Otilonium

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Otilonium is a spasmolytic medication used to treat irritable bowel syndrome (IBS).

Generic Name
Otilonium
DrugBank Accession Number
DB13500
Background

Not Available

Type
Small Molecule
Groups
Experimental, Investigational
Structure
Thumb
Weight
Average: 483.672
Monoisotopic: 483.321734293
Chemical Formula
C29H43N2O4
Synonyms
Not Available

Pharmacology

Indication

Not Available

Pharmacology
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Associated Conditions
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
1,2-Benzodiazepine1,2-Benzodiazepine may increase the central nervous system depressant (CNS depressant) activities of Otilonium.
AbametapirThe serum concentration of Otilonium can be increased when it is combined with Abametapir.
AbirateroneThe metabolism of Otilonium can be decreased when combined with Abiraterone.
AcarboseThe risk or severity of hypoglycemia can be increased when Otilonium is combined with Acarbose.
AcebutololAcebutolol may increase the arrhythmogenic activities of Otilonium.
AceclofenacThe risk or severity of hyperkalemia can be increased when Aceclofenac is combined with Otilonium.
AcemetacinThe risk or severity of hyperkalemia can be increased when Otilonium is combined with Acemetacin.
AcetazolamideAcetazolamide may increase the central nervous system depressant (CNS depressant) activities of Otilonium.
AcetohexamideThe risk or severity of hypoglycemia can be increased when Otilonium is combined with Acetohexamide.
AcetophenazineAcetophenazine may increase the central nervous system depressant (CNS depressant) activities of Otilonium.
Interactions
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Food Interactions
Not Available

Products

Products2
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Product Ingredients
IngredientUNIICASInChI Key
Otilonium bromide21HN3N72PV26095-59-0VWZPIJGXYWHBOW-UHFFFAOYSA-N
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
DOLOSPAS FILM TABLET ,30 ADETOtilonium bromide (40 mg) + Simethicone (80 mg)TabletTRIPHARMA İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
DOLOSPAS FILM TABLET ,90 ADETOtilonium bromide (40 mg) + Simethicone (80 mg)TabletTRIPHARMA İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
PİNİX 40 MG/80 MG FİLM KAPLI TABLET (SPANOL), 30 TABLETOtilonium bromide (40 mg) + Simethicone (80 mg)Tablet, coatedOralSANTA FARMA İLAÇ SAN. A.Ş.2020-08-14Not applicableTurkey flag
SIMFLAT 40MG/80 MG FİLM TABLET, 30 ADETOtilonium bromide (40 mg) + Simethicone (80 mg)Tablet, film coatedABDİ İBRAHİM İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
SIMFLAT 40MG/80 MG FİLM TABLET, 90 ADETOtilonium bromide (40 mg) + Simethicone (80 mg)Tablet, film coatedABDİ İBRAHİM İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag

Categories

ATC Codes
A03CA04 — Otilonium bromide and psycholepticsA03AB06 — Otilonium bromide
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as benzanilides. These are aromatic compounds containing an anilide group in which the carboxamide group is substituted with a benzene ring. They have the general structure RNC(=O)R', where R,R'= benzene.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Anilides
Direct Parent
Benzanilides
Alternative Parents
Benzoic acid esters / Benzamides / Benzoyl derivatives / Phenol ethers / Phenoxy compounds / Alkyl aryl ethers / Tetraalkylammonium salts / Carboxylic acid esters / Secondary carboxylic acid amides / Monocarboxylic acids and derivatives
show 6 more
Substituents
Alkyl aryl ether / Amine / Aromatic homomonocyclic compound / Benzamide / Benzanilide / Benzoate ester / Benzoic acid or derivatives / Benzoyl / Carboxamide group / Carboxylic acid derivative
show 17 more
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
6330179ARU
CAS number
105360-89-2
InChI Key
NQHNLNLJPDMBFN-UHFFFAOYSA-O
InChI
InChI=1S/C29H42N2O4/c1-5-8-9-10-11-14-22-34-27-16-13-12-15-26(27)28(32)30-25-19-17-24(18-20-25)29(33)35-23-21-31(4,6-2)7-3/h12-13,15-20H,5-11,14,21-23H2,1-4H3/p+1
IUPAC Name
diethyl(methyl)(2-{4-[2-(octyloxy)benzamido]benzoyloxy}ethyl)azanium
SMILES
CCCCCCCCOC1=CC=CC=C1C(=O)NC1=CC=C(C=C1)C(=O)OCC[N+](C)(CC)CC

References

General References
  1. Evangelista S, Traini C, Vannucchi MG: Otilonium Bromide: A Drug with a Complex Mechanism of Action. Curr Pharm Des. 2018;24(16):1772-1779. doi: 10.2174/1381612824666180507122935. [Article]
  2. Evangelista S: Otilonium bromide: a selective spasmolytic for the gastrointestinal tract. J Int Med Res. 1999 Sep-Oct;27(5):207-22. doi: 10.1177/030006059902700501. [Article]
  3. TITCK Product Information: Motigen (otilonium bromide) film-coated tablets for oral use [Link]
  4. TITCK Product Information: Pinix (otilonium bromide/simethicone) film-coated tablets for oral use [Link]
ChemSpider
65078
RxNav
32311
ChEBI
135780
ChEMBL
CHEMBL1433361
ZINC
ZINC000008214636
Wikipedia
Otilonium_bromide

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedDiagnosticGastroscopy1
4CompletedTreatmentIrritable Bowel Syndrome (IBS)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Tablet, coatedOral40 mg
Tablet
Tablet, film coatedOral40 mg
Tablet, film coatedOral
Tablet, coatedOral40 g
Tablet, film coated
TabletOral40 mg
Powder, for solution
Suppository
Tablet, coatedOral
Tablet, coatedOral
Powder
TabletOral
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility2.42e-05 mg/mLALOGPS
logP2.92ALOGPS
logP2.58ChemAxon
logS-7.3ALOGPS
pKa (Strongest Acidic)12.75ChemAxon
pKa (Strongest Basic)-3.9ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area64.63 Å2ChemAxon
Rotatable Bond Count17ChemAxon
Refractivity155.79 m3·mol-1ChemAxon
Polarizability58.63 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Enzymes

Kind
Protein
Organism
Humans
Pharmacological action
No
Actions
Substrate
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Uesawa Y, Takeuchi T, Mohri K: Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. [Article]

Drug created on June 23, 2017 20:43 / Updated on May 14, 2021 01:06