Otilonium

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Otilonium
Accession Number
DB13500
Description
Not Available
Type
Small Molecule
Groups
Experimental, Investigational
Structure
Thumb
Weight
Average: 483.672
Monoisotopic: 483.321734293
Chemical Formula
C29H43N2O4
Synonyms
Not Available

Pharmacology

Indication
Not Available
Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
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Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
Learn about our commercial Adverse Effects data.
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbametapirThe serum concentration of Otilonium can be increased when it is combined with Abametapir.
AcarboseThe risk or severity of hypoglycemia can be increased when Otilonium is combined with Acarbose.
AcebutololThe risk or severity of bradycardia can be increased when Acebutolol is combined with Otilonium.
AceclofenacThe risk or severity of hyperkalemia can be increased when Aceclofenac is combined with Otilonium.
AcemetacinThe risk or severity of hyperkalemia can be increased when Otilonium is combined with Acemetacin.
AcetazolamideAcetazolamide may increase the central nervous system depressant (CNS depressant) activities of Otilonium.
AcetohexamideThe risk or severity of hypoglycemia can be increased when Otilonium is combined with Acetohexamide.
AcetophenazineAcetophenazine may increase the central nervous system depressant (CNS depressant) activities of Otilonium.
AcetyldigitoxinOtilonium may increase the arrhythmogenic activities of Acetyldigitoxin.
Acetylsalicylic acidThe risk or severity of hyperkalemia can be increased when Acetylsalicylic acid is combined with Otilonium.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

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  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

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  • Action
    Action

    An effect category for each drug interaction. Know how this interaction affects the subject drug.

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Food Interactions
Not Available

Products

Product Ingredients
IngredientUNIICASInChI Key
Otilonium bromide21HN3N72PV26095-59-0VWZPIJGXYWHBOW-UHFFFAOYSA-N

Categories

ATC Codes
A03CA04 — Otilonium bromide and psycholepticsA03AB06 — Otilonium bromide
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as benzanilides. These are aromatic compounds containing an anilide group in which the carboxamide group is substituted with a benzene ring. They have the general structure RNC(=O)R', where R,R'= benzene.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Anilides
Direct Parent
Benzanilides
Alternative Parents
Benzoic acid esters / Benzamides / Benzoyl derivatives / Phenol ethers / Phenoxy compounds / Alkyl aryl ethers / Tetraalkylammonium salts / Carboxylic acid esters / Secondary carboxylic acid amides / Monocarboxylic acids and derivatives
show 6 more
Substituents
Alkyl aryl ether / Amine / Aromatic homomonocyclic compound / Benzamide / Benzanilide / Benzoate ester / Benzoic acid or derivatives / Benzoyl / Carboxamide group / Carboxylic acid derivative
show 17 more
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
Not Available

Chemical Identifiers

UNII
6330179ARU
CAS number
105360-89-2
InChI Key
NQHNLNLJPDMBFN-UHFFFAOYSA-O
InChI
InChI=1S/C29H42N2O4/c1-5-8-9-10-11-14-22-34-27-16-13-12-15-26(27)28(32)30-25-19-17-24(18-20-25)29(33)35-23-21-31(4,6-2)7-3/h12-13,15-20H,5-11,14,21-23H2,1-4H3/p+1
IUPAC Name
diethyl(methyl)(2-{4-[2-(octyloxy)benzamido]benzoyloxy}ethyl)azanium
SMILES
CCCCCCCCOC1=CC=CC=C1C(=O)NC1=CC=C(C=C1)C(=O)OCC[N+](C)(CC)CC

References

General References
Not Available
ChemSpider
65078
RxNav
32311
ChEBI
135780
ChEMBL
CHEMBL1433361
ZINC
ZINC000008214636
Wikipedia
Otilonium

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedDiagnosticGastroscopy1
4RecruitingTreatmentIrritable Bowel Syndrome (IBS)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Tablet, coatedOral40 mg
Tablet40 mg
Tablet, film coated40 mg
Tablet, film coatedOral40 mg
Tablet, coated40 mg
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility2.42e-05 mg/mLALOGPS
logP2.92ALOGPS
logP2.58ChemAxon
logS-7.3ALOGPS
pKa (Strongest Acidic)12.75ChemAxon
pKa (Strongest Basic)-3.9ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area64.63 Å2ChemAxon
Rotatable Bond Count17ChemAxon
Refractivity155.79 m3·mol-1ChemAxon
Polarizability58.63 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Enzymes

Kind
Protein
Organism
Humans
Pharmacological action
No
Actions
Substrate
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Uesawa Y, Takeuchi T, Mohri K: Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. [PubMed:22039822]

Drug created on June 23, 2017 14:43 / Updated on June 12, 2020 10:53

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