa

Dornase alfa is a biosynthetic form of human deoxyribunuclease I (DNase I) enzyme. It is produced in genetically modified Chinese hamster ovary (CHO) cells using recombinant DNA technology. The 260-amino acid sequence of dornase alfa is identical to the endogenous human enzyme. Dornase alfa cleaves extracellular DNA to 5´-phosphodinucleotide and...
Approved
Matched Synonyms: … Deoxyribonuclease (human clone 18-1 protein moiety) …
Matched Description: … Dornase alfa cleaves extracellular DNA to 5´-phosphodinucleotide and 5´-phosphooligonucleotide end products ... Enzymatic breakdown of this extracellular DNA appears to reduce sputum viscosity and viscoelasticity. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Cough and Cold Preparations ... Enzymes and Coenzymes ... Proteins …

COVID-19 Nucleocapsid-GM-CSF Protein Lactated Ringer's Injection

As of July 2020, Medicine Invention Design, Inc. is sponsoring a small, controlled clinical trial for the COVID-19 AP TP Vaccine for ‘proof of concept.’ The vaccine utilizes granulocyte macrophage-colony stimulating factor (GM-CSF), a cytokine known to enhance vaccine efficacy through prolongation of humoral and cell immunity.
Investigational
Matched Synonyms: … COVID-19 Therapeutic Vaccine - Nucleocapsid-GM-CSF Protein Lactated Ringer's Injection …
Matched Name: … COVID-19 Nucleocapsid-GM-CSF Protein Lactated Ringer's Injection …
Matched Description: … stimulating factor (GM-CSF), a cytokine known to enhance vaccine efficacy through prolongation of humoral and …
Displaying drugs 1476 - 1500 of 1920 in total