Displaying drugs 1651 - 1675 of 1990 in total
humanized SMART Anti-IL-12 Antibody
The humanized anti-IL-12 antibody is an important addition to PDL's already strong pipeline of humanized antibodies being developed for the treatment of autoimmune diseases. SMART Anti-IL-12 Antibody was humanized at PDL from a murine anti-IL-12 antibody that was licensed, together with certain intellectual property related to anti-IL-12 therapy, from Hoffmann-La...
Investigational
Grapiprant
Grapiprant, also known as AT-001 and CJ-023, is a drug from the piprant class. These molecules were derived from acylsulfonamide and are characterized to be a novel series of para-N-acylaminomethylbenzoic acid known to be prostaglandin receptor antagonists. This type of molecules is currently in development for veterinary patients. This class...
Investigational
Vet approved
Matched Description: … Grapiprant, also known as AT-001 and CJ-023, is a drug from the piprant class. ... These molecules were derived from acylsulfonamide and are characterized to be a novel series of para-N-acylaminomethylbenzoic …
Tosatoxumab
Tosatoxumab is a fully-human monoclonal antibody (IgG1λ) targeting the Staphylococcus aureus alpha-toxin or the S. aureus alpha-hemolysin[A191829, L31568, L31573] and thereby preserving human immune cells by protecting against destruction of host cells mediated by the toxin.
Investigational
Matched Description: … or the S. aureus alpha-hemolysin[A191829, L31568, L31573] and thereby preserving human immune cells ... Tosatoxumab is a fully-human monoclonal antibody (IgG1λ) targeting the Staphylococcus aureus alpha-toxin …
Etrolizumab
Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is typified by a chronic gastrointestinal inflammatory microenvironment, driven in part by the excessive infiltration and retention of intestinal-homing lymphocytes.[A244564, A244569, A244579, A244584] A recent class of drugs designed to impair lymphocyte homing, so-called "anti-trafficking agents" (ATAs), have shown some...
Investigational
Matched Description: … include approved drugs such as [natalizumab] and [vedolizumab], which target integrins and impair their ... Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is typified by a ... chronic gastrointestinal inflammatory microenvironment, driven in part by the excessive infiltration and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
CCR5 mAb
CCR5 mAb is a fully human monoclonal antibody that specifically recognizes and binds the chemokine receptor CCR5, which is known to be a key facilitator of infection with human immunodeficiency virus (HIV-1). It was generated by HGS using the Abgenix XenoMouse technology.
Investigational
Matched Description: … CCR5 mAb is a fully human monoclonal antibody that specifically recognizes and binds the chemokine receptor ... CCR5, which is known to be a key facilitator of infection with human immunodeficiency virus (HIV-1). …
UX053
UX053 is an mRNA encoding the human glycogen debranching enzyme.
Investigational
Matched Description: … UX053 is an mRNA encoding the human glycogen debranching enzyme. …
Humanized monoclonal antibody Hu1B7
Investigational
HGS-TR2J
HGS-TR2J is a novel agonistic human monoclonal antibody to TRAIL Receptor 2, in patients with advanced solid malignancies. It is developed by Human Genome Sciences, Inc and is under Phase I of clinical trial.
Investigational
Matched Description: … It is developed by Human Genome Sciences, Inc and is under Phase I of clinical trial. ... HGS-TR2J is a novel agonistic human monoclonal antibody to TRAIL Receptor 2, in patients with advanced …
SIG-205
SIG-205 is a Cultured human retinal pigment epithelial cells (ARPE-19) genetically modified with a non-viral vector to express human native alpha-L-iduronidase enzyme (hIDUA), encapsulated within two-layer modified alginate spheres
Investigational
Matched Description: … SIG-205 is a Cultured human retinal pigment epithelial cells (ARPE-19) genetically modified with a non-viral ... vector to express human native alpha-L-iduronidase enzyme (hIDUA), encapsulated within two-layer modified …
TBX-1400
TBX-1400 consists of human donor hematopoietic stem and progenitor cells.
Investigational
Matched Description: … TBX-1400 consists of human donor hematopoietic stem and progenitor cells. …
BCX10013
BCX10013 is a small molecule inhibitor of human complement factor D.
Investigational
Matched Description: … BCX10013 is a small molecule inhibitor of human complement factor D. …
Eritoran
Eritoran is a structural analogue of the lipid A portion of lipopolysaccharide (LPS). It is being developed by Eisai Research Institute of Boston for the treatment of severe sepsis.
Investigational
Humanized monoclonal antibody Hu11E6
Investigational
Theralizumab
Theralizumab is a humanized anti-CD28 monoclonal antibody designed for treating autoimmune diseases and cancer. After the first human trial, it was withdrawn due to severe toxicity (likely due to lymphopenia and human cytokine release).[A216527,A216532]
Investigational
Matched Description: … After the first human trial, it was withdrawn due to severe toxicity (likely due to lymphopenia and human ... Theralizumab is a humanized anti-CD28 monoclonal antibody designed for treating autoimmune diseases and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
LYT-200
LYT-200 is a fully human IgG4 monoclonal antibody directed against galectin-9.
Investigational
Matched Description: … LYT-200 is a fully human IgG4 monoclonal antibody directed against galectin-9. …
HMI-204
HMI-204 is an adeno-associated virus serotype HSC15 expressing human arylsulfatase A
Investigational
Matched Description: … HMI-204 is an adeno-associated virus serotype HSC15 expressing human arylsulfatase A …
ASP-7317
ASP-7317 consists of human embryonic stem cell-derived retinal pigment epithelium cells.
Investigational
Matched Description: … ASP-7317 consists of human embryonic stem cell-derived retinal pigment epithelium cells. …
CP-122721
CP-122721, neurokinin 1 (NK1) antagonist is developed by Pfizer to treat depression, emesis, and inflammatory diseases including asthma and irritable bowel syndrome.
Investigational
Matched Description: … diseases including asthma and irritable bowel syndrome. ... CP-122721, neurokinin 1 (NK1) antagonist is developed by Pfizer to treat depression, emesis, and inflammatory …
TPCA-1
TPCA-1 is a selective inhibitor of human IκB kinase 2 (IKK-2).
Investigational
Matched Description: … TPCA-1 is a selective inhibitor of human IκB kinase 2 (IKK-2).[A253152] …
Mitazalimab
Mitazalimab is under investigation in clinical trial NCT02379741 (ADC-1013 First-in-Human Study).
Investigational
Matched Description: … Mitazalimab is under investigation in clinical trial NCT02379741 (ADC-1013 First-in-Human Study). …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Aplaviroc
A spiro-diketo-piperazine; a potent noncompetitive allosteric antagonist of the CCR5 receptor with concomitantly potent antiviral effects for HIV-1.
Investigational
AdPEDF
AdPEDF is under development for the treatment of wet age-related macular degeneration (AMD). It has been shown to rapidly elevate the intraocular AdPEDF protein levels in the eye, inhibit abnormal blood vessel growth, and cause abnormal blood vessels to regress while protecting the eye’s photoreceptors.
Investigational
Matched Description: … rapidly elevate the intraocular AdPEDF protein levels in the eye, inhibit abnormal blood vessel growth, and …
Trenonacog alfa
Human coagulation factor IX (EC 3.4.21.22, Christmas factor, plasma thromboplastin component), produced in CHO cells.
Investigational
Matched Description: … Human coagulation factor IX (EC 3.4.21.22, Christmas factor, plasma thromboplastin component), produced …
Matched Categories: … Enzymes and Coenzymes ... Amino Acids, Peptides, and Proteins …
Matched Categories: … Enzymes and Coenzymes ... Amino Acids, Peptides, and Proteins …
EXOB-001
EXOB-001 consists of extracellular vesicles derived from cultured human umbilical cord mesenchymal stromal cells.
Investigational
Matched Description: … EXOB-001 consists of extracellular vesicles derived from cultured human umbilical cord mesenchymal stromal …
Thyrotropin
Thyrotropin is under investigation in clinical trial NCT01348191 (Detection of Thyrotrophin Receptor in Human Myometrium).
Investigational
Matched Description: … Thyrotropin is under investigation in clinical trial NCT01348191 (Detection of Thyrotrophin Receptor in Human …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Displaying drugs 1651 - 1675 of 1990 in total